CN104825494A - Mussel extract and application thereof in drugs for promoting post-natal uterine contraction - Google Patents
Mussel extract and application thereof in drugs for promoting post-natal uterine contraction Download PDFInfo
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- CN104825494A CN104825494A CN201510183453.7A CN201510183453A CN104825494A CN 104825494 A CN104825494 A CN 104825494A CN 201510183453 A CN201510183453 A CN 201510183453A CN 104825494 A CN104825494 A CN 104825494A
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Abstract
The present invention discloses a mussel extract and the application thereof in drugs for promoting the post-natal uterine contraction. The mussel extract comprises water-soluble materials extracted from the mussel meat and has the effect of contracting the uterus. Therefore, the mussel extract can be used for the treatment on uterus subinvolution after postpartum hemorrhage, drug abortion, and induced abortion.
Description
Technical field
The present invention relates to marine active substance mussel extract for the preparation of the novelty teabag in uterotonic medicine.
Background technology
Mussel (Latin name:
mytilidae) have another name called Mytilus, Fructus mail micromali, Qing Kou, be a kind of bivalve, shell pitchy, meat ecru to Chinese red not etc., live on the rock of beach, it belongs to the one of extra large freshwater mussel.Mussel is boiled and shells, and taste is extremely fresh, and nutrition is also very abundant, and economic worth is very high, also has certain medicine price cheating value.Mussel property is salty, taste temperature, enters liver, kidney channel, can be used for invigorating the liver and kidney, benefiting essence-blood, and disappear goiter.Control asthenia weakness and emaciation, dizzy, night sweat, sexual impotence, lumbago, spits blood, metrorrhagia, leukorrhagia, goiter, hernia abdominal mass.Supplement to the Herbal is recorded: the strain of main weakness with emaciation, thin and weak because producing, and vim and vigour knot is long-pending, abdomen is cold, borborygmus, dysentery, pain in the lumbar region, leukorrhagia, hernia abdominal mass." Japan hanako materia medica " is recorded: boil food, can tonifying five ZANG-organs, Yiyang thing, and manage waist beriberi, disappear dyspepsia, except cold air in abdomen, and mass beside the umbilicus.《 Jiayou Bencao " record: control asthenia wound exhausted, the few person of essence and blood, and spit blood, married woman's leukorrhagia, to leak down, husband's chronic dysentery, and cook it, but promote that uterine contraction effect has no report.
Uterus during Pregnancy increases gradually, uterine cavity capacity increase about 1000 times.Uterus weight increases nearly 20 times, in point puerperium, due to contraction, the retraction effect of uterus muscle, uterine volume is obviously reduced, the state before generally Zhou Shike returns to pregnancy in puerperal 5 ~ 6.If uterine contractions fatigue, more than, dripping unclean, the lower abdomen pain of lochia can be caused.Subinvolution of uterus, should take uterine contraction medicine, as oxytocin, and ergot fluid extract, ext leonuri sibirici liq; Easily there is uterine rupture in oxytocin, has cesarean history person to avoid use, multipara's (easily uterine rupture occurring) forbiddings more than 3 tires.Herba Leonuri can increase the weight of dysmenorrhea, cause puerperal uterine contraction pain, also has nephrotoxicity.Research and develop new promotion uterine contraction in puerperal, receive much concern in particular for Subinvoluted novel drugs in treatment puerperal, compare with traditional Herba Leonuri herein, prove that mussel extract has the contraction effect of uterus of similar Herba Leonuri, there is good potential applicability in clinical practice.
Summary of the invention
The present inventor finds that mussel extract has the effect of shrinking more by force uterus, can be used for promoting uterine contraction medicine in puerperal, in particular for treatment subinvolution in puerperal.
That is, the invention provides:
(1) mussel extract promotes the purposes in uterine contraction medicine in puerperal in preparation, and wherein the preparation method of mussel extract is as follows: 1. appropriate mussel meat, homogenate; 2. add 1.5 times to the distilled water of volume, extract 25min in 30 DEG C of ultrasonic assistant; 3. 30 DEG C of stirring in water bath extract the centrifugal 5min of 2h, 4000r/min, get supernatant, and residue repeats aforesaid operations, merging filtrate, and after being evaporated to 1/3 volume, lyophilization obtains mussel extract;
(2) according to the purposes of above-mentioned (1), it is characterized in that: mussel extract is made capsule, tablet, pill, powder, granule together with pharmaceutically acceptable carrier;
(3) according to the purposes of above-mentioned (1), it is characterized in that: described uterine contraction refers to normal labor, Cesarean esction, uterine contraction after Artificial or drug-induced abortion.
Detailed description of the invention
By the following examples foregoing of the present invention is described in further detail again.But the present invention is not by the restriction of following embodiment.All technology realized based on foregoing of the present invention all belong to scope of the present invention.
Embodiment 1, preparation have the mussel extract promoting uterine contraction effect in puerperal:
(1) appropriate mussel meat, homogenate;
(2) add 1.5 times to the distilled water of volume, extract 25min in 30 DEG C of ultrasonic assistant;
(3) 30 DEG C of stirring in water bath extract the centrifugal 5min of 2h, 4000r/min, get supernatant, and residue repeats aforesaid operations, and merging filtrate, after being evaporated to 1/3 volume, lyophilization obtains mussel extract.
Embodiment 2: mussel extract is on the uterotonic impact of isolated mouse
The preparation of mice isolated uterine: unpregnancy female mice in experiment first 2 days, every day lumbar injection estradiol valerate, to improve the sensitivity of uterus to medicine; Cervical dislocation puts to death mice rapidly, and the uterine muscle strips being about 1.0cm is made in taking-up uterus of cutting open the belly.To put into the Magnus' bath filling 20ml with the uterus of silk thread ligation, by the silk thread in ligation uterus, one end is fixed on the specimen fixation hook in bath, and the other end is connected on tonotransducer, gives the load of uterus 1g.Start to record normal shrinkage curve after uterine contraction is steady.Each group is dripped respectively to the mussel extract of Herba Leonuri aqueous solution 1 (in contrast), various concentration, after uterine contraction is steady, use Biolap420E
+biological Signal Collecting System record uterine myometrium moves, and the persistent period at the frequency of the uterine myometrium before and after the administration of each group record in 5min, amplitude and contraction interval, result is as following table.
Table 1 mussel extract on the impact of isolated uterine smooth muscle (
± S, n=12)
| Group | Frequency (point, secondary) | Amplitude (g) |
| Blank group | 3.1±0.7 | 0.50±0.11 |
| Herba Leonuri (0.1mg/ml) | 5.1±1.2 | 0.96±0.26 |
| Mussel extract (0.2mg/ml) | 3.7±0.5 | 0.76±0.17 |
| (0.4mg/ml) | 4.6±0.1 | 0.80±0.14 |
Embodiment 3: the preparation of mussel extract tablet
Prescription:
Mussel extract 100mg
Lactose 100mg
Starch 295mg
Magnesium stearate 5mg
500mg altogether
Weigh each main component separately, mussel extract is crossed the powder of 80 mesh sieves, lactose, starch mixes, and with wet granulation, dry, mix with magnesium stearate after integrating, tabletting, is pressed into the tablet of every sheet 500mg.
Embodiment 4: the preparation of mussel extract capsule
Prescription:
Mussel extract 100mg
Starch 395mg
Magnesium stearate 5mg
500mg altogether
Weigh each main component separately, mussel extract is crossed the powder of 80 mesh sieves, starch mixes, and filled capsules, makes the capsule of each pure heavy 500mg.
Claims (3)
1. mussel extract and the application in promotion uterine contraction medicine in puerperal thereof, the preparation of this mussel extract comprises the following steps:
(1) appropriate mussel meat, homogenate;
(2) add 1.5 times to the distilled water of volume, extract 25min in 30 DEG C of ultrasonic assistant;
(3) 30 DEG C of stirring in water bath extract the centrifugal 5min of 2h, 4000r/min, get supernatant, and residue repeats aforesaid operations, and merging filtrate, after being evaporated to 1/3 volume, lyophilization obtains mussel extract.
2. purposes according to claim 1, is characterized in that: mussel extract is made capsule, tablet, pill, powder, granule together with pharmaceutically acceptable carrier.
3. purposes according to claim 1, is characterized in that: described uterine contraction refers to normal labor, Cesarean esction, uterine contraction after Artificial or drug-induced abortion.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510183453.7A CN104825494A (en) | 2015-04-19 | 2015-04-19 | Mussel extract and application thereof in drugs for promoting post-natal uterine contraction |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201510183453.7A CN104825494A (en) | 2015-04-19 | 2015-04-19 | Mussel extract and application thereof in drugs for promoting post-natal uterine contraction |
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| CN104825494A true CN104825494A (en) | 2015-08-12 |
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Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1682769A (en) * | 2005-03-15 | 2005-10-19 | 中国人民解放军第二军医大学 | Trachyostracous mussel extract capable of increasing immunity function |
| CN1771997A (en) * | 2005-11-07 | 2006-05-17 | 上海新药研究开发中心 | Trachyostracous mussel extract and its prepn and use |
| CN104434986A (en) * | 2014-12-29 | 2015-03-25 | 青岛大学 | Razor clam extractive used for promoting postpartum uterus contraction |
| CN104558242A (en) * | 2013-10-28 | 2015-04-29 | 中国人民解放军第二军医大学 | Partially acidic hydrolyzed compound of mytilus coruscus polysaccharides as well as preparation method and application of compound |
-
2015
- 2015-04-19 CN CN201510183453.7A patent/CN104825494A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1682769A (en) * | 2005-03-15 | 2005-10-19 | 中国人民解放军第二军医大学 | Trachyostracous mussel extract capable of increasing immunity function |
| CN1771997A (en) * | 2005-11-07 | 2006-05-17 | 上海新药研究开发中心 | Trachyostracous mussel extract and its prepn and use |
| CN104558242A (en) * | 2013-10-28 | 2015-04-29 | 中国人民解放军第二军医大学 | Partially acidic hydrolyzed compound of mytilus coruscus polysaccharides as well as preparation method and application of compound |
| CN104434986A (en) * | 2014-12-29 | 2015-03-25 | 青岛大学 | Razor clam extractive used for promoting postpartum uterus contraction |
Non-Patent Citations (4)
| Title |
|---|
| ARTHUR DAVID等: "Temporal study of estrogenic responses of mussel (Mytilus galloprovinciallis) extracts applied to reporter cell lines", 《MARINE ENVIRONMENTAL RESEARCH》 * |
| 俞振良等: "紫贻贝水提取物对大鼠离体子宫平滑肌的作用", 《中国海洋药物》 * |
| 刘志峰等: "贻贝提取物抗高血脂作用的观察", 《中国海洋药物》 * |
| 熊川男等: "贻贝凝集素生物活性的研究", 《水产科学》 * |
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Application publication date: 20150812 |