CN101947290A - Medicament with yin-nourishing effect - Google Patents

Medicament with yin-nourishing effect Download PDF

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Publication number
CN101947290A
CN101947290A CN2010105036726A CN201010503672A CN101947290A CN 101947290 A CN101947290 A CN 101947290A CN 2010105036726 A CN2010105036726 A CN 2010105036726A CN 201010503672 A CN201010503672 A CN 201010503672A CN 101947290 A CN101947290 A CN 101947290A
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medicine
preparation
nourishing yin
extracting solution
radix ophiopogonis
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CN2010105036726A
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郭景龙
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Abstract

The invention belongs to the technical field of medicine, and discloses a medicament with yin-nourishing effect, which is characterized by comprising the following medicinal raw materials in part by weight: 0.01 to 0.1 part of cordyceps polysaccharide or 0.5 to 3 parts of fermented cordyceps powder, 5 to 40 parts of dendrobium and 3 to 10 parts of dwarf lilyturf tuber. On the basis of the theory of modern traditional Chinese medical science, the fermented cordyceps powder or the cordyceps polysaccharide is compatible with the dendrobium and the dwarf lilyturf tuber to obtain new medicinal raw materials. Pharmacological experiments prove that the medicinal composition has excellent pharmacological effect of treating deficiency of yin.

Description

A kind of medicine with nourishing yin effect
Technical field
The present invention relates to medical technical field, be specifically related to a kind of medicine with nourishing yin effect.
Background technology
The deficiency of YIN, traditional Chinese medical term, relative with yang deficiency, be meant the pathological phenomenon that essence and blood or body fluid lose.Because of essence and blood and body fluid all belong to the moon,, be more common in the patient who causes cloudy liquid in-fighting after strain prolonged illness or the calentura so claim the deficiency of YIN.Because the deficiency of YIN can not be made fire, heated and then burn cloudy liquid and more empty, both often interact.Deficiency of YIN primary symptom is dysphoria with feverish sensation in the chest palms and soles or hectic fever in the afternoon, night sweat, flushed cheeks, become thin, the few tongue of red tongue etc.
The deficiency of YIN is many by after the calentura or the miscellaneous diseases cloudy liquid of damage with the passing of time, or because of overaction of the five emotions, intemperate sexual intercourse, cross the product of obeying warm-dryness syndrome etc. and make the dark consumption of cloudy liquid form cloudy liquid to lose few, body loses to make moist and nourishes large soil, simultaneously since the moon do not make sun then the gas phase of positive heat the prosperous partially interior-heat of giving birth to is not moistened the not peaceful syndrome of asthenic fire restlessness so show as repeatedly one deficiency-heat drying.The deficiency of YIN can be lost chronic existence simultaneously of syndromes such as void and pathogenic dryness or reciprocal causation with the deficiency of vital energy, blood deficiency, yang deficiency, yang hyperactivity damage of essence, body fluid, show as patient's deficiency of qi and yin card, deficiency of YIN-blood card, deficiency syndrome of both YIN and YANG, syndrome of hyperactivity of yang due to yin deficiency, cloudy damage of essence deficiency syndrome, cloudy Tianjin (liquid) deficiency of YIN such as deficiency syndrome, deficiency of YIN syndrome of endogenous dryness thanks to, and then can develop into yang deficiency, the exhaustion of YIN deficiency of YIN can cause pathological changes such as wind symptom qi depression to blood stasis water retention.
Summary of the invention
For these reasons, the applicant is the basis according to the modern Chinese medicine theory, with fermented Cordyceps powder or Cordyceps polysaccharide and Herba Dendrobii, Radix Ophiopogonis compatibility, obtains new medicine material, and pharmacological testing shows that pharmaceutical composition of the present invention has good treatment deficiency of YIN pharmacological effect.
The present invention is achieved through the following technical solutions.
A kind of medicine with nourishing yin effect, medicine is made up of raw material and adjuvant, medicine material is Cordyceps polysaccharide 0.01-0.1 weight portion or fermented Cordyceps powder 0.5-3 weight portion, Herba Dendrobii 5-40 weight portion, Radix Ophiopogonis the 3-10 weight portion.
Wherein adjuvant comprises Mel, crystal sugar, chitosan, Herba Cymbopogonis Citrari or Pandan Leaves.
Its Chinese medicine is tablet, capsule, granule, pill or oral liquid.
Wherein feedstock production becomes beverage.
Above-mentioned medicine with nourishing yin effect, wherein the preparation method of pharmaceutical preparation includes but not limited to following:
Herba Dendrobii, Radix Ophiopogonis are pulverized, add the 30%-70% ethanol extraction, extracting solution reclaims ethanol, drying; Residue adds water, extracts, and the extracting solution concentrate drying with the ethanol extraction mix homogeneously, adds Cordyceps polysaccharide or fermented Cordyceps powder, is prepared into tablet, capsule, granule, pill or oral liquid according to the conventional medicine formulation preparation method.
Wherein the preparation method of beverage includes but not limited to following:
Herba Dendrobii, Radix Ophiopogonis are pulverized, add the 30%-70% ethanol extraction, extracting solution reclaims ethanol, drying; Residue adds water, extracts, and the extracting solution concentrate drying with the ethanol extraction mix homogeneously, adds Cordyceps polysaccharide or fermented Cordyceps powder, is prepared into beverage according to the preparation method of conventional beverage.
The food that above-mentioned raw materials and adjuvant are prepared into.
The test of pesticide effectiveness
Pharmacological research to deficiency of YIN animal
Test 1 pair of deficiency of YIN mice pain influence
Trial drug:
1 group of medicine: commercially available LIUWEI DIHUANG WAN;
2 groups of medicines: Cordyceps polysaccharide 0.01g, Herba Dendrobii 5g, Radix Ophiopogonis 3g;
3 groups of medicines: Cordyceps polysaccharide 0.1g, Herba Dendrobii 40g, Radix Ophiopogonis 10g;
4 groups of medicines: Cordyceps polysaccharide 0.05g, Herba Dendrobii 20g, Radix Ophiopogonis 6g;
5 groups of medicines: fermented Cordyceps powder 0.5g, Herba Dendrobii 5g, Radix Ophiopogonis 3g;
6 groups of medicines: fermented Cordyceps powder 3g, Herba Dendrobii 40g, Radix Ophiopogonis 10g;
7 groups of medicines: fermented Cordyceps powder 1.5g, Herba Dendrobii 25g, Radix Ophiopogonis 7g;
Experimental animal: NH mice, body weight 18-22g, male and female half and half.
Test method: mice random packet, i.e. normal group, model group different pharmaceutical group.Except that normal group, all the other each treated animal is irritated stomach and only give thyroxine 3mg, reserpine 0.02mg/, every day 1 time, continuous 7 days every day, meanwhile, each treated animal is irritated stomach and is given corresponding medicine, every day 1 time, continuous 7 days, dosage is 1.5g/kg, after the last administration 1 hour, each Mus lumbar injection 0.6% glacial acetic acid 0.2ml/ only observed each treated animal in 15 minutes then and turns round the body number of times by what acetic acid caused.
Result of the test sees Table 1:
Table 1 different pharmaceutical is to the influence of deficiency of YIN mice pain
Annotate: compare #P<0.05, ##P<0.01 with model group; Compare Δ P<0.05 for 1 group with medicine.
The influence of 2 pairs of blood glucose of test
Trial drug:
1 group of medicine: commercially available LIUWEI DIHUANG WAN;
2 groups of medicines: Cordyceps polysaccharide 0.07g, Herba Dendrobii 25g, Radix Ophiopogonis 4g;
3 groups of medicines: fermented Cordyceps powder 2g, Herba Dendrobii 30g, Radix Ophiopogonis 3g;
Grouping as stated above, modeling, administration.After the last administration, eye socket is got blood, uses determination of glucose oxidase blood glucose.
Result of the test sees Table 2.
The influence of table 2 pair deficiency of YIN mouse blood sugar
Figure BSA00000298692900041
Annotate: compare #P<0.05, ##P<0.01 with model group; Compare Δ P<0.05 for 1 group with medicine.
Clinical trial
Clinical out-patient's 89 examples, male's 59 examples, women's 30 examples, patient age 30 years old-57 years old, the deficiency of YIN is made a definite diagnosis in traditional Chinese medical science clinic, the oral informed consent of patient, give medicine of the present invention (Cordyceps polysaccharide 0.07g, Herba Dendrobii 20g, Radix Ophiopogonis 8g), every day 1 time, give 14 days, effective case 45 examples of the clinical conclusive evidence deficiency of YIN (50.1%), produce effects ratio 36 examples (40.4%), invalid 8 examples (9.5%).
Preparation embodiment
Embodiment 1
A kind of medicine with nourishing yin effect, raw material Cordyceps polysaccharide 0.01g wherein, Herba Dendrobii 5g, Radix Ophiopogonis 3g, pharmaceutic adjuvant Mel is an amount of.
Herba Dendrobii, Radix Ophiopogonis are pulverized, add 30% ethanol extraction, extracting solution reclaims ethanol, drying; Residue adds water, extracts, and the extracting solution concentrate drying with the ethanol extraction mix homogeneously, adds Cordyceps polysaccharide, is prepared into tablet, capsule, granule, pill or oral liquid according to the conventional medicine formulation preparation method.Perhaps the preparation method according to conventional beverage is prepared into beverage.
Embodiment 2
A kind of medicine with nourishing yin effect, raw material Cordyceps polysaccharide 0.1g wherein, Herba Dendrobii 40g, Radix Ophiopogonis 10 weight portion.The pharmaceutic adjuvant crystal sugar is an amount of.
Herba Dendrobii, Radix Ophiopogonis are pulverized, add 70% ethanol extraction, extracting solution reclaims ethanol, drying; Residue adds water, extracts, and the extracting solution concentrate drying with the ethanol extraction mix homogeneously, adds Cordyceps polysaccharide, is prepared into tablet, capsule, granule, pill or oral liquid according to the conventional medicine formulation preparation method.Perhaps the preparation method according to conventional beverage is prepared into beverage
Embodiment 3
A kind of medicine with nourishing yin effect, raw material Cordyceps polysaccharide 0.04g wherein, Herba Dendrobii 15g, Radix Ophiopogonis 7g.Pharmaceutic adjuvant Herba Cymbopogonis Citrari is an amount of.
Herba Dendrobii, Radix Ophiopogonis are pulverized, add 45% ethanol extraction, extracting solution reclaims ethanol, drying; Residue adds water, extracts, and the extracting solution concentrate drying with the ethanol extraction mix homogeneously, adds the Cordyceps polysaccharide powder, is prepared into tablet, capsule, granule, pill or oral liquid according to the conventional medicine formulation preparation method.Perhaps the preparation method according to conventional beverage is prepared into beverage
Embodiment 4
A kind of medicine with nourishing yin effect, raw material Cordyceps polysaccharide 0.09g wherein, Herba Dendrobii 35g, Radix Ophiopogonis 4g.The pharmaceutic adjuvant chitosan is an amount of.
Herba Dendrobii, Radix Ophiopogonis are pulverized, add 65% ethanol extraction, extracting solution reclaims ethanol, drying; Residue adds water, extracts, and the extracting solution concentrate drying with the ethanol extraction mix homogeneously, adds Cordyceps polysaccharide, is prepared into tablet, capsule, granule, pill or oral liquid according to the conventional medicine formulation preparation method.Perhaps the preparation method according to conventional beverage is prepared into beverage
Embodiment 5
A kind of medicine with nourishing yin effect, fermenting raw materials Cordyceps powder 0.5g wherein, Herba Dendrobii 5g, Radix Ophiopogonis 3g.The pharmaceutic adjuvant chitosan is an amount of.
Herba Dendrobii, Radix Ophiopogonis are pulverized, add 30% ethanol extraction, extracting solution reclaims ethanol, drying; Residue adds water, extracts, and the extracting solution concentrate drying with the ethanol extraction mix homogeneously, adds fermented Cordyceps powder, is prepared into tablet, capsule, granule, pill or oral liquid according to the conventional medicine formulation preparation method.Perhaps the preparation method according to conventional beverage is prepared into beverage
Embodiment 6
A kind of medicine with nourishing yin effect, fermenting raw materials Cordyceps powder 3g wherein, Herba Dendrobii 40g, Radix Ophiopogonis 10g.Pharmaceutic adjuvant Mel is an amount of.
Herba Dendrobii, Radix Ophiopogonis are pulverized, add 70% ethanol extraction, extracting solution reclaims ethanol, drying; Residue adds water, extracts, and the extracting solution concentrate drying with the ethanol extraction mix homogeneously, adds fermented Cordyceps powder, is prepared into tablet, capsule, granule, pill or oral liquid according to the conventional medicine formulation preparation method.Perhaps the preparation method according to conventional beverage is prepared into beverage
Embodiment 7
A kind of medicine with nourishing yin effect, fermenting raw materials Cordyceps powder 1g wherein, Herba Dendrobii 10g, Radix Ophiopogonis 5g.Pharmaceutic adjuvant Herba Cymbopogonis Citrari is an amount of.
Herba Dendrobii, Radix Ophiopogonis are pulverized, add 55% ethanol extraction, extracting solution reclaims ethanol, drying; Residue adds water, extracts, and the extracting solution concentrate drying with the ethanol extraction mix homogeneously, adds fermented Cordyceps powder, is prepared into tablet, capsule, granule, pill or oral liquid according to the conventional medicine formulation preparation method.Perhaps the preparation method according to conventional beverage is prepared into beverage
Embodiment 8
A kind of medicine with nourishing yin effect, fermenting raw materials Cordyceps powder 2.5g wherein, Herba Dendrobii 15g, Radix Ophiopogonis 9g.The pharmaceutic adjuvant Pandan Leaves is an amount of.
Herba Dendrobii, Radix Ophiopogonis are pulverized, add 40% ethanol extraction, extracting solution reclaims ethanol, drying; Residue adds water, extracts, and the extracting solution concentrate drying with the ethanol extraction mix homogeneously, adds fermented Cordyceps powder, is prepared into tablet, capsule, granule, pill or oral liquid according to the conventional medicine formulation preparation method.Perhaps the preparation method according to conventional beverage is prepared into beverage
The food that above-mentioned raw materials and adjuvant also can be prepared into.

Claims (7)

1. medicine with nourishing yin effect, medicine is made up of raw material and adjuvant, it is characterized in that medicine material is Cordyceps polysaccharide 0.01-0.1 weight portion or fermented Cordyceps powder 0.5-3 weight portion, Herba Dendrobii 5-40 weight portion, Radix Ophiopogonis the 3-10 weight portion.
2. a kind of medicine with nourishing yin effect according to claim 1, wherein adjuvant comprises Mel, crystal sugar, chitosan, Herba Cymbopogonis Citrari or Pandan Leaves.
3. a kind of medicine with nourishing yin effect according to claim 1 and 2, its Chinese medicine is tablet, capsule, granule, pill or oral liquid.
4. a kind of medicine with nourishing yin effect according to claim 1 and 2, wherein feedstock production becomes beverage.
5. a kind of medicine according to claim 3 with nourishing yin effect, wherein the preparation method of pharmaceutical preparation is:
Herba Dendrobii, Radix Ophiopogonis are pulverized, add the 30%-70% ethanol extraction, extracting solution reclaims ethanol, drying; Residue adds water, extracts, and the extracting solution concentrate drying with the ethanol extraction mix homogeneously, adds Cordyceps polysaccharide or fermented Cordyceps powder, is prepared into tablet, capsule, granule, pill or oral liquid according to the conventional medicine formulation preparation method.
6. a kind of medicine according to claim 4 with clearing away lung-heat to relieve cough, wherein the preparation method of beverage is:
Herba Dendrobii, Radix Ophiopogonis are pulverized, add the 30%-70% ethanol extraction, extracting solution reclaims ethanol, drying; Residue adds water, extracts, and the extracting solution concentrate drying with the ethanol extraction mix homogeneously, adds Cordyceps polysaccharide or fermented Cordyceps powder, is prepared into beverage according to the preparation method of conventional beverage.
7. a kind of medicine according to claim 1 and 2, the wherein food of raw material and adjuvant preparation with nourishing yin effect.
CN2010105036726A 2010-10-12 2010-10-12 Medicament with yin-nourishing effect Pending CN101947290A (en)

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Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104304491A (en) * 2014-09-30 2015-01-28 江苏奇力康皮肤药业有限公司 Traditional Chinese medicinal milk tablet and preparation method thereof
CN108210878A (en) * 2017-07-28 2018-06-29 楼良水 The cordyceps sinensis Saussurea Polysaccharide compound of kidney-tonifying sperm-generating
CN108853359A (en) * 2018-08-21 2018-11-23 西双版纳傣赞源生物科技有限公司 A kind of solution kidney poison dai medicine formula

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104304491A (en) * 2014-09-30 2015-01-28 江苏奇力康皮肤药业有限公司 Traditional Chinese medicinal milk tablet and preparation method thereof
CN108210878A (en) * 2017-07-28 2018-06-29 楼良水 The cordyceps sinensis Saussurea Polysaccharide compound of kidney-tonifying sperm-generating
CN108853359A (en) * 2018-08-21 2018-11-23 西双版纳傣赞源生物科技有限公司 A kind of solution kidney poison dai medicine formula

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Application publication date: 20110119