CN104780916B - 用于治疗休克的肾上腺素与抗抑郁剂的组合 - Google Patents

用于治疗休克的肾上腺素与抗抑郁剂的组合 Download PDF

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Publication number
CN104780916B
CN104780916B CN201380057617.0A CN201380057617A CN104780916B CN 104780916 B CN104780916 B CN 104780916B CN 201380057617 A CN201380057617 A CN 201380057617A CN 104780916 B CN104780916 B CN 104780916B
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China
Prior art keywords
shock
antidepressant
adrenaline
pharmaceutical composition
purposes
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Chinese (zh)
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CN104780916A (zh
Inventor
让-查尔斯·施瓦茨
泽维尔·利尼奥
劳伦特·弗朗索瓦·格拉尔德·朗代
大卫·佩林
让娜-马里·勒孔特
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Bioprojet SC
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Bioprojet SC
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cardiology (AREA)
  • Emergency Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Immunology (AREA)
  • Dermatology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pulmonology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
CN201380057617.0A 2012-10-03 2013-10-02 用于治疗休克的肾上腺素与抗抑郁剂的组合 Active CN104780916B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP12306207 2012-10-03
EP12306207.7 2012-10-03
PCT/EP2013/070598 WO2014053579A1 (en) 2012-10-03 2013-10-02 A combination of adrenalin with an antidepressant for use in the treatment of shocks

Publications (2)

Publication Number Publication Date
CN104780916A CN104780916A (zh) 2015-07-15
CN104780916B true CN104780916B (zh) 2019-02-26

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CN201380057617.0A Active CN104780916B (zh) 2012-10-03 2013-10-02 用于治疗休克的肾上腺素与抗抑郁剂的组合

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Country Link
US (2) US20150306065A1 (enExample)
EP (1) EP2903607B1 (enExample)
JP (1) JP6419074B2 (enExample)
KR (1) KR102145786B1 (enExample)
CN (1) CN104780916B (enExample)
AU (1) AU2013326470B2 (enExample)
BR (1) BR112015007524B1 (enExample)
CA (1) CA2887330C (enExample)
CY (1) CY1119514T1 (enExample)
DK (1) DK2903607T3 (enExample)
EA (1) EA030763B1 (enExample)
ES (1) ES2647597T3 (enExample)
HR (1) HRP20171442T1 (enExample)
HU (1) HUE034638T2 (enExample)
IL (1) IL238120B (enExample)
IN (1) IN2015DN02849A (enExample)
LT (1) LT2903607T (enExample)
MA (1) MA37970B2 (enExample)
MX (1) MX359198B (enExample)
NO (1) NO2903607T3 (enExample)
NZ (1) NZ707124A (enExample)
PH (1) PH12015500755A1 (enExample)
PL (1) PL2903607T3 (enExample)
PT (1) PT2903607T (enExample)
RS (1) RS56392B1 (enExample)
SG (1) SG11201502645VA (enExample)
SI (1) SI2903607T1 (enExample)
SM (1) SMT201700502T1 (enExample)
TN (1) TN2015000126A1 (enExample)
WO (1) WO2014053579A1 (enExample)
ZA (1) ZA201502441B (enExample)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP4706648A1 (en) 2024-09-05 2026-03-11 Bioprojet Formulations of adrenalin and antidepressant
EP4706649A1 (en) 2024-09-05 2026-03-11 Bioprojet Use of adrenalin for the treatment of shocks

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3705942A (en) * 1969-09-29 1972-12-12 Ciba Geigy Corp Treatment of glaucoma employing imipramine or desmethylimipramine
CN101987198A (zh) * 2009-08-06 2011-03-23 北京美倍他药物研究有限公司 药物组合物
CN102271499A (zh) * 2008-12-30 2011-12-07 维沃琳医药有限公司 用于向脑死亡的、心脏搏动的潜在器官供者施用的包含去甲肾上腺素和net抑制剂的组合物

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW200744568A (en) * 2006-02-28 2007-12-16 Verus Pharmaceuticals Inc Epinephrine dosing regimens
US20070293582A1 (en) * 2006-06-05 2007-12-20 Malcolm Hill Epinephrine dosing regimens comprising buccal, lingual or sublingual and injectable dosage forms
PT2818184T (pt) * 2007-11-16 2019-01-28 Aclaris Therapeutics Inc Composições e métodos para o tratamento de púrpura
US20100190860A1 (en) * 2009-01-09 2010-07-29 The Brigham And Women's Hospital, Inc. Methods for selectively enhancing antinociceptive potency of local anesthetics

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3705942A (en) * 1969-09-29 1972-12-12 Ciba Geigy Corp Treatment of glaucoma employing imipramine or desmethylimipramine
CN102271499A (zh) * 2008-12-30 2011-12-07 维沃琳医药有限公司 用于向脑死亡的、心脏搏动的潜在器官供者施用的包含去甲肾上腺素和net抑制剂的组合物
CN101987198A (zh) * 2009-08-06 2011-03-23 北京美倍他药物研究有限公司 药物组合物

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
Adrenaline in the treatment of anaphylaxis: what is the evidence?;Andrew P C McLean-Tooke等;《clinical review》;20031206;第327卷;1332-1335 *
six years of epinephrine digital injections: absence of significant local or systemic effects;Andrew E. Muck等;《Annals of Emergency Medicine》;20100930;第56卷(第3期);270-274 *

Also Published As

Publication number Publication date
MA20150396A1 (fr) 2015-11-30
DK2903607T3 (en) 2017-10-09
HRP20171442T1 (hr) 2018-01-12
BR112015007524A2 (pt) 2017-07-04
EP2903607A1 (en) 2015-08-12
WO2014053579A1 (en) 2014-04-10
US20150306065A1 (en) 2015-10-29
PH12015500755B1 (en) 2015-05-25
EA201500374A1 (ru) 2015-07-30
SG11201502645VA (en) 2015-05-28
EA030763B1 (ru) 2018-09-28
MX2015004323A (es) 2015-06-10
HUE034638T2 (en) 2018-02-28
EP2903607B1 (en) 2017-08-16
CA2887330A1 (en) 2014-04-10
SI2903607T1 (sl) 2017-12-29
ES2647597T3 (es) 2017-12-22
CY1119514T1 (el) 2018-03-07
ZA201502441B (en) 2015-12-23
TN2015000126A1 (en) 2016-10-03
AU2013326470B2 (en) 2017-08-24
IN2015DN02849A (enExample) 2015-09-11
MA37970B2 (fr) 2017-10-31
PH12015500755A1 (en) 2015-05-25
RS56392B1 (sr) 2017-12-29
CN104780916A (zh) 2015-07-15
LT2903607T (lt) 2017-10-25
MA37970B1 (fr) 2016-06-30
PL2903607T3 (pl) 2018-01-31
US10952987B2 (en) 2021-03-23
IL238120B (en) 2018-08-30
NZ707124A (en) 2017-12-22
AU2013326470A1 (en) 2015-04-30
JP2015536907A (ja) 2015-12-24
MX359198B (es) 2018-09-19
BR112015007524B1 (pt) 2022-06-21
PT2903607T (pt) 2017-11-14
CA2887330C (en) 2021-03-09
KR102145786B1 (ko) 2020-08-19
NO2903607T3 (enExample) 2018-01-13
HK1211846A1 (en) 2016-06-03
JP6419074B2 (ja) 2018-11-07
KR20150093656A (ko) 2015-08-18
SMT201700502T1 (it) 2017-11-15
US20190117614A1 (en) 2019-04-25

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