CN104434986A - Razor clam extractive used for promoting postpartum uterus contraction - Google Patents
Razor clam extractive used for promoting postpartum uterus contraction Download PDFInfo
- Publication number
- CN104434986A CN104434986A CN201410832674.8A CN201410832674A CN104434986A CN 104434986 A CN104434986 A CN 104434986A CN 201410832674 A CN201410832674 A CN 201410832674A CN 104434986 A CN104434986 A CN 104434986A
- Authority
- CN
- China
- Prior art keywords
- razor clam
- extract
- uterus
- clam extract
- puerperal
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/618—Molluscs, e.g. fresh-water molluscs, oysters, clams, squids, octopus, cuttlefish, snails or slugs
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Zoology (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Marine Sciences & Fisheries (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Plant Substances (AREA)
- Cosmetics (AREA)
Abstract
The invention discloses a razor clam extractive used for promoting postpartum uterus contraction; the razor clam extractive is the water-soluble matter extracted from the razor clam meat, has the function of contracting uterus and is used for treating postpartum hemorrhage and incomplete restoration of uterus after medical abortion operation and induced abortion operation.
Description
Technical field
The present invention relates to marine active substance razor clam extract for the preparation of the novelty teabag in uterotonic medicine.
Background technology
Razor clam is Bivalvia curtain clam order shell-fish, lives among ocean, is common ocean food materials.Carnis Sinonovacula is sweet, salty-cold, for puerperal deficiency and coldness, dysphoria with smothery sensation dysentery.The traditional Chinese medical science is thought, razor clam meat has heat-clearing and toxic substances removing, nourishing YIN relieving restlessness, kidney tonifying diuretic, puerperal the effect such as tonify deficiency.《 Jiayou Bencao " middle record: razor clam meat: " tonify deficiency, main cold-dysentery, cooks it, and housewife is deficient for puerperal, in the heart the unhappy gas of pathogenic heat ".Record in " occupying diet spectrum with breath ": razor clam meat " clearing stomach, control dysentery, relieving restlessness, benefit are deficient for puerperal ".Razor clam meat can treat that puerperal is deficient, and dysphoria with smothery sensation is thirsty, damp and hot edema, middle diarrhea due to summer-heat dysentery, the diseases such as dysuria, but promotes that uterine contraction effect has no report.
Uterus during Pregnancy increases gradually, uterine cavity capacity increase about 1000 times.Uterus weight increases nearly 20 times, in point puerperium, due to contraction, the retraction effect of uterus muscle, uterine volume is obviously reduced, the state before generally Zhou Shike returns to pregnancy in puerperal 5 ~ 6.If uterine contractions fatigue, more than, dripping unclean, the lower abdomen pain of lochia can be caused.Subinvolution of uterus, should take uterine contraction medicine, as oxytocin, and ergot fluid extract, ext leonuri sibirici liq; Easily there is uterine rupture in oxytocin, has cesarean history person to avoid use, multipara's (easily uterine rupture occurring) forbiddings more than 3 tires.Herba Leonuri can increase the weight of dysmenorrhea, cause puerperal uterine contraction pain, also has nephrotoxicity.Research and develop new promotion uterine contraction in puerperal, receive much concern in particular for Subinvoluted novel drugs in treatment puerperal, compare with traditional Herba Leonuri herein, prove that razor clam extract has the contraction effect of uterus of similar Herba Leonuri, there is good potential applicability in clinical practice.
Summary of the invention
The present inventor finds that razor clam extract has the effect of shrinking more by force uterus, can be used for promoting uterine contraction medicine in puerperal, in particular for treatment subinvolution in puerperal.
That is, the invention provides:
(1) razor clam extract promotes the purposes in uterine contraction medicine in puerperal in preparation, and wherein the preparation method of razor clam extract is as follows: 1. appropriate razor clam meat, homogenate; 2. add 1.5 times to the distilled water of volume, extract 25min in 30 DEG C of ultrasonic assistant; 3. 30 DEG C of stirring in water bath extract the centrifugal 5min of 2h, 4000r/min, get supernatant, and residue repeats aforesaid operations, merging filtrate, and after being evaporated to 1/3 volume, lyophilization obtains razor clam extract;
(2) according to the purposes of above-mentioned (1), it is characterized in that: razor clam extract is made capsule, tablet, pill, powder, granule together with pharmaceutically acceptable carrier;
(3) according to the purposes of above-mentioned (1), it is characterized in that: described uterine contraction refers to normal labor, Cesarean esction, uterine contraction after Artificial or drug-induced abortion.
Detailed description of the invention
By the following examples foregoing of the present invention is described in further detail again.But the present invention is not by the restriction of following embodiment.All technology realized based on foregoing of the present invention all belong to scope of the present invention.
Embodiment 1, preparation have the razor clam extract promoting uterine contraction effect in puerperal:
(1) appropriate razor clam meat, homogenate;
(2) add 1.5 times to the distilled water of volume, extract 25min in 30 DEG C of ultrasonic assistant;
(3) 30 DEG C of stirring in water bath extract the centrifugal 5min of 2h, 4000r/min, get supernatant, and residue repeats aforesaid operations, and merging filtrate, after being evaporated to 1/3 volume, lyophilization obtains razor clam extract.
Embodiment 2: razor clam extract is on the uterotonic impact of isolated mouse
The preparation of mice isolated uterine: unpregnancy female mice in experiment first 2 days, every day lumbar injection estradiol valerate, to improve the sensitivity of uterus to medicine; Cervical dislocation puts to death mice rapidly, and the uterine muscle strips being about 1.0cm is made in taking-up uterus of cutting open the belly.To put into the Magnus' bath filling 20ml with the uterus of silk thread ligation, by the silk thread in ligation uterus, one end is fixed on the specimen fixation hook in bath, and the other end is connected on tonotransducer, gives the load of uterus 1g.Start to record normal shrinkage curve after uterine contraction is steady.Each group is dripped respectively to the razor clam extract of Herba Leonuri aqueous solution 1 (in contrast), various concentration, after uterine contraction is steady, use Biolap420E
+biological Signal Collecting System record uterine myometrium moves, and the persistent period at the frequency of the uterine myometrium before and after the administration of each group record in 5min, amplitude and contraction interval, result is as following table.
Table 1 razor clam extract is on the impact of isolated uterine smooth muscle
( ± S, n=12)
| Group | Frequency (point, secondary) | Amplitude (g) |
| Blank group | 3.5±0.8 | 0.55±0.17 |
| Herba Leonuri (0.1mg/ml) | 4.8±0.6 | 0.88±0.06 |
| Razor clam extract (0.1mg/ml) | 3.5±0.7 | 0.56±0.18 |
| Razor clam extract (0.2mg/ml) | 4.4±0.5 | 0.67±0.10 |
| Razor clam extract (0.4mg/ml) | 4.6±0.2 | 0.77±0.14 |
Embodiment 3: the preparation of razor clam extract tablet
Prescription:
Razor clam extract 100mg
Lactose 100mg
Starch 295mg
Magnesium stearate 5mg
500mg altogether
Weigh each main component separately, razor clam extract is crossed the powder of 80 mesh sieves, lactose, starch mixes, and with wet granulation, dry, mix with magnesium stearate after integrating, tabletting, is pressed into the tablet of every sheet 500mg.
Embodiment 4: the preparation of razor clam extract capsule
Prescription:
Razor clam extract 100mg
Starch 395mg
Magnesium stearate 5mg
500mg altogether
Weigh each main component separately, razor clam extract is crossed the powder of 80 mesh sieves, starch mixes, and filled capsules, makes the capsule of each pure heavy 500mg.
Claims (3)
1., for promoting a uterotonic razor clam extract in puerperal, the preparation of this razor clam extract comprises the following steps:
(1) appropriate razor clam meat, homogenate;
(2) add 1.5 times to the distilled water of volume, extract 25min in 30 DEG C of ultrasonic assistant;
(3) 30 DEG C of stirring in water bath extract the centrifugal 5min of 2h, 4000r/min, get supernatant, and residue repeats aforesaid operations, and merging filtrate, after being evaporated to 1/3 volume, lyophilization obtains razor clam extract.
2. purposes according to claim 1, is characterized in that: razor clam extract is made capsule, tablet, pill, powder, granule together with pharmaceutically acceptable carrier.
3. purposes according to claim 1, is characterized in that: described uterine contraction refers to normal labor, Cesarean esction, uterine contraction after Artificial or drug-induced abortion.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410832674.8A CN104434986B (en) | 2014-12-29 | 2014-12-29 | One kind is for promoting postpartum uterotonic razor clam extract |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410832674.8A CN104434986B (en) | 2014-12-29 | 2014-12-29 | One kind is for promoting postpartum uterotonic razor clam extract |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN104434986A true CN104434986A (en) | 2015-03-25 |
| CN104434986B CN104434986B (en) | 2018-10-02 |
Family
ID=52882248
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201410832674.8A Expired - Fee Related CN104434986B (en) | 2014-12-29 | 2014-12-29 | One kind is for promoting postpartum uterotonic razor clam extract |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN104434986B (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104825496A (en) * | 2015-04-19 | 2015-08-12 | 青岛大学 | Blood clam extract and application thereof in medicaments for promoting postpartum uterine contraction |
| CN104825494A (en) * | 2015-04-19 | 2015-08-12 | 青岛大学 | Mussel extract and application thereof in drugs for promoting post-natal uterine contraction |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1547951A (en) * | 2003-05-15 | 2004-11-24 | 福建农林大学 | Serial dewatered razor clam food products and their processing method |
-
2014
- 2014-12-29 CN CN201410832674.8A patent/CN104434986B/en not_active Expired - Fee Related
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1547951A (en) * | 2003-05-15 | 2004-11-24 | 福建农林大学 | Serial dewatered razor clam food products and their processing method |
Non-Patent Citations (4)
| Title |
|---|
| MARTÍNEZ-MIR等。: ""Characteristics of histamine tachyphylaxis in rat uterine smooth"", 《INFLAMMATION RESEARCH》 * |
| 吕俊锦: ""促进子宫收缩中药的筛选与组方试验"", 《中国优秀硕士学位论文全文数据库》 * |
| 李淑荣，等。: ""复宁胶囊对动物子宫收缩的影响及其镇痛、止血作用的实验研究"", 《中国中医药科技》 * |
| 许静: ""超声波提取缢蛏多糖及脱蛋白工艺"", 《食品研究与开发》 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104825496A (en) * | 2015-04-19 | 2015-08-12 | 青岛大学 | Blood clam extract and application thereof in medicaments for promoting postpartum uterine contraction |
| CN104825494A (en) * | 2015-04-19 | 2015-08-12 | 青岛大学 | Mussel extract and application thereof in drugs for promoting post-natal uterine contraction |
Also Published As
| Publication number | Publication date |
|---|---|
| CN104434986B (en) | 2018-10-02 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN104324103A (en) | Medicated leaven pure powder superfine decoction piece and preparation method thereof | |
| WO2006137122A1 (en) | Anti-aids drug | |
| CN104434986A (en) | Razor clam extractive used for promoting postpartum uterus contraction | |
| CN102631525A (en) | Health care product with function of blood pressure reduction and preparation method thereof | |
| CN104434984A (en) | Sea cucumber flower extractive used for promoting postpartum uterus contraction | |
| CN101199806A (en) | Drug for treating laxness, preparing method and quality controlling method thereof | |
| CN104825496A (en) | Blood clam extract and application thereof in medicaments for promoting postpartum uterine contraction | |
| CN103330721A (en) | Holothurian flower extract for treatment of female POF and its preparation method | |
| CN100408058C (en) | Stomach-power Chinese medicine preparation and preparing method | |
| CN103860689B (en) | A kind of Chinese medicine composition | |
| CN102488813A (en) | Medicine for curing fibroid | |
| CN104825494A (en) | Mussel extract and application thereof in drugs for promoting post-natal uterine contraction | |
| CN106581236A (en) | Medicinal composition for promoting gastric motility, and preparation method and application thereof | |
| CN104825495A (en) | Oyster extract and application thereof in medicaments for promoting postpartum uterine contraction | |
| CN101461877B (en) | Medicament composition for recovery of physical strength for women | |
| CN109820913A (en) | The purposes and soft capsule of Zanthoxylum essential oil or Tengjiao oil | |
| CN104800681A (en) | Traditional Chinese medicine composition for treating irregular menstruation | |
| CN103585206A (en) | Preparation method of Chrysosplenium extract and its application | |
| CN108310031A (en) | A kind of ginseng fruit saponins bulk pharmaceutical chemicals, preparation, preparation method and its application | |
| CN102370655B (en) | Application of alginate oligosaccharide to preparation of medicament for facilitating postnatal uterine contraction | |
| CN105125594B (en) | A kind of antrodia Anethol Trithione composition that treating liver cancer and preparation method | |
| CN107432440A (en) | A kind of composition for significantly improving anti-fatigue effect and its preparation method and application | |
| CN101632707A (en) | Deer embryo ointment and preparation method thereof | |
| CN106215164A (en) | Fructus Phyllanthi pharmaceutical composition and preparation method thereof, preparation and anti-Ai Yingyong | |
| CN104825683A (en) | Application method of traditional Chinese medicine composition in preparation of drugs for vascular dilation |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20181002 Termination date: 20181229 |
|
| CF01 | Termination of patent right due to non-payment of annual fee |