CN104825495A - Oyster extract and application thereof in medicaments for promoting postpartum uterine contraction - Google Patents
Oyster extract and application thereof in medicaments for promoting postpartum uterine contraction Download PDFInfo
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- CN104825495A CN104825495A CN201510183455.6A CN201510183455A CN104825495A CN 104825495 A CN104825495 A CN 104825495A CN 201510183455 A CN201510183455 A CN 201510183455A CN 104825495 A CN104825495 A CN 104825495A
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- concha ostreae
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Abstract
The present invention discloses an oyster extract and the application thereof in medicaments for promoting the postpartum uterine contraction. The oyster extract contains water-soluble materials extracted from the meat of the oyster and has the uterine contraction function. The oyster extract can be used for the treatment on uterus subinvolution after postpartum hemorrhage, drug abortion, and induced abortion.
Description
Technical field
The present invention relates to marine active substance Concha Ostreae extract for the preparation of the novelty teabag in uterotonic medicine.
Background technology
Concha Ostreae another name is oysters again, and being the entirety of Ostreidae (ostreae) animal Concha Ostreae (ostreagigastnunb) and near edge animal thereof, is seashell, salty in the mouth; Cold nature.Suppressing the hyperactive liver and subsiding YANG; Tranquillization with heavy prescription; Hard masses softening and resolving; Restrain astringent or styptic treatment for spontaneous sweating.Cure mainly: vertigo and tinnitus; Palpitation with fear insomnia; Scrofula goiter; Lump in the abdomen mass in the abdomen; Spontaneous sweating; Seminal emission; Metrorrhagia; Leukorrhagia.Compendium of Material Medica is recorded: record " (Concha Ostreae) takes for a long time, and bone strengthening saves, and kills pathogen, prolongs life " in Carnis ostreae " polyphagia it, can fine work skin, kidney invigorating and YANG supporting, and can control void, separates erysipelas " Shennong's Herbal.Record Concha Ostreae in " Empirical formula " and control night sweat and polyhidrosis around the external genitals.Record Concha Ostreae " control metrorrhagia and metrostaxis red white more than, the deficiency of vital energy exhausts " in " prescriptions worth thousand gold ", but promote that uterine contraction effect has no report.
Uterus during Pregnancy increases gradually, uterine cavity capacity increase about 1000 times.Uterus weight increases nearly 20 times, in point puerperium, due to contraction, the retraction effect of uterus muscle, uterine volume is obviously reduced, the state before generally Zhou Shike returns to pregnancy in puerperal 5 ~ 6.If uterine contractions fatigue, more than, dripping unclean, the lower abdomen pain of lochia can be caused.Subinvolution of uterus, should take uterine contraction medicine, as oxytocin, and ergot fluid extract, ext leonuri sibirici liq; Easily there is uterine rupture in oxytocin, has cesarean history person to avoid use, multipara's (easily uterine rupture occurring) forbiddings more than 3 tires.Herba Leonuri can increase the weight of dysmenorrhea, cause puerperal uterine contraction pain, also has nephrotoxicity.Research and develop new promotion uterine contraction in puerperal, receive much concern in particular for Subinvoluted novel drugs in treatment puerperal, compare with traditional Herba Leonuri herein, prove that Concha Ostreae extract has the contraction effect of uterus of similar Herba Leonuri, there is good potential applicability in clinical practice.
Summary of the invention
The present inventor finds that Concha Ostreae extract has the effect of shrinking more by force uterus, can be used for promoting uterine contraction medicine in puerperal, in particular for treatment subinvolution in puerperal.
That is, the invention provides:
(1) Concha Ostreae extract promotes the purposes in uterine contraction medicine in puerperal in preparation, and wherein the preparation method of Concha Ostreae extract is as follows: 1. appropriate Carnis ostreae, homogenate; 2. add 1.5 times to the distilled water of volume, extract 25min in 30 DEG C of ultrasonic assistant; 3. 30 DEG C of stirring in water bath extract the centrifugal 5min of 2h, 4000r/min, get supernatant, and residue repeats aforesaid operations, merging filtrate, and after being evaporated to 1/3 volume, lyophilization obtains Concha Ostreae extract;
(2) according to the purposes of above-mentioned (1), it is characterized in that: Concha Ostreae extract is made capsule, tablet, pill, powder, granule together with pharmaceutically acceptable carrier;
(3) according to the purposes of above-mentioned (1), it is characterized in that: described uterine contraction refers to normal labor, Cesarean esction, uterine contraction after Artificial or drug-induced abortion.
Detailed description of the invention
By the following examples foregoing of the present invention is described in further detail again.But the present invention is not by the restriction of following embodiment.All technology realized based on foregoing of the present invention all belong to scope of the present invention.
Embodiment 1, preparation have the Concha Ostreae extract promoting uterine contraction effect in puerperal:
(1) appropriate Carnis ostreae, homogenate;
(2) add 1.5 times to the distilled water of volume, extract 25min in 30 DEG C of ultrasonic assistant;
(3) 30 DEG C of stirring in water bath extract the centrifugal 5min of 2h, 4000r/min, get supernatant, and residue repeats aforesaid operations, and merging filtrate, after being evaporated to 1/3 volume, lyophilization obtains Concha Ostreae extract.
Embodiment 2: Concha Ostreae extract is on the uterotonic impact of isolated mouse
The preparation of mice isolated uterine: unpregnancy female mice in experiment first 2 days, every day lumbar injection estradiol valerate, to improve the sensitivity of uterus to medicine; Cervical dislocation puts to death mice rapidly, and the uterine muscle strips being about 1.0cm is made in taking-up uterus of cutting open the belly.To put into the Magnus' bath filling 20ml with the uterus of silk thread ligation, by the silk thread in ligation uterus, one end is fixed on the specimen fixation hook in bath, and the other end is connected on tonotransducer, gives the load of uterus 1g.Start to record normal shrinkage curve after uterine contraction is steady.Each group is dripped respectively to the Concha Ostreae extract of Herba Leonuri aqueous solution 1 (in contrast), various concentration, after uterine contraction is steady, use Biolap420E
+biological Signal Collecting System record uterine myometrium moves, and the persistent period at the frequency of the uterine myometrium before and after the administration of each group record in 5min, amplitude and contraction interval, result is as following table.
Table 1 Concha Ostreae extract on the impact of isolated uterine smooth muscle (
± S, n=12)
| Group | Frequency (point, secondary) | Amplitude (g) |
| Blank group | 3.2±0.8 | 0.55±0.20 |
| Herba Leonuri (0.1mg/ml) | 5.3±1.6 | 0.90±0.14 |
| Concha Ostreae extract (0.2mg/ml) | 3.5±0.6 | 0.67±0.10 |
| (0.4mg/ml) | 4.3±1.1 | 0.84±0.24 |
Embodiment 3: the preparation of Concha Ostreae extract tablet
Prescription:
Concha Ostreae extract 100mg
Lactose 100mg
Starch 295mg
Magnesium stearate 5mg
500mg altogether
Weigh each main component separately, Concha Ostreae extract is crossed the powder of 80 mesh sieves, lactose, starch mixes, and with wet granulation, dry, mix with magnesium stearate after integrating, tabletting, is pressed into the tablet of every sheet 500mg.
Embodiment 4: the preparation of Concha Ostreae extract capsule
Prescription:
Concha Ostreae extract 100mg
Starch 395mg
Magnesium stearate 5mg
500mg altogether
Weigh each main component separately, Concha Ostreae extract is crossed the powder of 80 mesh sieves, starch mixes, and filled capsules, makes the capsule of each pure heavy 500mg.
Claims (3)
1. Concha Ostreae extract and the application in promotion uterine contraction medicine in puerperal thereof, the preparation of this Concha Ostreae extract comprises the following steps:
(1) appropriate Carnis ostreae, homogenate;
(2) add 1.5 times to the distilled water of volume, extract 25min in 30 DEG C of ultrasonic assistant;
(3) 30 DEG C of stirring in water bath extract the centrifugal 5min of 2h, 4000r/min, get supernatant, and residue repeats aforesaid operations, and merging filtrate, after being evaporated to 1/3 volume, lyophilization obtains Concha Ostreae extract.
2. purposes according to claim 1, is characterized in that: Concha Ostreae extract is made capsule, tablet, pill, powder, granule together with pharmaceutically acceptable carrier.
3. purposes according to claim 1, is characterized in that: described uterine contraction refers to normal labor, Cesarean esction, uterine contraction after Artificial or drug-induced abortion.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510183455.6A CN104825495A (en) | 2015-04-19 | 2015-04-19 | Oyster extract and application thereof in medicaments for promoting postpartum uterine contraction |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201510183455.6A CN104825495A (en) | 2015-04-19 | 2015-04-19 | Oyster extract and application thereof in medicaments for promoting postpartum uterine contraction |
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| CN201510183455.6A Pending CN104825495A (en) | 2015-04-19 | 2015-04-19 | Oyster extract and application thereof in medicaments for promoting postpartum uterine contraction |
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1265910A (en) * | 1999-03-03 | 2000-09-13 | 宁枝 | Traditional Chinese medicine for treating women uterine bleeding |
| JP2003095971A (en) * | 2001-09-27 | 2003-04-03 | National Institute Of Health & Nutrition | Therapeutic agent or composition for osteoporosis |
| CN1439416A (en) * | 2003-03-24 | 2003-09-03 | 于少华 | Agent for protecting womb from profuse menstuation and its preparing method |
-
2015
- 2015-04-19 CN CN201510183455.6A patent/CN104825495A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1265910A (en) * | 1999-03-03 | 2000-09-13 | 宁枝 | Traditional Chinese medicine for treating women uterine bleeding |
| JP2003095971A (en) * | 2001-09-27 | 2003-04-03 | National Institute Of Health & Nutrition | Therapeutic agent or composition for osteoporosis |
| CN1439416A (en) * | 2003-03-24 | 2003-09-03 | 于少华 | Agent for protecting womb from profuse menstuation and its preparing method |
Non-Patent Citations (3)
| Title |
|---|
| 钟梅等: "微量元素锌与子宫收缩力的关系", 《广东医学》 * |
| 陈荣忠等: "牡蛎肉提取物主要营养成份的分析", 《台湾海峡》 * |
| 马永甄等: "牡蛎提取物拮抗维甲酸致小鼠神经管畸形的实验研究", 《生殖与避孕》 * |
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Application publication date: 20150812 |