CN103860689B - A kind of Chinese medicine composition - Google Patents

A kind of Chinese medicine composition Download PDF

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CN103860689B
CN103860689B CN201410124138.2A CN201410124138A CN103860689B CN 103860689 B CN103860689 B CN 103860689B CN 201410124138 A CN201410124138 A CN 201410124138A CN 103860689 B CN103860689 B CN 103860689B
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chinese medicine
weight portion
fat
medicine composition
breast
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CN103860689A (en
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王兴伟
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Abstract

The invention belongs to food or pharmaceutical technology field, be specifically related to a kind of Chinese medicine composition.Chinese medicine composition of the present invention includes Flos Rosae Rugosae, Radix Puerariae, Fructus Chaenomelis, Folium Mori, the Radix Astragali, dry Folium Nelumbinis.Composition quality of the present invention is controlled, uses safety, pharmacology and clinical trial to show, the present invention has the pharmacological actions such as good breast augmentation and health, fat-reducing;Product described in invention is suitable for commercial production.

Description

A kind of Chinese medicine composition
Technical field
The invention belongs to food or pharmaceutical technology field, be specifically related to a kind of Chinese medicine composition.
Background technology
Beautiful requirement as a new branch of science, is improved constantly and body day by day by cosmetic dermatology recently as people Now its importance.Due to molecular biology, immunologic further investigation, cosmetic dermatology achieves in terms of breast enlarging and beautifying New progress.
Breast is modest, flat, lax, sagging annoyings many women, with regard to its reason, can be summarized as three aspects: the first Girlhood breast development is incomplete;It two is to maintain after suckling not in place, is finally that estrogen secretion is inadequate before and after climacteric.
Currently, with respect to the product of strong breast breast enlargement, mostly being synthetic hormone, its curative effect is not good enough, in life-time service can cause Parasecretion, damages hepatic and renal function, causes chloasma, acne etc. to damage U.S. dermatoses, even induction carcinoma of endometrium and mammary gland Cancer;Although also having many herbal product but effect there are no the most outstanding.So research and development and female pathology match, effect Progressive and stable, do not harm health, be main to hold concurrently with the pure green pure nature ecosystem taken stopgap measures, can again can by breast enlargement to effect a permanent cure The product of U.S. breast is only trend of the times.
Fat-reducing belongs to the way of act for the purpose of reducing the excessive fat of human body, body weight.Refer to certain class overweight Obese people is by various methods such as: dancing, Yoga etc., becomes curve build again.Manage to correct overweight people's abnormal response to cause not Work as behavior, i.e. analyze feature and the type of sports of overweight people's trophic behavior by behavioral science, based on this, rationally revise and cause Fat action.Research shows, the overweight people caused because diet is irregular the most more or less have bowel problems.Drink with modern The problems such as feeding habits excessively fine, irregular, the food safety of diet are relevant.Absorption high fiber food is few, sitting, is all city The animation that white collar is common.If things go on like this it is easy to cause toxin, heavy-metal residual to deposit in intestinal fold, more easily causes Fat local accumulation.For easily piling up the women of fat, more easily cause water wing, little tripe sirloin, lower abdomen proud flesh.Once open Begin that these problems occur, the method such as majority select to go on a diet, drug administration, because not finding the root of problem, often it is difficult to Play effect.People are typically chosen product natural, that have no side effect to solve Similar Problems abroad, such as Chinese medicine.
Summary of the invention
For these reasons, applicant is on the basis of clinical research for many years, based on theory of Chinese medical science, in conjunction with modern doctor Theory, finds a kind of new Chinese medicine composition, and said composition includes Flos Rosae Rugosae, Radix Puerariae, Fructus Chaenomelis, Folium Mori, the Radix Astragali, dry Folium Nelumbinis, Pharmacology test and clinical trial test show, the present composition has the pharmacological action of good breast augmentation and health, fat-reducing.
It is an object of the invention to provide a kind of Chinese medicine composition, it contains clear and definite effective ingredient, quality controllable.
It is an object of the invention to provide a kind of Chinese medicine composition, it is suitable for commercial production.
For reaching above-mentioned purpose, the solution that the present invention is taked is:
Concrete grammar is as follows:
A kind of Chinese medicine composition, including Flos Rosae Rugosae, Radix Puerariae, Fructus Chaenomelis, Folium Mori, the Radix Astragali, dry Folium Nelumbinis.
A kind of Chinese medicine composition includes Flos Rosae Rugosae 8-12 weight portion, Radix Puerariae 18-22 weight portion, Fructus Chaenomelis 15-25 weight portion, Mulberry Leaf 14-16 weight portion, Radix Astragali 15-25 weight portion, dry Folium Nelumbinis 15-25 weight portion.
A kind of Chinese medicine composition, including Flos Rosae Rugosae 10 weight portion, Radix Puerariae 20 weight portion, Fructus Chaenomelis 20 weight portion, Folium Mori 15 weight Amount part, the Radix Astragali 20 weight portion, dry Folium Nelumbinis 20 weight portion.
Applicant seminar, concentrates on studies through for many years, animal experiment proves that again, it is determined that with Flos Rosae Rugosae and Radix Puerariae is monarch drug, with Fructus Chaenomelis, Folium Mori as ministerial drug, the Radix Astragali and dry Folium Nelumbinis as adjuvant, become an organic Chinese medicine combination Thing, opens effect of breast enlargement, fat-reducing altogether.
Described a kind of Chinese medicine composition is prepared as pharmaceutical preparation.
Described a kind of Chinese medicine composition is prepared as food or health food.
The application in preparing Breast plumping up medicine of the described a kind of Chinese medicine composition.
The application in preparing food for enlarging breast of the described a kind of Chinese medicine composition.
The application in preparing slimming medicine of the described a kind of Chinese medicine composition.
The application in preparing diet food of the described a kind of Chinese medicine composition.
The technique effect that the present composition is useful:
(1) present invention has good breast augmentation and health and fat-reducing effect.
(2) composition quality of the present invention is controlled, uses safety.
(3) compositions of the present invention is suitable for commercial production.
Prescription feature of the present invention:
Primary draft, natural activity.
Integration of edible and medicinal herbs becomes to be grouped into, and treats, nurses one's health, improves, keeps healthy, health preserving by the way of dietetic therapy.
Treating both the principal and secondary aspects of a disease, property of medicine gentleness safety.
Product prescription, uses proving effect definite through thousand of patients.
Specific embodiment
The following example is provided, to describe and to be further elucidated with certain embodiments of the present invention and aspect, can not recognize Limit the scope of the present invention for it.
The following test of the present invention is in repeatedly creative experimental basis, the concluding carried out according to technical solution of the present invention Test.
Experimental example 1: breast enlargement is tested
1. object and method
1.1 trier
This test points four groups is carried out, and one group is matched group, another three groups of products being respectively adopted the embodiment of the present invention 1,2,5 for oral administration Product.
1.2 study subject
Capsules group: selection 18~45 years old, has breast inaesthetic experimenter 60 example, often each 15 examples of group group.
1.2.1 diagnostic criteria:
China's female breast standard:
The most plentiful, tall and straight, flexible, in hemispherical;
2. breast is positioned at 2-6 intercostal, and nipple is positioned at the 4th intercostal;
3. breast basal surface diameter 10-12cm, two teat spacings more than 20cm or two shoulder away from 1/2;
4. chest measurement is equal to hip circumference;
Breast is flat or less than normal:
1. less than the 1/3 of fat corrected milk(FCM) foundations basal diameter;2. chest measurement is less than hip circumference 1/3.
Breast relaxes sagging:
1. breast tension force, elastic force reduce;If 2. teat placement is that I degree is sagging less than broken line below breast;Breast position is low It is that II degree is sagging in the 6th rib edge;It is that III degree is sagging that breast position reaches umbilical part.
The vigorous and graceful standard of table breast
In conjunction with " the aesthstic position of breast " and " the vigorous and graceful standard of breast ", < less than 60 points persons include observation model in every total score Enclose.Every total score is the nonstandard breast of I degree the 40-60 person of dividing;The 20-40 person of dividing is the nonstandard breast of II degree;20 points of persons of < are III Spend nonstandard breast.
1.2.2 do not include person's standard in: above-mentioned volunteer, through medical fitness person.
1.3 usings method:
Tested group of 15 example this product, three times a day, each 3, one after each meal, continuous 90 days.Matched group takes multiple dimension Raw element, uses the tablet of same color, and usage is still three times a day, each 3, and one after each meal takes 90 days continuously.
2. observation index
2.1 ordinary circumstance
Medical history, history of present illness, diet, main detection: the situation such as cyclomastopathy, menoxenia.
2.2 lab index
Routine blood test, routine urinalysis, stool routine, biochemical indicator, B ultrasonic (abdominal part), electrocardiogram, x-ray fluoroscopy of chest.
2.3 caring and enlarging breast U.S. breast measuring methods
2.3.1 chest measurement: naturally upright, both feet separately same shoulder breadth, both shoulders loosen, and upper limb naturally droops, by mark upper limb warp Dorsal scapular bone inferior horn lower edge found range to front around one week from.
2.3.2 breast basal surface diameter: the distance that mark is measured to breast medial and lateral by nipple.
2.3.3 hip circumference: around one week distance of buttocks peak.
2.3.4 other is according to macroscopic appearance.
3. experimental result
3.1 ordinary circumstance
After tested group and matched group such as former clinical manifestation person without exception were observed at 90 days, mammary gland has no that hypertrophy, menstruation have no different Often.Tested group and matched group such as mammary gland have proliferative conditions, and person observed rear udder attachment pain relief through 90 days, hypertrophy reduces;Menoxenia Change is had no before and after person.
3.2 experimental index
Tested group and matched group routine blood test, routine urinalysis, stool routine, biochemical indicator, B ultrasonic (abdominal part), electrocardiogram, x-ray chest Perspective change the most without exception before and after test-meal.Tested group and matched group such as cyclomastopathy person then have in various degree reduce trend, Illustrate that massage contributes to the treatment of cyclomastopathy.
3.3 caring and enlarging breast U.S. breast indexs
Embodiment 1 group: observation for oral administration calculated its gross score after 90 days, and tested group of 15 example marks all have varying strength to rise, Average rising 16 points, the highest rising 35 points, minimum rising 10 points;
Embodiment 2 groups: observation for oral administration calculated its gross score after 90 days, and tested group of 15 example marks all have varying strength to rise, Average rising 15 points, the highest rising 33 points, minimum rising 9 points;
Embodiment 5 groups: observation for oral administration calculated its gross score after 90 days, and tested group of 15 example marks all have varying strength to rise, Average rising 17 points, the highest rising 34 points, minimum rising 10 points;
Comfort group 15 example averagely rises 2 points, the highest rising 7 points, minimum without rising.
4. conclusion
Above-mentioned test proves, the oral preparations of the present invention has obvious breast augmentation and health effect.Lot of experiments also confirms that, this The medicine of other dosage forms of invention, such as externally applied formulations such as the oral preparations such as tablet, pill, capsule, unguentum, liniments and press Transfer cream, unguentum prepared by production technology etc., there is obvious breast augmentation and health effect equally.
Experimental example 2: fat-reducing test
Laboratory animal: healthy male SD rat 50, body weight (180 ± 10) g, laboratory adaptability is fed 7 days.
Experimental technique: select 30 rats at random and be divided into 2 groups, respectively as matched group, administration group, all organizes feed height for two groups Fat feedstuff 6 weeks, but administration group gastric infusion the most three times a day.
High lipid food: normal feedstuff 80%, Adeps Sus domestica 10%, yolk powder 10%.
Medicine: Flos Rosae Rugosae 10g, Radix Puerariae 20g, Fructus Chaenomelis 20g, Folium Mori 15g, Radix Astragali 20g, dry Folium Nelumbinis 20g, join 1000ml Soaking after 36 hours standby in water, dosage is 0.1ml/kg.
During experiment every animal of meter record to appetite, surplus appetite and berley amount, weigh weekly 1 time, at the end of experiment Weigh, take body fat (nethike embrane, testis week and perirenal fat pad) and weigh, calculating fat/body ratio.Fat/body ratio (%)=(perirenal fat+ Testis week fat+omental adipose)/body weight × 100.
The results are shown in Table 1,2:
Table 1: change that the body weight of rat and body weight increase (n=10,)
Group Original body mass (g) Whole opisthosoma weight (g) Weightening finish (g)
Matched group 183.08±6.22 434.55±13.30 251.48±14.91
Administration group 184.11±6.54 366.27±39.34* 182.17±40.73*
Note: * compares P < 0.05 with matched group
Conclusion: when experiment starts, the weight differences of two groups of rats is not statistically significant.After experiment terminates, matched group is big The body weight of Mus and body weight evolution are above administration group rat.
Table 2: the change of the body fat content of rat and fat/body ratio (n=10,)
Group Testis week fat (g) Perirenal fat (g) Omental adipose (g) Fat/body (%)
Matched group 7.15±1.01 9.86±0.97 6.38±0.99 5.39±0.53
Administration group 4.34±1.49* 6.72±1.87* 3.71±1.29* 4.02±1.03*
Note: * compares P < 0.05 with matched group
Conclusion: the testis week fat, perirenal fat, omental adipose content and the fat/body ratio that are administered rat are the most right According to group rat.
Embodiment
Embodiment 1:
Prescription: Flos Rosae Rugosae 8g, Radix Puerariae 18g, Fructus Chaenomelis 15g, Folium Mori 14g, Radix Astragali 15g, dry Folium Nelumbinis 15g.
Preparation method: by Flos Rosae Rugosae 8g, Radix Puerariae 18g, Fructus Chaenomelis 15g, Folium Mori 14g, Radix Astragali 15g, dry Folium Nelumbinis 15g 1000ml Water extraction three times, united extraction liquid, concentrate drying, pulverized 80 mesh sieves, after mixing add lactose 50g, carboxymethyl starch sodium 5g, Pulvis Talci 3g mix homogeneously;Direct compression after being mixed homogeneously with polyvidone by ready press sheet mixture, to obtain final product.
Embodiment 2:
Prescription: Flos Rosae Rugosae 12g, Radix Puerariae 22g, Fructus Chaenomelis 25g, Folium Mori 16g, Radix Astragali 25g, dry Folium Nelumbinis 25g.
Preparation method: Flos Rosae Rugosae 12g, Radix Puerariae 22g, Fructus Chaenomelis 25g, Folium Mori 16g, Radix Astragali 25g, dry Folium Nelumbinis 25g are used 1000ml water extraction three times, united extraction liquid, concentrate drying, cross 100 mesh sieves after pulverizing, after mixing, add lactose 40g, carboxymethyl Starch Sodium 6g, Pulvis Talci 3.5g mix homogeneously;Ready press sheet mixture is mixed homogeneously with polyvidone granulation after tabletting, i.e. ?.
Embodiment 3:
Prescription: Flos Rosae Rugosae 10g, Radix Puerariae 20g, Fructus Chaenomelis 20g, Folium Mori 15g, Radix Astragali 20g, dry Folium Nelumbinis 20g.
Preparation method: Flos Rosae Rugosae 10g, Radix Puerariae 20g, Fructus Chaenomelis 20g, Folium Mori 15g, Radix Astragali 20g, dry Folium Nelumbinis 20g are ground respectively Cross 100 mesh sieves after mill, after mixing, add Icing Sugar 45g, low-substituted hydroxypropyl cellulose 3.2g mix homogeneously;By mixture and poly-dimension Pelletizing after ketone mix homogeneously, after mixing homogeneously with micropowder silica gel 5g, fill capsule obtains capsule.
Embodiment 4:
Prescription: Flos Rosae Rugosae 10g, Radix Puerariae 20g, Fructus Chaenomelis 20g, Folium Mori 15g, Radix Astragali 20g, dry Folium Nelumbinis 20g.
Preparation method: Flos Rosae Rugosae 10g, Radix Puerariae 20g, Fructus Chaenomelis 20g, Folium Mori 15g, Radix Astragali 20g, dry Folium Nelumbinis 20gg are added 400g olive wine is soaked 30 days, filters, sterilizing, and packaging to obtain final product.
Embodiment 5:
Prescription: Flos Rosae Rugosae 10g, Radix Puerariae 20g, Fructus Chaenomelis 20g, Folium Mori 15g, Radix Astragali 20g, dry Folium Nelumbinis 20g.
Preparation method: Flos Rosae Rugosae 10g, Radix Puerariae 20g, Fructus Chaenomelis 20g, Folium Mori 15g, Radix Astragali 20g, dry Folium Nelumbinis 20g are used 1000ml water extraction three times, united extraction liquid, concentrate drying, pulverize, cross 100 mesh sieves, add mannitol 54g, crosslinked polyethylene Ketopyrrolidine 15g, magnesium stearate 2.5g mix homogeneously;Directly press after ready press sheet mixture is mixed homogeneously with polyvidone Sheet.
Embodiment 6:
Prescription: Flos Rosae Rugosae 10g, Radix Puerariae 20g, Fructus Chaenomelis 20g, Folium Mori 15g, Radix Astragali 20g, dry Folium Nelumbinis 20g.
Preparation method: after Flos Rosae Rugosae 10g, Radix Puerariae 20g, Fructus Chaenomelis 20g, Folium Mori 15g, Radix Astragali 20g, dry Folium Nelumbinis 20g are ground Mix homogeneously;In mixture, add pure water, pelletize;Adding micropowder silica gel 1.2g mix homogeneously in mixture, subpackage is extremely Capsule is made capsule.
Embodiment 7:
Prescription: Flos Rosae Rugosae 10g, Radix Puerariae 20g, Fructus Chaenomelis 20g, Folium Mori 15g, Radix Astragali 20g, dry Folium Nelumbinis 20g.
Preparation method: Flos Rosae Rugosae 10g, Radix Puerariae 20g, Fructus Chaenomelis 20g, Folium Mori 15g, Radix Astragali 20g, dry Folium Nelumbinis 20g are ground respectively Clay into power, be dissolved in 1000g drinking water, filter, sterilizing, packaging, to obtain final product.
Embodiment 8:
Prescription: Flos Rosae Rugosae 10g, Radix Puerariae 20g, Fructus Chaenomelis 20g, Folium Mori 15g, Radix Astragali 20g, dry Folium Nelumbinis 20g.
Preparation method: Flos Rosae Rugosae 10g, Radix Puerariae 20g, Fructus Chaenomelis 20g, Folium Mori 15g, Radix Astragali 20g, dry Folium Nelumbinis 20g are ground respectively Clay into power, be dissolved in 400g wine fermented with osmanthus flower, filter, sterilizing, packaging, to obtain final product.
Embodiment 9:
Prescription: Flos Rosae Rugosae 10g, Radix Puerariae 20g, Fructus Chaenomelis 20g, Folium Mori 15g, Radix Astragali 20g, dry Folium Nelumbinis 20g.
Preparation method: Flos Rosae Rugosae 10g, Radix Puerariae 20g, Fructus Chaenomelis 20g, Folium Mori 15g, Radix Astragali 20g, dry Folium Nelumbinis 20g are ground respectively Clay into power, be dissolved in 500g yellow wine, filter, sterilizing, packaging, to obtain final product.
Embodiment 10:
Prescription: Flos Rosae Rugosae 10g, Radix Puerariae 20g, Fructus Chaenomelis 20g, Folium Mori 15g, Radix Astragali 20g, dry Folium Nelumbinis 20g.
Preparation method: Flos Rosae Rugosae 10g, Radix Puerariae 20g, Fructus Chaenomelis 20g, Folium Mori 15g, Radix Astragali 20g, dry Folium Nelumbinis 20g are joined 600g tea wine is soaked 10 days, filters, sterilizing, packaging, to obtain final product.

Claims (4)

1. a Chinese medicine composition with fat-reducing, function of breast augmentation, it is characterised in that compositions consists of: Flos Rosae Rugosae, Radix Puerariae, wood Melon, Folium Mori, the Radix Astragali, dry Folium Nelumbinis;Wherein Flos Rosae Rugosae 8-12 weight portion, Radix Puerariae 18-22 weight portion, Fructus Chaenomelis 15-25 weight portion, Folium Mori 14-16 weight portion, Radix Astragali 15-25 weight portion, dry Folium Nelumbinis 15-25 weight portion.
A kind of Chinese medicine composition with fat-reducing, function of breast augmentation the most according to claim 1, wherein Flos Rosae Rugosae 10 weight Part, Radix Puerariae 20 weight portion, Fructus Chaenomelis 20 weight portion, Folium Mori 15 weight portion, the Radix Astragali 20 weight portion, dry Folium Nelumbinis 20 weight portion.
A kind of Chinese medicine composition with fat-reducing, function of breast augmentation the most according to claim 1 and 2, it is characterised in that Chinese medicine Compositions is prepared as pharmaceutical preparation.
A kind of Chinese medicine composition with fat-reducing, function of breast augmentation the most according to claim 1 and 2, it is characterised in that Chinese medicine Compositions is prepared as health food.
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CN107927781B (en) * 2017-11-30 2021-01-12 陈洁真 Traditional Chinese medicine weight-losing meal replacement
CN110433240A (en) * 2019-09-03 2019-11-12 北京利普松生物科技有限公司 A kind of Chinese medicine composition and preparation method thereof for chest enlarge

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