CN104825724A - Traditional Chinese medicine preparation for chronic cervicitis postoperative rehabilitation - Google Patents
Traditional Chinese medicine preparation for chronic cervicitis postoperative rehabilitation Download PDFInfo
- Publication number
- CN104825724A CN104825724A CN201510283299.0A CN201510283299A CN104825724A CN 104825724 A CN104825724 A CN 104825724A CN 201510283299 A CN201510283299 A CN 201510283299A CN 104825724 A CN104825724 A CN 104825724A
- Authority
- CN
- China
- Prior art keywords
- parts
- herba
- chinese medicine
- radix
- medicine preparation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Medicines Containing Plant Substances (AREA)
Abstract
The invention belongs to the field of traditional Chinese medicine, and in particular relates to a traditional Chinese medicine preparation for chronic cervicitis postoperative rehabilitation. The traditional Chinese medicine preparation is carefully made with hirsute shiny bugleweed herb, motherwort herb, nutgrass galingale rhizome, angelica root, atrina glass, twotoothed achyranthes root, rhubarb rhizome, hairyvein agrimonia herb, dodder seed, glossy privet fruit and malaytea scurfpea fruit according to a certain ratio of parts by weight. The traditional Chinese medicine preparation has the advantages of being capable of performing postoperative conditioning on a patient from multiple aspects, and significantly improving symptoms of postoperative vaginal discharging and bleeding generated by physical therapy used for chronic cervicitis operation; and being convenient to take, low in cost, free of toxic and side effects, and low in recurrence rate after being recovery. Therefore, the objective of resolving current problems and eliminating root causes is achieved, and wild clinical promotion and application are deserved to be done.
Description
Technical field
The invention belongs to the field of Chinese medicines, be specifically related to a kind of Chinese medicine preparation for chronic cervicitis postoperative rehabilitation.
Background technology
Chronic cervicitis is modal one in female sex organ inflammation, and sickness rate is higher, accounts for the more than half of married woman, has the chronic inflammatory disease performances such as cervical erosion, Nabothcyst, cervix uteri hypertrophy, cervical canal polyp.Pathogenic factor is how relevant with life, as long in unclean sexual life, artificial abortion, delivery laceration, menstruation persistent period and pathogen invasion etc.For those asymptomatic patients, generally do not advocate treatment, make regular check on; But have contact bleeding for those, secretions increase and jaundice, lumbosacral aching pain, the patient of the clinical manifestations such as sagging distention in the smaller abdomen then needs to carry out Canonical management.
At present, although clinical treatment is more, physiotherapy and the operative therapy etc. such as oral or regional, electricity is pressed, microwave, freezing, laser.Though oral medicine has bactericidal antiphlogistic effect, partial result is also not obvious, can only as a kind of auxiliary treatment means; External used medicine (rinsing class medicine and thromboembolism class medicine) therapy is only applicable to the patient that rotten to the corn area is less and inflammatory infiltration is more shallow; Operative therapy is mainly applicable to merge the comparatively dark and samples from Patients with Chronic Cervicitis of Implicates pipe of cervical erosion, cervical hypertrophy, cervical polyp or cervical erosion area, but it is large to there is damage, in art and the shortcoming such as postoperative hemorrhage amount is many; Although physiotherapy is applicable to the patient that rotten to the corn area is comparatively large and inflammatory infiltration is darker, and there is short treating period, eutherapeutic advantage, but its side effect is comparatively large, and vaginal walls nerve sensitivity may be caused to reduce, affects life quality and also there is relapse rate and the shortcoming such as cicatrix incidence rate is higher.
The cardinal principle of naturopathy cervical erosion is that local-pathological-changed tissues generation degeneration necrosis is come off, for the stratified squamous epithelium of new life covers, it is a kind of destructive treatment, postoperative due to cervical tissue destroy, edema extinction and slough come off, and occur that vagina watery secretion is many, hemorrhage for a long time, and have abnormal flavour, add the chance of vaginal infection, have impact on patients ' life quality.
How to solve postoperative vaginal discharge opeing and hemorrhage be the problem received much concern always, doctor trained in Western medicine has not yet to see bibliographical information, and the traditional Chinese medical science is to the treatment of the postoperative side effect of physiotherapy and wound healing, there is it unique, as postoperative use Pseudobulbus Bletillae (Rhizoma Bletillae) powder, YUNNAN BAIYAO, Radix Notoginseng powder, the cervix uteri local applications such as burn cream, but it uses inconvenience, and increasing superinfection probability, Clinical Compliance is poor.
Summary of the invention
The traditional Chinese medical science thinks that physiotherapy causes cervix uteri local tissue damage, the impaired then qi depression to blood stasis of venation, fresh blood not life, and new flesh is not long, causes wound disunion of a specified duration.Inventor is according to clinical practice experience for many years, provide a kind of Chinese medicine preparation for physical therapy treatment chronic cervicitis postoperative rehabilitation, this Chinese medicine preparation is peroral dosage form, taking convenience, body is regulated from number of ways, significantly can improve the postoperative vaginal discharge opeing of physical therapy treatment chronic cervicitis and bleeding, accelerate healing.
For achieving the above object, the technical solution used in the present invention is as follows:
A kind of Chinese medicine preparation for chronic cervicitis postoperative rehabilitation, it is medicinal raw material by Herba Lycopi, Herba Leonuri, Rhizoma Cyperi, Radix Angelicae Sinensis, Herba Patriniae, Radix Achyranthis Bidentatae, Radix Et Rhizoma Rhei, Herba Agrimoniae, Semen Cuscutae, Fructus Ligustri Lucidi, Fructus Psoraleae, meticulously modulates form according to certain weight.
In the present invention, the main pharmacological effect of medicinal raw material is described below.
Herba Lycopi: bitter, pungent, tepor.Return liver, spleen channel.Function cures mainly: blood circulation promoting and blood stasis dispelling, line water detumescence.For menoxenia, amenorrhea, dysmenorrhea, postnatal blood stasis is suffered from abdominal pain, edema.
Herba Leonuri: bitter, pungent, is slightly cold.Return liver, pericardium channel.Function cures mainly: promoting blood flow to regulate menstruation, inducing diuresis to remove edema.For menoxenia, dysmenorrhea, amenorrhea, lochiorrhea, edema oliguria; Acute nephritis edema.
Rhizoma Cyperi: pungent, micro-hardship, micro-sweet, flat.Return liver, spleen, tri-jiao channel.Function cures mainly: promoting QI circulation for relieving depression, menstruction regulating and pain relieving.For stagnation of QI due to depression of the liver, breast, the side of body, abdominal distention, dyspepsia, breast gastral cavity painful abdominal mass is vexed, and colic of cold type is suffered from abdominal pain, distending pain of the breast, menoxenia, amenorrhea dysmenorrhea.
Radix Angelicae Sinensis: sweet, acrid, warm.Return liver, the heart, spleen channel.Function cures mainly: enrich blood and invigorate blood circulation, menstruction regulating and pain relieving, loosening bowel to relieve constipation.For blood deficiency and yellow complexion, dizzy cardiopalmus, menoxenia, amenorrhea dysmenorrhea, asthenia cold abdominalgia, dryness of the intestine constipation, rheumatic arthralgia, injury from falling down, ulcer sores.Radix Angelicae Sinensis (processed with wine) promoting blood circulation to restore menstrual flow.For amenorrhea dysmenorrhea, rheumatic arthralgia, injury from falling down.
Herba Patriniae: pungent, bitter, cool.Enter stomach, large intestine, Liver Channel.Function cures mainly: heat-clearing and toxic substances removing, eliminating carbuncle evacuation of pus, blood circulation promoting competent silt.For acute appendicitis, lung abscess and sore and toxic, the stagnant caused breast abdomen pain of the excess-heat stasis of blood, the diseases such as the stagnant stomachache of the stasis of blood in puerperal.
Radix Achyranthis Bidentatae: sweet, micro-hardship is flat.Return liver, kidney channel.Function cures mainly: invigorating the liver and kidney, bone and muscle strengthening, eliminating blood stasis and inducing menstruation, conducting blood to flow downwards.For soreness of waist and knee joint, muscles and bones is unable, amenorrhea lump in the abdomen, dizziness due to hyperactivity of liver-YANG.
Radix Et Rhizoma Rhei: bitter, cold.Return spleen, stomach, large intestine, liver, pericardium channel.Function cures mainly: purging heat and dredging bowels, removing pathogenic heat from blood and toxic substance from the body, eliminating blood stasis and inducing menstruation.For excess-heat constipation, stagnant stomachache, dysentery is not well, jaundice due to damp-heat, and heat in blood tells nosebleed, conjunctival congestion, pharyngeal swelling, abdominalgia with intestinal abscess, carbuncle furuncle, blood stasis amenorrhea, traumatic injury, external treatment burn due to hot liquid or fire; Upper gastrointestinal hemorrhage.
Herba Agrimoniae: bitter, puckery is flat.GUIXIN, Liver Channel.Function cures mainly: astringing to arrest bleeding, preventing the attack (or recurrence) of malaria, dysentery relieving, removing toxic substances.For hemoptysis, spit blood, metrostaxis, malaria, dysentery, de-power impairment caused by overstrain, carbuncle sore tumefacting virus, pudendal pruritus leukorrhagia.
Semen Cuscutae: sweet, temperature.Return liver,kidney,spleen warp.Function cures mainly: nourishing the liver and kidney, controlling nocturnal emission with astringent drugs reducing urination, antiabortive, improving eyesight, antidiarrheal.For impotence and seminal emission, dripping urination, enuresis frequent micturition, soreness of the waist and knees, blurred vision tinnitus, vaginal bleeding due to deficiency of the kidney during pregnancy, frequent fetal movement, spleen is suffered from a deficiency of the kidney and is rushed down; Externally treating leucoderma.
Fructus Ligustri Lucidi: sweet, bitter, cold.Return liver, kidney channel.Function cures mainly: nourishing the liver and kidney, improving eyesight black hair.For vertigo and tinnitus, soreness of the waist and knees, early whitening of beard and hair, poor vision.
Fructus Psoraleae: pungent, bitter, temperature.Return kidney, spleen channel.Function cures mainly: warming the kidney to activate YANG, improving inspiration by invigorating kidney-QI, antidiarrheal.For impotence and seminal emission, enuresis frequent micturition, chills and pain of the waist and kness, suffers from a deficiency of the kidney and breathes heavily, Diarrhoea; External curing vitiligo, alopecia areata.
The consumption of the medicinal raw material of Chinese medicine preparation of the present invention is groped to sum up to draw through inventor in a large number, and each raw material dosage all has good curative effect in following weight parts scope: Herba Lycopi 18-23 part, Herba Leonuri 13-18 part, Rhizoma Cyperi 5-9 part, Radix Angelicae Sinensis 12-17 part, Herba Patriniae 15-20 part, Radix Achyranthis Bidentatae 6-11 part, Radix Et Rhizoma Rhei 2-5 part, Herba Agrimoniae 9-15 part, Semen Cuscutae 11-16 part, Fructus Ligustri Lucidi 6-11 part, Fructus Psoraleae 5-8 part.
Side of the present invention separates: Herba Lycopi, Herba Leonuri, pungent drugs can disperse and bitter drugs can purge, and temperature is trembled with fear and use, and promoting blood flow to regulate menstruation, promoting tissue regeneration by removing blood stasis, line water detumescence is monarch drug.Herba Patriniae heat-clearing and toxic substances removing, blood circulation promoting competent silt; Radix Et Rhizoma Rhei removing pathogenic heat from blood and toxic substance from the body, eliminating blood stasis and inducing menstruation, two medicines share removing, and in utero residual poison is evil, and principal drug assistance promoting tissue regeneration by removing blood stasis is ministerial drug.Rhizoma Cyperi circulation of qi promoting, with QI and blood regulating, is invigorated blood circulation with Chinese angelica blood supplementing, and two medicines 5 reach with both making QI and blood bar, channels and collaterals dredging, and blood stasis dispelling is with tissue regeneration promoting again, are adjuvant drug.Semen Cuscutae, Fructus Ligustri Lucidi, Fructus Psoraleae three medicine 5 nourishing the liver and kidney, adjusting and runing yang, body can be made to reach equilibrium between yin and yang, is also adjuvant drug.Key is entered, with Herba Agrimoniae astringing to arrest bleeding with Radix Achyranthis Bidentatae priming.We's blood stasis dispelling is not just being hindered, and enriches blood and does not stay the stasis of blood, carry out postoperative conditioning, Be very effective from multi-angle.
One of preferred version optimized is: a kind of Chinese medicine preparation for chronic cervicitis postoperative rehabilitation, it is characterized in that it is made up of the medicinal raw material of following weight parts: Herba Lycopi 22 parts, Herba Leonuri 16 parts, Rhizoma Cyperi 7 parts, Radix Angelicae Sinensis 13 parts, Herba Patriniae 16 parts, Radix Achyranthis Bidentatae 8 parts, Radix Et Rhizoma Rhei 3 parts, Herba Agrimoniae 10 parts, Semen Cuscutae 12 parts, Fructus Ligustri Lucidi 8 parts, Fructus Psoraleae 6 parts.
Two of the preferred version optimized is: a kind of Chinese medicine preparation for chronic cervicitis postoperative rehabilitation, it is characterized in that it is made up of the medicinal raw material of following weight parts: Herba Lycopi 18 parts, Herba Leonuri 14 parts, Rhizoma Cyperi 6 parts, Radix Angelicae Sinensis 15 parts, Herba Patriniae 18 parts, Radix Achyranthis Bidentatae 10 parts, Radix Et Rhizoma Rhei 4 parts, Herba Agrimoniae 12 parts, Semen Cuscutae 15 parts, Fructus Ligustri Lucidi 10 parts, Fructus Psoraleae 6 parts.
Chinese medicine preparation of the present invention extracting method conveniently such as water extraction, alcohol extracting method, decoction and alcohol sedimentation technique etc. can extract the active component of medicinal raw material, add pharmaceutically acceptable carrier or/and adjuvant, as starch, dextrin, microcrystalline cellulose, amylum pregelatinisatum, magnesium stearate, micropowder silica gel, sucrose, carboxymethyl starch sodium, hydroxypropyl emthylcellulose, vegetable oil, lecithin, Polyethylene Glycol, propylene glycol, ethyl hydroxybenzoate etc., make peroral dosage form suitable on pharmaceutics, as granule, tablet, capsule, oral liquid, soft capsule, drop pill, water pill etc.
The preferred preparation method of Chinese medicine preparation of the present invention comprises the following steps: Herba Lycopi, Herba Leonuri, Rhizoma Cyperi, Radix Angelicae Sinensis are pulverized, add the alcoholic solution of concentration 65% ~ 80%, reduced-pressure backflow extracts 2 times, add the amount of 4 ~ 8 times at every turn, extract 1 ~ 2 hour, filter, be concentrated into thick paste after the ethanol of extraction is reclaimed ethanol, vacuum drying is for subsequent use to constant weight; Medicinal residues after Herba Patriniae, Radix Achyranthis Bidentatae, Radix Et Rhizoma Rhei, Herba Agrimoniae, Semen Cuscutae, Fructus Ligustri Lucidi, Fructus Psoraleae and alcohol extraction merge, decoct with water extraction 2 times, add the water yield of 6 ~ 10 times of medical materials at every turn, decoct 1 ~ 2 hour at every turn, filter, the filtrate obtained after decocting in water is concentrated to obtain extractum, and adding alcoholic solution to ethanol content is 45%, stirs evenly, leave standstill, leaching supernatant, reclaim ethanol and be concentrated into thick paste, vacuum drying is for subsequent use to constant weight; Twice dry extract is merged and is ground into fine powder, then add appropriate amount of auxiliary materials mixing, make clinical receptible peroral dosage form by conventional formulation method.As granule, tablet, capsule, oral liquid, soft capsule, drop pill, water pill etc.
Preferably, Chinese medicine composition of the present invention conveniently preparation technology is prepared into tablet, capsule, granule, most preferably makes capsule.
The beneficial effect of medicine of the present invention is set forth further below by way of animal experiment and clinical observation test.
Animal experiment: Chinese medicine preparation Pyrogentisinic Acid rubber cement of the present invention causes the impact of cervicitis rat model:
1. experimental animal: SD rat, female, unpregnancy, cleaning grade, body weight 200-220g, is purchased from Beijing Vital River Experimental Animals Technology Co., Ltd..
2. medicine and reagent: Traditional Chinese medicine preparation capsule prepared by the embodiment of the present invention 2, every 0.34g, is equivalent to crude drug 1.40g.FUKE QIANJIN PIAN 0.32g/ sheet, Zhuzhou Qianjin Pharmacy Co., Ltd produces; Estradiol benzoate injection, hydrocortisone injection; Hydroxybenzene mucilage (phenol, glycerol, tragcanth form, and concentration is decided to be 25%).
3. modeling: get female rats 70, after adaptability feeds one week, gets 10 at random for sham operated rats, remains 60 for modeling.Rat pre-operative anxiety, lumbar injection 10% chloral hydrate (300mg/kg) is anaesthetized, and lies on the back fixing, lower abdominal surgery position unhairing, routine disinfection.In the bottom of midline abdominal, cut off lcm and indulge opening, find ovary, extract bilateral ovaries.Postoperative muscle injection penicillin is protected from infection.2d rises and does vaginal smear examination, continuous 3d, has no vagina epithelium keratinocyte under microscope, shows that rat is in diestrus, shows that ovary has been extractd completely.Postoperative 4d start subcutaneous injection estradiol benzoate injection 2mg/kg and hydrogenation can injection pine 60mg/kg, object causes false rutting period and general immunity hypofunction, once a day, continuous 3d, postoperative 7d, connect mouse stomach syringe needle with sterilizing syringe, extract Hydroxybenzene mucilage 0.1mL, inject in vagina cervix uteri, original position stops 1 ~ 2min, prevents overflow.Once a day, totally 3 times.(during modeling, death and wound have giving it up of abscess)
4. grouping and administration: the rat of modeling is divided into 5 groups at random, often organize 10, i.e. model control group, FUKE QIANJIN PIAN group (7.2g/kg), the large, medium and small dosage group (7.0g/kg, 3.5g/kg, 1.4g/kg) of Traditional Chinese medicine preparation capsule of the present invention, once a day, administration volume is that 10m1/kg body weight calculates, sham operated rats and model control group gavage equal-volume deionized water, successive administration 7d.
5. observation index: vagina cervix uteri organ index: get vagina and weigh to subangle place, uterus tissue, calculates vagina and cervix uteri organ index, organ index=organ weights/body weight × 100.
6. data analysis: all data, all through the process of SPSS15.0 statistical software, adopting variance analysis, adopting t to check, with P<0.05 for there being statistical significance between group.
7. result: compared with sham operated rats, model control group vagina cervix uteri organ index increases, and pathological examination finds model group rats vagina cervical epithelial tissue hypertrophy or ulcer, and squama degree is obvious, congestion and edema degree is also obvious, and the success of vagina cervicitis model is described.
Chinese medicine preparation of the present invention is on the impact of vagina cervicitis rat model vagina and cervix uteri organ index: compare with model control group, the large, medium and small dosage group of Traditional Chinese medicine preparation capsule of the present invention and FUKE QIANJIN PIAN group can make rat vagina cervix uteri organ index reduce, and difference has statistical significance (P<0.05 or P<0.01); Compare with FUKE QIANJIN PIAN group, the heavy dose of group of Traditional Chinese medicine preparation capsule of the present invention can make rat vagina cervix uteri organ index reduce, and difference has statistical significance (P<0.05).In table 1.
Table 1 Chinese medicine preparation of the present invention is on the impact of rat model vagina and cervix uteri organ index
Note: compare with sham operated rats,
aap<0.01; Compare with model control group,
bbp<0.01; Compare with FUKE QIANJIN PIAN group,
cp<0.05.
This experiment shows that Traditional Chinese medicine preparation capsule of the present invention has certain improvement result to vagina cervicitis rat model, vagina cervix uteri organ index can be made to reduce, can improve cervix uteri inflammatory infiltration, reduces congestion and edema.
Clinical observation is tested: Chinese medicine preparation of the present invention is on the impact of chronic cervicitis postoperative patient:
1. physical data: this group patient is totally 380 examples, and be married puerpera female, the age is between 23 ~ 46 years old.All patients all have vaginal secretions increase and turn to be yellow, and are mingled with the blood streak or contact bleeding, lumbosacral aching pain, the clinical manifestations such as sagging distention in the smaller abdomen in leucorrhea, and gynecologial examination is shown in cervix uteri, severe is rotten to the corn, loose or companion's Nabothcyst, polyp or have contact bleeding; The colpitis such as colpitis mycotica, trichomonal vaginitis is all got rid of in leucorrhea routine examination; Papanicolaou test all gets rid of cervical cancer.380 routine patients are divided into observation group and matched group at random according to random digits table, observation group (190 example): 24 ~ 45 years old age, average (31.3 ± 3.7) year, parity 1 ~ 3 time, moderate cervical erosion example 87, moderate and severe cervical 103 example; Matched group (190 example): 23 ~ 46 years old age, average (31.5 ± 3.9) year, parity 1 ~ 3 time, moderate cervical erosion 86 example, moderate and severe cervical 104 example.Two groups of patient ages, pregnant time, the base values such as parity, cervical erosion degree through statistical analysis no difference of science of statistics (P > 0.05), there is comparability.
2. Therapeutic Method: select electricity to press treatment or micro-wave therapeutic according to patients'wT, but Operation type compares no difference of science of statistics, has comparability.Postoperative 2 groups of all oral levofloxacin tablets, each 0.2g, one day twice, is used in conjunction 3 days, prevention infection.After this matched group patient does not give any Drug therapy; Observation group patient takes Traditional Chinese medicine preparation capsule prepared by the embodiment of the present invention 1, and every day, sooner or later respectively once each 2-3 grain, warm water took, and is used in conjunction one month.Advise patient to keep pudendum cleaning, avoid in postoperative 2 weeks waiting aggravating activities by bike, in 2 ~ 3 months, prohibit bath in a tub, sexual intercourse and vaginadouche.
3. observation index: carry out further consultation respectively in postoperative 1 week, 2 weeks and 4 weeks, observed and recorded neoplasm amount, drain time, vaginal bleeding time, wound healing situation and cicatrix incidence rate; Follow up a case by regular visits to 6 months, observed and recorded two groups of Patients on Recurrence rates.
Amount of bleeding or lifting rate computational methods: it is a small amount of for being no more than 1 protective pad not need to drench in protective pad or 24h; Drenched more than 1 protective pad in 24h, but to be no more than 3 protective pad be middle amount; Drenched in 24h is volume more than 3 protective pad.
4. curative effect judging standard: " obstetrics and gynecology (sixth version) " according to Le Jie chief editor is formulated: cure: cervical erosion face disappears, and cervix uteri is smooth; Effective: cervical erosion reduction of area small size >=50%; Effective: cervical erosion reduction of area small size < 50%; Invalid: cervical erosion area is unchanged; Recurrence: the cervix uteri of healing occurs erosion again, before rotten to the corn area returns to treatment or before exceeding treatment.Total effective rate=(curing number of cases+effective number of cases+effectively number of cases)/total number of cases × 100%.
5. statistical method: adopt SPSS17.0 statistical software to carry out statistical analysis, measurement data adopts rank test, with mean ± standard deviation
represent, the comparison of rate adopts X 2 test, with P < 0.05 for difference has statistical significance.
6. result
6.1 postoperative one month two groups of patient clinical Comparison of therapeutic: two groups of patient clinical Comparison of therapeutic situations are in table 2.Observation group cures 143 examples, effective 37 examples, effective 10 examples, total effective rate 100.0%; And matched group cures 117 examples, effective 28 examples, effective 24 examples, total effective rate 88.95%, the therapeutic effect of observation group is obviously better than matched group, and difference has statistical significance (P < 0.05).In table 2.
Clinical efficacy comparison after table 2 liang group treatment, example.
6.2 liang of group patient's vaginal hemorrhage amounts and lifting rate contrast: two groups of patient vaginal hemorrhage amounts and lifting rate contrast situation are in table 3.Two groups of patient vaginal hemorrhage amounts through rank test, P < 0.01, difference has statistical significance; Two groups of patient's neoplasm amounts are through rank test, and P < 0.01, difference has statistical significance, and the therapeutic effect of observation group is obviously better than matched group.
Table 3 liang group patient's vaginal hemorrhage amount and lifting rate contrast, example
6.3 postoperative vaginal bleeding times compared: observation group's postoperative vaginal bleeding time is less than 7 days person 72 examples, 8 ~ 14 days person 103 examples, 15 days and above person 15 example, and the average bleeding time is (8.8 ± 2.5) sky; And matched group vaginal bleeding time is less than 7 days person 42 examples, 8 ~ 14 days person 56 examples, 15 days and above person 92 example, the average bleeding time is (13.8 ± 3.5) sky, two groups of comparing differences have statistical significance (P < 0.01), and the therapeutic effect of observation group is obviously better than matched group.
6.4 postoperative recurrence and complication compare: observation group's postoperative recurrence 5 example (2.63%), have no complication and occur; Matched group recurs 18 examples (9.47%), and two groups of comparing differences have statistical significance (P < 0.05), the concurrent cervical orifice of the latter narrow 7 example, in cervix uteri different 5 example, give respectively dilatation of the cervix and again electricity press treatment.
Two groups of patient's cicatrix incidence rates, through rank test, no significant difference.Routine blood test, routine urinalysis, stool routine, pelvic cavity color ultrasound, hepatic and renal function, electrocardiogram change without exception before and after observation group's patient treatment, in therapeutic process, vital sign steadily and without the untoward reaction such as nausea and vomiting, allergy, illustrate that clinical application of the present invention is safe and reliable.
In a word: selected by Chinese medicine preparation of the present invention, medical material compatibility is suitable, meet Chinese medicine and pharmacy and modern medicine theory, and there is the effect such as eliminating blood stasis to promote regeneration of blood, activating blood and promoting diuresis, significantly can improve the postoperative vaginal discharge opeing of physical therapy treatment chronic cervicitis and bleeding, accelerate healing.And taking convenience, with low cost, without any side effects, control recurrence rate after healing low, the object for the treatment of both the principal and secondary aspects of a disease can be reached, clinic wide popularization and application.
Detailed description of the invention
Further describe the present invention below by way of specific embodiment, the present invention is not limited only to following examples.Within the scope of the invention or not departing from content of the present invention, spirit and scope, the change carried out the present invention, combination or replacement, be apparent for a person skilled in the art, and be included within the scope of the present invention.
Embodiment 1
Prescription: Herba Lycopi 22 parts, Herba Leonuri 16 parts, Rhizoma Cyperi 7 parts, Radix Angelicae Sinensis 13 parts, Herba Patriniae 16 parts, Radix Achyranthis Bidentatae 8 parts, Radix Et Rhizoma Rhei 3 parts, Herba Agrimoniae 10 parts, Semen Cuscutae 12 parts, Fructus Ligustri Lucidi 8 parts, Fructus Psoraleae 6 parts.
Preparation method: Herba Lycopi, Herba Leonuri, Rhizoma Cyperi, Radix Angelicae Sinensis are pulverized, add the alcoholic solution of concentration 70%, reduced-pressure backflow extracts 2 times, add the amount of 6 times at every turn, extract 1.5 hours, filter, be concentrated into thick paste after the ethanol of extraction is reclaimed ethanol, vacuum drying is for subsequent use to constant weight; Medicinal residues after Herba Patriniae, Radix Achyranthis Bidentatae, Radix Et Rhizoma Rhei, Herba Agrimoniae, Semen Cuscutae, Fructus Ligustri Lucidi, Fructus Psoraleae and alcohol extraction merge, decoct with water extraction 2 times, add the water yield of 7 times of medical materials at every turn, each decoction 1.5 hours, filter, the filtrate obtained after decocting in water is concentrated to obtain extractum, and adding alcoholic solution to ethanol content is 45%, stirs evenly, leave standstill, leaching supernatant, reclaim ethanol and be concentrated into thick paste, vacuum drying is for subsequent use to constant weight; Twice dry extract is merged and is ground into fine powder, then add appropriate amount of auxiliary materials mixing, make capsule by conventional formulation method.
Embodiment 2
Prescription: Herba Lycopi 18 parts, Herba Leonuri 14 parts, Rhizoma Cyperi 6 parts, Radix Angelicae Sinensis 15 parts, Herba Patriniae 18 parts, Radix Achyranthis Bidentatae 10 parts, Radix Et Rhizoma Rhei 4 parts, Herba Agrimoniae 12 parts, Semen Cuscutae 15 parts, Fructus Ligustri Lucidi 10 parts, Fructus Psoraleae 6 parts.
Preparation method: Herba Lycopi, Herba Leonuri, Rhizoma Cyperi, Radix Angelicae Sinensis are pulverized, add the alcoholic solution of concentration 75%, reduced-pressure backflow extracts 2 times, add the amount of 6 times at every turn, extract 1.5 hours, filter, be concentrated into thick paste after the ethanol of extraction is reclaimed ethanol, vacuum drying is for subsequent use to constant weight; Medicinal residues after Herba Patriniae, Radix Achyranthis Bidentatae, Radix Et Rhizoma Rhei, Herba Agrimoniae, Semen Cuscutae, Fructus Ligustri Lucidi, Fructus Psoraleae and alcohol extraction merge, decoct with water extraction 2 times, add the water yield of 8 times of medical materials at every turn, each decoction 1.5 hours, filter, the filtrate obtained after decocting in water is concentrated to obtain extractum, and adding alcoholic solution to ethanol content is 45%, stirs evenly, leave standstill, leaching supernatant, reclaim ethanol and be concentrated into thick paste, vacuum drying is for subsequent use to constant weight; Twice dry extract is merged and is ground into fine powder, then add appropriate amount of auxiliary materials mixing, make capsule by conventional formulation method.
Embodiment 3
Prescription: Herba Lycopi 18-part, Herba Leonuri 13 parts, Rhizoma Cyperi 5 parts, Radix Angelicae Sinensis 12 parts, Herba Patriniae 15 parts, Radix Achyranthis Bidentatae 6 parts, Radix Et Rhizoma Rhei 3 parts, Herba Agrimoniae 10 parts, Semen Cuscutae 11 parts, Fructus Ligustri Lucidi 7 parts, Fructus Psoraleae 5 parts.
Preparation method: Herba Lycopi, Herba Leonuri, Rhizoma Cyperi, Radix Angelicae Sinensis are pulverized, add the alcoholic solution of concentration 65%, reduced-pressure backflow extracts 2 times, add the amount of 4 times at every turn, extract 1 hour, filter, be concentrated into thick paste after the ethanol of extraction is reclaimed ethanol, vacuum drying is for subsequent use to constant weight; Medicinal residues after Herba Patriniae, Radix Achyranthis Bidentatae, Radix Et Rhizoma Rhei, Herba Agrimoniae, Semen Cuscutae, Fructus Ligustri Lucidi, Fructus Psoraleae and alcohol extraction merge, decoct with water extraction 2 times, add the water yield of 6 times of medical materials at every turn, each decoction 1 hour, filter, the filtrate obtained after decocting in water is concentrated to obtain extractum, and adding alcoholic solution to ethanol content is 45%, stirs evenly, leave standstill, leaching supernatant, reclaim ethanol and be concentrated into thick paste, vacuum drying is for subsequent use to constant weight; Twice dry extract is merged and is ground into fine powder, then add appropriate amount of auxiliary materials mixing, make capsule by conventional formulation method.
Embodiment 4
Prescription: Herba Lycopi 23 parts, Herba Leonuri 18 parts, Rhizoma Cyperi 9 parts, Radix Angelicae Sinensis 17 parts, Herba Patriniae 20 parts, Radix Achyranthis Bidentatae 10 parts, Radix Et Rhizoma Rhei 5 parts, Herba Agrimoniae 15 parts, Semen Cuscutae 15 parts, Fructus Ligustri Lucidi 10 parts, Fructus Psoraleae 8 parts.
Preparation method: Herba Lycopi, Herba Leonuri, Rhizoma Cyperi, Radix Angelicae Sinensis are pulverized, add the alcoholic solution of concentration 80%, reduced-pressure backflow extracts 2 times, add the amount of 8 times at every turn, extract 2 hours, filter, be concentrated into thick paste after the ethanol of extraction is reclaimed ethanol, vacuum drying is for subsequent use to constant weight; Medicinal residues after Herba Patriniae, Radix Achyranthis Bidentatae, Radix Et Rhizoma Rhei, Herba Agrimoniae, Semen Cuscutae, Fructus Ligustri Lucidi, Fructus Psoraleae and alcohol extraction merge, decoct with water extraction 2 times, add the water yield of 10 times of medical materials at every turn, each decoction 2 hours, filter, the filtrate obtained after decocting in water is concentrated to obtain extractum, and adding alcoholic solution to ethanol content is 45%, stirs evenly, leave standstill, leaching supernatant, reclaim ethanol and be concentrated into thick paste, vacuum drying is for subsequent use to constant weight; Twice dry extract is merged and is ground into fine powder, then add appropriate amount of auxiliary materials mixing, make capsule by conventional formulation method.
Embodiment 5
Prescription: Herba Lycopi 20 parts, Herba Leonuri 15 parts, Rhizoma Cyperi 9 parts, Radix Angelicae Sinensis 17 parts, Herba Patriniae 18 parts, Radix Achyranthis Bidentatae 8 parts, Radix Et Rhizoma Rhei 5 parts, Herba Agrimoniae 15 parts, Semen Cuscutae 16 parts, Fructus Ligustri Lucidi 11 parts, Fructus Psoraleae 8 parts.
Preparation method: Herba Lycopi, Herba Leonuri, Rhizoma Cyperi, Radix Angelicae Sinensis are pulverized, add the alcoholic solution of concentration 70%, reduced-pressure backflow extracts 2 times, add the amount of 6 times at every turn, extract 1.5 hours, filter, be concentrated into thick paste after the ethanol of extraction is reclaimed ethanol, vacuum drying is for subsequent use to constant weight; Medicinal residues after Herba Patriniae, Radix Achyranthis Bidentatae, Radix Et Rhizoma Rhei, Herba Agrimoniae, Semen Cuscutae, Fructus Ligustri Lucidi, Fructus Psoraleae and alcohol extraction merge, decoct with water extraction 2 times, add the water yield of 7 times of medical materials at every turn, each decoction 1.5 hours, filter, the filtrate obtained after decocting in water is concentrated to obtain extractum, and adding alcoholic solution to ethanol content is 45%, stirs evenly, leave standstill, leaching supernatant, reclaim ethanol and be concentrated into thick paste, vacuum drying is for subsequent use to constant weight; Twice dry extract is merged and is ground into fine powder, then add appropriate amount of auxiliary materials mixing, make tablet by conventional formulation method.
Embodiment 6
Prescription: Herba Lycopi 18 parts, Herba Leonuri 15 parts, Rhizoma Cyperi 5 parts, Radix Angelicae Sinensis 17 parts, Herba Patriniae 20 parts, Radix Achyranthis Bidentatae 11 parts, Radix Et Rhizoma Rhei 5 parts, Herba Agrimoniae 15 parts, Semen Cuscutae 15 parts, Fructus Ligustri Lucidi 9 parts, Fructus Psoraleae 6 parts
Preparation method: Herba Lycopi, Herba Leonuri, Rhizoma Cyperi, Radix Angelicae Sinensis are pulverized, add the alcoholic solution of concentration 70%, reduced-pressure backflow extracts 2 times, add the amount of 6 times at every turn, extract 1.5 hours, filter, be concentrated into thick paste after the ethanol of extraction is reclaimed ethanol, vacuum drying is for subsequent use to constant weight; Medicinal residues after Herba Patriniae, Radix Achyranthis Bidentatae, Radix Et Rhizoma Rhei, Herba Agrimoniae, Semen Cuscutae, Fructus Ligustri Lucidi, Fructus Psoraleae and alcohol extraction merge, decoct with water extraction 2 times, add the water yield of 7 times of medical materials at every turn, each decoction 1.5 hours, filter, the filtrate obtained after decocting in water is concentrated to obtain extractum, and adding alcoholic solution to ethanol content is 45%, stirs evenly, leave standstill, leaching supernatant, reclaim ethanol and be concentrated into thick paste, vacuum drying is for subsequent use to constant weight; Twice dry extract is merged and is ground into fine powder, then add appropriate amount of auxiliary materials mixing, make granule by conventional formulation method.
Embodiment 7
Prescription: Herba Lycopi 23 parts, Herba Leonuri 15 parts, Rhizoma Cyperi 7 parts, Radix Angelicae Sinensis 16 parts, Herba Patriniae 18 parts, Radix Achyranthis Bidentatae 10 parts, Radix Et Rhizoma Rhei 4 parts, Herba Agrimoniae 10 parts, Semen Cuscutae 12 parts, Fructus Ligustri Lucidi 10 parts, Fructus Psoraleae 8 parts.
Preparation method: Herba Lycopi, Herba Leonuri, Rhizoma Cyperi, Radix Angelicae Sinensis are pulverized, add the alcoholic solution of concentration 75%, reduced-pressure backflow extracts 2 times, add the amount of 6 times at every turn, extract 2 hours, filter, be concentrated into thick paste after the ethanol of extraction is reclaimed ethanol, vacuum drying is for subsequent use to constant weight; Medicinal residues after Herba Patriniae, Radix Achyranthis Bidentatae, Radix Et Rhizoma Rhei, Herba Agrimoniae, Semen Cuscutae, Fructus Ligustri Lucidi, Fructus Psoraleae and alcohol extraction merge, decoct with water extraction 2 times, add the water yield of 9 times of medical materials at every turn, each decoction 2 hours, filter, the filtrate obtained after decocting in water is concentrated to obtain extractum, and adding alcoholic solution to ethanol content is 45%, stirs evenly, leave standstill, leaching supernatant, reclaim ethanol and be concentrated into thick paste, vacuum drying is for subsequent use to constant weight; Twice dry extract is merged and is ground into fine powder, then add appropriate amount of auxiliary materials mixing, make tablet by conventional formulation method.
Claims (7)
1., for a Chinese medicine preparation for chronic cervicitis postoperative rehabilitation, it is characterized in that it is that medicinal raw material is made by Herba Lycopi, Herba Leonuri, Rhizoma Cyperi, Radix Angelicae Sinensis, Herba Patriniae, Radix Achyranthis Bidentatae, Radix Et Rhizoma Rhei, Herba Agrimoniae, Semen Cuscutae, Fructus Ligustri Lucidi, Fructus Psoraleae.
2. Chinese medicine preparation as claimed in claim 1, its feature is that it is made up of the medicinal raw material of following preferred weight part: Herba Lycopi 18-23 part, Herba Leonuri 13-18 part, Rhizoma Cyperi 5-9 part, Radix Angelicae Sinensis 12-17 part, Herba Patriniae 15-20 part, Radix Achyranthis Bidentatae 6-11 part, Radix Et Rhizoma Rhei 2-5 part, Herba Agrimoniae 9-15 part, Semen Cuscutae 11-16 part, Fructus Ligustri Lucidi 6-11 part, Fructus Psoraleae 5-8 part.
3. Chinese medicine preparation as claimed in claim 2, is characterized in that it is made up of the medicinal raw material of following preferred weight part: Herba Lycopi 22 parts, Herba Leonuri 16 parts, Rhizoma Cyperi 7 parts, Radix Angelicae Sinensis 13 parts, Herba Patriniae 16 parts, Radix Achyranthis Bidentatae 8 parts, Radix Et Rhizoma Rhei 3 parts, Herba Agrimoniae 10 parts, Semen Cuscutae 12 parts, Fructus Ligustri Lucidi 8 parts, Fructus Psoraleae 6 parts.
4. Chinese medicine preparation as claimed in claim 2, is characterized in that it is made up of the medicinal raw material of following preferred weight part: Herba Lycopi 18 parts, Herba Leonuri 14 parts, Rhizoma Cyperi 6 parts, Radix Angelicae Sinensis 15 parts, Herba Patriniae 18 parts, Radix Achyranthis Bidentatae 10 parts, Radix Et Rhizoma Rhei 4 parts, Herba Agrimoniae 12 parts, Semen Cuscutae 15 parts, Fructus Ligustri Lucidi 10 parts, Fructus Psoraleae 6 parts.
5. the Chinese medicine preparation as described in claim 1-4, it is characterized in that its preferred preparation method comprises the following steps: Herba Lycopi, Herba Leonuri, Rhizoma Cyperi, Radix Angelicae Sinensis are pulverized, add the alcoholic solution of concentration 65% ~ 80%, reduced-pressure backflow extracts 2 times, add the amount of 4 ~ 8 times at every turn, extract 1 ~ 2 hour, filter, be concentrated into thick paste after the ethanol of extraction is reclaimed ethanol, vacuum drying is for subsequent use to constant weight; Medicinal residues after Herba Patriniae, Radix Achyranthis Bidentatae, Radix Et Rhizoma Rhei, Herba Agrimoniae, Semen Cuscutae, Fructus Ligustri Lucidi, Fructus Psoraleae and alcohol extraction merge, decoct with water extraction 2 times, add the water yield of 6 ~ 10 times of medical materials at every turn, decoct 1 ~ 2 hour at every turn, filter, the filtrate obtained after decocting in water is concentrated to obtain extractum, and adding alcoholic solution to ethanol content is 45%, stirs evenly, leave standstill, leaching supernatant, reclaim ethanol and be concentrated into thick paste, vacuum drying is for subsequent use to constant weight; Twice dry extract is merged and is ground into fine powder, then add appropriate amount of auxiliary materials mixing, make clinical receptible peroral dosage form by conventional formulation method.As granule, tablet, capsule, oral liquid, soft capsule, drop pill, water pill etc.
6. Chinese medicine preparation as claimed in claim 5, is characterized in that described peroral dosage form is preferably tablet, capsule, granule.
7. Chinese medicine preparation as claimed in claim 6, is characterized in that described peroral dosage form is preferably capsule.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510283299.0A CN104825724A (en) | 2015-05-28 | 2015-05-28 | Traditional Chinese medicine preparation for chronic cervicitis postoperative rehabilitation |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510283299.0A CN104825724A (en) | 2015-05-28 | 2015-05-28 | Traditional Chinese medicine preparation for chronic cervicitis postoperative rehabilitation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN104825724A true CN104825724A (en) | 2015-08-12 |
Family
ID=53804173
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201510283299.0A Pending CN104825724A (en) | 2015-05-28 | 2015-05-28 | Traditional Chinese medicine preparation for chronic cervicitis postoperative rehabilitation |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN104825724A (en) |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101485863A (en) * | 2008-01-16 | 2009-07-22 | 北京天科仁祥医药科技有限公司 | Chinese medicinal composition for treating gynaecologic disease and technique for preparing the same |
| CN101791377A (en) * | 2010-04-12 | 2010-08-04 | 汤永顺 | Traditional Chinese medicine preparation for post-operation rehabilitation of cervicitis and cervical hypertrophy |
| CN102335392A (en) * | 2011-09-28 | 2012-02-01 | 林凡友 | Rhizoma smilacis chinensis dispersion tablet and preparing process thereof |
-
2015
- 2015-05-28 CN CN201510283299.0A patent/CN104825724A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101485863A (en) * | 2008-01-16 | 2009-07-22 | 北京天科仁祥医药科技有限公司 | Chinese medicinal composition for treating gynaecologic disease and technique for preparing the same |
| CN101791377A (en) * | 2010-04-12 | 2010-08-04 | 汤永顺 | Traditional Chinese medicine preparation for post-operation rehabilitation of cervicitis and cervical hypertrophy |
| CN102335392A (en) * | 2011-09-28 | 2012-02-01 | 林凡友 | Rhizoma smilacis chinensis dispersion tablet and preparing process thereof |
Non-Patent Citations (4)
| Title |
|---|
| 宋桂荣等: "《中药化学（中药专业）》", 28 February 2003, 中国中医药出版社 * |
| 潘鸿鹄: "《中医药治疗炎症学》", 31 January 2000, 军事医学科学出版社 * |
| 王东梅等: "《妇产科病学》", 31 October 1997, 山西科学技术出版社 * |
| 车翠云等: "中西医结合治疗子宫内膜异位症30例", 《中医研究》 * |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN103432270B (en) | Traditional Chinese medicine composition for treating chronic prostatitis | |
| CN103007093A (en) | Medicine for treating gynecological inflammation and preparation method thereof | |
| CN104548054A (en) | Traditional Chinese medicine composition for treating gynecological diseases and preparation methods of traditional Chinese medicine composition | |
| CN104069443A (en) | Traditional Chinese medicine for treating acute purulent osteomyelitis and preparation method of traditional Chinese medicine | |
| CN103720980A (en) | Medicine for treating chronic nephritis | |
| CN103446500A (en) | Traditional Chinese medicine composition for treating cyclomastopathy, mammary pain and postpartum milk obstruction | |
| CN103301373B (en) | Pharmaceutical composition for treating postpartum perineal mucosal lesions | |
| CN106729457B (en) | Traditional Chinese medicine pill for treating tissue residues in uterine cavity after abortion | |
| CN102973876B (en) | Drug for treating pathological leukorrhagia | |
| CN102743550B (en) | Medicine composition for accelerating healing after fracture surgery, preparation method and application | |
| CN105770691A (en) | Medicinal preparation for treating cervical cancer and application thereof | |
| CN104825724A (en) | Traditional Chinese medicine preparation for chronic cervicitis postoperative rehabilitation | |
| CN104784489A (en) | Traditional Chinese medicine preparation for treating chronic cervicitis accompanied HPV (human papillomavirus) infection | |
| CN104288518A (en) | Traditional Chinese medicine composition for treating cervicitis | |
| CN105106846B (en) | Treat the formula of Chinese materia medica preparation of uterus adenomyosis | |
| CN103656063A (en) | Medicine for treating chronic prostatitis | |
| CN103656460A (en) | Traditional Chinese medicinal composition for treating diabetes | |
| CN103520354A (en) | Traditional Chinese medicine for treatment of blood-insufficiency type mammary gland hyperplasia and preparation method thereof | |
| CN103599379A (en) | Traditional Chinese medicine for treatment of liver and kidney deficient type chronic osteomyelitis and its preparation method | |
| CN103494991B (en) | Traditional Chinese medicine preparation for treating female metrorrhagia and preparation method thereof | |
| CN103316270B (en) | Preparation method of powder of medicine for treating postnatal perineum mucosal lesion | |
| CN105232997A (en) | Chinese herba preparation used for treating endometritis and preparing method | |
| CN105535674A (en) | A medicine for treating chronic cervicitis | |
| CN108354998B (en) | Extract for treating pelvic inflammation and preparation method thereof | |
| CN104435734A (en) | Traditional Chinese medicine preparation for nursing uterine leiomyoma and preparation method of traditional Chinese medicine preparation |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| EXSB | Decision made by sipo to initiate substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20150812 |