CN104803957A - 苄基化糖苷衍生物及其用法 - Google Patents
苄基化糖苷衍生物及其用法 Download PDFInfo
- Publication number
- CN104803957A CN104803957A CN201510041214.8A CN201510041214A CN104803957A CN 104803957 A CN104803957 A CN 104803957A CN 201510041214 A CN201510041214 A CN 201510041214A CN 104803957 A CN104803957 A CN 104803957A
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- CN
- China
- Prior art keywords
- chloro
- tetrahydrochysene
- pyrans
- phenyl
- hydroxymethyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 239000001301 oxygen Substances 0.000 claims description 66
- 150000003839 salts Chemical class 0.000 claims description 57
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 56
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims description 44
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims description 35
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- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims description 25
- HZVOZRGWRWCICA-UHFFFAOYSA-N methanediyl Chemical compound [CH2] HZVOZRGWRWCICA-UHFFFAOYSA-N 0.000 claims description 21
- 125000003601 C2-C6 alkynyl group Chemical group 0.000 claims description 19
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Classifications
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- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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Landscapes
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| US90967207P | 2007-04-02 | 2007-04-02 | |
| US60/909,672 | 2007-04-02 | ||
| CN200880011535A CN101652377A (zh) | 2007-04-02 | 2008-04-01 | 苄基化糖苷衍生物及其用法 |
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| CN200880011535A Division CN101652377A (zh) | 2007-04-02 | 2008-04-01 | 苄基化糖苷衍生物及其用法 |
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| CN104803957A true CN104803957A (zh) | 2015-07-29 |
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| CN200880011535A Pending CN101652377A (zh) | 2007-04-02 | 2008-04-01 | 苄基化糖苷衍生物及其用法 |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110337442A (zh) * | 2017-02-24 | 2019-10-15 | 东亚St株式会社 | 作为2型钠依赖性葡萄糖转运蛋白抑制剂的新型葡萄糖衍生物 |
| CN110551088A (zh) * | 2018-06-01 | 2019-12-10 | 轩竹(北京)医药科技有限公司 | 氘修饰的苄基-4-氯苯基的c-糖苷衍生物 |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AR051446A1 (es) * | 2004-09-23 | 2007-01-17 | Bristol Myers Squibb Co | Glucosidos de c-arilo como inhibidores selectivos de transportadores de glucosa (sglt2) |
| UA101004C2 (en) * | 2007-12-13 | 2013-02-25 | Теракос, Инк. | Derivatives of benzylphenylcyclohexane and use thereof |
| EP2242745A1 (de) * | 2008-02-07 | 2010-10-27 | Sanofi-Aventis | Neue phenyl-substituierte imidazolidine, verfahren zu deren herstellung, diese verbindungen enthaltende arzneimittel und deren verwendung |
| MX2011000637A (es) * | 2008-07-15 | 2011-05-02 | Theracos Inc | Derivados deuretados de bencilbenceno y metodos de uso. |
| EP2324002B1 (en) * | 2008-08-22 | 2016-10-05 | Theracos Sub, LLC | Processes for the preparation of sglt2 inhibitors |
| US8778998B2 (en) | 2009-04-10 | 2014-07-15 | Auspex Pharmaceuticals, Inc. | Biphenyl-3-carboxylic acid modulators of beta-3-adrenoreceptor |
| AR079438A1 (es) | 2009-12-09 | 2012-01-25 | Panacea Biotec Ltd | Derivados de azucar, composiciones farmaceuticas y sus usos |
| US20110160143A1 (en) * | 2009-12-28 | 2011-06-30 | Perricone Nicholas V | Topical Acyl Glutathione Psoriasis Compositions |
| CN102134226B (zh) * | 2010-01-26 | 2013-06-12 | 天津药物研究院 | 一类苯基c-葡萄糖苷衍生物、其制备方法和用途 |
| WO2011107494A1 (de) | 2010-03-03 | 2011-09-09 | Sanofi | Neue aromatische glykosidderivate, diese verbindungen enthaltende arzneimittel und deren verwendung |
| WO2011153712A1 (en) | 2010-06-12 | 2011-12-15 | Theracos, Inc. | Crystalline form of benzylbenzene sglt2 inhibitor |
| EP2582709B1 (de) | 2010-06-18 | 2018-01-24 | Sanofi | Azolopyridin-3-on-derivate als inhibitoren von lipasen und phospholipasen |
| US8530413B2 (en) | 2010-06-21 | 2013-09-10 | Sanofi | Heterocyclically substituted methoxyphenyl derivatives with an oxo group, processes for preparation thereof and use thereof as medicaments |
| TW201215387A (en) | 2010-07-05 | 2012-04-16 | Sanofi Aventis | Spirocyclically substituted 1,3-propane dioxide derivatives, processes for preparation thereof and use thereof as a medicament |
| TW201215388A (en) | 2010-07-05 | 2012-04-16 | Sanofi Sa | (2-aryloxyacetylamino)phenylpropionic acid derivatives, processes for preparation thereof and use thereof as medicaments |
| TW201221505A (en) | 2010-07-05 | 2012-06-01 | Sanofi Sa | Aryloxyalkylene-substituted hydroxyphenylhexynoic acids, process for preparation thereof and use thereof as a medicament |
| US9907767B2 (en) | 2010-08-03 | 2018-03-06 | Velicept Therapeutics, Inc. | Pharmaceutical compositions and the treatment of overactive bladder |
| WO2012025857A1 (en) | 2010-08-23 | 2012-03-01 | Hetero Research Foundation | Cycloalkyl methoxybenzyl phenyl pyran derivatives as sodium dependent glucose co transporter (sglt2) inhibitors |
| WO2012030165A2 (ko) | 2010-08-31 | 2012-03-08 | 서울대학교산학협력단 | P P A R δ 활성물질의 태자재프로그래밍용도 |
| JP6105489B2 (ja) * | 2011-02-18 | 2017-03-29 | シャンハイ インリ ファーマシューティカル カンパニー リミティド | アリールグルコシド化合物、その調製方法及び使用 |
| CN102675378A (zh) * | 2011-03-09 | 2012-09-19 | 天津药物研究院 | 一类含环丙烷结构的c-葡萄糖苷衍生物、其制备方法和用途 |
| WO2013037390A1 (en) | 2011-09-12 | 2013-03-21 | Sanofi | 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
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| US9193751B2 (en) | 2012-04-10 | 2015-11-24 | Theracos, Inc. | Process for the preparation of benzylbenzene SGLT2 inhibitors |
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| US8652527B1 (en) | 2013-03-13 | 2014-02-18 | Upsher-Smith Laboratories, Inc | Extended-release topiramate capsules |
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| CN104478967A (zh) * | 2015-01-14 | 2015-04-01 | 佛山市赛维斯医药科技有限公司 | 含腈基苯噻唑基的o-半乳糖苷衍生物、其制备方法和用途 |
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- 2008-04-01 CN CN200880011535A patent/CN101652377A/zh active Pending
- 2008-04-01 US US12/060,767 patent/US7838498B2/en not_active Expired - Fee Related
- 2008-04-01 EP EP08744883.3A patent/EP2064222B1/en active Active
- 2008-04-01 KR KR1020097022926A patent/KR101506935B1/ko not_active Expired - Fee Related
- 2008-04-01 AR ARP080101366A patent/AR065913A1/es not_active Application Discontinuation
- 2008-04-01 WO PCT/US2008/059047 patent/WO2008122014A1/en not_active Ceased
- 2008-04-01 BR BRPI0809607-4A patent/BRPI0809607A2/pt not_active IP Right Cessation
- 2008-04-01 CN CN201510041214.8A patent/CN104803957A/zh active Pending
- 2008-04-01 AU AU2008232419A patent/AU2008232419B2/en not_active Ceased
- 2008-04-01 DK DK08744883.3T patent/DK2064222T3/da active
- 2008-04-01 JP JP2010502246A patent/JP5583003B2/ja not_active Expired - Fee Related
- 2008-04-01 CA CA2682202A patent/CA2682202C/en not_active Expired - Fee Related
- 2008-04-02 TW TW097112029A patent/TWI405575B/zh not_active IP Right Cessation
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2009
- 2009-09-21 IL IL201065A patent/IL201065A/en active IP Right Grant
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2016
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110337442A (zh) * | 2017-02-24 | 2019-10-15 | 东亚St株式会社 | 作为2型钠依赖性葡萄糖转运蛋白抑制剂的新型葡萄糖衍生物 |
| CN110337442B (zh) * | 2017-02-24 | 2023-05-12 | 东亚St株式会社 | 作为2型钠依赖性葡萄糖转运蛋白抑制剂的新型葡萄糖衍生物 |
| CN110551088A (zh) * | 2018-06-01 | 2019-12-10 | 轩竹(北京)医药科技有限公司 | 氘修饰的苄基-4-氯苯基的c-糖苷衍生物 |
| CN110551088B (zh) * | 2018-06-01 | 2022-10-21 | 北京惠之衡生物科技有限公司 | 氘修饰的苄基-4-氯苯基的c-糖苷衍生物 |
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|---|---|
| IL201065A0 (en) | 2010-05-17 |
| CA2682202A1 (en) | 2008-10-09 |
| WO2008122014A1 (en) | 2008-10-09 |
| BRPI0809607A2 (pt) | 2014-09-30 |
| EP2064222B1 (en) | 2014-05-07 |
| RU2492175C2 (ru) | 2013-09-10 |
| TWI405575B (zh) | 2013-08-21 |
| AU2008232419A1 (en) | 2008-10-09 |
| EP2064222A1 (en) | 2009-06-03 |
| AU2008232419B2 (en) | 2013-06-20 |
| DK2064222T3 (da) | 2014-07-21 |
| AR110968A2 (es) | 2019-05-22 |
| ES2466672T3 (es) | 2014-06-10 |
| KR101506935B1 (ko) | 2015-03-31 |
| RU2009140298A (ru) | 2011-05-10 |
| IL201065A (en) | 2015-09-24 |
| US20080242596A1 (en) | 2008-10-02 |
| EP2064222A4 (en) | 2011-12-14 |
| CN101652377A (zh) | 2010-02-17 |
| AR065913A1 (es) | 2009-07-08 |
| JP5583003B2 (ja) | 2014-09-03 |
| HK1212982A1 (zh) | 2016-06-24 |
| KR20100016151A (ko) | 2010-02-12 |
| US7838498B2 (en) | 2010-11-23 |
| CA2682202C (en) | 2016-01-12 |
| JP2010523583A (ja) | 2010-07-15 |
| TW200846012A (en) | 2008-12-01 |
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