CN104829599B - 雷迪帕韦及其衍生物的制备方法及用于制备雷迪帕韦的中间体化合物 - Google Patents
雷迪帕韦及其衍生物的制备方法及用于制备雷迪帕韦的中间体化合物 Download PDFInfo
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- CN104829599B CN104829599B CN201510117997.3A CN201510117997A CN104829599B CN 104829599 B CN104829599 B CN 104829599B CN 201510117997 A CN201510117997 A CN 201510117997A CN 104829599 B CN104829599 B CN 104829599B
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- 0 C*[C@](CC1(CC1)C1)(C(O)=O)N1C([C@](C(C)C)NC(OC)=O)=O Chemical compound C*[C@](CC1(CC1)C1)(C(O)=O)N1C([C@](C(C)C)NC(OC)=O)=O 0.000 description 16
- JYVIKHMCGMOOEI-UHFFFAOYSA-N CC(C)C(C(N(C1CC2CC1)C2c1nc2ccc(B3OC(C)(C)C(C)(C)O3)cc2[nH]1)=O)NC(C)=O Chemical compound CC(C)C(C(N(C1CC2CC1)C2c1nc2ccc(B3OC(C)(C)C(C)(C)O3)cc2[nH]1)=O)NC(C)=O JYVIKHMCGMOOEI-UHFFFAOYSA-N 0.000 description 1
- SGVUHPSBDNVHKL-UHFFFAOYSA-N CC1CC(C)CCC1 Chemical compound CC1CC(C)CCC1 SGVUHPSBDNVHKL-UHFFFAOYSA-N 0.000 description 1
- QMYOJBGREFLHRG-UHFFFAOYSA-N CCC/[O]=C(\C#N)/OC Chemical compound CCC/[O]=C(\C#N)/OC QMYOJBGREFLHRG-UHFFFAOYSA-N 0.000 description 1
- XCYFYRCLZZNQRJ-LJLRPYGHSA-N CC[C@H](C(C(C)C)C(N)N(C1CC2CC1)C2C([C@H](C)C=NC1C2)=CC1C=CC2c(cc1)cc(C(c2c3)(F)F)c1-c2ccc3-c1cnc(C(CC2(CC2)C2)N2C(C(C(C)C)NC(O)OC)=O)[nH]1)C(CC)=[U] Chemical compound CC[C@H](C(C(C)C)C(N)N(C1CC2CC1)C2C([C@H](C)C=NC1C2)=CC1C=CC2c(cc1)cc(C(c2c3)(F)F)c1-c2ccc3-c1cnc(C(CC2(CC2)C2)N2C(C(C(C)C)NC(O)OC)=O)[nH]1)C(CC)=[U] XCYFYRCLZZNQRJ-LJLRPYGHSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Virology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Oncology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Communicable Diseases (AREA)
- Molecular Biology (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Epidemiology (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
Priority Applications (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510117997.3A CN104829599B (zh) | 2015-03-17 | 2015-03-17 | 雷迪帕韦及其衍生物的制备方法及用于制备雷迪帕韦的中间体化合物 |
| CN201680000917.9A CN106459014B (zh) | 2015-03-17 | 2016-03-02 | 雷迪帕韦及其衍生物的制备方法及用于制备雷迪帕韦的中间体化合物 |
| PCT/CN2016/075358 WO2016145990A1 (zh) | 2015-03-17 | 2016-03-02 | 雷迪帕韦及其衍生物的制备方法及用于制备雷迪帕韦的中间体化合物 |
| KR1020177029938A KR20170131508A (ko) | 2015-03-17 | 2016-03-02 | 레디파스비르 및 이의 유도체의 제조방법 및 레디파스비르를 제조하기 위한 중간체 화합물 |
| JP2017567518A JP2018511653A (ja) | 2015-03-17 | 2016-03-02 | レジパスビルおよびその誘導体の製造方法ならびにレジパスビルを製造するための中間体化合物 |
| US15/559,137 US20180079744A1 (en) | 2015-03-17 | 2016-03-02 | Method of preparation for ledipasvir and derivative thereof, and intermediate compound for preparation of ledipasvir |
| EP16764171.1A EP3272747A1 (en) | 2015-03-17 | 2016-03-02 | Method of preparation for ledipasvir and derivative thereof, and intermediate compound for preparation of ledipasvir |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510117997.3A CN104829599B (zh) | 2015-03-17 | 2015-03-17 | 雷迪帕韦及其衍生物的制备方法及用于制备雷迪帕韦的中间体化合物 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN104829599A CN104829599A (zh) | 2015-08-12 |
| CN104829599B true CN104829599B (zh) | 2017-06-09 |
Family
ID=53807840
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201510117997.3A Active CN104829599B (zh) | 2015-03-17 | 2015-03-17 | 雷迪帕韦及其衍生物的制备方法及用于制备雷迪帕韦的中间体化合物 |
| CN201680000917.9A Active CN106459014B (zh) | 2015-03-17 | 2016-03-02 | 雷迪帕韦及其衍生物的制备方法及用于制备雷迪帕韦的中间体化合物 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201680000917.9A Active CN106459014B (zh) | 2015-03-17 | 2016-03-02 | 雷迪帕韦及其衍生物的制备方法及用于制备雷迪帕韦的中间体化合物 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US20180079744A1 (ja) |
| EP (1) | EP3272747A1 (ja) |
| JP (1) | JP2018511653A (ja) |
| KR (1) | KR20170131508A (ja) |
| CN (2) | CN104829599B (ja) |
| WO (1) | WO2016145990A1 (ja) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104829599B (zh) * | 2015-03-17 | 2017-06-09 | 上海众强药业有限公司 | 雷迪帕韦及其衍生物的制备方法及用于制备雷迪帕韦的中间体化合物 |
| KR101919194B1 (ko) * | 2015-09-15 | 2018-11-15 | 주식회사 엘지화학 | 헤테로고리 화합물 및 이를 포함하는 유기 발광 소자 |
| WO2017048060A1 (ko) * | 2015-09-15 | 2017-03-23 | 주식회사 엘지화학 | 헤테로고리 화합물 및 이를 포함하는 유기 발광 소자 |
| CN105237516B (zh) * | 2015-10-13 | 2018-01-02 | 厦门市蔚嘉化学科技有限公司 | 一种雷迪帕韦的制备方法 |
| CN106608870A (zh) * | 2015-10-26 | 2017-05-03 | 广东东阳光药业有限公司 | 一种制备雷迪帕韦杂质的方法 |
| CN106892905A (zh) * | 2015-12-17 | 2017-06-27 | 常州市勇毅生物药业有限公司 | 一种雷迪帕韦的制备方法 |
| CN106432197B (zh) * | 2016-09-07 | 2019-12-10 | 上海众强药业有限公司 | 一种雷迪帕韦中间体单对甲苯磺酸盐、其晶型及其制备方法 |
| CN106632275B (zh) * | 2016-12-20 | 2018-03-06 | 上海同昌生物医药科技有限公司 | 一种雷迪帕韦的制备方法及制备雷迪帕韦的中间体 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US1256391A (en) * | 1917-09-11 | 1918-02-12 | Harry Andrew Taylor | Glove. |
| EP2857394A1 (en) * | 2009-05-13 | 2015-04-08 | Gilead Pharmasset LLC | Antiviral compounds |
| US9056860B2 (en) * | 2012-06-05 | 2015-06-16 | Gilead Pharmasset Llc | Synthesis of antiviral compound |
| WO2016103232A1 (en) * | 2014-12-24 | 2016-06-30 | Granules India Limited | An improved process for the preparation of hcv inhibitor |
| CN104829599B (zh) * | 2015-03-17 | 2017-06-09 | 上海众强药业有限公司 | 雷迪帕韦及其衍生物的制备方法及用于制备雷迪帕韦的中间体化合物 |
| CN104926796A (zh) * | 2015-06-17 | 2015-09-23 | 南通常佑药业科技有限公司 | 一种新的ns5a抑制剂药物的制备方法 |
-
2015
- 2015-03-17 CN CN201510117997.3A patent/CN104829599B/zh active Active
-
2016
- 2016-03-02 EP EP16764171.1A patent/EP3272747A1/en not_active Withdrawn
- 2016-03-02 US US15/559,137 patent/US20180079744A1/en not_active Abandoned
- 2016-03-02 JP JP2017567518A patent/JP2018511653A/ja not_active Withdrawn
- 2016-03-02 WO PCT/CN2016/075358 patent/WO2016145990A1/zh active Application Filing
- 2016-03-02 KR KR1020177029938A patent/KR20170131508A/ko not_active Application Discontinuation
- 2016-03-02 CN CN201680000917.9A patent/CN106459014B/zh active Active
Also Published As
| Publication number | Publication date |
|---|---|
| CN106459014B (zh) | 2019-09-06 |
| WO2016145990A1 (zh) | 2016-09-22 |
| CN106459014A (zh) | 2017-02-22 |
| CN104829599A (zh) | 2015-08-12 |
| EP3272747A1 (en) | 2018-01-24 |
| JP2018511653A (ja) | 2018-04-26 |
| US20180079744A1 (en) | 2018-03-22 |
| KR20170131508A (ko) | 2017-11-29 |
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| CB03 | Change of inventor or designer information |
Inventor after: Huang Chengjun Inventor after: Fu Gang Inventor after: Fu Shaojun Inventor after: Wei Zhewen Inventor after: Li Wei Inventor after: Ren Yi Inventor before: Huang Chengjun Inventor before: Fu Gang Inventor before: Fu Shaojun Inventor before: Wei Zhewen Inventor before: Li Wei Inventor before: Zhang Xixuan |
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