CN104906438A

CN104906438A - Medicine for treating acute myocarditis

Info

Publication number: CN104906438A
Application number: CN201510381334.2A
Authority: CN
Inventors: 车莉
Original assignee: Individual
Current assignee: Individual
Priority date: 2015-07-03
Filing date: 2015-07-03
Publication date: 2015-09-16

Abstract

The invention relates to a medicine for treating acute myocarditis. The medicine is prepared from raw herbal materials including, by weight, 12 parts of cyrtomium fortunei, 12 parts of schisandra, 10 parts of allium macrostemon, 15 parts of heteropanax fragrans, 12 parts of grey green boehmeria platyphylla, 13 parts of berchemia lineata, 13 parts of artemisia dubia and 12 parts of latouchea fokiensis. Clinical experiments prove that the acute myocarditis can be safely and effectively treated.

Description

A kind of medicine being used for the treatment of acute myocarditis

Technical field

The present invention relates to a kind of Chinese medicine, be specifically related to a kind of medicine being used for the treatment of acute myocarditis.

Background technology

Acute myocarditis is a kind of myocardial damage disease, often betides active stage of rheumatic fever or is secondary to some infectious disease as diphtheria, septicemia, pneumonia, scarlet fever and typhoid fever etc.The symptom of acute myocarditis and sign have respiratory tract or intestinal infection in a few days or 2 weeks before heart sympton occurs, can generate heat, swallow the symptoms such as pain, diarrhoea, erythra, then occur heart sympton with moderate.Cardinal symptom has fatigue and weak, inappetence, Nausea and vomiting, dyspnea, pale complexion, and heating, Annual wool yield can tell pareordia discomfort, cardiopalmus, dizziness, stomachache, myalgia.Check has apex the 1st hear sounds blunt more, can have gallop rhythm, tachycardias or excessively slow, or have arrhythmia, and can hear pericardium crunch because merging pericarditis, heart circle is normal or expand, and blood pressure drops, pulse pressure is low.

Myocarditis belongs to the category such as the traditional Chinese medical science " cardiopalmus ", " severe palpitation ", because ferritic is not enough, disease-resistant unable, feels again exopathogen, is defended involve to the heart by lung, the sad use of sad body, consumes the moon of feeling frustrated.Motive the moon is impaired, and fortune blood is unable, moistens and supports deficiency, or yin asthenia generating intrinsic heat, and bright liquid becomes the stasis of blood, and heart arteries and veins is unfavorable, and the heart is become homeless foster.Focus on eliminating evil going out in advance, and add righting, guard against the change of disease.Then supplementing QI and nourishing YIN righting is main subsequently, and need mend and not dry, grows and oiliness, should mend clearly and avoid high benefit, in case hold back heresy, and add the product of mind calming of invigorating blood circulation all the time.

Medical material present Research involved in the present invention is as follows:

Rhizoma Osmundae [the another name] pivot membrane inside the rush stalk, Luo, pass through joint, pass through canal, hundred, tiger volume, flat symbol, in passing through, pass through clock, pass through, canal is female, uncle celery, medicine canal, bronze bell, uncle duckweed, happy algae, careless Caput Circi cyanei, primary medicine, medicine algae, Herba Pteridis Multifidae, Herba pteridii latiusculi common vetch dish root, black dog ridge, cyrtomium fortunei, Herba potentillae fulgentis.[source] is mainly Dryopteridaceae plant dryopteris crassirhizoma, Athyriaceae plant lunathyrium acrostichoidesChing, ball Pteridiaceae plant Matteuccia strthiopteris, Osmundaceae plant osmund, the rhizome of Blechnaceae plant Blechnum orientale Linn., Brainea insignis, Rhizoma Osmundae etc.Spring, autumn excavate, petiole of pruning, fibrous root, and Ex-all earth, dries.[nature and flavor] are bitter, cool.[return through] enters liver, stomach warp.[function cures mainly] kills ascarid, silk ribbon, pinworm, heat clearing away, removing toxic substances, removing heat from blood, hemostasis.Control anemopyretic cold.Warm macule, spits blood, epistaxis, discharging fresh blood stool, dysentery, metrorrhagia, leukorrhagia, skin infection, hematuria, menorrhagia, and knife injury is hemorrhage, ascarid, rich worm, taeniasis, artificial abortion, postpartum hemorrhage.[usage and dosage] takes orally: decoct soup, 3 ~ 12g.[attention] yin asthenia generating intrinsic heat and Deficiency and coldness of spleen and stomach person unsuitable, anemia of pregnant woman is cautious use of.[extracts] " China's book on Chinese herbal medicine ".

Fructus Schisandrae Chinensis [another name] Wei, Chi Zhu, profound and, meeting and, five Fructus Armeniacae Mumes, Radix Schisandrae Bicoloris, FRUCTUS SCHISANDRAE from Liaoning of China.[source] this product is the dry mature fruit of magnoliaceae schisandra or schisandra chinensis.The former practises title " Radix Schisandrae Bicoloris ", and the latter practises title " Fructus Schisandrae Sphenantherae ".Pluck during fruit maturation in autumn, dry or dry after steaming, removing carpopodium and impurity.[nature and flavor] are sour, sweet, temperature.[return through] returns lung, the heart, kidney channel.[function cures mainly] restrains astringent or styptic treatment for spontaneous sweating, supplementing QI for promoting the production of body fluid, kidney calming.For chronic cough dyspnea due to deficiency, emission, enuresis frequent micturition, incessant chronic diarrhea, spontaneous perspiration, night sweat, Tianjin wound is thirsty, and deficient pulse of losing heart, interior-heat is quenched one's thirst, palpitation and insomnia.[usage and dosage] takes orally: decoct soup, 3 ~ 12g.Have pathogenic factor in the exterior outside [attention], inside have excess-heat, or cough from the beginning of, acute diseases such as cholera and sunstroke rash just originator avoid clothes.[extracts] " China's book on Chinese herbal medicine ".

Bulbus Allii Macrostemonis [another name] Chinese onion root, Allium chinense, major part colza, wild Bulbus Allii, little DUSUAN, Bulbus Allii schoenoprasi, residence Bulbus Allii, Bulbus Allii Macrostemonis head.The bulb that [source] is liliaceous plant Allium macrostemon or Chinese onion.The north is many in spring, and south is many gathers between the autumn in summer.Grub out, removing stem and leaf and fibrous root, cleaned, well-done with boiling water, dry or dry.This product must put dry place, damp-proof and moth-proof.[nature and flavor] are pungent, bitter, temperature.[return through] enters liver, lung, heart channel.[function cures mainly] regulates the flow of vital energy, and the chest stuffiness relieving activates yang, eliminating stagnation.Control the thorough back of the body of obstruction of qi in the chest and cardialgia, gastral cavity painful abdominal mass is not relaxed, and retches, heavy after dysentery, furuncle.[usage and dosage] takes orally: decoct soup, 6 ~ 15g.The careful clothes of [attention] deficiency of vital energy person.[extracts] " China's book on Chinese herbal medicine ".

Heavy curtain umbrella maple [another name] Radix seu Cortex Heteropanacis Fragrantis, slender acanthopanax lead to, sunshade is wooden.[source] is the tender stem of grass phragmites communis.Phytomorph is " Rhizoma Phragmitis " bar in detail.Araliaceae different ginseng platymiscium heavy curtain umbrella maple is used as medicine with root, bark.The whole year can adopt, and dries.[nature and flavor] are bitter, cool.[return through] enters the heart, lung.[function cures mainly] heat-clearing and toxic substances removing, promoting blood circulation and detumescence, pain relieving.For flu, heatstroke is had a headache; Carbuncle furuncle and phyma poison is controlled in external, lymphadenitis, fracture, burn and scald, bruise, venom.[usage and dosage] takes orally: decoct soup, 10 ~ 25g.[extracts] " China's book on Chinese herbal medicine ".

The herb that grayish green Herba Boehmeriae platyphllae [source] is the grayish green Herba Boehmeriae platyphllae of contrayerva.Gather and store: summer, autumn gather, using fresh herb or dry.[nature and flavor] micro-hardship; Property flat [return through] return lung, liver, kidney channel.[function cures mainly] removing toxic substances and promoting subsidence of swelling.Removing heat from blood removes and steams, lung heat clearing pathogenic fire reducing.For deficiency of YIN hectic fever, hectic fever due to YIN-deficiency night sweat, cough due to lung-heat, spitting of blood, epistaxis, interior-heat is quenched one's thirst.[usage and dosage] takes orally: decoct soup, 9 ~ 15g.[extracts] " China's book on Chinese herbal medicine ".

Radix berchemiae lineatae [another name] Canis familiaris L. foot profit, carry cloud grass, ratan or root that little Flos persicae, mouse grass, Ramulus et Folium Berchemiae Lineatae, mouse crow, molluscum contagiosum head, coal rattan [source] this product are Rhamnaceae plant iron gold filled and Herba Berchemiae leiocladae.It is the end of summer, just turning into autumn, before pregnant flower bud, extract young stem and leaf, removing impurity, chopping, using fresh herb or dry; Adopt root, using fresh herb or section are dried after autumn.[nature and flavor] are bitter; Micro-puckery; Flat.[return through] heart; Lung meridian.[function cures mainly] subduing swelling and detoxicating; Hemostatic analgesia; Expelling wind and removing dampness.Main carbuncle furunculosis; Cough spitting of blood; Digestive tract hemorrhage; Traumatic injury; Scald; Rheumatic ostalgia; Wind-fire cough due to lung-heat.[usage and dosage] takes orally: decoct soup, 15-30g; Fresh goods 30-60g.External: appropriate, smashes deposited.[extracts] " China's book on Chinese herbal medicine ".

Subdigitate wormwood herb [another name] wild Artemisia, tea floss, purple bar Artemisia, refer to that leaf Artemisia, water Artemisia, Radix Artemisia ordosicae, rice Artemisia [source] are feverfew subdigitate wormwood herb and the herb without hair subdigitate wormwood herb.Autumn gathers, and using fresh herb or binding are dried.[habitats distribution] is distributed in the ground such as the Inner Mongol, Gansu, Sichuan, Yunnan, Tibet.[nature and flavor] bitter in the mouth; Micro-pungent; Cool in nature.[function cures mainly] heat clearing away; Removing heat from blood; Removing toxic substances; Parasite killing.Main acute calenture; Cough due to lung-heat; Laryngopharynx swelling and pain; Epistaxis; Itching eruption due to wind-heat in blood; Know parasitosis.[usage and dosage] takes orally: decoct soup 9-15g; Or endure cream painting.[extracts] " China's book on Chinese herbal medicine ".

The herb that Radix limonii sinensis [another name] mother honker leaf, red shrimp toad leaf [source] are gentianaceae plant Radix limonii sinensis.Summer, autumn gather, and clean, dry.[nature and flavor] are bitter; Pungent; Cold in nature.[return through] lung; Liver; Large intestine channel.[function cures mainly] blood circulation promoting and blood stasis dispelling; Clearing and antitussive.Blood stasis mass in the abdomen in main abdomen; Epersalgia cough.[usage and dosage] takes orally: decoct soup, 10 ~ 15g.[extracts] " China's book on Chinese herbal medicine ".

Summary of the invention

The present invention aims to provide a kind of medicine being used for the treatment of acute myocarditis, by selecting suitable medical material and proportioning thereof, reaches the object of safe and effective healing acute myocarditis.

In order to achieve the above object, the present invention is by the following technical solutions:

A kind of medicine being used for the treatment of acute myocarditis, it is characterized in that, it is prepared from by the raw medicinal material of following weight proportion: Rhizoma Osmundae 12 parts, Fructus Schisandrae Chinensis 12 parts, Bulbus Allii Macrostemonis 10 parts, 15 parts, heavy curtain umbrella maple, grayish green Herba Boehmeriae platyphllae 12 parts, Radix berchemiae lineatae 13 parts, subdigitate wormwood herb 13 parts, Radix limonii sinensis 12 parts.

Below in conjunction with clinical laboratory data, beneficial effect of the present invention is described:

1, physical data

Outpatient service is collected and acute myocarditis patient 72 example of being in hospital altogether in inventor in October, 2012 ~ 2013 between year October, be divided into treatment group 36 example and matched group 36 example at random, treatment group man 14 example, and female 22,20 ~ 55 years old age, 21.5 years old mean age; Matched group man 15 example, female 21 example, 17 ~ 53 years old age, 31.4 years old mean age.2 groups of sexes, age and course of disease comparing difference not statistically significants, have comparability.

Diagnostic criteria

Diagnostic criteria according to the meeting of national acute myocarditis clinical speciality: (1) often betide active stage of rheumatic fever or be secondary to other infectious disease and chemicals poisoning etc.; (2) clinical manifestation such as had palpitation, tachypnea, uncomfortable in chest and chest pain; (3) health check-up can have increased heart rate, cardiac dilatation, decreased loudness of first sound, DG and each valve area audible and systolic murmur, and heart failure or cardiogenic shock then occur severe one; (4) can have during laboratory examination: 1. numeration of leukocyte can increase; 2. erythrocyte sedimentation rate is accelerated; 3. glutamic oxaloacetic transaminase, GOT, lactic acid dehydrogenase and creatine phosphokinase increase; (5) x-ray inspection can have cardiac dilatation, to expand as master left; (6) ECG Change can have various arrhythmia, and conduction is blocked and non-specific ST section is raised, the inversion of T ripple and QT interval prolongation etc.

2, test method

2.1 Therapeutic Method

The capsule that the oral the present invention for the treatment of group obtains according to specific embodiment 3, every day 3 times.One month course for the treatment of.

The oral amantadine of matched group, every day 200mg; Agate quinoline guanidine 0.1g, oral, every day 3 times.One month course for the treatment of.

3, criterion of therapeutical effect and therapeutic outcome

3.1 criterion of therapeutical effect

Effective: transference cures such as pain uncomfortable in chest is uncomfortable, have palpitation, breathe hard, weak or alleviate > 8O%;

Effective: symptom alleviates >50%;

Invalid: symptom alleviates < 5O%.

Electrocardiogram:

Effective: ST-T recovers normal, and arrhythmia reduces >80%;

Effective: ST-T improves, arrhythmia reduces >50%;

Invalid: ST-T does not take a turn for the better or arrhythmia reduces <50%.

3.2 therapeutic outcomes are in table 1 and table 2.

Table 1 liang group sign comparitive study

Group	n	Effective	Effectively	Invalid	Total effective rate (%)	Serious adverse reaction example
							Treatment group	36	20	15	1	97.2%	0
Matched group	36	14	18	4	88.89%	0

A table 2 liang group ECG curative effect compares

Group	n	Effective	Effectively	Invalid	Total effective rate (%)	Serious adverse reaction example
							Treatment group	36	21	11	4	88.9%	0
Matched group	36	15	9	12	66.7%	0

Visible, the medicine that the present invention obtains can safe and effective treatment acute myocarditis, has promotional value.

Detailed description of the invention

In order to understand better and implement the present invention, further illustrate the present invention below in conjunction with specific embodiment.

Embodiment 1

Take: Rhizoma Osmundae 12 grams, Fructus Schisandrae Chinensis 12 grams, Bulbus Allii Macrostemonis 10 grams, 15 grams, heavy curtain umbrella maple, grayish green Herba Boehmeriae platyphllae 12 grams, Radix berchemiae lineatae 13 grams, subdigitate wormwood herb 13 grams, Radix limonii sinensis 12 grams; Add 8 times of water gagings, decoct 1.5 hours, filter; Filtering residue adds 6 times of water gagings, decocts 1 hour, filters; Merging filtrate, is concentrated into 120 grams, must meet the decoct of adult normal's one day consumption.

Be used for the treatment of acute myocarditis.Oral, every bu Morning Afternoon Evening is taken for three times.

Embodiment 2

Take: Rhizoma Osmundae 12 grams, Fructus Schisandrae Chinensis 12 grams, Bulbus Allii Macrostemonis 10 grams, 15 grams, heavy curtain umbrella maple, grayish green Herba Boehmeriae platyphllae 12 grams, Radix berchemiae lineatae 13 grams, subdigitate wormwood herb 13 grams, Radix limonii sinensis 12 grams; Add 10 times of water gagings, decoct 2 hours, filter; Filtering residue adds 8 times of water gagings, decocts 1.5 hours, filters; Merging filtrate, concentrated, dry, packaging, must meet the powder of adult normal's one day consumption.

Embodiment 3

Take: Rhizoma Osmundae 12 grams, Fructus Schisandrae Chinensis 12 grams, Bulbus Allii Macrostemonis 10 grams, 15 grams, heavy curtain umbrella maple, grayish green Herba Boehmeriae platyphllae 12 grams, Radix berchemiae lineatae 13 grams, subdigitate wormwood herb 13 grams, Radix limonii sinensis 12 grams; Add 6 times of water gagings, decoct 3 times, each decoction 1 hour, merges decoction liquor, concentrated, dry, incapsulates shell, must meet the capsule of adult normal's one day consumption.

Claims

1. one kind is used for the treatment of the medicine of acute myocarditis, it is characterized in that, it is prepared from by the raw medicinal material of following weight proportion: Rhizoma Osmundae 12 parts, Fructus Schisandrae Chinensis 12 parts, Bulbus Allii Macrostemonis 10 parts, 15 parts, heavy curtain umbrella maple, grayish green Herba Boehmeriae platyphllae 12 parts, Radix berchemiae lineatae 13 parts, subdigitate wormwood herb 13 parts, Radix limonii sinensis 12 parts.