CN104903715B - 纳米孔阵列 - Google Patents
纳米孔阵列 Download PDFInfo
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- CN104903715B CN104903715B CN201480003939.1A CN201480003939A CN104903715B CN 104903715 B CN104903715 B CN 104903715B CN 201480003939 A CN201480003939 A CN 201480003939A CN 104903715 B CN104903715 B CN 104903715B
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- lipid bilayer
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- 239000011148 porous material Substances 0.000 claims abstract description 135
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- 239000000232 Lipid Bilayer Substances 0.000 claims description 69
- 238000005259 measurement Methods 0.000 claims description 29
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- 150000002632 lipids Chemical class 0.000 description 5
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- 239000007788 liquid Substances 0.000 description 4
- UKDDQGWMHWQMBI-UHFFFAOYSA-O 1,2-diphytanoyl-sn-glycero-3-phosphocholine Chemical compound CC(C)CCCC(C)CCCC(C)CCCC(C)CC(=O)OCC(COP(O)(=O)OCC[N+](C)(C)C)OC(=O)CC(C)CCCC(C)CCCC(C)CCCC(C)C UKDDQGWMHWQMBI-UHFFFAOYSA-O 0.000 description 3
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 description 3
- XUIMIQQOPSSXEZ-UHFFFAOYSA-N Silicon Chemical compound [Si] XUIMIQQOPSSXEZ-UHFFFAOYSA-N 0.000 description 3
- 108020004682 Single-Stranded DNA Proteins 0.000 description 3
- 239000012491 analyte Substances 0.000 description 3
- 229910052802 copper Inorganic materials 0.000 description 3
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- HQVNEWCFYHHQES-UHFFFAOYSA-N silicon nitride Chemical compound N12[Si]34N5[Si]62N3[Si]51N64 HQVNEWCFYHHQES-UHFFFAOYSA-N 0.000 description 3
- 239000007787 solid Substances 0.000 description 3
- KILNVBDSWZSGLL-KXQOOQHDSA-N 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCCCCCCCCCC KILNVBDSWZSGLL-KXQOOQHDSA-N 0.000 description 2
- 108010006464 Hemolysin Proteins Proteins 0.000 description 2
- XOJVVFBFDXDTEG-UHFFFAOYSA-N Norphytane Natural products CC(C)CCCC(C)CCCC(C)CCCC(C)C XOJVVFBFDXDTEG-UHFFFAOYSA-N 0.000 description 2
- GGYKPYDKXLHNTI-UHFFFAOYSA-N Phytane Natural products CCC(C)CCCC(C)CCCC(C)CCCC(C)C GGYKPYDKXLHNTI-UHFFFAOYSA-N 0.000 description 2
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- WTJKGGKOPKCXLL-RRHRGVEJSA-N phosphatidylcholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCCC=CCCCCCCCC WTJKGGKOPKCXLL-RRHRGVEJSA-N 0.000 description 2
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- 229910052709 silver Inorganic materials 0.000 description 2
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- PORPENFLTBBHSG-MGBGTMOVSA-N 1,2-dihexadecanoyl-sn-glycerol-3-phosphate Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP(O)(O)=O)OC(=O)CCCCCCCCCCCCCCC PORPENFLTBBHSG-MGBGTMOVSA-N 0.000 description 1
- TZCPCKNHXULUIY-RGULYWFUSA-N 1,2-distearoyl-sn-glycero-3-phosphoserine Chemical compound CCCCCCCCCCCCCCCCCC(=O)OC[C@H](COP(O)(=O)OC[C@H](N)C(O)=O)OC(=O)CCCCCCCCCCCCCCCCC TZCPCKNHXULUIY-RGULYWFUSA-N 0.000 description 1
- LRYZPFWEZHSTHD-HEFFAWAOSA-O 2-[[(e,2s,3r)-2-formamido-3-hydroxyoctadec-4-enoxy]-hydroxyphosphoryl]oxyethyl-trimethylazanium Chemical class CCCCCCCCCCCCC\C=C\[C@@H](O)[C@@H](NC=O)COP(O)(=O)OCC[N+](C)(C)C LRYZPFWEZHSTHD-HEFFAWAOSA-O 0.000 description 1
- 229910002696 Ag-Au Inorganic materials 0.000 description 1
- 101710092462 Alpha-hemolysin Proteins 0.000 description 1
- JZNWSCPGTDBMEW-UHFFFAOYSA-N Glycerophosphorylethanolamin Natural products NCCOP(O)(=O)OCC(O)CO JZNWSCPGTDBMEW-UHFFFAOYSA-N 0.000 description 1
- ZWZWYGMENQVNFU-UHFFFAOYSA-N Glycerophosphorylserin Natural products OC(=O)C(N)COP(O)(=O)OCC(O)CO ZWZWYGMENQVNFU-UHFFFAOYSA-N 0.000 description 1
- 108010014603 Leukocidins Proteins 0.000 description 1
- 108010036176 Melitten Proteins 0.000 description 1
- 229910001260 Pt alloy Inorganic materials 0.000 description 1
- 229910021607 Silver chloride Inorganic materials 0.000 description 1
- ATBOMIWRCZXYSZ-XZBBILGWSA-N [1-[2,3-dihydroxypropoxy(hydroxy)phosphoryl]oxy-3-hexadecanoyloxypropan-2-yl] (9e,12e)-octadeca-9,12-dienoate Chemical compound CCCCCCCCCCCCCCCC(=O)OCC(COP(O)(=O)OCC(O)CO)OC(=O)CCCCCCC\C=C\C\C=C\CCCCC ATBOMIWRCZXYSZ-XZBBILGWSA-N 0.000 description 1
- 239000003513 alkali Substances 0.000 description 1
- 229910045601 alloy Inorganic materials 0.000 description 1
- 239000000956 alloy Substances 0.000 description 1
- AWUCVROLDVIAJX-UHFFFAOYSA-N alpha-glycerophosphate Natural products OCC(O)COP(O)(O)=O AWUCVROLDVIAJX-UHFFFAOYSA-N 0.000 description 1
- 239000002585 base Substances 0.000 description 1
- 238000005842 biochemical reaction Methods 0.000 description 1
- 239000012620 biological material Substances 0.000 description 1
- 238000004364 calculation method Methods 0.000 description 1
- 239000003054 catalyst Substances 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- GTKRFUAGOKINCA-UHFFFAOYSA-M chlorosilver;silver Chemical compound [Ag].[Ag]Cl GTKRFUAGOKINCA-UHFFFAOYSA-M 0.000 description 1
- 229960001231 choline Drugs 0.000 description 1
- OEYIOHPDSNJKLS-UHFFFAOYSA-N choline Chemical compound C[N+](C)(C)CCO OEYIOHPDSNJKLS-UHFFFAOYSA-N 0.000 description 1
- 238000003745 diagnosis Methods 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 239000003792 electrolyte Substances 0.000 description 1
- 239000011810 insulating material Substances 0.000 description 1
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- VDXZNPDIRNWWCW-JFTDCZMZSA-N melittin Chemical compound NCC(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(N)=O)CC1=CNC2=CC=CC=C12 VDXZNPDIRNWWCW-JFTDCZMZSA-N 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012544 monitoring process Methods 0.000 description 1
- 239000000178 monomer Substances 0.000 description 1
- 239000002773 nucleotide Substances 0.000 description 1
- 125000003729 nucleotide group Chemical group 0.000 description 1
- 230000035699 permeability Effects 0.000 description 1
- 125000001095 phosphatidyl group Chemical group 0.000 description 1
- 150000008104 phosphatidylethanolamines Chemical class 0.000 description 1
- 150000003905 phosphatidylinositols Chemical class 0.000 description 1
- 229940067626 phosphatidylinositols Drugs 0.000 description 1
- 229910052698 phosphorus Inorganic materials 0.000 description 1
- 239000011574 phosphorus Substances 0.000 description 1
- 108090000765 processed proteins & peptides Proteins 0.000 description 1
- 102000004196 processed proteins & peptides Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- BFKJFAAPBSQJPD-UHFFFAOYSA-N tetrafluoroethene Chemical compound FC(F)=C(F)F BFKJFAAPBSQJPD-UHFFFAOYSA-N 0.000 description 1
- 230000026683 transduction Effects 0.000 description 1
- 238000010361 transduction Methods 0.000 description 1
- 230000009466 transformation Effects 0.000 description 1
- 230000010148 water-pollination Effects 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/483—Physical analysis of biological material
- G01N33/487—Physical analysis of biological material of liquid biological material
- G01N33/48707—Physical analysis of biological material of liquid biological material by electrical means
- G01N33/48721—Investigating individual macromolecules, e.g. by translocation through nanopores
-
- G—PHYSICS
- G11—INFORMATION STORAGE
- G11C—STATIC STORES
- G11C16/00—Erasable programmable read-only memories
- G11C16/02—Erasable programmable read-only memories electrically programmable
- G11C16/06—Auxiliary circuits, e.g. for writing into memory
- G11C16/34—Determination of programming status, e.g. threshold voltage, overprogramming or underprogramming, retention
-
- G—PHYSICS
- G11—INFORMATION STORAGE
- G11C—STATIC STORES
- G11C7/00—Arrangements for writing information into, or reading information out from, a digital store
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Physics & Mathematics (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Immunology (AREA)
- Biochemistry (AREA)
- Pathology (AREA)
- Spectroscopy & Molecular Physics (AREA)
- Nanotechnology (AREA)
- General Physics & Mathematics (AREA)
- General Health & Medical Sciences (AREA)
- Analytical Chemistry (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Biophysics (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Investigating Or Analyzing Materials By The Use Of Electric Means (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Electrochemistry (AREA)
Abstract
Description
Claims (33)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US13/759701 | 2013-02-05 | ||
US13/759,701 US9759711B2 (en) | 2013-02-05 | 2013-02-05 | Nanopore arrays |
PCT/US2014/013304 WO2014123716A1 (en) | 2013-02-05 | 2014-01-28 | Nanopore arrays |
Publications (2)
Publication Number | Publication Date |
---|---|
CN104903715A CN104903715A (zh) | 2015-09-09 |
CN104903715B true CN104903715B (zh) | 2018-06-26 |
Family
ID=51259718
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201480003939.1A Active CN104903715B (zh) | 2013-02-05 | 2014-01-28 | 纳米孔阵列 |
Country Status (7)
Country | Link |
---|---|
US (4) | US9759711B2 (zh) |
EP (1) | EP2954316A4 (zh) |
JP (1) | JP6063062B2 (zh) |
CN (1) | CN104903715B (zh) |
AU (1) | AU2014215659B2 (zh) |
CA (1) | CA2893787C (zh) |
WO (1) | WO2014123716A1 (zh) |
Families Citing this family (23)
Publication number | Priority date | Publication date | Assignee | Title |
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US9664702B2 (en) | 2011-09-25 | 2017-05-30 | Theranos, Inc. | Fluid handling apparatus and configurations |
US9632102B2 (en) | 2011-09-25 | 2017-04-25 | Theranos, Inc. | Systems and methods for multi-purpose analysis |
US8475739B2 (en) | 2011-09-25 | 2013-07-02 | Theranos, Inc. | Systems and methods for fluid handling |
US20140170735A1 (en) | 2011-09-25 | 2014-06-19 | Elizabeth A. Holmes | Systems and methods for multi-analysis |
US9810704B2 (en) | 2013-02-18 | 2017-11-07 | Theranos, Inc. | Systems and methods for multi-analysis |
CN106463463B (zh) | 2014-03-31 | 2019-07-26 | 穆尔泰拉生物公司 | 用于流体元件和设备协整的低成本封装 |
JP6401588B2 (ja) * | 2014-11-28 | 2018-10-10 | 株式会社アドバンテスト | 電流測定装置および塩基配列解析装置、測定用チップ |
JP6416600B2 (ja) * | 2014-11-28 | 2018-10-31 | 株式会社アドバンテスト | 測定装置 |
US10935512B2 (en) * | 2015-09-24 | 2021-03-02 | Roche Sequencing Solutions, Inc. | Encoding state change of nanopore to reduce data size |
US10102338B2 (en) | 2015-09-24 | 2018-10-16 | Genia Technologies, Inc. | Adaptive compression and modification of nanopore measurement data |
US10155979B2 (en) * | 2016-03-30 | 2018-12-18 | Roche Molecular Systems, Inc. | Non-destructive bilayer monitoring using measurement of bilayer response to electrical stimulus |
US10577653B2 (en) * | 2016-06-27 | 2020-03-03 | Roche Sequencing Solutions, Inc. | Counteracting osmotic imbalance in a sequencing cell |
CN116515973A (zh) * | 2016-12-15 | 2023-08-01 | 豪夫迈·罗氏有限公司 | 自适应纳米孔信号压缩 |
US10921284B2 (en) * | 2017-04-19 | 2021-02-16 | Roche Sequencing Solutions, Inc. | Phased nanopore array |
WO2020002621A2 (en) | 2018-06-29 | 2020-01-02 | F. Hoffmann-La Roche Ag | Detection of microsatellite instability |
JP7318951B2 (ja) * | 2018-07-11 | 2023-08-01 | アイポア株式会社 | 流路 |
EP3847649A4 (en) * | 2018-09-07 | 2022-08-31 | Iridia, Inc. | IMPROVED SYSTEMS AND METHODS FOR WRITING AND READING DATA STORED IN A POLYMER |
GB201907243D0 (en) * | 2019-05-22 | 2019-07-03 | Oxford Nanopore Tech Ltd | Sensing interactions between molecular entities and nanapores |
US20210172929A1 (en) * | 2019-12-05 | 2021-06-10 | Nooma Bio, Inc. | Multi-Pore Device with Material Sorting Applications |
US11837302B1 (en) | 2020-08-07 | 2023-12-05 | Iridia, Inc. | Systems and methods for writing and reading data stored in a polymer using nano-channels |
CN113061531B (zh) * | 2021-06-03 | 2021-08-20 | 成都齐碳科技有限公司 | 芯片结构、芯片组件、成膜方法、纳米孔测序装置及应用 |
CN113552332B (zh) * | 2021-09-22 | 2022-04-22 | 成都齐碳科技有限公司 | 用于感测包含在液体中的分析物的装置和设备 |
CN118302668A (zh) * | 2021-11-24 | 2024-07-05 | 豪夫迈·罗氏有限公司 | 用于通过频率检测来确定目标分析物的方法 |
Citations (1)
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WO2011103424A2 (en) * | 2010-02-19 | 2011-08-25 | The Trustees Of The University Of Pennsylvania | High-resolution analysis devices and related methods |
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