CN104800717A - Medicine for treating parasitic diarrhea of primates - Google Patents
Medicine for treating parasitic diarrhea of primates Download PDFInfo
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- CN104800717A CN104800717A CN201510211064.0A CN201510211064A CN104800717A CN 104800717 A CN104800717 A CN 104800717A CN 201510211064 A CN201510211064 A CN 201510211064A CN 104800717 A CN104800717 A CN 104800717A
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Abstract
The invention discloses a medicine for treating parasitic diarrhea of primates. The medicine consists of master materials and auxiliary materials, wherein the mass ratio of the master materials to the auxiliary materials is (1-2.5):1; the master materials are prepared from the following raw materials in parts by weight: 10-20 parts of cyrtomium rhizomes, 5-15 parts of quisqualis indica, 5-10 parts of betel nut, 7-15 parts of chinaberry bark, 10-25 parts of fructus ulmi, 8-15 parts of stemona roots and 10-20 parts of albendazole; the auxiliary materials are prepared from the following raw materials in parts by weight: 6-10 parts of cnidium monnieri, 12-20 parts of brucea javanica and 15-30 parts of pumpkin seed. The medicine disclosed by the invention is prepared from natural raw materials, the materials all have the function of killing parasites, through combination, the materials having the function of killing different parasites are made into the medicine which can kill the parasites with which the primates are liable to infection in the growth process, the medicine has an obvious curative effect on treating the parasitic diarrhea of the primates, when the medicine is used for a long time, the physiological functions of the primates are not influenced, and the primates are not easy to generate medicine tolerance, so that the medicine has wide market prospects.
Description
Technical field
The invention belongs to field of veterinary, particularly a kind of medicine for the treatment of primate parasitic diarrhea.
Background technology
Primate diarrhoea is a kind of very common disease, its grievous injury health of primate.The reason causing primate to suffer from diarrhoea is varied, can be divided into two large classes generally, and first class is pathogenicity diarrhoea, is divided into three groups.First group is by the bacterial bacterial diarrhea such as escherichia coli, Escherichia coli; Second group is the viral diarrhea caused by viruses such as rotavirus; 3rd group is the parasitic diarrhea caused by the parasite such as ascarid, coccidiosis.Second largest class is avirulence diarrhoea, the diarrhoea that the such as avirulence such as temperature jump, nutritional deficiency factor causes.Especially parasitic diarrhea, sickness rate is very high, all can fall ill throughout the year.Annual have a large amount of primates to cause that primate cub survival rate is low, poor growth, had a strong impact on the growth of primate population because of parasitic diarrhea.At present, the medicine for the treatment of primate diarrhoea is varied, but the most popular or Western medicine of antibiotics, although have certain therapeutic effect, but antibiotics Western medicine has certain toxicity, easily remain in animal body, more seriously due to the abuse of antibiotic medicine, cause the antibacterial in animal body, virus and parasite create certain drug resistance to these medicines, in order to reach therapeutic effect, people must not continue to increase the use amount of antibiotics, make the antibacterial in animal body, viral and parasitic drug resistance becomes stronger, finally cause antibiotics invalid to these cause of diseases, particularly for the diarrhoea that parasitic causes.In China, the use of Chinese medicine has had long history, and Chinese medicine has green non-poisonous, not easily to produce drug resistance advantage, comes, for the preparation of the medicine for the treatment of primate diarrhoea, to have broad application prospects with Chinese medicine.Now commercially had the diarrhoea medicine of the treatment primate that Chinese medicine miscellaneous is made, but these pharmaceutical manufacturing process are complicated, cost is high, and curative effect is not obvious.
Summary of the invention
For the deficiency that prior art exists, the invention provides a kind of medicine for the treatment of primate parasitic diarrhea, this medicine has evident in efficacy, and manufacture method is simple, the feature that cost is low.
For solving the problem, the present invention realizes by the following technical solutions:
A kind of medicine for the treatment of primate parasitic diarrhea, be made up of by the mass ratio of 1 ~ 2.5:1 major ingredient and adjuvant, wherein said major ingredient is made up of the raw material of following weight portion: Rhizoma Osmundae 10 ~ 20 parts, Fructus Quisqualis 5 ~ 15 parts, Semen Arecae 5 ~ 10 parts, Cortex Meliae 7 ~ 15 parts, Fructus Ulmus preparatium 10 ~ 25 parts, the Radix Stemonae 8 ~ 15 parts, zental 10 ~ 20 parts.
In such scheme, further, described adjuvant can be made up of the raw material of following weight portion: Fructus Cnidii 6 ~ 10 parts, Fructus Bruceae 12 ~ 20 parts, Semen Cucurbitae 15 ~ 30 parts.
In such scheme, preferably, the medicine of described treatment primate parasitic diarrhea, is made up of by the mass ratio mixing of 1:1 major ingredient and adjuvant.
Described major ingredient can be made up of the raw material of following weight portion: Rhizoma Osmundae 10 ~ 15 parts, Fructus Quisqualis 10 ~ 15 parts, Semen Arecae 5 ~ 10 parts, Cortex Meliae 7 ~ 10 parts, Fructus Ulmus preparatium 15 ~ 25 parts, the Radix Stemonae 10 ~ 15 parts, zental 15 ~ 20 parts.
Further preferably, described adjuvant is made up of the raw material of following weight portion: Fructus Cnidii 7 ~ 10 parts, Fructus Bruceae 15 ~ 20 parts, Semen Cucurbitae 20 ~ 30 parts.
The preparation method of the medicine of described treatment primate parasitic diarrhea, comprises the following steps:
1) preparation of major ingredient: take Rhizoma Osmundae, Fructus Quisqualis, Semen Arecae, Cortex Meliae, Fructus Ulmus preparatium, the Radix Stemonae 6 taste Chinese medicine by weight respectively, clean with cold water, put into distillation equipment, and in distillation equipment, add the water that gross mass is 2 ~ 4 times of 6 taste Chinese medicines, then add acetic acid and regulate the pH value of the solution in whole distillation equipment to be 3 ~ 5, heating decoction 15 ~ 30min, filter, obtain herb liquid, obtained herb liquid is distilled 1 ~ 2h at 200 DEG C, is then concentrated into the traditional Chinese medicine thick paste that water content is 8 ~ 12%; After again traditional Chinese medicine thick paste being carried out thermal dehydration, obtain Chinese medicinal powder, then mix homogeneously with the zental after pulverizing, finally temperature 220 ~ 250 DEG C, pressure is under the condition of 10 ~ 12Mpa, and sterilizing 3 ~ 5min, obtains major ingredient;
2) preparation of adjuvant: take Fructus Cnidii, Fructus Bruceae, Semen Cucurbitae 3 taste Chinese medicine by weight respectively, first by Fructus Cnidii, Fructus Bruceae co-grinding, put into marmite, add described Semen Cucurbitae, and add the water of 3 taste Chinese medicine gross weight 4 times, heated and boiled 30 ~ 50min, cooling, obtains adjuvant;
3) pack: step 1) is obtained major ingredient and step 2) obtained adjuvant separately carries out packaging storage, real-time proportioning time to be used.
Using method of the present invention is: by major ingredient during use: the mass ratio mixing of adjuvant=1 ~ 2.5:1, then carries out filling by the every kg body weight of primate with this medicine 0.1g and feeds, continuously treatment 3-4 days.
Pharmacology of the present invention is as follows:
Rhizoma Osmundae is rhizome and the petiole residual base of Dryopteridaceae plant dryopteris crassirhizoma.For seasonal pathogen sense, partial heat person, heating is heavy, aversion to cold light, have a headache, swallow red, pharyngeal swelling, xerostomia and thirsty, red tongue, white and thin fur, floating pulse person, heat-clearing and toxic substances removing, cooling blood for hemostasis, parasite killing.
Fructus Quisqualis, another name: scoop and ask son, history gentleman, four gentleman.Modern pharmacological research shows, Fructus Quisqualis has parasiticide effect.
Semen Arecae, contained arecoline has paralysis armed tapeworm, dwarf tapeworm, ascarid effect, makes polypide produce flaccid paralysis, more powerful to armed tapeworm's effect, can make polypide each portion paralysis.
Cortex Meliae, modern pharmacological research shows: Melia azedarach L. contained by Cortex Meliae have and drives ascarid effect. its alcoholic extract, in vitro to ascaris suum, has paralysis effect to its head especially.Azedarachin, through polypide epidermis, directly acts on Ascaris Suum muscle, upsets its energy metabolism, causes contraction fatigue and spasm, finally makes polypide not adhere to intestinal wall and to be purged external.25% ~ 50% Cortex Meliae medicinal liquid also has paralysis effect to mice pinworm in vitro.Cortex Meliae extractive liquid still has certain anti-schistosome function.
Fructus Ulmus preparatium, eliminating stagnated food and killing intestinal worms.For infantile malnutrition, ascariasis, enterobiasis.
The Radix Stemonae, also known as mother-in-law woman grass, medicine louse medicine is the plant of Stemonaceae.Root is used as medicine, outward for parasite killing, antipruritic, delousing; For oral administration have lung moistening, cough-relieving, the effect of eliminating the phlegm.
Fructus Cnidii,
another name Daucus carota L.son, for
umbelliferaethe drying of plant cnidium monnieri
ripefruit.Heat clearing and damp drying, killing parasites for relieving itching, removing toxic substances pain relieving, anticorrosion detumescence.
Fructus Bruceae, have another name called crow gallbladder,
crow gallbladder, bitter Semen coryli heterophyllae, Semen Sophorae Flavescentis, crow egg-shaped thing,
ovum Anas domestica,
fructus Bruceae, separate Melia azedarach L., little Melia azedarach L..Fructus Bruceae crude extract can drive away dog intestinal nematodes and
cestode.
Semen Cucurbitae, anthelmintic, detumescence.For control cestode, ascarid, puerperal brothers' edema, pertussis, hemorrhoid.
The invention has the beneficial effects as follows:
The raw material that the present invention adopts is natural material, often kind of natural material can kill different types of parasite, by the combination of multiple material, make the combination of these material effective ingredient can kill different types of parasite, to the parasitic diarrhea of primate, there is good therapeutic effect, and not easily produce drug resistance.Feeding way of the present invention adopts the mode of filling with and feeding and carrying out with complementary feeding simultaneously simultaneously, enhances therapeutic effect.
Detailed description of the invention
Further illustrate the present invention with specific embodiment below, the present invention is not limited only to following examples.
Embodiment 1
A kind of medicine for the treatment of primate parasitic diarrhea, be made up of major ingredient and adjuvant two parts, wherein the mass ratio of major ingredient and adjuvant is 1:1, wherein said major ingredient is made up of the raw material of following weight portion: Rhizoma Osmundae 10g, Fructus Quisqualis 5g, Semen Arecae 5g, Cortex Meliae 10g, Fructus Ulmus preparatium 10g, Radix Stemonae 8g, zental 10g, and described adjuvant is made up of the raw material of following weight portion: Fructus Cnidii 6g, Fructus Bruceae 12g, Semen Cucurbitae 15g.
The preparation method of the medicine of above-mentioned treatment primate parasitic diarrhea, comprises the following steps:
1) preparation of major ingredient: take Rhizoma Osmundae, Fructus Quisqualis, Semen Arecae, Cortex Meliae, Fructus Ulmus preparatium, the Radix Stemonae 6 taste Chinese medicine by weight respectively, clean with cold water, put into distillation equipment, and in distillation equipment, add the water that gross mass is 4 times of 6 taste Chinese medicines, then add acetic acid and regulate the pH value of the solution in whole distillation equipment to be 3, heating decocts 15min, filter, obtain herb liquid, obtained herb liquid is distilled 2h at 200 DEG C, is then concentrated into the traditional Chinese medicine thick paste that water content is 8%; After again traditional Chinese medicine thick paste being carried out thermal dehydration, obtain Chinese medicinal powder, then mix homogeneously with the zental after pulverizing, finally temperature 250 DEG C, pressure is under the condition of 10Mpa, and sterilizing 3min, obtains major ingredient;
2) preparation of adjuvant: take Fructus Cnidii, Fructus Bruceae, Semen Cucurbitae 3 taste Chinese medicine by weight respectively, first by Fructus Cnidii, Fructus Bruceae co-grinding, put into marmite, add described Semen Cucurbitae, and add the water of 3 taste Chinese medicine gross weight 4 times, heated and boiled 50min, cooling, obtains adjuvant;
3) pack: step 1) is obtained major ingredient and step 2) obtained adjuvant separately carries out packaging storage, real-time proportioning time to be used.
Embodiment 2
A kind of medicine for the treatment of primate parasitic diarrhea, be made up of major ingredient and adjuvant two parts, wherein the mass ratio of major ingredient and adjuvant is 2.5:1, wherein said major ingredient is made up of the raw material of following weight portion: Rhizoma Osmundae 15g, Fructus Quisqualis 15g, Semen Arecae 10g, Cortex Meliae 15g, Fructus Ulmus preparatium 20g, Radix Stemonae 10g, zental 15g, and described adjuvant is made up of the raw material of following weight portion: Fructus Cnidii 10g, Fructus Bruceae 15g, Semen Cucurbitae 20g.
The preparation method of the medicine of above-mentioned treatment primate parasitic diarrhea, comprises the following steps:
1) preparation of major ingredient: take Rhizoma Osmundae, Fructus Quisqualis, Semen Arecae, Cortex Meliae, Fructus Ulmus preparatium, the Radix Stemonae 6 taste Chinese medicine by weight respectively, clean with cold water, put into distillation equipment, and in distillation equipment, add the water that gross mass is 2 times of 6 taste Chinese medicines, then add acetic acid and regulate the pH value of the solution in whole distillation equipment to be 5, heating decocts 30min, filter, obtain herb liquid, obtained herb liquid is distilled 1h at 200 DEG C, is then concentrated into the traditional Chinese medicine thick paste that water content is 12%; After again traditional Chinese medicine thick paste being carried out thermal dehydration, obtain Chinese medicinal powder, then mix homogeneously with the zental after pulverizing, finally temperature 220 DEG C, pressure is under the condition of 12Mpa, and sterilizing 5min, obtains major ingredient;
2) preparation of adjuvant: take Fructus Cnidii, Fructus Bruceae, Semen Cucurbitae 3 taste Chinese medicine by weight respectively, first by Fructus Cnidii, Fructus Bruceae co-grinding, put into marmite, add described Semen Cucurbitae, and add the water of 3 taste Chinese medicine gross weight 4 times, heated and boiled 30min, cooling, obtains adjuvant;
3) pack: step 1) is obtained major ingredient and step 2) obtained adjuvant separately carries out packaging storage, real-time proportioning time to be used.
Embodiment 3
A kind of medicine for the treatment of primate parasitic diarrhea, be made up of major ingredient and adjuvant two parts, wherein the mass ratio of major ingredient and adjuvant is 2:1, wherein said major ingredient is made up of the raw material of following weight portion: Rhizoma Osmundae 20g, Fructus Quisqualis 10g, Semen Arecae 7g, Cortex Meliae 10g, Fructus Ulmus preparatium 15g, Radix Stemonae 15g, zental 20g, and described adjuvant is made up of the raw material of following weight portion: Fructus Cnidii 8g, Fructus Bruceae 20g, Semen Cucurbitae 30g.
The preparation method of the medicine of above-mentioned treatment primate parasitic diarrhea, comprises the following steps:
1) preparation of major ingredient: take Rhizoma Osmundae, Fructus Quisqualis, Semen Arecae, Cortex Meliae, Fructus Ulmus preparatium, the Radix Stemonae 6 taste Chinese medicine by weight respectively, clean with cold water, put into distillation equipment, and in distillation equipment, add the water that gross mass is 3 times of 6 taste Chinese medicines, then add acetic acid and regulate the pH value of the solution in whole distillation equipment to be 4, heating decocts 25min, filter, obtain herb liquid, obtained herb liquid is distilled 1.5h at 200 DEG C, is then concentrated into the traditional Chinese medicine thick paste that water content is 10%; After again traditional Chinese medicine thick paste being carried out thermal dehydration, obtain Chinese medicinal powder, then mix homogeneously with the zental after pulverizing, finally temperature 235 DEG C, pressure is under the condition of 11Mpa, and sterilizing 4min, obtains major ingredient;
2) preparation of adjuvant: take Fructus Cnidii, Fructus Bruceae, Semen Cucurbitae 3 taste Chinese medicine by weight respectively, first by Fructus Cnidii, Fructus Bruceae co-grinding, put into marmite, add described Semen Cucurbitae, and add the water of 3 taste Chinese medicine gross weight 4 times, heated and boiled 40min, cooling, obtains adjuvant;
3) pack: step 1) is obtained major ingredient and step 2) obtained adjuvant separately carries out packaging storage, real-time proportioning time to be used.
Embodiment 4
A kind of medicine for the treatment of primate parasitic diarrhea, be made up of major ingredient and adjuvant two parts, wherein the mass ratio of major ingredient and adjuvant is 2:1, wherein said major ingredient is made up of the raw material of following weight portion: Rhizoma Osmundae 20g, Fructus Quisqualis 10g, Semen Arecae 7g, Cortex Meliae 7g, Fructus Ulmus preparatium 25g, Radix Stemonae 10g, zental 15g, and described adjuvant is made up of the raw material of following weight portion: Fructus Cnidii 7g, Fructus Bruceae 15g, Semen Cucurbitae 15g.
The preparation method of the medicine of above-mentioned treatment primate parasitic diarrhea is identical with embodiment 3.
Therapeutic effect of the present invention is as follows:
Case 1
Orangutan 10 is raised in certain zoo, and wherein grow up orangutan 6, and body weight counterpoise is 50KG; Young 4 of orangutan, body weight counterpoise is 2KG.There is inappetence in adult orangutan, vomiting, slow movement symptom, symptom of diarrhea appears in orangutan son, and feces is completely mashed shape, and color is brown, is parasitic diarrhea through Disease Diagnosis of Veterinary.The medicine of the treatment primate parasitic diarrhea that the orangutan feeding embodiment 2 of veterinary to these 10 morbidities provides, wherein feeding amount is: every kg body weight is filled with this medicine 0.1g and fed, continuously treatment 4 days.After treatment first day, orangutan symptoms of emesis of growing up reduces, and the young symptom of diarrhea of orangutan alleviates; Treat after second day, orangutan appetite of growing up strengthens, and slow movement symptom alleviates, and orangutan son diarrhoea excrement part recovers normal; After treating the 3rd day, orangutan symptoms of emesis of growing up disappears completely, honey stomach, and be swift in motion agility, and the young symptom of diarrhea of orangutan disappears completely, and feces recovers normal completely.After 10 orangutans stop treatment, in 30 days, phenomenon without exception occurs, whole process occurs without dead example.
Case 2
Certain zoo is raised the Gibbon 8 of attaching the names of pre-determined candidates that grows up, average weight 20KG, and lethargy appears in Gibbon of attaching the names of pre-determined candidates, and food-intake is few, has water sample loose stool in raising garden, and veterinary carries out diagnosis to 8 Gibbons of attaching the names of pre-determined candidates and finds have 5 to be diagnosed as parasitic diarrhea.Veterinary carries out disinfection to raising garden immediately, ill Gibbon of attaching the names of pre-determined candidates is isolated, the medicine of the treatment primate parasitic diarrhea provided by embodiment 4 carries out feeding to ill Gibbon of attaching the names of pre-determined candidates, and every kg body weight is filled with this medicine 0.1g and fed, continuously treatment 3 days.After 3 days, 5 Gibbon mental status of attaching the names of pre-determined candidates, food-intake and feces all recover normal, confirm that physical recovery is to normal condition after Disease Diagnosis of Veterinary.
Claims (6)
1. treat the medicine of primate parasitic diarrhea for one kind, it is characterized in that: be made up of by the mass ratio of 1 ~ 2.5:1 major ingredient and adjuvant, wherein said major ingredient is made up of the raw material of following weight portion: Rhizoma Osmundae 10 ~ 20 parts, Fructus Quisqualis 5 ~ 15 parts, Semen Arecae 5 ~ 10 parts, Cortex Meliae 7 ~ 15 parts, Fructus Ulmus preparatium 10 ~ 25 parts, the Radix Stemonae 8 ~ 15 parts, zental 10 ~ 20 parts.
2. the medicine for the treatment of primate parasitic diarrhea according to claim 1, is characterized in that: described adjuvant is made up of the raw material of following weight portion: Fructus Cnidii 6 ~ 10 parts, Fructus Bruceae 12 ~ 20 parts, Semen Cucurbitae 15 ~ 30 parts.
3. the medicine for the treatment of primate parasitic diarrhea according to claim 1, is characterized in that: be made up of by the mass ratio mixing of 1:1 major ingredient and adjuvant.
4. the medicine for the treatment of primate parasitic diarrhea according to claim 1, is characterized in that: described major ingredient is made up of the raw material of following weight portion: Rhizoma Osmundae 10 ~ 15 parts, Fructus Quisqualis 10 ~ 15 parts, Semen Arecae 5 ~ 10 parts, Cortex Meliae 7 ~ 10 parts, Fructus Ulmus preparatium 15 ~ 25 parts, the Radix Stemonae 10 ~ 15 parts, zental 15 ~ 20 parts.
5. the medicine for the treatment of primate parasitic diarrhea according to claim 2, is characterized in that: described adjuvant is made up of the raw material of following weight portion: Fructus Cnidii 7 ~ 10 parts, Fructus Bruceae 15 ~ 20 parts, Semen Cucurbitae 20 ~ 30 parts.
6. according to any one of Claims 1 to 5, treat the preparation method of the medicine of primate parasitic diarrhea, comprise the following steps:
1) preparation of major ingredient: take Rhizoma Osmundae, Fructus Quisqualis, Semen Arecae, Cortex Meliae, Fructus Ulmus preparatium, the Radix Stemonae 6 taste Chinese medicine by weight respectively, clean with cold water, put into distillation equipment, and in distillation equipment, add the water that gross mass is 2 ~ 4 times of 6 taste Chinese medicines, then add acetic acid and regulate the pH value of the solution in whole distillation equipment to be 3 ~ 5, heating decoction 15 ~ 30min, filter, obtain herb liquid, obtained herb liquid is distilled 1 ~ 2h at 200 DEG C, is then concentrated into the traditional Chinese medicine thick paste that water content is 8 ~ 12%; After again traditional Chinese medicine thick paste being carried out thermal dehydration, obtain Chinese medicinal powder, then mix homogeneously with the zental after pulverizing, finally temperature 220 ~ 250 DEG C, pressure is under the condition of 10 ~ 12Mpa, and sterilizing 3 ~ 5min, obtains major ingredient;
2) preparation of adjuvant: take Fructus Cnidii, Fructus Bruceae, Semen Cucurbitae 3 taste Chinese medicine by weight respectively, first by Fructus Cnidii, Fructus Bruceae co-grinding, put into marmite, add described Semen Cucurbitae, and add the water of 3 taste Chinese medicine gross weight 4 times, heated and boiled 30 ~ 50min, cooling, obtains adjuvant;
3) pack: step 1) is obtained major ingredient and step 2) obtained adjuvant separately carries out packaging storage, real-time proportioning time to be used.
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| CN201510211064.0A CN104800717A (en) | 2015-04-29 | 2015-04-29 | Medicine for treating parasitic diarrhea of primates |
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| CN201510211064.0A CN104800717A (en) | 2015-04-29 | 2015-04-29 | Medicine for treating parasitic diarrhea of primates |
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101152526A (en) * | 2007-09-28 | 2008-04-02 | 吴明星 | Traditional Chinese medicine for treating uncinariasis lax |
| CN103505669A (en) * | 2012-06-17 | 2014-01-15 | 陈绍爱 | Medicament for treating enterobiasis |
-
2015
- 2015-04-29 CN CN201510211064.0A patent/CN104800717A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101152526A (en) * | 2007-09-28 | 2008-04-02 | 吴明星 | Traditional Chinese medicine for treating uncinariasis lax |
| CN103505669A (en) * | 2012-06-17 | 2014-01-15 | 陈绍爱 | Medicament for treating enterobiasis |
Non-Patent Citations (2)
| Title |
|---|
| 朱大年: "下虫丸加减治疗小儿蛔虫病", 《上海中医药杂志》 * |
| 汤存生: "不循常规治泄泻", 《黑龙江中医药》 * |
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Application publication date: 20150729 |