CN104853751B - 用于包衣药物成分的无溶剂混合方法 - Google Patents

用于包衣药物成分的无溶剂混合方法 Download PDF

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Publication number
CN104853751B
CN104853751B CN201380053927.5A CN201380053927A CN104853751B CN 104853751 B CN104853751 B CN 104853751B CN 201380053927 A CN201380053927 A CN 201380053927A CN 104853751 B CN104853751 B CN 104853751B
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coating
particle
particles
water
coated
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Chinese (zh)
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CN104853751A (zh
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拉杰什·N·戴夫
丹尼尔·多
马克思·卡佩斯
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New Jersey Institute of Technology
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New Jersey Institute of Technology
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin
    • A61K9/5042—Cellulose; Cellulose derivatives, e.g. phthalate or acetate succinate esters of hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5063—Compounds of unknown constitution, e.g. material from plants or animals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5089—Processes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Zoology (AREA)
  • Botany (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Obesity (AREA)
  • Diabetes (AREA)
  • Nutrition Science (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CN201380053927.5A 2012-10-15 2013-10-09 用于包衣药物成分的无溶剂混合方法 Active CN104853751B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US13/651,977 US9107851B2 (en) 2012-10-15 2012-10-15 Solventless mixing process for coating pharmaceutical ingredients
US13/651,977 2012-10-15
PCT/US2013/064058 WO2014062444A1 (en) 2012-10-15 2013-10-09 Solventless mixing process for coating pharmaceutical ingredients

Publications (2)

Publication Number Publication Date
CN104853751A CN104853751A (zh) 2015-08-19
CN104853751B true CN104853751B (zh) 2018-06-22

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CN201380053927.5A Active CN104853751B (zh) 2012-10-15 2013-10-09 用于包衣药物成分的无溶剂混合方法

Country Status (16)

Country Link
US (1) US9107851B2 (cg-RX-API-DMAC7.html)
EP (1) EP2906205B1 (cg-RX-API-DMAC7.html)
JP (1) JP6159504B2 (cg-RX-API-DMAC7.html)
CN (1) CN104853751B (cg-RX-API-DMAC7.html)
AR (1) AR093013A1 (cg-RX-API-DMAC7.html)
BR (1) BR112015008285B1 (cg-RX-API-DMAC7.html)
CY (1) CY1121241T1 (cg-RX-API-DMAC7.html)
DK (1) DK2906205T3 (cg-RX-API-DMAC7.html)
ES (1) ES2688889T3 (cg-RX-API-DMAC7.html)
HR (1) HRP20181463T1 (cg-RX-API-DMAC7.html)
HU (1) HUE039772T2 (cg-RX-API-DMAC7.html)
PL (1) PL2906205T3 (cg-RX-API-DMAC7.html)
PT (1) PT2906205T (cg-RX-API-DMAC7.html)
RS (1) RS57918B1 (cg-RX-API-DMAC7.html)
SI (1) SI2906205T1 (cg-RX-API-DMAC7.html)
WO (1) WO2014062444A1 (cg-RX-API-DMAC7.html)

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WO2016011412A1 (en) 2014-07-17 2016-01-21 Ada Technologies, Inc. Extreme long life, high energy density batteries and method of making and using the same
CN104587472B (zh) * 2014-12-31 2017-12-15 广东国方医药科技有限公司 一种含纳米SiO2的包衣剂及其制备方法
WO2016209460A2 (en) 2015-05-21 2016-12-29 Ada Technologies, Inc. High energy density hybrid pseudocapacitors and method of making and using the same
US12401042B2 (en) 2015-06-01 2025-08-26 Forge Nano Inc. Nano-engineered coatings for anode active materials, cathode active materials, and solid-state electrolytes and methods of making batteries containing nano-engineered coatings
US12027661B2 (en) 2015-06-01 2024-07-02 Forge Nano Inc. Nano-engineered coatings for anode active materials, cathode active materials, and solid-state electrolytes and methods of making batteries containing nano-engineered coatings
US11996564B2 (en) 2015-06-01 2024-05-28 Forge Nano Inc. Nano-engineered coatings for anode active materials, cathode active materials, and solid-state electrolytes and methods of making batteries containing nano-engineered coatings
US10692659B2 (en) 2015-07-31 2020-06-23 Ada Technologies, Inc. High energy and power electrochemical device and method of making and using same
JP7069538B2 (ja) * 2016-12-05 2022-05-18 マルボシ酢株式会社 食酢含有飲料組成物
US11024846B2 (en) 2017-03-23 2021-06-01 Ada Technologies, Inc. High energy/power density, long cycle life, safe lithium-ion battery capable of long-term deep discharge/storage near zero volt and method of making and using the same
JPWO2019009335A1 (ja) * 2017-07-04 2020-07-02 村上　正裕 微粒子の製造方法及び微粒子
AU2020223894B2 (en) * 2019-02-22 2025-09-18 Catalent U.K. Swindon Zydis Limited Minimizing agglomeration, aeration, and preserving the coating of pharmaceutical compositions comprising Ibuprofen
HUE064287T2 (hu) * 2019-02-22 2024-02-28 Catalent Uk Swindon Zydis Ltd Hatóanyagrészecske-bevonóanyag agglomerálódásának minimalizálása tárolás során, gyógyszerészeti termékek szétesési idejének stabilizálására
EP3927313B1 (en) * 2019-02-22 2025-12-24 Catalent U.K. Swindon Zydis Limited Preserving functionally-coated api particles produced by solventless mixing processes in aqueous suspension
ES2961850T3 (es) 2019-02-22 2024-03-14 Catalent Uk Swindon Zydis Ltd Minimización de la aireación de suspensiones durante la mezcla en línea
US20210009767A1 (en) * 2019-07-11 2021-01-14 International Flavors & Fragrances Inc. Solventless particle coating via acoustic mixing
US12285731B2 (en) 2019-09-12 2025-04-29 United States Of America, As Represented By The Secretary Of The Army Acoustic mixing system for creating propellant mixture
MX2023001004A (es) 2020-07-31 2023-03-01 Catalent Uk Swindon Zydis Ltd Composiciones farmaceuticas que comprenden un ingrediente farmaceutico activo (api) recubierto.

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CN101060835A (zh) * 2004-12-10 2007-10-24 罗姆有限公司 包含粘膜粘附性配制的核酸活性成分的多颗粒状药物剂型以及制备所述药物剂型的方法
WO2011155451A1 (ja) * 2010-06-08 2011-12-15 学校法人神戸学院 コーティング粒子及びコーティング粒子の製造方法

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WO2011155451A1 (ja) * 2010-06-08 2011-12-15 学校法人神戸学院 コーティング粒子及びコーティング粒子の製造方法

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Also Published As

Publication number Publication date
ES2688889T3 (es) 2018-11-07
PT2906205T (pt) 2018-11-07
JP6159504B2 (ja) 2017-07-05
CN104853751A (zh) 2015-08-19
US20140106059A1 (en) 2014-04-17
HUE039772T2 (hu) 2019-02-28
HRP20181463T1 (hr) 2018-12-14
PL2906205T3 (pl) 2019-03-29
BR112015008285A2 (pt) 2017-07-04
EP2906205B1 (en) 2018-06-13
SI2906205T1 (sl) 2018-12-31
US9107851B2 (en) 2015-08-18
AR093013A1 (es) 2015-05-13
JP2015533162A (ja) 2015-11-19
BR112015008285B1 (pt) 2022-11-16
CY1121241T1 (el) 2020-05-29
EP2906205A1 (en) 2015-08-19
RS57918B1 (sr) 2019-01-31
DK2906205T3 (en) 2018-09-24
WO2014062444A1 (en) 2014-04-24

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