CN104888179A - Traditional Chinese medicine capsule for treating wind-cold and preparation method of traditional Chinese medicine capsule - Google Patents

Abstract

The invention discloses a traditional Chinese medicine capsule for treating wind-cold and a preparation method of the traditional Chinese medicine capsule. The traditional Chinese medicine capsule comprises active ingredients which include, by mass, 25-38 parts of fineleaf schizonepeta herb, 7-19 parts of perilla leaf, 13-24 parts of divaricate saposhnikovia root, 11-26 parts of notopterygium root, 5-19 parts of ligusticum sinense Oliv., 13-28 parts of radix angelicae dahuricae, 5-26 parts of flos magnoliae, 11-22 parts of herba centipedae, 5-23 parts of Chinese mosla herb, 13-26 parts of tamarix chinensis Lour., 13-28 parts of coriandrum sativum L, 14-27 parts of ginger, 7-26 parts of fructus arctii, 12-27 parts of folium mori, 6-25 parts of radix puerariae, 6-26 parts of equisetum hyemale L., 11-28 parts of periostracum cicadae, 5-22 parts of lemna minor, 10-26 parts of fermented soybean and 10-21 parts of liquorice. The traditional Chinese medicine capsule is capable of promoting wind-cold treatment, and the total effective rate of treatment is above 98%.

Description

A kind of Chinese medicinal capsule for the treatment of wind and cold and preparation method thereof

Technical field

The present invention relates to treatment wind and cold technical field, specifically a kind of Chinese medicinal capsule for the treatment of wind and cold and preparation method thereof.

Background technology

Wind and cold is the inflammation of the pulmonary parenchyma caused by multiple pathogens (as antibacterial, virus, fungus, parasite etc.), and other also can cause wind and cold as lonizing radiation, chemistry, intolerance factors etc.Clinical cardinal symptom is shiver with cold.High heat, cough, cough up phlegm, chest pain etc.The wind and cold four seasons all can fall ill, and are mainly in winter and spring.Between twenty and fifty common, man is more than female.If primary disease diagnosis and treatment in time, prognosis bona.Wind and cold belongs to the category such as the traditional Chinese medical science " pathogenic wind-warm ", " cough ", " pyretic pulmonary disease ".

The cause of disease that the traditional Chinese medical science sums up wind and cold often betides overstrain, and when the human righteousness such as wind are not enough after liquor-saturated, table is experienced the heresy of wind heat or the heresy of wind and cold, entered caused by inner heat-transformation when defending and not consolidating.Pathological change is positive QI-insufficiency, table Wei Bugu, and can not drive evil in outward, evil impairing the lung is defended, and ailment said due to cold or exposure bundle table, defends the stagnation of QI and close, and see fever with aversion to cold; Block of lung-QI, loses a surname Yu and reaches and cough; Lung is cloth Tianjin not, gathers and is expectorant, and hindering in cold-evil is then white rare expectorant, hinders and then sees white glutinous expectorant or yellow sputum in pathogenic heat or cold-evil's heat-transformation.Pathogen retardance lung network, can cause chest pain, contain in pathogenic heat. lung network of burning, spit blood as seen.If pathogen crosses Sheng, vital QI cannot conquer pathogen, pathogen entering the interior, interior biography nutrient blood, very then pathogenic heat are caved in, the pathogen attacking the pericardium adversely, can cause Kidney-Yin for exhausting, and yang-energy is collapsed.

Current doctor trained in Western medicine Major Clinical commonly uses the antibiotic therapy wind and cold such as penicillin, use antibiotic medication can produce certain side effect, life-time service can cause pathogen to produce drug resistance, thus treatment difficulty is further increased, use exists certain drawback, and Western medicine can only be killed to pathogenic bacterium, but the treatments such as expelling wind and cold can not be carried out to patient's body, make wind and cold recur probability high, bring certain limitation to the treatment of wind and cold.

Summary of the invention

The object of the invention is to overcome the above problems, and provide to responding well to treatment to wind and cold soon, a kind of Chinese medicinal capsule for the treatment of wind and cold that cure rate is high and preparation method thereof.

The technical solution used in the present invention is: a kind of Chinese medicinal capsule for the treatment of wind and cold, the crude drug effective ingredient mass fraction making capsule comprises: Herba Schizonepetae 25 ~ 38 parts, Folium Perillae 7 ~ 19 parts, Radix Saposhnikoviae 13 ~ 24 parts, Rhizoma Et Radix Notopterygii 11 ~ 26 parts, Rhizoma Ligustici 5 ~ 19 parts, the Radix Angelicae Dahuricae 13 ~ 28 parts, Flos Magnoliae 5 ~ 26 parts, Herba Centipedae 11 ~ 22 parts, Herba Moslae 5 ~ 23 parts, Ramulus et Folium Tamaricis 13 ~ 26 parts, coriander 13 ~ 28 parts, 14 ~ 27 parts, Rhizoma Zingiberis Recens, Fructus Arctii 7 ~ 26 parts, 12 ~ 27 parts, Folium Mori, Radix Puerariae 6 ~ 25 parts, Herba Equiseti Hiemalis 6 ~ 26 parts, Periostracum Cicadae 11 ~ 28 parts, 5 ~ 22 parts, Herba Spirodelae, Semen Sojae Preparatum 10 ~ 26 parts, 10 ~ 21 parts, Radix Glycyrrhizae.

Further, a kind of Chinese medicinal capsule for the treatment of wind and cold, the crude drug effective ingredient mass fraction making capsule comprises: Herba Schizonepetae 28 ~ 33 parts, Folium Perillae 12 ~ 15 parts, Radix Saposhnikoviae 18 ~ 22 parts, Rhizoma Et Radix Notopterygii 15 ~ 21 parts, Rhizoma Ligustici 10 ~ 14 parts, the Radix Angelicae Dahuricae 18 ~ 23 parts, Flos Magnoliae 9 ~ 24 parts, Herba Centipedae 17 ~ 20 parts, Herba Moslae 11 ~ 16 parts, Ramulus et Folium Tamaricis 18 ~ 22 parts, coriander 17 ~ 23 parts, 19 ~ 24 parts, Rhizoma Zingiberis Recens, Fructus Arctii 12 ~ 21 parts, 18 ~ 21 parts, Folium Mori, Radix Puerariae 11 ~ 20 parts, Herba Equiseti Hiemalis 13 ~ 20 parts, Periostracum Cicadae 16 ~ 22 parts, 12 ~ 15 parts, Herba Spirodelae, Semen Sojae Preparatum 15 ~ 20 parts, 14 ~ 18 parts, Radix Glycyrrhizae.

Further, treat a Chinese medicinal capsule for wind and cold, the crude drug effective ingredient mass fraction making capsule comprises: Herba Schizonepetae 30 parts, Folium Perillae 13 parts, Radix Saposhnikoviae 20 parts, Rhizoma Et Radix Notopterygii 17 parts, Rhizoma Ligustici 12 parts, the Radix Angelicae Dahuricae 20 parts, Flos Magnoliae 16 parts, Herba Centipedae 18 parts, Herba Moslae 14 parts, Ramulus et Folium Tamaricis 20 parts, coriander 21 parts, 20 parts, Rhizoma Zingiberis Recens, Fructus Arctii 16 parts, 20 parts, Folium Mori, Radix Puerariae 15 parts, Herba Equiseti Hiemalis 16 parts, Periostracum Cicadae 18 parts, 13 parts, Herba Spirodelae, Semen Sojae Preparatum 17 parts, 15 parts, Radix Glycyrrhizae.

Further, a kind of preparation method for the treatment of the Chinese medicinal capsule of wind and cold, preparation method is as follows:

(1) first Pulvis Talci is put in pot, be heated to Pulvis Talci light, when easily stirring, drop into Herba Schizonepetae, Folium Perillae, Radix Saposhnikoviae, Rhizoma Et Radix Notopterygii, Rhizoma Ligustici, the Radix Angelicae Dahuricae, Flos Magnoliae, Herba Centipedae, Herba Moslae, Ramulus et Folium Tamaricis, Pulvis Talci amount floods spice, fry and dredge to the expansion of medicine body, pine, treat cold standby;

(2) again pot is burnt heat, sprinkle the rice soaked, make on its smooth pot, be heated to rice when smoldering, drop into coriander, Rhizoma Zingiberis Recens, Fructus Arctii, Folium Mori, Radix Puerariae, Herba Equiseti Hiemalis, Periostracum Cicadae, Herba Spirodelae, Semen Sojae Preparatum, Radix Glycyrrhizae, stir gently, frying to rice is that coke yellow takes out, remove rice, treat cold standby;

(3) will obtain loading ball mill grinding 2h through step (1) (2), and cross 80 mesh sieves, obtain grounds travel;

(4) boil 2h after the grounds travel that step (3) obtains being heated to boiling, be separated and take out fried liquid, continue the purified water adding 4 parts in medical material, continue to boil 1.5h after being heated to boiling, merge twice fried liquid and be extracting solution;

(5) extracting solution that step (4) obtains is positioned in the extraction kettle in supercritical extraction instrument, carbon dioxide is utilized to extract as medium, extraction kettle pressure is 40Mpa, extraction temperature is 45 DEG C, separator pressure 12Mpa, separator temperature is 70 DEG C, extracts 2 hours, is extracted liquid; Extract concentrates at outer circulation concentrator, and concentrated condition is: pressure 0.03Mpa, temperature 70 C, is concentrated into the extractum that relative density is 1.13 ~ 1.14;

(6) extractum obtained to step (5), in 50 DEG C of dryings, is crossed 16 mesh sieves, is obtained xeraphium, add the dextrin accounting for capsule gross mass 70% in xeraphium, and mixing, capsule machine makes capsule, and per kilogram obtains 700 1# capsules.

Instructions of taking: adult every day 2 times, sooner or later each once, within 5 days, be a course for the treatment of.

Medical material effect of the present invention is resolved as follows:

Herba Schizonepetae is pungent, temperature.Return lung, Liver Channel, induce sweat loose wind, and rash disappears skin ulcer, hemostasis.Cure mainly cold, fever, headache, pharynx pain, measles without adequate eruption, rubella pruritus, skin infection from the beginning of, spit blood, epistaxis, has blood in stool, metrorrhagia.Folium Perillae is pungent, temperature.Return lung, spleen channel, dispersing wind-cold, circulation of qi promoting and in, antiabortive.Cure mainly anemofrigid cold, cough and asthma, vomiting and nausea uncomfortable in chest, vomiting during pregnancy, frequent fetal movement, fish Eriocheir sinensis is poisoning, vomits and rushes down stomachache.Radix Saposhnikoviae acrid, sweet, warm.Return bladder, liver, spleen channel, induce sweat, dispel the wind, victory is wet, pain relieving, spasmolytic.Cure mainly exterior syndrome due to wind-cold, headache body pain, anemofrigid-damp arthralgia, rubella pruritus, tetanus.Rhizoma Et Radix Notopterygii is pungent, bitter, temperature.Return bladder, kidney channel, dispel the wind, cold expelling, dehumidifying, pain relieving.Cure mainly anemofrigid cold, cold and heat are had a headache, anemofrigid-damp arthralgia, shoulder arm pain.Rhizoma Ligustici is pungent, temperature.Return urinary bladder channel, expelling wind and cold, removing damp and stopping pain.Cure mainly affection of exogenous wind-cold, top of the head pain or migraine, rheumatism podomere arthralgia pain, cold-damp is suffered from abdominal pain.The Radix Angelicae Dahuricae is pungent, temperature.Return lung, spleen, stomach warp, expelling wind and removing dampness, understand things pain-stopping, eliminating carbuncle evacuation of pus.Cure mainly anemofrigid cold, headache nasal obstruction, nasal sinusitis, supraorbital bone pain, toothache, cold-damp leukorrhagia, carbuncle skin infection, skin pruritus.Flos Magnoliae is pungent, temperature.Attach to the lung and stomach meridians, dispersing wind and cold, clearing the nasal passage.Cure mainly nasal sinusitis, headache, cold stuffy nasal obstruction.Herba Centipedae is pungent, temperature.Return lung meridian, expelling pathogenic wind and restoring the functions of orifices in face, preventing phlegm from forming and stopping coughing, removing nebula improving eyesight.Cure mainly anemofrigid cold, headache nasal obstruction, nasal sinusitis, nasal polyp, asthma, pertussis, cataract, Nu climbs eyeball, traumatic injury, carbuncle sore scabies.Herba Moslae is pungent, tepor.Attach to the lung and stomach meridians, relieving the exterior syndrome by diaphoresis, dispelling summer-heat and dampness, and in, diuretic.Cure mainly flu heat-damp in summer, fever with aversion to cold is lossless, headache, and stomachache is vomited and diarrhoea, edema, beriberi, dysuria.Ramulus et Folium Tamaricis is pungent, sweet, flat.Return lung, stomach, heart channel, loose wind, induces sweat, rash.Cure mainly measles without adequate eruption, rubella pruritus, rheumatic arthralgia.Coriander is pungent, temperature.Return lung, spleen, stomach warp, deliver rash, removing stagnancy of indigested food and making QI downward.Curing mainly measles sends out not smooth thoroughly, dyspepsia abdominal distention, cold syndrome of the stomach distending pain.Rhizoma Zingiberis Recens is pungent, tepor.Return lung, stomach, spleen channel, deliver cold expelling, warming middle-JIAO to arrest vomiting, warming the lung to relieve cough.Cure mainly affection of exogenous wind-cold, gastrofrigid vomiting, cough due to wind and cold, and separate the Rhizoma Pinelliae, Rhizoma Arisaematis and fish Eriocheir sinensis poison.Fructus Arctii is pungent, bitter, cold.Attach to the lung and stomach meridians, dispelling wind and heat pathogens, lung qi dispersing, sore-throat relieving, rash, removing toxic substances.Cure mainly anemopyretic cold, cough with copious phlegm, laryngopharynx swelling and pain, measles without adequate eruption, rubella, mumps, carbuncle sore tumefacting virus.Folium Mori are bitter, sweet, cold.Return liver, lung meridian, dispelling wind and heat pathogens, clearing away lung-heat and moistening for dryness, suppressing the hyperactive liver improving eyesight.Cure mainly affection due to external wind and heat, epidemic febrile disease from the beginning of, lung-heat type cough, headache and dizzy, conjunctival congestion photophobia.Radix Puerariae is sweet, pungent, flat.Return spleen, stomach warp, expelling pathogenic factors from muscles for reducing heat, rash, promoting the production of body fluid to quench thirst, yang invigorating antidiarrheal.Cure mainly cold, fever, headache stiffness of the nape, measles is sent out not smooth thoroughly, excessive thirst, and water is thirsty, diarrhea of heat type hematodiarrhoea, insufficiency of the spleen chronic diarrhea.Herba Equiseti Hiemalis is sweet, bitter, flat.Return lung, liver, gallbladder meridian, dispelling wind and heat pathogens, improving acuity of vision and removing nebula, hemostasis.Cure mainly wind heat conjunctival congestion and swelling pain, epiphora induced by wind, pterygium, discharging fresh blood stool.Periostracum Cicadae is sweet, salty, cool.Return lung, Liver Channel, dispelling wind-heat, sore-throat relieving, rash, improving acuity of vision and removing nebula, spasmolytic.Cure mainly affection due to external wind and heat, cough, pharyngalgia hoarseness, measles without adequate eruption, cataract, pediatric epilepsy scared, tetanus.Herba Spirodelae is pungent, cold.Return lung, urinary bladder channel, relieving the exterior syndrome by diaphoresis, rash is antipruritic, inducing diuresis to remove edema.Cure mainly wind heat exterior syndrome, fever without perspiration, measles without adequate eruption, rubella pruritus, edema all over is demonstrate,proved in edema due to wind pathogen, dysuria.Semen Sojae Preparatum is bitter, pungent, is slightly cold.Attach to the lung and stomach meridians, relieving restlessness of inducing sweat, a surname sends out hot and suffocating.Cure mainly fever caused by exogenous pathogens, aversion to cold is had a headache, breast gastral cavity feeling of distension and oppression, restlessness of asrhenia type and insomnia.Radix Glycyrrhizae sweet in the mouth, property are flat, and it contains number of chemical composition, and effect is replenishing QI to invigorate the spleen, expelling phlegm for arresting cough, heat-clearing and toxic substances removing, relieving spasm to stop pain.

The present invention has following beneficial effect:

(1) Herba Schizonepetae is induced sweat loose wind, and the rash skin ulcer that disappears is monarch drug.Herba Schizonepetae is containing volatile oil, and main component is D-menthone, racemization menthone, d-limonen, effectively can treat and cure mainly cold, fever, headache, pharynx pain, measles without adequate eruption, rubella pruritus.Folium Perillae dispersing wind-cold, circulation of qi promoting and in, Radix Saposhnikoviae inducing diaphoresis to dispel wind, removing dampness to relieve pain, spasmolytic, notopterygium wind dispelling cold expelling, removing damp and stopping pain, Rhizoma Ligustici expelling wind and cold, removing damp and stopping pain, Radix Angelicae Dahuricae expelling wind and removing dampness, understand things pain-stopping, eliminating carbuncle evacuation of pus, Magnoliae Powder wind and cold, clearing the nasal passage, Herba Centipedae expelling pathogenic wind and restoring the functions of orifices in face, preventing phlegm from forming and stopping coughing, Herba Moslae relieving the exterior syndrome by diaphoresis, dispelling summer-heat and dampness, and middle diuretic, Ramulus et Folium Tamaricis dispersing wind, relieving exterior syndrome.The symptoms such as Folium Perillae, Radix Saposhnikoviae, Rhizoma Et Radix Notopterygii, Rhizoma Ligustici, the Radix Angelicae Dahuricae, Flos Magnoliae, Herba Centipedae, Herba Moslae, Ramulus et Folium Tamaricis are ministerial drug, and auxiliary monarch drug effectively treats flu heat-damp in summer, and fever with aversion to cold is lossless, exterior syndrome due to wind-cold, headache body pain.

Coriander delivers rash, and cold expelling delivered by Rhizoma Zingiberis Recens, warming middle-JIAO to arrest vomiting, warming the lung to relieve cough, Fructus Arctii dispelling wind and heat pathogens, lung qi dispersing sore-throat relieving, rash, removing toxic substances.Folium Mori dispelling wind and heat pathogens, clearing away lung-heat and moistening for dryness, suppressing the hyperactive liver improving eyesight, Radix Puerariae expelling pathogenic factors from muscles for reducing heat rash, promoting the production of body fluid to quench thirst, yang invigorating antidiarrheal, Herba Equiseti Hiemalis's dispelling wind and heat pathogens, improving acuity of vision and removing nebula, coriander, Rhizoma Zingiberis Recens, Fructus Arctii, Folium Mori, Radix Puerariae, Herba Equiseti Hiemalis are adjuvant drug, and monarch drug can be assisted to eliminate because wind and cold often causes removing stagnancy of indigested food and making QI downward, gastrofrigid vomiting, cough due to wind and cold, cough with copious phlegm, the symptoms such as laryngopharynx swelling and pain.

Periostracum Cicadae dispelling wind-heat, sore-throat relieving rash, improving acuity of vision and removing nebula, Herba Spirodelae relieving the exterior syndrome by diaphoresis, rash is antipruritic, inducing diuresis to remove edema, Semen Sojae Preparatum induces sweat relieving restlessness, a surname sends out hot and suffocating, Radix Glycyrrhizae replenishing QI to invigorate the spleen, expelling phlegm for arresting cough, heat-clearing and toxic substances removing, relieving spasm to stop pain, and Periostracum Cicadae, Herba Spirodelae, Semen Sojae Preparatum, Radix Glycyrrhizae are for making medicine, auxiliary monarch drug treatment fever caused by exogenous pathogens, aversion to cold is had a headache, breast gastral cavity feeling of distension and oppression, the symptoms such as restlessness of asrhenia type and insomnia.

(2) Pulvis Talci makes medicaments uniformity be heated, and makes medicine crisp frangible, is convenient to make capsule and take, and can strengthen the curative effect delivering cold expelling; Utilize moisturizing and nourishing effect of rice, the burnt odor abnormal smells from the patient sent after frying, can strengthen the effect of the replenishing QI to invigorate the spleen of medicine; Ball milling makes the starch in medical material, protein is separated out more fully at subsequent step; Steaming and decocting, supercritical extraction, concentration step retain the effective ingredient in Chinese medicine of the present invention to greatest extent, thus improve capsule reach refining object.

Detailed description of the invention

Below in conjunction with embodiment, the present invention is further elaborated.

Embodiment 1:

Treat a Chinese medicinal capsule for wind and cold, the crude drug effective ingredient mass fraction making capsule comprises: Herba Schizonepetae 25 parts, Folium Perillae 7 parts, Radix Saposhnikoviae 13 parts, Rhizoma Et Radix Notopterygii 11 parts, Rhizoma Ligustici 5 parts, the Radix Angelicae Dahuricae 13 parts, Flos Magnoliae 5 parts, Herba Centipedae 11 parts, Herba Moslae 5 parts, Ramulus et Folium Tamaricis 13 parts, coriander 13 parts, 14 parts, Rhizoma Zingiberis Recens, Fructus Arctii 7 parts, 12 parts, Folium Mori, Radix Puerariae 6 parts, Herba Equiseti Hiemalis 6 parts, Periostracum Cicadae 11 parts, 5 parts, Herba Spirodelae, Semen Sojae Preparatum 10 parts, 10 parts, Radix Glycyrrhizae.

A kind of preparation method for the treatment of the Chinese medicinal capsule of wind and cold:

(1) first Pulvis Talci is put in pot, be heated to Pulvis Talci light, when easily stirring, drop into Herba Schizonepetae, Folium Perillae, Radix Saposhnikoviae, Rhizoma Et Radix Notopterygii, Rhizoma Ligustici, the Radix Angelicae Dahuricae, Flos Magnoliae, Herba Centipedae, Herba Moslae, Ramulus et Folium Tamaricis, Pulvis Talci amount floods spice, fry and dredge to the expansion of medicine body, pine, treat cold standby;

(2) again pot is burnt heat, sprinkle the rice soaked, make on its smooth pot, be heated to rice when smoldering, drop into coriander, Rhizoma Zingiberis Recens, Fructus Arctii, Folium Mori, Radix Puerariae, Herba Equiseti Hiemalis, Periostracum Cicadae, Herba Spirodelae, Semen Sojae Preparatum, Radix Glycyrrhizae, stir gently, frying to rice is that coke yellow takes out, remove rice, treat cold standby;

(3) will obtain loading ball mill grinding 2h through step (1) (2), and cross 80 mesh sieves, obtain grounds travel;

(4) boil 2h after the grounds travel that step (3) obtains being heated to boiling, be separated and take out fried liquid, continue the purified water adding 4 parts in medical material, continue to boil 1.5h after being heated to boiling, merge twice fried liquid and be extracting solution;

(5) extracting solution that step (4) obtains is positioned in the extraction kettle in supercritical extraction instrument, carbon dioxide is utilized to extract as medium, extraction kettle pressure is 40Mpa, extraction temperature is 45 DEG C, separator pressure 12Mpa, separator temperature is 70 DEG C, extracts 2 hours, is extracted liquid; Extract concentrates at outer circulation concentrator, and concentrated condition is: pressure 0.03Mpa, temperature 70 C, is concentrated into the extractum that relative density is 1.13 ~ 1.14;

(6) extractum obtained to step (5), in 50 DEG C of dryings, is crossed 16 mesh sieves, is obtained xeraphium, add the dextrin accounting for capsule gross mass 70% in xeraphium, and mixing, capsule machine makes capsule, and per kilogram obtains 700 1# capsules.

Embodiment 2:

Treat a Chinese medicinal capsule for wind and cold, the crude drug effective ingredient mass fraction making capsule comprises: Herba Schizonepetae 38 parts, Folium Perillae 19 parts, Radix Saposhnikoviae 24 parts, Rhizoma Et Radix Notopterygii 26 parts, Rhizoma Ligustici 19 parts, the Radix Angelicae Dahuricae 28 parts, Flos Magnoliae 26 parts, Herba Centipedae 22 parts, Herba Moslae 23 parts, Ramulus et Folium Tamaricis 26 parts, coriander 28 parts, 27 parts, Rhizoma Zingiberis Recens, Fructus Arctii 26 parts, 27 parts, Folium Mori, Radix Puerariae 25 parts, Herba Equiseti Hiemalis 26 parts, Periostracum Cicadae 28 parts, 22 parts, Herba Spirodelae, Semen Sojae Preparatum 26 parts, 21 parts, Radix Glycyrrhizae.

A kind of preparation method for the treatment of the Chinese medicinal capsule of wind and cold:

(1) first Pulvis Talci is put in pot, be heated to Pulvis Talci light, when easily stirring, drop into Herba Schizonepetae, Folium Perillae, Radix Saposhnikoviae, Rhizoma Et Radix Notopterygii, Rhizoma Ligustici, the Radix Angelicae Dahuricae, Flos Magnoliae, Herba Centipedae, Herba Moslae, Ramulus et Folium Tamaricis, Pulvis Talci amount floods spice, fry and dredge to the expansion of medicine body, pine, treat cold standby;

(2) again pot is burnt heat, sprinkle the rice soaked, make on its smooth pot, be heated to rice when smoldering, drop into coriander, Rhizoma Zingiberis Recens, Fructus Arctii, Folium Mori, Radix Puerariae, Herba Equiseti Hiemalis, Periostracum Cicadae, Herba Spirodelae, Semen Sojae Preparatum, Radix Glycyrrhizae, stir gently, frying to rice is that coke yellow takes out, remove rice, treat cold standby;

(3) will obtain loading ball mill grinding 2h through step (1) (2), and cross 80 mesh sieves, obtain grounds travel;

(4) boil 2h after the grounds travel that step (3) obtains being heated to boiling, be separated and take out fried liquid, continue the purified water adding 4 parts in medical material, continue to boil 1.5h after being heated to boiling, merge twice fried liquid and be extracting solution;

(5) extracting solution that step (4) obtains is positioned in the extraction kettle in supercritical extraction instrument, carbon dioxide is utilized to extract as medium, extraction kettle pressure is 40Mpa, extraction temperature is 45 DEG C, separator pressure 12Mpa, separator temperature is 70 DEG C, extracts 2 hours, is extracted liquid; Extract concentrates at outer circulation concentrator, and concentrated condition is: pressure 0.03Mpa, temperature 70 C, is concentrated into the extractum that relative density is 1.13 ~ 1.14;

(6) extractum obtained to step (5), in 50 DEG C of dryings, is crossed 16 mesh sieves, is obtained xeraphium, add the dextrin accounting for capsule gross mass 70% in xeraphium, and mixing, capsule machine makes capsule, and per kilogram obtains 700 1# capsules.

Embodiment 3:

Treat a Chinese medicinal capsule for wind and cold, the crude drug effective ingredient mass fraction making capsule comprises: Herba Schizonepetae 28 parts, Folium Perillae 12 parts, Radix Saposhnikoviae 18 parts, Rhizoma Et Radix Notopterygii 15 parts, Rhizoma Ligustici 10 parts, the Radix Angelicae Dahuricae 18 parts, Flos Magnoliae 9 parts, Herba Centipedae 17 parts, Herba Moslae 11 parts, Ramulus et Folium Tamaricis 18 parts, coriander 17 parts, 19 parts, Rhizoma Zingiberis Recens, Fructus Arctii 12 parts, 18 parts, Folium Mori, Radix Puerariae 11 parts, Herba Equiseti Hiemalis 13 parts, Periostracum Cicadae 16 parts, 12 parts, Herba Spirodelae, Semen Sojae Preparatum 15 parts, 14 parts, Radix Glycyrrhizae.

A kind of preparation method for the treatment of the Chinese medicinal capsule of wind and cold:

(1) first Pulvis Talci is put in pot, be heated to Pulvis Talci light, when easily stirring, drop into Herba Schizonepetae, Folium Perillae, Radix Saposhnikoviae, Rhizoma Et Radix Notopterygii, Rhizoma Ligustici, the Radix Angelicae Dahuricae, Flos Magnoliae, Herba Centipedae, Herba Moslae, Ramulus et Folium Tamaricis, Pulvis Talci amount floods spice, fry and dredge to the expansion of medicine body, pine, treat cold standby;

(2) again pot is burnt heat, sprinkle the rice soaked, make on its smooth pot, be heated to rice when smoldering, drop into coriander, Rhizoma Zingiberis Recens, Fructus Arctii, Folium Mori, Radix Puerariae, Herba Equiseti Hiemalis, Periostracum Cicadae, Herba Spirodelae, Semen Sojae Preparatum, Radix Glycyrrhizae, stir gently, frying to rice is that coke yellow takes out, remove rice, treat cold standby;

(3) will obtain loading ball mill grinding 2h through step (1) (2), and cross 80 mesh sieves, obtain grounds travel;

(4) boil 2h after the grounds travel that step (3) obtains being heated to boiling, be separated and take out fried liquid, continue the purified water adding 4 parts in medical material, continue to boil 1.5h after being heated to boiling, merge twice fried liquid and be extracting solution;

(5) extracting solution that step (4) obtains is positioned in the extraction kettle in supercritical extraction instrument, carbon dioxide is utilized to extract as medium, extraction kettle pressure is 40Mpa, extraction temperature is 45 DEG C, separator pressure 12Mpa, separator temperature is 70 DEG C, extracts 2 hours, is extracted liquid; Extract concentrates at outer circulation concentrator, and concentrated condition is: pressure 0.03Mpa, temperature 70 C, is concentrated into the extractum that relative density is 1.13 ~ 1.14;

(6) extractum obtained to step (5), in 50 DEG C of dryings, is crossed 16 mesh sieves, is obtained xeraphium, add the dextrin accounting for capsule gross mass 70% in xeraphium, and mixing, capsule machine makes capsule, and per kilogram obtains 700 1# capsules.

Embodiment 4:

Treat a Chinese medicinal capsule for wind and cold, the crude drug effective ingredient mass fraction making capsule comprises: Herba Schizonepetae 33 parts, Folium Perillae 15 parts, Radix Saposhnikoviae 22 parts, Rhizoma Et Radix Notopterygii 21 parts, Rhizoma Ligustici 14 parts, the Radix Angelicae Dahuricae 23 parts, Flos Magnoliae 24 parts, Herba Centipedae 20 parts, Herba Moslae 16 parts, Ramulus et Folium Tamaricis 22 parts, coriander 23 parts, 24 parts, Rhizoma Zingiberis Recens, Fructus Arctii 21 parts, 21 parts, Folium Mori, Radix Puerariae 20 parts, Herba Equiseti Hiemalis 20 parts, Periostracum Cicadae 22 parts, 15 parts, Herba Spirodelae, Semen Sojae Preparatum 20 parts, 18 parts, Radix Glycyrrhizae.

A kind of preparation method for the treatment of the Chinese medicinal capsule of wind and cold:

(1) first Pulvis Talci is put in pot, be heated to Pulvis Talci light, when easily stirring, drop into Herba Schizonepetae, Folium Perillae, Radix Saposhnikoviae, Rhizoma Et Radix Notopterygii, Rhizoma Ligustici, the Radix Angelicae Dahuricae, Flos Magnoliae, Herba Centipedae, Herba Moslae, Ramulus et Folium Tamaricis, Pulvis Talci amount floods spice, fry and dredge to the expansion of medicine body, pine, treat cold standby;

(2) again pot is burnt heat, sprinkle the rice soaked, make on its smooth pot, be heated to rice when smoldering, drop into coriander, Rhizoma Zingiberis Recens, Fructus Arctii, Folium Mori, Radix Puerariae, Herba Equiseti Hiemalis, Periostracum Cicadae, Herba Spirodelae, Semen Sojae Preparatum, Radix Glycyrrhizae, stir gently, frying to rice is that coke yellow takes out, remove rice, treat cold standby;

(3) will obtain loading ball mill grinding 2h through step (1) (2), and cross 80 mesh sieves, obtain grounds travel;

(4) boil 2h after the grounds travel that step (3) obtains being heated to boiling, be separated and take out fried liquid, continue the purified water adding 4 parts in medical material, continue to boil 1.5h after being heated to boiling, merge twice fried liquid and be extracting solution;

(5) extracting solution that step (4) obtains is positioned in the extraction kettle in supercritical extraction instrument, carbon dioxide is utilized to extract as medium, extraction kettle pressure is 40Mpa, extraction temperature is 45 DEG C, separator pressure 12Mpa, separator temperature is 70 DEG C, extracts 2 hours, is extracted liquid; Extract concentrates at outer circulation concentrator, and concentrated condition is: pressure 0.03Mpa, temperature 70 C, is concentrated into the extractum that relative density is 1.13 ~ 1.14;

(6) extractum obtained to step (5), in 50 DEG C of dryings, is crossed 16 mesh sieves, is obtained xeraphium, add the dextrin accounting for capsule gross mass 70% in xeraphium, and mixing, capsule machine makes capsule, and per kilogram obtains 700 1# capsules.

Embodiment 5:

Treat a Chinese medicinal capsule for wind and cold, the crude drug effective ingredient mass fraction making capsule comprises: Herba Schizonepetae 30 parts, Folium Perillae 13 parts, Radix Saposhnikoviae 20 parts, Rhizoma Et Radix Notopterygii 17 parts, Rhizoma Ligustici 12 parts, the Radix Angelicae Dahuricae 20 parts, Flos Magnoliae 16 parts, Herba Centipedae 18 parts, Herba Moslae 14 parts, Ramulus et Folium Tamaricis 20 parts, coriander 21 parts, 20 parts, Rhizoma Zingiberis Recens, Fructus Arctii 16 parts, 20 parts, Folium Mori, Radix Puerariae 15 parts, Herba Equiseti Hiemalis 16 parts, Periostracum Cicadae 18 parts, 13 parts, Herba Spirodelae, Semen Sojae Preparatum 17 parts, 15 parts, Radix Glycyrrhizae.

A kind of preparation method for the treatment of the Chinese medicinal capsule of wind and cold:

(1) first Pulvis Talci is put in pot, be heated to Pulvis Talci light, when easily stirring, drop into Herba Schizonepetae, Folium Perillae, Radix Saposhnikoviae, Rhizoma Et Radix Notopterygii, Rhizoma Ligustici, the Radix Angelicae Dahuricae, Flos Magnoliae, Herba Centipedae, Herba Moslae, Ramulus et Folium Tamaricis, Pulvis Talci amount floods spice, fry and dredge to the expansion of medicine body, pine, treat cold standby;

(2) again pot is burnt heat, sprinkle the rice soaked, make on its smooth pot, be heated to rice when smoldering, drop into coriander, Rhizoma Zingiberis Recens, Fructus Arctii, Folium Mori, Radix Puerariae, Herba Equiseti Hiemalis, Periostracum Cicadae, Herba Spirodelae, Semen Sojae Preparatum, Radix Glycyrrhizae, stir gently, frying to rice is that coke yellow takes out, remove rice, treat cold standby;

(3) will obtain loading ball mill grinding 2h through step (1) (2), and cross 80 mesh sieves, obtain grounds travel;

(4) boil 2h after the grounds travel that step (3) obtains being heated to boiling, be separated and take out fried liquid, continue the purified water adding 4 parts in medical material, continue to boil 1.5h after being heated to boiling, merge twice fried liquid and be extracting solution;

(5) extracting solution that step (4) obtains is positioned in the extraction kettle in supercritical extraction instrument, carbon dioxide is utilized to extract as medium, extraction kettle pressure is 40Mpa, extraction temperature is 45 DEG C, separator pressure 12Mpa, separator temperature is 70 DEG C, extracts 2 hours, is extracted liquid; Extract concentrates at outer circulation concentrator, and concentrated condition is: pressure 0.03Mpa, temperature 70 C, is concentrated into the extractum that relative density is 1.13 ~ 1.14;

(6) extractum obtained to step (5), in 50 DEG C of dryings, is crossed 16 mesh sieves, is obtained xeraphium, add the dextrin accounting for capsule gross mass 70% in xeraphium, and mixing, capsule machine makes capsule, and per kilogram obtains 700 1# capsules.

1, zoopery

Animal acute toxicity experiment, selects white mice 40, each 20 of male and female, sodium carboxymethyl cellulose solution with 1% makes the suspension of 50mg/ml, gavage body 0.56ml/10g, every day three times, observe animal activity after gavage 15 days, diet, feces, hair color and death condition, the results are shown in Table 1.

Animal acute toxicity experiment result:

Table 1

After experimental result gavage, the diet of animal, feces, none example of hair are abnormal, and after second, third gavage, much more slightly animal moves, and within about 10 minutes, the many emotionally conditions of animal disappear, and none example was dead on 15th.

Conclusion: maximum tolerated dose is ﹥ 7.35mg/kg is 147 times of the clinical maximal dose of people.

2, bacteriostatic test inspection

Adopt penicillin sheet to contrast, embodiment 1 gained Chinese medicinal capsule is that experimental group carries out antibacterial inspection.

The preparation of culture medium: take in the water-soluble 800mL of beef extract 5g, adds peptone 10g and dissolves, and adds casein 34g and dissolves, then adds NaCl 5g and dissolve, and is adjusted to pH7.6 ~ 7.8, is diluted to 1000mL.Add agar powder 18g, autoclaving 15min, when being cooled to 40 DEG C ~ 50 DEG C, a kind of rhyme scheme in Chinese operas serving as the prelude to a complete score for voices, solidifies, and the 4 DEG C of refrigerators placing no bacteria pollution are for subsequent use.

Strain is: wind and cold streptococcus, staphylococcus aureus, wind and cold klebsiella.

Matched group antibacterial liquid is prepared: be dissolved in respectively in 10ml sterile deionized water by 3 penicillins, diluted respectively by liquor strength, with stock solution than being 1:2,1:4,1:8,1:16,1:32.

Experimental group antibacterial liquid is prepared: be dissolved in respectively in 10ml sterile deionized water by 3 Chinese medicinal capsules, diluted respectively by liquor strength, with stock solution than being 1:2,1:4,1:8,1:16,1:32.Wind and cold streptococcus is antibacterial the results are shown in Table 2, and staphylococcus aureus is antibacterial the results are shown in Table 3, and wind and cold klebsiella is antibacterial the results are shown in Table 4.

Table 2

Table 3

Table 4

Interpretation of result: result of the test shows, Chinese medicinal capsule of the present invention has better bactericidal effect.

3, clinical data and case:

In order to show therapeutic effect of the present invention, system clinical observation treatment being carried out to 100 routine wind and cold patients, in the process of above-mentioned clinical observation, record is carried out to the medical history of above-mentioned patient, the state of an illness and curative effect.

Clinical therapeutic efficacy criterion is:

Cure: common symptom is disliked cough, itching throat, nasal obstruction, watery nasal discharge, sneezed more, aversion to wind, expectoration color white matter be rare, mouth is thirsty, headache, lossless, light red tongue tongue is white, and floating pulse etc. are disappearance all.

Take a turn for the better: common sympton cough, itching throat, nasal obstruction, watery nasal discharge, to sneeze more, aversion to wind, expectoration color white matter be rare, mouth is thirsty, headache, lossless, light red tongue tongue is white, the basic disappearance such as floating pulse.

Invalid: symptom is not improved.

Therapeutic effect: the present invention is through treating 100 routine wind and cold patients, and 98 examples are cured, and 2 examples are invalid, and total effective rate reaches 98%, and nobody occurs side effect.

Model case:

Case 1: patient Jiang so-and-so, man, 29 years old, patient's aversion to cold weight, heating was light, headache, general pain, nasal obstruction watery nasal discharge, cough, thin white fur of tongue, floating and tense pulse, and after using 1 course for the treatment of of Chinese medicinal capsule of the present invention, symptom obviously alleviates, 1 course for the treatment of of continuation use, and symptom all disappears.

Case 2: patient Lee, man, 42 years old, patient's aversion to cold was heavily had a stuffy nose, watery nasal discharge, sneeze more, and aversion to wind, expectoration color white matter are rare, mouth is thirsty, headache, and after using 2 courses for the treatment of of Chinese medicinal capsule of the present invention, symptom is obviously improved, 2 courses for the treatment of of continuation use, and symptom all disappears.

Case 3: patient Jiang, female, 37 years old, patient's cough, itching throat, nasal obstruction, watery nasal discharge, sneeze, aversion to wind, expectoration color white matter are rare more, after using 1 course for the treatment of of Chinese medicinal capsule of the present invention, symptom is clearly better, and after continuing to use 2 courses for the treatment of of Chinese medicinal capsule of the present invention, symptom all disappears.

The above is the preferred embodiment of the present invention; its object is to allow person skilled in the art understand content of the present invention and to be implemented; should be understood that; for those skilled in the art; under the premise without departing from the principles of the invention; can also make some improvements and modifications, these improvements and modifications are also considered as protection scope of the present invention.

Claims (4)

1. treat the Chinese medicinal capsule of wind and cold for one kind, it is characterized in that, the effective ingredient mass fraction making capsule comprises: Herba Schizonepetae 25 ~ 38 parts, Folium Perillae 7 ~ 19 parts, Radix Saposhnikoviae 13 ~ 24 parts, Rhizoma Et Radix Notopterygii 11 ~ 26 parts, Rhizoma Ligustici 5 ~ 19 parts, the Radix Angelicae Dahuricae 13 ~ 28 parts, Flos Magnoliae 5 ~ 26 parts, Herba Centipedae 11 ~ 22 parts, Herba Moslae 5 ~ 23 parts, Ramulus et Folium Tamaricis 13 ~ 26 parts, coriander 13 ~ 28 parts, 14 ~ 27 parts, Rhizoma Zingiberis Recens, Fructus Arctii 7 ~ 26 parts, 12 ~ 27 parts, Folium Mori, Radix Puerariae 6 ~ 25 parts, Herba Equiseti Hiemalis 6 ~ 26 parts, Periostracum Cicadae 11 ~ 28 parts, 5 ~ 22 parts, Herba Spirodelae, Semen Sojae Preparatum 10 ~ 26 parts, 10 ~ 21 parts, Radix Glycyrrhizae.

2. a kind of Chinese medicinal capsule for the treatment of wind and cold according to claim 1, it is characterized in that, the effective ingredient mass fraction making capsule comprises: Herba Schizonepetae 28 ~ 33 parts, Folium Perillae 12 ~ 15 parts, Radix Saposhnikoviae 18 ~ 22 parts, Rhizoma Et Radix Notopterygii 15 ~ 21 parts, Rhizoma Ligustici 10 ~ 14 parts, the Radix Angelicae Dahuricae 18 ~ 23 parts, Flos Magnoliae 9 ~ 24 parts, Herba Centipedae 17 ~ 20 parts, Herba Moslae 11 ~ 16 parts, Ramulus et Folium Tamaricis 18 ~ 22 parts, coriander 17 ~ 23 parts, 19 ~ 24 parts, Rhizoma Zingiberis Recens, Fructus Arctii 12 ~ 21 parts, 18 ~ 21 parts, Folium Mori, Radix Puerariae 11 ~ 20 parts, Herba Equiseti Hiemalis 13 ~ 20 parts, Periostracum Cicadae 16 ~ 22 parts, 12 ~ 15 parts, Herba Spirodelae, Semen Sojae Preparatum 15 ~ 20 parts, 14 ~ 18 parts, Radix Glycyrrhizae.

3. a kind of Chinese medicinal capsule for the treatment of wind and cold according to claim 1, it is characterized in that, the effective ingredient mass fraction making capsule comprises: Herba Schizonepetae 30 parts, Folium Perillae 13 parts, Radix Saposhnikoviae 20 parts, Rhizoma Et Radix Notopterygii 17 parts, Rhizoma Ligustici 12 parts, the Radix Angelicae Dahuricae 20 parts, Flos Magnoliae 16 parts, Herba Centipedae 18 parts, Herba Moslae 14 parts, Ramulus et Folium Tamaricis 20 parts, coriander 21 parts, 20 parts, Rhizoma Zingiberis Recens, Fructus Arctii 16 parts, 20 parts, Folium Mori, Radix Puerariae 15 parts, Herba Equiseti Hiemalis 16 parts, Periostracum Cicadae 18 parts, 13 parts, Herba Spirodelae, Semen Sojae Preparatum 17 parts, 15 parts, Radix Glycyrrhizae.

4. treat a preparation method for the Chinese medicinal capsule of wind and cold, it is characterized in that, described preparation method concrete steps are as follows:

(1) first Pulvis Talci is put in pot, be heated to Pulvis Talci light, when easily stirring, drop into Herba Schizonepetae, Folium Perillae, Radix Saposhnikoviae, Rhizoma Et Radix Notopterygii, Rhizoma Ligustici, the Radix Angelicae Dahuricae, Flos Magnoliae, Herba Centipedae, Herba Moslae, Ramulus et Folium Tamaricis, Pulvis Talci amount floods spice, fry and dredge to the expansion of medicine body, pine, treat cold standby;

(2) again pot is burnt heat, sprinkle the rice soaked, make on its smooth pot, be heated to rice when smoldering, drop into coriander, Rhizoma Zingiberis Recens, Fructus Arctii, Folium Mori, Radix Puerariae, Herba Equiseti Hiemalis, Periostracum Cicadae, Herba Spirodelae, Semen Sojae Preparatum, Radix Glycyrrhizae, stir gently, frying to rice is that coke yellow takes out, remove rice, treat cold standby;

(3) will obtain loading ball mill grinding 2h through step (1) (2), and cross 80 mesh sieves, obtain grounds travel;

(4) boil 2h after the grounds travel that step (3) obtains being heated to boiling, be separated and take out fried liquid, continue the purified water adding 4 parts in medical material, continue to boil 1.5h after being heated to boiling, merge twice fried liquid and be extracting solution;

(5) extracting solution that step (4) obtains is positioned in the extraction kettle in supercritical extraction instrument, carbon dioxide is utilized to extract as medium, extraction kettle pressure is 40Mpa, extraction temperature is 45 DEG C, separator pressure 12Mpa, separator temperature is 70 DEG C, extracts 2 hours, is extracted liquid; Extract concentrates at outer circulation concentrator, and concentrated condition is: pressure 0.03Mpa, temperature 70 C, is concentrated into the extractum that relative density is 1.13 ~ 1.14;

(6) extractum obtained to step (5), in 50 DEG C of dryings, is crossed 16 mesh sieves, is obtained xeraphium, add the dextrin accounting for capsule gross mass 70% in xeraphium, and mixing, capsule machine makes capsule, and per kilogram obtains 700 1# capsules.