CN104825496A - Blood clam extract and application thereof in medicaments for promoting postpartum uterine contraction - Google Patents
Blood clam extract and application thereof in medicaments for promoting postpartum uterine contraction Download PDFInfo
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- CN104825496A CN104825496A CN201510183462.6A CN201510183462A CN104825496A CN 104825496 A CN104825496 A CN 104825496A CN 201510183462 A CN201510183462 A CN 201510183462A CN 104825496 A CN104825496 A CN 104825496A
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- blood clam
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Abstract
The present invention discloses a blood clam extract and the application thereof in medicaments for promoting the postpartum uterine contraction. The blood clam extract contains water-soluble materials extracted from the meat of the blood clam and has the uterine contraction function. The blood clam extract can be used for the treatment on uterus subinvolution after postpartum hemorrhage, drug abortion, and induced abortion.
Description
Technical field
The present invention relates to marine active substance fiber crops blood clam extract for the preparation of the novelty teabag in uterotonic medicine.
Background technology
Fiber crops blood clam is commonly called as Scapharca subcrenata, numb clam, Mollusca, lamellibranchiata, Carnis Arca inflata order, Carnis Arca inflata section, and Scapharca subcrenata belongs to, and is mainly distributed in China, Korea and Japan coastal.Warm in nature, sweet in the mouth has enriches blood, the effects such as stomach invigorating." Bencao Jingshu " is recorded: " property is also nontoxic for wax, sweet in the mouth temperature, and sweet temperature can QI invigorating and invigorating middle warmer; then the five internal organs peace, and gastric qi is good for, the air-cooled all carbuncles of trusted subordinate's spinal column, and the strong then food of stomach is from disappearing; dirty warm then sun from, gas fill then blood from China ", but the effect of promotion uterine contraction has no report.
Uterus during Pregnancy increases gradually, uterine cavity capacity increase about 1000 times.Uterus weight increases nearly 20 times, in point puerperium, due to contraction, the retraction effect of uterus muscle, uterine volume is obviously reduced, the state before generally Zhou Shike returns to pregnancy in puerperal 5 ~ 6.If uterine contractions fatigue, more than, dripping unclean, the lower abdomen pain of lochia can be caused.Subinvolution of uterus, should take uterine contraction medicine, as oxytocin, and ergot fluid extract, ext leonuri sibirici liq; Easily there is uterine rupture in oxytocin, has cesarean history person to avoid use, multipara's (easily uterine rupture occurring) forbiddings more than 3 tires.Herba Leonuri can increase the weight of dysmenorrhea, cause puerperal uterine contraction pain, also has nephrotoxicity.Research and develop new promotion uterine contraction in puerperal, receive much concern in particular for Subinvoluted novel drugs in treatment puerperal, compare with traditional Herba Leonuri herein, prove that numb blood clam extract has the contraction effect of uterus of similar Herba Leonuri, there is good potential applicability in clinical practice.
Summary of the invention
The present inventor finds that numb blood clam extract has the effect of shrinking more by force uterus, can be used for promoting uterine contraction medicine in puerperal, in particular for treatment subinvolution in puerperal.
That is, the invention provides:
(1) numb blood clam extract promotes the purposes in uterine contraction medicine in puerperal in preparation, and wherein the preparation method of numb blood clam extract is as follows: 1. appropriate numb blood clam meat, homogenate; 2. add 1.5 times to the distilled water of volume, extract 25min in 30 DEG C of ultrasonic assistant; 3. 30 DEG C of stirring in water bath extract the centrifugal 5min of 2h, 4000r/min, get supernatant, and residue repeats aforesaid operations, merging filtrate, and after being evaporated to 1/3 volume, lyophilization obtains numb blood clam extract;
(2) according to the purposes of above-mentioned (1), it is characterized in that: numb blood clam extract is made capsule, tablet, pill, powder, granule together with pharmaceutically acceptable carrier;
(3) according to the purposes of above-mentioned (1), it is characterized in that: described uterine contraction refers to normal labor, Cesarean esction, uterine contraction after Artificial or drug-induced abortion.
Detailed description of the invention
By the following examples foregoing of the present invention is described in further detail again.But the present invention is not by the restriction of following embodiment.All technology realized based on foregoing of the present invention all belong to scope of the present invention.
Embodiment 1, preparation have the numb blood clam extract promoting uterine contraction effect in puerperal:
(1) appropriate numb blood clam meat, homogenate;
(2) add 1.5 times to the distilled water of volume, extract 25min in 30 DEG C of ultrasonic assistant;
(3) 30 DEG C of stirring in water bath extract the centrifugal 5min of 2h, 4000r/min, get supernatant, and residue repeats aforesaid operations, and merging filtrate, after being evaporated to 1/3 volume, lyophilization obtains numb blood clam extract.
Embodiment 2: numb blood clam extract is on the uterotonic impact of isolated mouse
The preparation of mice isolated uterine: unpregnancy female mice in experiment first 2 days, every day lumbar injection estradiol valerate, to improve the sensitivity of uterus to medicine; Cervical dislocation puts to death mice rapidly, and the uterine muscle strips being about 1.0cm is made in taking-up uterus of cutting open the belly.To put into the Magnus' bath filling 20ml with the uterus of silk thread ligation, by the silk thread in ligation uterus, one end is fixed on the specimen fixation hook in bath, and the other end is connected on tonotransducer, gives the load of uterus 1g.Start to record normal shrinkage curve after uterine contraction is steady.Each group is dripped respectively to the numb blood clam extract of Herba Leonuri aqueous solution 1 (in contrast), various concentration, after uterine contraction is steady, use Biolap420E
+biological Signal Collecting System record uterine myometrium moves, and the persistent period at the frequency of the uterine myometrium before and after the administration of each group record in 5min, amplitude and contraction interval, result is as following table.
The numb blood clam extract of table 1 on the impact of isolated uterine smooth muscle (
± S, n=12)
| Group | Frequency (point, secondary) | Amplitude (g) |
| Blank group | 3.4±0.7 | 0.56±0.16 |
| Herba Leonuri (0.1mg/ml) | 5.0±0.8 | 0.95±0.26 |
| Fiber crops blood clam extract (0.1mg/ml) | 4.0±1.3 | 0.71±0.10 |
| (0.3mg/ml) | 4.7±1.2 | 0.79±0.11 |
Embodiment 3: the preparation of numb blood clam extract tablet
Prescription:
Fiber crops blood clam extract 100mg
Lactose 100mg
Starch 295mg
Magnesium stearate 5mg
500mg altogether
Weigh each main component separately, numb blood clam extract is crossed the powder of 80 mesh sieves, lactose, starch mixes, and with wet granulation, dry, mix with magnesium stearate after integrating, tabletting, is pressed into the tablet of every sheet 500mg.
Embodiment 4: the preparation of numb blood clam extract capsule
Prescription:
Fiber crops blood clam extract 100mg
Starch 395mg
Magnesium stearate 5mg
500mg altogether
Weigh each main component separately, numb blood clam extract is crossed the powder of 80 mesh sieves, starch mixes, and filled capsules, makes the capsule of each pure heavy 500mg.
Claims (3)
1. numb blood clam extract and the application in promotion uterine contraction medicine in puerperal thereof, the preparation of this numb blood clam extract comprises the following steps:
(1) appropriate numb blood clam meat, homogenate;
(2) add 1.5 times to the distilled water of volume, extract 25min in 30 DEG C of ultrasonic assistant;
(3) 30 DEG C of stirring in water bath extract the centrifugal 5min of 2h, 4000r/min, get supernatant, and residue repeats aforesaid operations, and merging filtrate, after being evaporated to 1/3 volume, lyophilization obtains numb blood clam extract.
2. purposes according to claim 1, is characterized in that: numb blood clam extract is made capsule, tablet, pill, powder, granule together with pharmaceutically acceptable carrier.
3. purposes according to claim 1, is characterized in that: described uterine contraction refers to normal labor, Cesarean esction, uterine contraction after Artificial or drug-induced abortion.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510183462.6A CN104825496A (en) | 2015-04-19 | 2015-04-19 | Blood clam extract and application thereof in medicaments for promoting postpartum uterine contraction |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510183462.6A CN104825496A (en) | 2015-04-19 | 2015-04-19 | Blood clam extract and application thereof in medicaments for promoting postpartum uterine contraction |
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| Publication Number | Publication Date |
|---|---|
| CN104825496A true CN104825496A (en) | 2015-08-12 |
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| CN201510183462.6A Pending CN104825496A (en) | 2015-04-19 | 2015-04-19 | Blood clam extract and application thereof in medicaments for promoting postpartum uterine contraction |
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Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103954704A (en) * | 2014-05-06 | 2014-07-30 | 济南康众医药科技开发有限公司 | Method for assaying content of blood clam protein |
| CN103969367A (en) * | 2014-05-06 | 2014-08-06 | 济南康众医药科技开发有限公司 | Identification method of arca subcrenata protein |
| CN103969384A (en) * | 2014-05-06 | 2014-08-06 | 济南康众医药科技开发有限公司 | Content determination method of arca subcrenata hyperglycemia |
| CN104434986A (en) * | 2014-12-29 | 2015-03-25 | 青岛大学 | Razor clam extractive used for promoting postpartum uterus contraction |
-
2015
- 2015-04-19 CN CN201510183462.6A patent/CN104825496A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103954704A (en) * | 2014-05-06 | 2014-07-30 | 济南康众医药科技开发有限公司 | Method for assaying content of blood clam protein |
| CN103969367A (en) * | 2014-05-06 | 2014-08-06 | 济南康众医药科技开发有限公司 | Identification method of arca subcrenata protein |
| CN103969384A (en) * | 2014-05-06 | 2014-08-06 | 济南康众医药科技开发有限公司 | Content determination method of arca subcrenata hyperglycemia |
| CN104434986A (en) * | 2014-12-29 | 2015-03-25 | 青岛大学 | Razor clam extractive used for promoting postpartum uterus contraction |
Non-Patent Citations (4)
| Title |
|---|
| YONGBO BAO等: "Polymorphism of the multiple hemoglobins in blood clam Tegillarca granosa and its association with disease resistance to Vibrio parahaemolyticus", 《FISH & SHELLFISH IMMUNOLOGY》 * |
| 李谦等: "毛蚶提取物生化性质初步分析", 《药物生物技术》 * |
| 赵光环等: "浅海毛蚶养殖技术", 《河北农业科技》 * |
| 钟梅等: "微量元素锌与子宫收缩力的关系", 《广东医学》 * |
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Application publication date: 20150812 |