CN104838864B - A kind of novel use of half heel of Chinese herbal medicine - Google Patents

A kind of novel use of half heel of Chinese herbal medicine Download PDF

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CN104838864B
CN104838864B CN201510268664.0A CN201510268664A CN104838864B CN 104838864 B CN104838864 B CN 104838864B CN 201510268664 A CN201510268664 A CN 201510268664A CN 104838864 B CN104838864 B CN 104838864B
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herbal medicine
chinese herbal
half heel
crops
heel
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CN104838864A (en
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张述仁
张述智
岳川
张栩晨
姜梦希
耿波
张继国
张培军
李晓玲
牟赵杰
周涛
岳旺
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QINGDAO ZHONGREN ANIMAL MEDICINE CO., LTD.
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QINGDAO ZHONGREN ANIMAL MEDICINE Co Ltd
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    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01GHORTICULTURE; CULTIVATION OF VEGETABLES, FLOWERS, RICE, FRUIT, VINES, HOPS OR SEAWEED; FORESTRY; WATERING
    • A01G22/00Cultivation of specific crops or plants not otherwise provided for
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01NPRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N65/00Biocides, pest repellants or attractants, or plant growth regulators containing material from algae, lichens, bryophyta, multi-cellular fungi or plants, or extracts thereof
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01NPRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N65/00Biocides, pest repellants or attractants, or plant growth regulators containing material from algae, lichens, bryophyta, multi-cellular fungi or plants, or extracts thereof
    • A01N65/08Magnoliopsida [dicotyledons]
    • A01N65/12Asteraceae or Compositae [Aster or Sunflower family], e.g. daisy, pyrethrum, artichoke, lettuce, sunflower, wormwood or tarragon
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01NPRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N65/00Biocides, pest repellants or attractants, or plant growth regulators containing material from algae, lichens, bryophyta, multi-cellular fungi or plants, or extracts thereof
    • A01N65/40Liliopsida [monocotyledons]
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01NPRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N65/00Biocides, pest repellants or attractants, or plant growth regulators containing material from algae, lichens, bryophyta, multi-cellular fungi or plants, or extracts thereof
    • A01N65/40Liliopsida [monocotyledons]
    • A01N65/48Zingiberaceae [Ginger family], e.g. ginger or galangal

Abstract

The invention belongs to half heel applied technical field of Chinese herbal medicine, is related to a kind of novel use of half heel of Chinese herbal medicine --- and particular functionality crops are cultivated, the crops that production is cultivated can be made to have effects that to alleviate and suppress vomiting;Half heel of Chinese herbal medicine is made in ginger leftover bits and pieces and tuber of pinellia leftover bits and pieces after mixing, half heel of Chinese herbal medicine soak twice, is decocted, filtering, it is spare to obtain uniformly mixed filtrate, and will half heel slag of Chinese herbal medicine collect after dry that half heel cake of Chinese herbal medicine is made is spare;With after dilution soak by the filtrate crop seeds after sow and routinely technology irrigate and management, according to needed for the different growing stages of every kind of crops, crops are applied with the half heel cake of Chinese herbal medicine after crushing in growth phase, flowering phase, and/or result stage respectively, the crops with emesis can be harvested to the maturity period;This method is easy to operate, and raw material is easy to get, and gained crops natural green, has no toxic side effect and evident in efficacy.

Description

A kind of novel use of half heel of Chinese herbal medicine
Technical field:
The invention belongs to half heel applied technical field of Chinese herbal medicine, is related to a kind of novel use of half heel of Chinese herbal medicine --- Particular functionality crops are cultivated, can have the crops such as grain, water fruits and vegetables that production cultivates and alleviate and suppression is vomitted The effect of spitting.
Background technology:
Herbal health care functional food applies history in existing thousand in China, and the theory of traditional Chinese medical science of Chinese herbal medicine emphasizes overall health, Negative and positive, which reconcile, and " correction " theory is also early is spread and is rooted in the hearts of the people in the form of pearls of wisdom, world-renowned Chinese Medicine ancient books and records, Embody the theory of doctor's food homology (also referred to as integration of drinking and medicinal herbs), such as Ming Dynasty《Compendium of Materia Medica》Record " stomach is controlled with stomach, with the heart thoughts of returning home, Blood is led with blood, is exactly to natural products health care and disease preventing and treating with famous discuss of Pi Zhipi " with marrow mends marrow with bone to the marrow The discussion that knows best.Modern study proves that material can be utilized with the absorption pattern of small molecule or endocytosis by body, such as With the precursor absorbed in bone Psoralen using calcium as preceding raw material, ancients are fully demonstrated in the scientific and unrivaled of health field Wisdom.
At present under the background of aging society, health becomes the wealth of human maximum, and industrialization rapid development is desalinated Threat of the people to natural reasonable development application, chemicals, food additives, pesticide etc., causes air, water source and soil dirty Dye, species quickly become extinct, human health crisis, and returning the Nature of global village, establishing the development model that green ecological circulates is The only way of human health development.The increase of environmental pollution, chemicals abuse and the life stress brought in face of modern civilization, Various chronic diseases, inferior health and ageing populations are made to be had the greatest esteem for functional food, " sage's not treating the disease affected, is controlled with ancients for this The philosophical thinking of not disease " coincide, and functional food already becomes a kind of trend of new century maintaining healthy, while people are desirable to it Energy beauty, weight-reducing, increase intelligence, muscle power and promote longevity.
Health functional food development history is looked back, first nourishes on behalf of tradition, and second compounds product on behalf of extraction, and the third generation is The natural product of purification, also there is genetic modification, if transgenosis " antiallergy clover " and beta carotene are higher than tens times of nature rice " gold rice ", above-mentioned three generations's health functional food are characterized in being industrialization product, not only consume energy that it is manufactured and purification process The effect of producing secondary waste pollution, extracting after sterling, is likely lower than the regulatory function of Chinese herbal medicine entirety Mutiple Targets, medicine strength mistake Greatly, it is unfavorable for the function using health care as the entirety " correction " of target to adjust, purifies the additive of food also toxic side effect, because The invention people through concentrating on studies for many years, and having formulated forth generation has the natural grain fruit-vegetable plant of specific health function, it is special Sign is to break traditional industrialized production health food frame, avoids the secondary pollution of industrialized production and high cost, utilizes agriculture The crops with healthcare function are produced in the circulation of industry green ecological.
Specific crops are fed using the Chinese herbal medicine and relevant portion of specific function in the present invention, are produced with specific The grain fruits and vegetables of healthcare function, and for the purpose clinical test of body-care, obtained unexpected health care and prevention disease Effect;Annual several hundred million ten thousand tons of Chinese herbal medicine byproduct leftover bits and pieces and the pollution problem of the dregs of a decoction are not only solved, avoids industrialization Secondary pollution is produced, and improves agricultural product added value, accomplished to recover one's original simplicity, gone back to nature.What the present invention worked out A kind of half heel of Chinese herbal medicine for being used to cultivate crops (specifically refers to mix made of different Chinese herbal medicine leftover bits and pieces scientific matchings Thing), including the active component of Small Pinelliae Decoction disclosed in Chinese patent 201210022289.8 and 201110417242.7 and its A kind of Small Pinelliae Decoction dosage form preparation technology disclosed in preparation method and application, Chinese patent 201110180641.6 and A kind of natural drug composition its preparation method disclosed in its production method, Chinese patent 200810104556.X and its preparing Ginger and building disclosed in purposes and Chinese patent 201110079461.9 in the medicine of carcinosis radiotherapy and chemotherapy China attenuation synergistic Fragrant composition its preparation method and its purposes in attenuation synergistic medicine in preparing carcinosis radiotherapy and chemotherapy etc. are in the prior art not Refer to, therefore with the perspective and creative of protrusion, not only conform with the main trend of the circulating ecological economy, and be production A new generation high-end green plants product, agricultural products, health food and medicine open one newly by way of.
The content of the invention:
Present invention aims to overcome that a large amount of Chinese herbal medicines are planted and the leftover bits and pieces quilt in process of manufacture in the prior art The shortcomings of discarding, triggering environment, ecological pollution, classical TCM pharmacy and modern agriculture science are combined, worked out in one kind The new application of half heel of herbal medicine --- the crops of specific health-care effect are cultivated, realize recycling for natural green product.
In order to achieve the above object, experimental study and clinical practice of the inventor by a large amount of formula rates, have been invented in one kind The novel use of half heel of herbal medicine, using crops such as half heel directive breeding grain of Chinese herbal medicine, water fruits and vegetables, generates meaning Unexpected effect so that the crops cultivated have effects that to alleviate, suppress and treat to vomiting;The concrete application of the purposes Method comprises the following steps that:
(1) preparation of half heel of filtrate and Chinese herbal medicine:It is 1-15 by weight ratio:1 ginger leftover bits and pieces and tuber of pinellia leftover bits and pieces mixes Half heel of Chinese herbal medicine is made after closing uniformly, 60-80 points of the freshwater soaking of 10-16 times of gross weight is added into half heel of Chinese herbal medicine Clock, is then placed within 70-90 DEG C of heating of temperature control on the electric furnace for adding asbestos gauge and decocts 30-60 minutes, filter is preserved after being filtered with silk Liquid;The fresh water of 5-8 times of weight is added into half heel of Chinese herbal medicine after filtering again, with method immersion, decocts, filtering, will decoct twice Filtrate after boiling is uniformly mixed spare, and naturally dry after half heel slag of Chinese herbal medicine is collected, that half heel cake of Chinese herbal medicine is made is standby With;
(2) application of half heel of Chinese herbal medicine:Crop seeds are soaked after uniformly mixed filtrate is diluted with 1-5 times of fresh water When 1-50 is small, the weight ratio of filtrate and crop seeds after dilution is 1-15:1, then the crop seeds after immersion are broadcast Kind and routinely technology are irrigated and management;According to needed for the different growing stages of every kind of crops, growth phase in crops, open Stage, and/or result stage are spent, 0.5-20kg/m is pressed to crops2/ every time, it is total to using the half heel cake of Chinese herbal medicine after crushing 2-10 times, the crops with emesis can be harvested to the maturity period.
The ratio between the dry weight of half heel of Chinese herbal medicine involved in the present invention and the dry weight of crop seeds are 1:5-500;It is related to Crops include the crop such as grain, fruit and/or vegetables;The fresh water includes tap water, pure water, mineral water, well water, river Water or lake water etc.;It is 1-15 that half heel of Chinese herbal medicine, which further includes weight ratio,:1 ginger leftover bits and pieces and elecampane leftover bits and pieces mixture Or other Chinese herbal medicine leftover bits and pieces proportionings with specific health-care efficacy form;Ginger leftover bits and pieces, tuber of pinellia leftover bits and pieces and the building being related to Fragrant leftover bits and pieces can be directly from obtained by the place categorised collection such as farm, Chinese medicine plant garden, Chinese medicine processing factory, hospital.
Compared with prior art, the present invention the fresh ginger with anti-nausea in classical Chinese herbal medicine, the fresh tuber of pinellia are used With the leftover bits and pieces of fresh elecampane, (leftover bits and pieces refers to the remaining separate section in crude drug medicine materical crude slice process or is separated from medicine position Leftover bits and pieces or pharmacy after waste material etc.), wherein ginger leftover bits and pieces, tuber of pinellia leftover bits and pieces and elecampane leftover bits and pieces are plantation or processing During stem tuber beyond root, stem, leaf and seed etc.;Cultivated in the present invention using the leftover bits and pieces of ginger and the tuber of pinellia/elecampane Crops have alleviate, treatment vomiting the effect of, not only solve and put into practice the defects of Chinese and Western medicine toxic side effect is big, and solve The waste pollution problem of a large amount of leftover bits and pieces, improves the added value of the crops such as grain fruits and vegetables, realizes green circulatory in practice Formula Commercial cultivation;This method is easy to operate, and raw material is easy to get, safe to use, pollution-free, nuisanceless, gained crops natural green, Have no toxic side effect and evident in efficacy, securely and reliably.
Embodiment:
Below by a kind of new use of half heel of embodiment and the test example Chinese herbal medicine that the present invention is further explained is related to On the way, but the present invention is not limited in implementation below.
Embodiment 1:
By taking half heel of Chinese herbal medicine is used to cultivate emesis type Chinese yam as an example, the concrete application method being related to includes the present embodiment Following processing step:
(1) preparation of half heel of filtrate and Chinese herbal medicine:It is 1-15 by weight ratio:1 ginger leftover bits and pieces and tuber of pinellia leftover bits and pieces mixes Half heel of Chinese herbal medicine is made after closing uniformly, the freshwater soaking of 10 times of gross weight is added into half heel of Chinese herbal medicine 80 minutes, then It is placed on 70-90 DEG C of heating of temperature control on the electric furnace for adding asbestos gauge to decoct 60 minutes, filtrate is preserved after being filtered with silk;Again to filtering The fresh water of 5 times of weight is added in half heel of Chinese herbal medicine afterwards, with method immersion, decocts, filtering, the filtrate after decocting twice is mixed It is uniformly spare, and naturally dry after half heel slag of Chinese herbal medicine is collected, that half heel cake of Chinese herbal medicine is made is spare;
(2) application of half heel of Chinese herbal medicine:Chinese yam stem tuber 1- is soaked after uniformly mixed filtrate is diluted with 1-5 times of fresh water 5 it is small when, filtrate after dilution and the weight ratio of Chinese yam kind are 1-15:1, then by the Chinese yam stem tuber natural drying 2-5 after immersion In placing into the soil after it and level land, routinely technology is irrigated and managed;According to the growth phase of Chinese yam kind, the flowering phase, And/or needed for the different growing stages such as result stage, routinely technology applies various organic fertilizer, and 20 before fertilising day are right every time Crop presses 0.5kg/m2/ every time, using the half heel cake of Chinese herbal medicine after crushing to ferment, cure and to absorb, it is to the maturity period The Chinese yam for having anti-nausea effect can be harvested.
The ratio between the dry weight of half heel of Chinese herbal medicine and the dry weight of Chinese yam stem tuber are 1 in the present embodiment:5-500;The step (1) In ginger leftover bits and pieces and tuber of pinellia leftover bits and pieces can be directly from place categorised collections such as farm, Chinese medicine plant garden, Chinese medicine processing factory, hospitals Gained.
Embodiment 2:
In the present embodiment by taking half heel of Chinese herbal medicine is used to cultivate emesis type potato as an example, the specific breeding method that is related to Essentially identical in embodiment 1, main difference is:(1) when cultivating potato, the fresh water of half heel of Chinese herbal medicine, 16 times of gross weight Immersion 60 minutes, decocts 30 minutes on electric furnace, and the fresh water that 8 times of weight is added into half heel of Chinese herbal medicine after filtering is soaked with method Bubble, decoct, filtering;When applying fertilizer to potato 1kg/m is pressed in the other organic fertilizers of administration within preceding 10-30 days2/ every time, after crushing Half heel of Chinese herbal medicine and routinely irrigate and manage.
Embodiment 3:
In the present embodiment by taking half heel of Chinese herbal medicine is used to cultivate and has the sweet potato of preventing or arresting vomiting effect as an example, the specific cultivation side that is related to With essentially identical in embodiment 1, main difference is method:Half heel of Chinese herbal medicine being related to is 1-15 by weight ratio:Under 1 ginger Heel and elecampane leftover bits and pieces are made after mixing.
Embodiment 4:
Mountain to being cultivated according to the breeding method in embodiment 1, embodiment 2 and embodiment 3 respectively in the present embodiment Medicine, potato and the emesis of sweet potato effect, to edible for patients and carry out after being processed by usual diet style (such as steam, boil mode) Research experiment, specific research are as follows:
Experiment one:
(1) test method:Two groups are randomly divided into vomitting patient 16 after carcinosis radiotherapy and chemotherapy, every group of 8 people (n=8) carries out Comparative study, when chemotherapy, first give the Chinese yam cultivated on one group of same field with commonsense method and press (as a control group) 1g·kg-1·d-1It is one week edible, patient's reaction in 7d after the treatment is observed, records the vomiting number of its 7d;Another group of chemotherapy When give by the use of half heel of Chinese herbal medicine cultivate emesis Chinese yam (as treatment group) 1gkg-1·d-1It is one week edible, observe patient Reaction in 7d after the treatment, records the vomiting number of its 7d;
(2) curative effect differentiates:Cure:Vomiting control;Improve:Vomiting number is reduced, or the intermittent time extends;It is invalid:Vomit Spit without improvement or aggravate;Total effective rate=healing+improvement;
(3) experimental result:Compared with control group, emesis Chinese yam is taken a favorable turn to vomitting curative effect after cancer patient's chemicotherapy Trend (P=0.07), calculates p=0.07, comparing result is as shown in table 1 through Fisher exact tests:
Effect of the Chinese yam that 1 Chinese herbal medicine of table, half heel is cultivated to being vomitted after chemicotherapy
Compared with the control group,aP=0.07
Experiment two:
(1) test method:Two groups are randomly divided into vomitting patient 16 after carcinosis radiotherapy and chemotherapy, every group of 8 people (n=8) carries out Comparative study, one of which give common potato (control group) 1gkg of same piece of land commonsense method cultivation-1·d-1Edible one In week, observe patient's reaction in 7d after the treatment, records the vomiting number of its 7d;Another set gives the cultivation of half heel of Chinese herbal medicine Health care potato (treatment group) 1gkg-1·d-1It is one week edible, patient's reaction in 7d after the treatment is observed, records its 7d's Vomiting number;
(2) curative effect differentiates, cures:Vomiting control;Improve:Vomiting number is reduced, or the intermittent time extends;It is invalid:Vomit Spit without improvement or aggravate;Total effective rate=healing+improvement;
(3) experimental result:Compared with control group, health care potato after cancer patient's chemicotherapy to vomitting (P evident in efficacy< 0.01), comparing result is as shown in table 2:
Effect of the potato that 2 Chinese herbal medicine of table, half heel is cultivated to being vomitted after chemicotherapy
Compared with the control group,ap<0.01
Experiment three:
(1) test method:Be randomly divided into two groups to vomitting patient 20 after carcinosis radiotherapy and chemotherapy, every group of 10 people (n=10) into Row comparative study, one of which give common sweet potato (control group) 1gkg of same piece of land commonsense method cultivation-1·d-1It is edible One week, patient's reaction in 7d after the treatment is observed, records the vomiting number of its 7d;Another set gives the training of half heel of Chinese herbal medicine Emesis sweet potato (treatment group) 1gkg educated-1·d-1It is one week edible, patient's reaction in 7d after the treatment is observed, records it The vomiting number of 7d;
(2) curative effect differentiates, cures:Vomiting control;Improve:Vomiting number is reduced, or the intermittent time extends;It is invalid:Vomit Spit without improvement or aggravate;Total effective rate=healing+improvement;
(3) experimental result:Compared with control group, emesis sweet potato is taken a favorable turn to vomitting curative effect after cancer patient's chemicotherapy Trend (P<0.01), comparing result is as shown in table 2:
Effect of the sweet potato that 2 Chinese herbal medicine of table, half heel is cultivated to being vomitted after chemicotherapy
Compared with the control group,ap<0.01
Above example is merely illustrative of the technical scheme, and involved half heel of Chinese herbal medicine is all kinds of spies Determine the mixture of the Chinese herbal medicine leftover bits and pieces proportioning of effect, the involved crops that can be applicable in cultivation include potato class, rice The crops such as cereal, sweet potato class, potato class, Chinese yam class, corn class, wheat class, specific crops are using breeding method and have Health-care efficacy, therapeutic efficiency respectively meets plant itself production and cultivates rule and prescription itself health-care efficacy;Through multinomial examination Test research to show, the health plant yield that the present invention cultivates has no significant change with color, smell and taste, also has no that patient goes out after being eaten Existing adverse reaction;The invention is not restricted to example provided above, the leftover bits and pieces after the processing of all kinds of prescription Chinese herbal medicines involved in practice Half heel of Chinese herbal medicine can be made in material through scientific matching, and can grain fruit-vegetable plant of the ecological circulation for cultivating specific function.

Claims (1)

1. a kind of novel use of half heel of Chinese herbal medicine, it is characterised in that for cultivating the crops of specific health-care effect, realize Natural green product recycles, and concrete application method comprises the following steps that:
(1) preparation of half heel of filtrate and Chinese herbal medicine:It is 1-15 by weight ratio:1 ginger leftover bits and pieces and the tuber of pinellia leftover bits and pieces mixing is equal Half heel of Chinese herbal medicine is made after even, the freshwater soaking of 10-16 times of gross weight is added into half heel of Chinese herbal medicine 60-80 minutes, so 70-90 DEG C of heating of temperature control on the electric furnace for adding asbestos gauge is placed on afterwards to decoct 30-60 minutes, and filtrate is preserved after being filtered with silk;Again The fresh water of 5-8 times of weight is added into half heel of Chinese herbal medicine after filtering, with method immersion, is decocted, filtering, after decocting twice Filtrate is uniformly mixed spare, and naturally dry after half heel slag of Chinese herbal medicine is collected, that half heel cake of Chinese herbal medicine is made is spare;
(2) application of half heel of Chinese herbal medicine:Crop seeds 1-50 is soaked after uniformly mixed filtrate is diluted with 1-5 times of fresh water Hour, the weight ratio of filtrate and crop seeds after dilution is 1-15:1, then by the crop seeds sowing after immersion simultaneously Routinely technology is irrigated and managed;According to needed for the different growing stages of every kind of crops, crops growth phase to farming Thing presses 0.5-20kg/m2/ every time, 2-10 times common using the half heel cake of Chinese herbal medicine after crushing, can be harvested to the maturity period has The crops of emesis effect;The ratio between the dry weight of half heel of Chinese herbal medicine and the dry weight of crop seeds are 1:5-500;The fresh water Including tap water, pure water, mineral water, well water, river water or lake water.
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