CN103690832A - Traditional Chinese medicinal composition for treating viral myocarditis - Google Patents

Abstract

The invention discloses a traditional Chinese medicine composition for treating viral myocarditis. The medicine is prepared from the following Chinese medicinal materials in parts by weight: 10-18 parts of Coptidis Rhizome, 20-30 parts of Melaleuca Pagoda, 20-30 parts of Scallops, and Schisandra 10-18 parts, 20-30 parts of bamboo leaves, 10-18 parts of perilla leaves, 25-40 parts of coix seed, 8-15 parts of Tribulus terrestris, 6-12 parts of roasted licorice, 10-18 parts of Tinglizi. The traditional Chinese medicine composition of the invention has remarkable clinical curative effect in treating primary viral myocarditis, not only can obviously improve symptoms, but also can reduce the levels of AST, CK, CK-MB, LDH and a-HBDB, regulate immunity and improve heart function.

Description

A kind of traditional Chinese medicine composition for treating viral myocarditis

technical field

The invention belongs to the technical field of traditional Chinese medicine, and in particular relates to a traditional Chinese medicine composition for treating viral myocarditis.

Background technique

Viral myocarditis can occur at any age, and it is more common in adolescents. The course of treatment is long and the condition is prone to recurrence. If the treatment is not timely, it can be chronic and even develop into cardiomyopathy, which seriously affects the health of children. In the early stage of viral myocarditis, the main manifestation is that the virus directly damages the myocardium, and in the later stage, the main manifestation is immune injury. The pathogenesis of viral myocarditis is not yet fully understood, but the direct lytic effect of the virus on myocardial cells and the autoimmune damage induced by the virus to myocardial tissue are important pathogenesis of viral myocarditis. In recent years, its incidence is on the rise, and there is no specific treatment. Western medicine treatment is mainly aimed at two aspects of primary infection and myocardial inflammation, but the curative effect of existing antiviral drugs on viral myocarditis is uncertain. Traditional Chinese medicine believes that viral myocarditis belongs to the categories of "palpitations" and "chest pain". Moreover, traditional Chinese medicine has shown obvious advantages in this respect.

Contents of the invention

The purpose of the present invention is to provide a traditional Chinese medicine composition for treating viral myocarditis with good curative effect, quick effect and little side effect by recombining prescriptions after studying the pharmacology of traditional medicines.

The purpose of the present invention is achieved like this:

A traditional Chinese medicine composition for treating viral myocarditis, which is prepared from the following raw materials of Chinese medicinal materials in parts by weight: 10-18 parts of Coptidis Rhizoma, 20-30 parts of Melaleuca, 20-30 parts of Scallops, 10-18 parts of Schisandra, bamboo 20-30 parts of leaves, 10-18 parts of perilla leaves, 25-40 parts of Coix seed, 8-15 parts of Tribulus terrestris, 6-12 parts of roasted licorice, 10-18 parts of Tinglizi.

Preferably, the traditional Chinese medicine composition for treating viral myocarditis as described above is prepared from the following Chinese medicinal materials in parts by weight: Coptidis 13-15 parts, Melaleuca 23-27 parts, Scallops 23-27 parts, Schisandra 13 parts -15 parts, 23-27 parts of bamboo leaves, 13-15 parts of perilla leaves, 30-35 parts of coix seed, 10-13 parts of Tribulus terrestris, 8-10 parts of roasted licorice, 13-15 parts of Tinglizi.

In a most preferred embodiment of the present invention, the above-mentioned traditional Chinese medicine composition is prepared from the following raw materials of Chinese medicinal materials in parts by weight: 14 parts of Coptidis Rhizome, 25 parts of Melaleuca, 25 parts of Scallop, 14 parts of Schisandra, bamboo 25 parts of leaves, 14 parts of perilla leaves, 32 parts of coix seed, 12 parts of Tribulus terrestris, 8 parts of roasted licorice, and 14 parts of Tinglizi.

Preferably, the above-mentioned traditional Chinese medicine composition for treating viral myocarditis is an oral preparation.

Still further preferably, the above-mentioned traditional Chinese medicine composition for treating viral myocarditis is a granule.

The Chinese medicinal materials involved in the present invention have the following sources: the rhizomes of Coptis chinensis Franch, Coptis deltoidea C.Y. Chenget Hsiao or Coptis teeta Wall. The thousand-story pagoda is made of the whole herb of the perennial herb Huperus serrata of the Huperzaceae family. The dried bulbs of Allium macrostemon Bge. are selected from Liliaceae plant Allium macrostemon Bge. They are excavated in summer and autumn, washed, removed fibrous roots, steamed or scalded in boiling water, and dried in the sun. Bamboo leaves are selected from the dry leaves of Gramineae Pachyphyllum. Perilla leaves are selected from the dry leaves of Lamiaceae plants such as wrinkled perilla and pointed perilla. Coix lacryma-jobi L. var. meyuan (Romen.) Stapf seeds are selected from the gramineous plant Coix lacryma-jobi L. var. meyuan (Romen.) Stapf. Tribulus terrestris is selected from the dried ripe fruit of Tribulus terrestris L. of Tribulus terrestris plant. Roasted licorice is obtained by roasting the root and rhizome of Glycyrrhiza uralensis Fisch., G. inflata Bat., or G. glabra L. Tinglizi is selected from the mature seeds of Lepidium apetalum.

The preparation method of the compound granules prepared from the above-mentioned Chinese medicinal materials comprises the following steps: weighing 10-18 parts of Coptis chinensis, 20-30 parts of Melaleuca pagoda, 20-30 parts of Scallops, and 10 parts of Schisandra chinensis according to the prescription amount -18 parts, 20-30 parts of bamboo leaves, 10-18 parts of sage leaves, 25-40 parts of coix seed, 8-15 parts of Tribulus terrestris, 6-12 parts of roasted licorice and 10-18 parts of Tinglizi, combine and decoct Boil twice, add water 10 times the weight of the medicinal material for the first time, decoct for 1.5h, add water for the second time 8 times the weight of the medicinal material, decoct for 1.5h, combine the decoction, 0.07MPa, 60-70℃ Concentrate under reduced pressure to extract with a relative density of 1.15 at 65°C, add 95% (v/v) ethanol to make the alcohol content reach 75% (v/v), stir, let stand for 24 hours, filter, and the filtrate is at 0.07MPa , Concentrate under reduced pressure at 65°C to a relative density of 1.25 at 65°C, and recover ethanol to obtain a concentrated solution, which is spray-dried (conditions are that the inlet air temperature is 100°C, the outlet air temperature is 80°C, and the material temperature 80°C, atomization pressure 0.2 MPa, spray speed 5ml/s), crushed through 80-mesh sieve to obtain clear paste powder; Paste powder and dextrin, put the clear paste powder and dextrin into the tank mixer, stir for 20 minutes, slowly add an appropriate amount of ethanol solution while stirring, until the soft material is made, granulate with a 12-mesh stainless steel sieve, 65~ Dry at 75°C for 2 hours, take it out, and let it cool to obtain the granules.

The traditional Chinese medicine composition of the present invention has remarkable clinical curative effect in treating primary viral myocarditis, not only can obviously improve symptoms, but also can reduce AST, CK, CK-MB, LDH, a-HBDB levels, regulate immunity, improve heart function, prompting Its effect may be related to increasing myocardial blood supply, improving myocardial metabolism, nourishing damaged myocardium, and improving the immune status of the body. In addition, the medicine of the present invention has the characteristics of low medical expenses, easy acceptance by patients, and little toxic and side effects.

Detailed ways

The following are specific examples of the present invention, and further describe the technical solution of the present invention, but the protection scope of the present invention is not limited to these examples. All changes or equivalent substitutions that do not depart from the concept of the present invention are included in the protection scope of the present invention.

Example 1

Herbal medicine prescription: Coptidis 14 parts, Melaleuca 25 parts, Scallop 25 parts, Schisandra chinensis 14 parts, bamboo leaves 25 parts, perilla leaves 14 parts, coix seed 32 parts, tribulus terrestris 12 parts, roasted licorice 8 parts, Tinglizi 14 parts .

Preparation process: Weigh the above-mentioned Chinese medicinal materials cleaned according to the prescription amount, combine them, add water to decoct twice, add water for the first time to 10 times the weight of the medicinal materials, decoct for 1.5 hours, and add water for the second time to 8 times the weight of the medicinal materials amount, decoct for 1.5h, combine the decoction, concentrate under reduced pressure at 0.07MPa, 60-70°C to an extract with a relative density of 1.15 at 65°C, add 95% (v/v) ethanol to make the alcohol content reach 75% (v/v), stir, stand still for 24 hours, filter, the filtrate is concentrated under reduced pressure at 0.07MPa and 65°C to a relative density of 1.25 at 65°C, and ethanol is recovered to obtain a concentrated solution, which is spray-dried (Conditions are that the inlet air temperature is 100°C, the outlet air temperature is 80°C, the material temperature is 80°C, the atomization pressure is 0.2 MPa, and the spray speed is 5ml/s.), crushed through a 80-mesh sieve to obtain clear cream powder ;Weigh the cream powder and dextrin according to the weight ratio of cream powder: dextrin 1:2.5, put the cream powder and dextrin into the tank mixer, stir for 20 minutes, and slowly add 55% ethanol while stirring , until soft material is made, granulate with 12 mesh stainless steel sieves, dry at 65～75°C for 2 hours, take out, let cool to get the described granules, pack in 15g per bag.

Example 2

Herbal medicine prescription: Coptidis 16 parts, Melaleuca 22 parts, Allium 26 parts, Schisandra 10 parts, Bamboo leaves 28 parts, Perilla leaves 15 parts, Coix seed 35 parts, Tribulus terrestris 8 parts, Roasted licorice 8 parts, Tinglizi 18 parts .

Preparation process: Weigh the above-mentioned Chinese medicinal materials cleaned according to the prescription amount, combine them, add water to decoct twice, add water for the first time to 10 times the weight of the medicinal materials, decoct for 1.5 hours, and add water for the second time to 8 times the weight of the medicinal materials amount, decoct for 1.5h, combine the decoction, concentrate under reduced pressure at 0.07MPa, 60-70°C to an extract with a relative density of 1.15 at 65°C, add 95% (v/v) ethanol to make the alcohol content reach 75% (v/v), stir, stand still for 24 hours, filter, the filtrate is concentrated under reduced pressure at 0.07MPa and 65°C to a relative density of 1.25 at 65°C, and ethanol is recovered to obtain a concentrated solution, which is spray-dried (Conditions are that the inlet air temperature is 100°C, the outlet air temperature is 80°C, the material temperature is 80°C, the atomization pressure is 0.2 MPa, and the spray speed is 5ml/s.), crushed through a 80-mesh sieve to obtain clear cream powder ;Weigh the clear cream powder and dextrin according to the weight ratio of clear cream powder: dextrin 1:3, put the clear cream powder and dextrin into the tank mixer, stir for 20 minutes, and slowly add 55% ethanol while stirring , until soft material is made, granulate with 12 mesh stainless steel sieves, dry at 65～75°C for 2 hours, take out, let cool to get the described granules, pack in 15g per bag.

Example 3

Herbal medicine prescription: Coptis 10 parts, Melaleuca 25 parts, Allium 28 parts, Schisandra chinensis 15 parts, Bamboo leaves 25 parts, Perilla leaves 12 parts, Coix seed 40 parts, Tribulus terrestris 12 parts, Roasted licorice 12 parts, Tinglizi 10 parts .

Preparation process: Weigh the above-mentioned Chinese medicinal materials cleaned according to the prescription amount, combine them, add water to decoct twice, add water for the first time to 10 times the weight of the medicinal materials, decoct for 1.5 hours, and add water for the second time to 8 times the weight of the medicinal materials amount, decoct for 1.5h, combine the decoction, concentrate under reduced pressure at 0.07MPa, 60-70°C to an extract with a relative density of 1.15 at 65°C, add 95% (v/v) ethanol to make the alcohol content reach 75% (v/v), stir, stand still for 24 hours, filter, the filtrate is concentrated under reduced pressure at 0.07MPa and 65°C to a relative density of 1.25 at 65°C, and ethanol is recovered to obtain a concentrated solution, which is spray-dried (Conditions are that the inlet air temperature is 100°C, the outlet air temperature is 80°C, the material temperature is 80°C, the atomization pressure is 0.2 MPa, and the spray speed is 5ml/s.), crushed through a 80-mesh sieve to obtain clear cream powder ;Weigh the clear cream powder and dextrin according to the weight ratio of clear cream powder: dextrin 1:3, put the clear cream powder and dextrin into the tank mixer, stir for 20 minutes, and slowly add 55% ethanol while stirring , until soft material is made, granulate with 12 mesh stainless steel sieves, dry at 65～75°C for 2 hours, take out, let cool to get the described granules, pack in 15g per bag. the

Example 4

Herbal medicine prescription: Coptidis 18 parts, Melaleuca 20 parts, Scallop 21 parts, Schisandra chinensis 18 parts, bamboo leaves 22 parts, perilla leaves 18 parts, coix seed 26 parts, tribulus terrestris 15 parts, roasted licorice 10 parts, Tinglizi 15 parts .

Preparation process: Weigh the above-mentioned Chinese medicinal materials cleaned according to the prescription amount, combine them, add water to decoct twice, add water for the first time to 10 times the weight of the medicinal materials, decoct for 1.5 hours, and add water for the second time to 8 times the weight of the medicinal materials amount, decoct for 1.5h, combine the decoction, concentrate under reduced pressure at 0.07MPa, 60-70°C to an extract with a relative density of 1.15 at 65°C, add 95% (v/v) ethanol to make the alcohol content reach 75% (v/v), stir, stand still for 24 hours, filter, the filtrate is concentrated under reduced pressure at 0.07MPa and 65°C to a relative density of 1.25 at 65°C, and ethanol is recovered to obtain a concentrated solution, which is spray-dried (Conditions are that the inlet air temperature is 100°C, the outlet air temperature is 80°C, the material temperature is 80°C, the atomization pressure is 0.2 MPa, and the spray speed is 5ml/s.), crushed through a 80-mesh sieve to obtain clear cream powder ;Weigh the clear cream powder and dextrin according to the weight ratio of clear cream powder: dextrin 1:3, put the clear cream powder and dextrin into the tank mixer, stir for 20 minutes, and slowly add 55% ethanol while stirring , until soft material is made, granulate with 12 mesh stainless steel sieves, dry at 65～75°C for 2 hours, take out, let cool to get the described granules, pack in 15g per bag. the

Example 5 Study on the curative effect of Chinese medicine granules on patients with viral myocarditis

42 patients with viral myocarditis who met the diagnostic criteria for viral myocarditis in children were patients with Qi and Yin deficiency and syndrome differentiation of liver depression, including 22 males and 20 females; 8 cases were under 4 years old, and 23 cases were 5-10 years old. 11 cases aged 11 to 14; the average course of disease was 17.1 days. All patients took 3 bags of traditional Chinese medicine granules (prepared according to the prescription and process of Example 1 of the present invention) every day, one bag each in the morning, noon and evening, for 3 consecutive weeks. Observe and record the clinical symptoms and signs before and after medication. After the treatment, the curative effect was counted according to the following standards:

Significantly effective: after 7-21 days of medication, the main symptoms disappear or most of them disappear, and the signs, electrocardiogram and myocardial enzyme spectrum are normal or close to normal;

Effective: after 7 to 21 days of medication, the main symptoms partially disappeared, and the signs, electrocardiogram and myocardial enzyme spectrum were significantly improved;

Ineffective: After 7-21 days of medication, the curative effect standard is not reached or severe arrhythmia or cardiogenic shock occurs.

The treatment results of 42 patients with viral myocarditis by adopting the traditional Chinese medicine granules of the present invention are: 25 cases are markedly effective, 14 cases are effective, 3 cases are ineffective, and the total effective rate is 92.86%.

The improvement of myocardial enzyme spectrum before and after treatment is compared in Table 1.

Table 1 Comparison of improvement of myocardial enzyme spectrum in patients before and after treatment

^* P <0.05 compared with before treatment.

In addition, after the treatment, no allergic reaction or intolerance to the drug was found in the patient, and no abnormalities were found in blood, urine, stool routine, electrocardiogram, liver and kidney function.

Claims (5)

1. a Chinese medicine composition for the treatment of viral myocarditis, is characterized in that: described Chinese medicine composition is prepared from by the traditional Chinese medicinal material raw materials of following weight portion: Rhizoma Coptidis 10-18 part, Herba Lycopodii serrati 20-30 part, Bulbus Allii Macrostemonis 20-30 part, Fructus Schisandrae Chinensis 10-18 part, Folium Bambusae 20-30 part, Folium Perillae 10-18 part, Semen Coicis 25-40 part, Fructus Tribuli 8-15 part, Radix Glycyrrhizae Preparata 6-12 part, Semen Lepidii (Semen Descurainiae) 10-18 part.

2. the Chinese medicine composition for the treatment of viral myocarditis according to claim 1, is characterized in that: described Chinese medicine composition is prepared from by the traditional Chinese medicinal material raw materials of following weight portion: Rhizoma Coptidis 13-15 part, Herba Lycopodii serrati 23-27 part, Bulbus Allii Macrostemonis 23-27 part, Fructus Schisandrae Chinensis 13-15 part, Folium Bambusae 23-27 part, Folium Perillae 13-15 part, Semen Coicis 30-35 part, Fructus Tribuli 10-13 part, Radix Glycyrrhizae Preparata 8-10 part, Semen Lepidii (Semen Descurainiae) 13-15 part.

3. treat according to claim 2 the Chinese medicine composition of viral myocarditis, it is characterized in that: described Chinese medicine composition is prepared from by the traditional Chinese medicinal material raw materials of following weight portion: 14 parts of Rhizoma Coptidis, 25 parts of Herba Lycopodii serratis, 25 parts of Bulbus Allii Macrostemonis, 14 parts of Fructus Schisandrae Chinensis, 25 parts, Folium Bambusae, 14 parts of Folium Perillae, 32 parts of Semen Coiciss, 12 parts of Fructus Tribulis, 8 parts of Radix Glycyrrhizae Preparatas, 14 parts of Semen Lepidii (Semen Descurainiae)s.

4. according to the Chinese medicine composition for the treatment of viral myocarditis described in claim 1 or 2 or 3, it is characterized in that: described Chinese medicine composition is oral formulations.

5. according to the Chinese medicine composition for the treatment of viral myocarditis described in claim 1 or 2 or 3, it is characterized in that: described Chinese medicine composition is granule.