CN104853757A - 作为RORγT抑制剂的4-杂芳基取代的苯甲酸化合物及其用途 - Google Patents

作为RORγT抑制剂的4-杂芳基取代的苯甲酸化合物及其用途 Download PDF

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CN104853757A
CN104853757A CN201380053463.8A CN201380053463A CN104853757A CN 104853757 A CN104853757 A CN 104853757A CN 201380053463 A CN201380053463 A CN 201380053463A CN 104853757 A CN104853757 A CN 104853757A
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chloro
trifluoromethyl
benzoyl
indazol
alkyl
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Chinese (zh)
Inventor
K·J·巴尔
C·比恩斯托克
J·麦克莱恩
H·张
R·T·贝尔西斯
D·张
N·安东尼
B·拉波因特
Y·田
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Merck Sharp & Dohme LLC
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Merck Sharp & Dohme LLC
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Priority to CN201380053463.8A priority Critical patent/CN104853757A/zh
Publication of CN104853757A publication Critical patent/CN104853757A/zh
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    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
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  • Orthopedic Medicine & Surgery (AREA)
  • Endocrinology (AREA)
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
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  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Indole Compounds (AREA)
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CN201380053463.8A 2012-08-15 2013-08-14 作为RORγT抑制剂的4-杂芳基取代的苯甲酸化合物及其用途 Pending CN104853757A (zh)

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Application Number Priority Date Filing Date Title
CN201380053463.8A CN104853757A (zh) 2012-08-15 2013-08-14 作为RORγT抑制剂的4-杂芳基取代的苯甲酸化合物及其用途

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
CNPCT/CN2012/080131 2012-08-15
PCT/CN2012/080131 WO2014026327A1 (en) 2012-08-15 2012-08-15 4-heteroaryl substituted benzoic acid compounds as rorgammat inhibitors and uses thereof
PCT/US2013/054887 WO2014028589A2 (en) 2012-08-15 2013-08-14 4-HETEROARYL SUBSTITUTED BENZOIC ACID COMPOUNDS AS RORgammaT INHIBITORS AND USES THEREOF
CN201380053463.8A CN104853757A (zh) 2012-08-15 2013-08-14 作为RORγT抑制剂的4-杂芳基取代的苯甲酸化合物及其用途

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CN104853757A true CN104853757A (zh) 2015-08-19

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US (2) US9745265B2 (enExample)
EP (1) EP2884981B1 (enExample)
JP (1) JP6422438B2 (enExample)
KR (1) KR20150042266A (enExample)
CN (1) CN104853757A (enExample)
AU (1) AU2013302725A1 (enExample)
BR (1) BR112015003188A2 (enExample)
CA (1) CA2881688A1 (enExample)
IN (1) IN2015DN01156A (enExample)
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Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107935842A (zh) * 2017-12-27 2018-04-20 珠海奥博凯生物医药技术有限公司 一种2‑氯‑4‑溴‑6‑甲基苯甲酸的制备方法
WO2018188590A1 (en) * 2017-04-11 2018-10-18 Sunshine Lake Pharma Co., Ltd. Fluorine-substituted indazole compounds and uses thereof
WO2020220562A1 (zh) * 2019-04-29 2020-11-05 上海和誉生物医药科技有限公司 苯并呋喃-6-甲酰胺衍生物、其制备方法和药学上的应用

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2487159A1 (en) 2011-02-11 2012-08-15 MSD Oss B.V. RorgammaT inhibitors
WO2014026329A1 (en) 2012-08-15 2014-02-20 Merck Sharp & Dohme Corp. N-alkylated indole and indazole compounds as rorgammat inhibitors and uses thereof
WO2014026328A1 (en) * 2012-08-15 2014-02-20 Merck Sharp & Dohme Corp. 3-cyclohexenyl substituted indole and indazole compounds as rorgammat inhibitors and uses thereof
WO2014026330A1 (en) 2012-08-15 2014-02-20 Merck Sharp & Dohme Corp. 3-AMINOCYCLOALKYL COMPOUNDS AS RORgammaT INHIBITORS AND USES THEREOF
WO2014026327A1 (en) 2012-08-15 2014-02-20 Merck Sharp & Dohme Corp. 4-heteroaryl substituted benzoic acid compounds as rorgammat inhibitors and uses thereof
WO2015095795A1 (en) 2013-12-20 2015-06-25 Merck Sharp & Dohme Corp. TETRAHYDRONAPHTHYRIDINE, BENZOXAZINE, AZA-BENZOXAZINE, AND RELATED BICYCLIC COMPOUNDS FOR INHIBITION OF RORgamma ACTIVITY AND THE TREATMENT OF DISEASE
DK3102576T3 (da) 2014-02-03 2019-07-22 Vitae Pharmaceuticals Llc Dihydropyrrolopyridininhibitorer af ror-gamma
AU2015222917A1 (en) 2014-02-27 2016-09-15 Lycera Corporation Adoptive cellular therapy using an agonist of retinoic acid receptor-related orphan receptor gamma and related therapeutic methods
WO2015139621A1 (zh) * 2014-03-18 2015-09-24 北京韩美药品有限公司 4-杂芳基取代的苯甲酸或苯甲酰胺类化合物
EP3140291A4 (en) 2014-05-05 2018-01-10 Lycera Corporation Tetrahydroquinoline sulfonamide and related compounds for use as agonists of rory and the treatment of disease
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