CN104902879B - 掩味活性粉末药物组合物及其制备方法 - Google Patents

掩味活性粉末药物组合物及其制备方法 Download PDF

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Publication number
CN104902879B
CN104902879B CN201380053749.6A CN201380053749A CN104902879B CN 104902879 B CN104902879 B CN 104902879B CN 201380053749 A CN201380053749 A CN 201380053749A CN 104902879 B CN104902879 B CN 104902879B
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China
Prior art keywords
polymer
silica
ibuprofen
coated
coating
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Chinese (zh)
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CN104902879A (zh
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丹尼尔·多
拉杰什·N·戴夫
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New Jersey Institute of Technology
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New Jersey Institute of Technology
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/501—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5026—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin
    • A61K9/5042—Cellulose; Cellulose derivatives, e.g. phthalate or acetate succinate esters of hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5089—Processes

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Inorganic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Glanulating (AREA)
CN201380053749.6A 2012-10-15 2013-10-09 掩味活性粉末药物组合物及其制备方法 Active CN104902879B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US13/651,829 2012-10-15
US13/651,829 US8993041B2 (en) 2012-10-15 2012-10-15 Taste masked active pharmaceutical powder compositions and processes for making them
PCT/US2013/064064 WO2014062446A1 (en) 2012-10-15 2013-10-09 Taste masked active pharmaceutical powder compositions and processes for making them

Publications (2)

Publication Number Publication Date
CN104902879A CN104902879A (zh) 2015-09-09
CN104902879B true CN104902879B (zh) 2018-07-17

Family

ID=49447846

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201380053749.6A Active CN104902879B (zh) 2012-10-15 2013-10-09 掩味活性粉末药物组合物及其制备方法

Country Status (7)

Country Link
US (1) US8993041B2 (https=)
EP (1) EP2906204B1 (https=)
JP (1) JP6166859B2 (https=)
CN (1) CN104902879B (https=)
AR (1) AR093012A1 (https=)
BR (1) BR112015008284B1 (https=)
WO (1) WO2014062446A1 (https=)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9107851B2 (en) * 2012-10-15 2015-08-18 New Jersey Institute Of Technology Solventless mixing process for coating pharmaceutical ingredients
US9801820B2 (en) 2012-11-12 2017-10-31 New Jersey Institute Of Technology Pharmaceutical core-shell composite powder and processes for making the same
CN104587472B (zh) * 2014-12-31 2017-12-15 广东国方医药科技有限公司 一种含纳米SiO2的包衣剂及其制备方法
JP6067154B1 (ja) * 2016-01-25 2017-01-25 株式会社樋口商会 コーティング粒子の製造方法
KR20250150154A (ko) 2016-03-15 2025-10-17 에이서 테라퓨틱스 인크. 소듐 페닐부티레이트를 포함하는 맛우수한 조성물 및 그의 용도
US11794161B1 (en) 2018-11-21 2023-10-24 Trucapsol, Llc Reduced permeability microcapsules
US12302933B2 (en) 2021-06-25 2025-05-20 Trucapsol Llc Flavor delivery system
US12187829B2 (en) 2021-08-12 2025-01-07 Trucapsol Llc Environmentally biodegradable microcapsules
US11878280B2 (en) 2022-04-19 2024-01-23 Trucapsol Llc Microcapsules comprising natural materials
US11904288B1 (en) 2023-02-13 2024-02-20 Trucapsol Llc Environmentally biodegradable microcapsules
US11969491B1 (en) 2023-02-22 2024-04-30 Trucapsol Llc pH triggered release particle

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1373658A (zh) * 1999-07-08 2002-10-09 伊西法姆公司 制备遮味的且活性物质即释的包衣颗粒的方法

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JPS63258809A (ja) * 1987-04-16 1988-10-26 Towa Yakuhin Kk 医薬活性成分の放出性にすぐれ、かつ苦味を隠蔽した細粒剤
CA2076983A1 (en) 1990-04-11 1991-10-12 Robert Wu-Wei Shen Taste masking of ibuprofen by fluid bed coating
JPH08333240A (ja) * 1995-06-02 1996-12-17 Shin Etsu Chem Co Ltd 粉末またはペレット状ワックスを用いる無溶媒腸溶性コーティング剤で被覆した腸溶性製剤
GB9515182D0 (en) 1995-07-24 1995-09-20 Co Ordinated Drug Dev Improvements in and relating to powders for use in dry powder inhalers
JP2000053563A (ja) * 1998-08-07 2000-02-22 Bayer Yakuhin Ltd 苦味がマスクされた速放性細粒剤
US6740341B1 (en) * 1998-11-25 2004-05-25 Cima Labs Inc. Taste masking rapid release coating system
GB0010446D0 (en) * 2000-04-28 2000-06-14 Glaxo Wellcome Kk Pharmaceutical formulation
US7276249B2 (en) 2002-05-24 2007-10-02 Elan Pharma International, Ltd. Nanoparticulate fibrate formulations
JP2005538105A (ja) * 2002-07-25 2005-12-15 ファルマシア・コーポレーション 水不溶性ポリマーおよび水溶性の小孔形成物質からなる２層により被覆された固体剤形の製造方法
US8252370B1 (en) 2005-10-20 2012-08-28 The United States Of America As Represented By The Secretary Of The Army Continuous high-speed coating of finely ground particulates
DE102005062270A1 (de) * 2005-12-24 2007-06-28 Bayer Technology Services Gmbh Geschmacksmaskierung von Pulvern
US8550698B2 (en) * 2006-11-10 2013-10-08 Orion Engineered Carbons Gmbh Fluidized mixing and blending of nanopowders with secondary gas flow
EP2201939A1 (en) 2008-12-25 2010-06-30 Zentiva Kimyasal Ürünler Sanayi ve Ticaret A.S. Method for producing coated spiramycin and novel formulations containing the same
JP5845172B2 (ja) * 2009-05-01 2016-01-20 アデア ファーマスーティカルズ，インコーポレイテッド 高および低用量薬物の組み合わせを含む口腔内崩壊錠組成物

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1373658A (zh) * 1999-07-08 2002-10-09 伊西法姆公司 制备遮味的且活性物质即释的包衣颗粒的方法

Also Published As

Publication number Publication date
WO2014062446A1 (en) 2014-04-24
US20140106058A1 (en) 2014-04-17
JP6166859B2 (ja) 2017-07-19
EP2906204B1 (en) 2022-09-28
BR112015008284A2 (pt) 2017-07-04
JP2015533164A (ja) 2015-11-19
EP2906204A1 (en) 2015-08-19
US8993041B2 (en) 2015-03-31
BR112015008284B1 (pt) 2022-05-24
CN104902879A (zh) 2015-09-09
AR093012A1 (es) 2015-05-13

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