CN104777314B - 抑郁症的生物标记物、抑郁症的生物标记物的测定方法、计算机程序及记录介质 - Google Patents

抑郁症的生物标记物、抑郁症的生物标记物的测定方法、计算机程序及记录介质 Download PDF

Info

Publication number
CN104777314B
CN104777314B CN201510161121.9A CN201510161121A CN104777314B CN 104777314 B CN104777314 B CN 104777314B CN 201510161121 A CN201510161121 A CN 201510161121A CN 104777314 B CN104777314 B CN 104777314B
Authority
CN
China
Prior art keywords
acid
depression
healthy
blood
phosphoethanolamine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CN201510161121.9A
Other languages
English (en)
Chinese (zh)
Other versions
CN104777314A (zh
Inventor
川村则行
篠田幸作
大桥由明
石川贵正
佐藤基
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Human Metabolome Technologies Inc
Original Assignee
Human Metabolome Technologies Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Human Metabolome Technologies Inc filed Critical Human Metabolome Technologies Inc
Publication of CN104777314A publication Critical patent/CN104777314A/zh
Application granted granted Critical
Publication of CN104777314B publication Critical patent/CN104777314B/zh
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/30—Psychoses; Psychiatry
    • G01N2800/304—Mood disorders, e.g. bipolar, depression
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/16—Phosphorus containing
    • Y10T436/163333—Organic [e.g., chemical warfare agents, insecticides, etc.]

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Chemical & Material Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Cell Biology (AREA)
  • Analytical Chemistry (AREA)
  • Biotechnology (AREA)
  • Pathology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
CN201510161121.9A 2009-08-12 2010-08-12 抑郁症的生物标记物、抑郁症的生物标记物的测定方法、计算机程序及记录介质 Expired - Fee Related CN104777314B (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
JP2009-187521 2009-08-12
JP2009187521 2009-08-12
JP2009-291029 2009-12-22
JP2009291029 2009-12-22
CN201080046087.6A CN102667485B (zh) 2009-08-12 2010-08-12 抑郁症的生物标记物、抑郁症的生物标记物的测定方法、计算机程序及记录介质

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CN201080046087.6A Division CN102667485B (zh) 2009-08-12 2010-08-12 抑郁症的生物标记物、抑郁症的生物标记物的测定方法、计算机程序及记录介质

Publications (2)

Publication Number Publication Date
CN104777314A CN104777314A (zh) 2015-07-15
CN104777314B true CN104777314B (zh) 2017-01-04

Family

ID=43586246

Family Applications (2)

Application Number Title Priority Date Filing Date
CN201510161121.9A Expired - Fee Related CN104777314B (zh) 2009-08-12 2010-08-12 抑郁症的生物标记物、抑郁症的生物标记物的测定方法、计算机程序及记录介质
CN201080046087.6A Active CN102667485B (zh) 2009-08-12 2010-08-12 抑郁症的生物标记物、抑郁症的生物标记物的测定方法、计算机程序及记录介质

Family Applications After (1)

Application Number Title Priority Date Filing Date
CN201080046087.6A Active CN102667485B (zh) 2009-08-12 2010-08-12 抑郁症的生物标记物、抑郁症的生物标记物的测定方法、计算机程序及记录介质

Country Status (6)

Country Link
US (2) US8951739B2 (cg-RX-API-DMAC7.html)
EP (1) EP2466312B1 (cg-RX-API-DMAC7.html)
JP (3) JPWO2011019072A1 (cg-RX-API-DMAC7.html)
CN (2) CN104777314B (cg-RX-API-DMAC7.html)
DK (1) DK2466312T3 (cg-RX-API-DMAC7.html)
WO (1) WO2011019072A1 (cg-RX-API-DMAC7.html)

Families Citing this family (47)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5731860B2 (ja) * 2011-03-11 2015-06-10 テルモ株式会社 腹膜組織の傷害検出方法
DK2778233T3 (en) 2011-11-10 2017-03-20 Human Metabolome Tech Inc METHOD OF MEASURING ETHANOLAMINPHOSPHATE
CA3216579A1 (en) 2013-01-22 2014-07-31 Vistagen Therapeutics, Inc. Dosage forms and therapeutic uses of l-4-chlorokynurenine
CN103630678A (zh) * 2013-03-29 2014-03-12 中国科学院城市环境研究所 男性不育的生物标志物及其应用
JP6211283B2 (ja) * 2013-03-29 2017-10-11 ヒューマン・メタボローム・テクノロジーズ株式会社 脳症の検出方法
EP2799878A1 (en) * 2013-05-03 2014-11-05 SALION GmbH In vitro method for the early detection of a potential inflammation, in particular associated with rejection of a transplant using kynurenine as a marker.
EP3000088A4 (en) * 2013-05-23 2018-06-27 Iphenotype LLC Method and system for maintaining or improving wellness
US20150056605A1 (en) * 2013-08-21 2015-02-26 Purdue Research Foundation Identification of blood based metabolite biomarkers of pancreatic cancer
CN103529159B (zh) * 2013-10-18 2015-05-13 哈尔滨医科大学 一种血液非靶标代谢组学研究样品的前处理方法
EA034419B1 (ru) * 2014-09-26 2020-02-06 Хьюман Метаболоми Текнолоджис Инк. Способ выбора лекарственного препарата для лечения депрессии
KR101604074B1 (ko) * 2015-05-14 2016-03-17 한국과학기술원 대사체 프로파일링을 이용한 정신질환의 진단 또는 진행성 예측 방법 및 바이오마커
CN105177117A (zh) * 2015-07-03 2015-12-23 张理义 重症抑郁障碍生物标记物、筛选方法及试剂盒
CN104991010B (zh) * 2015-07-29 2017-10-13 中国药科大学 一种区分乳腺癌亚型生物标志物的组合物
JP6882776B2 (ja) * 2015-11-12 2021-06-02 国立大学法人九州大学 うつ病診断用バイオマーカー及びその使用
CN105445408B (zh) * 2016-01-25 2018-06-12 齐炼文 诊断区分冠状动脉粥样硬化和稳定型心绞痛的代谢标志物
CN105486778B (zh) * 2016-01-25 2017-11-03 齐炼文 诊断区分稳定型心绞痛和急性冠脉综合征的代谢标志物
EP3465202B1 (en) * 2016-06-02 2023-07-05 Metabolon, Inc. Mass spectrometry method for detection and quantitation of metabolites
IL314752A (en) * 2016-09-16 2024-10-01 Takeda Pharmaceuticals Co Metabolite biomarkers for diseases associated with the contact activation system
WO2018117064A1 (ja) * 2016-12-21 2018-06-28 国立大学法人徳島大学 うつ状態を呈する疾患を検査する方法
US11869633B2 (en) * 2017-12-15 2024-01-09 The Board Of Trustees Of The University Of Illinois Analytics and machine learning framework for actionable intelligence from clinical and omics data
EP3740200B1 (en) * 2018-01-17 2024-12-11 University Of Southampton Methods to predict risk of and to stratify sarcopenia and nad deficiency
CN112689755A (zh) * 2018-09-11 2021-04-20 梅塔博隆股份有限公司 用于检测和定量微生物区系相关代谢物的质谱测定法
JPWO2020122231A1 (ja) 2018-12-13 2021-10-21 キッコーマン株式会社 エタノールアミンリン酸の定量方法、定量用のオキシドレダクターゼ、定量用組成物、定量用キット及び定量用センサー
WO2020185580A1 (en) * 2019-03-13 2020-09-17 Duke University Methods and compositions for diagnosing depression
CN110286191A (zh) * 2019-06-27 2019-09-27 山西大学 一种生物样品中代谢标志物检测方法及应用
EP4042165B1 (en) * 2019-10-11 2023-11-15 Société des Produits Nestlé S.A. 2-methylbutyrate, a biomarker for improvements of mood disorders
GB201916185D0 (en) * 2019-11-07 2019-12-25 Randox Laboratories Ltd Biomarker of drug-induced cellular toxicity and depression
AU2021292943B2 (en) * 2020-06-15 2024-04-04 Universitätsspital Basel MDMA response prediction
JP7891922B2 (ja) 2020-06-17 2026-07-17 キッコーマン株式会社 エタノールアミンリン酸の定量方法、定量用のオキシドレダクターゼ、定量用組成物、定量用キット、センサーチップ、及びセンサー
CN111693624B (zh) * 2020-06-22 2021-07-09 南京市中医院 一种与儿童多发性抽动症诊断相关的血浆代谢标志物在制备儿童多发性抽动症诊断试剂盒中的应用
CN112630311B (zh) * 2020-07-09 2023-07-18 深圳云合医药科技合伙企业(有限合伙) 用于检测情感障碍的代谢标记物和试剂盒及使用方法
WO2022094178A1 (en) * 2020-10-30 2022-05-05 The Regents Of The University Of California Compositions and methods for diagnosing and treating patients with a history of early life adversity
CN114544826B (zh) * 2020-11-24 2023-12-08 重庆医科大学 检测血浆中组氨酸的试剂在制备抑郁症检测试剂盒中的用途
CN114624345B (zh) * 2020-12-10 2023-06-06 中国科学院大连化学物理研究所 一种联合生物标志物及其应用
US11854684B2 (en) * 2020-12-29 2023-12-26 Kpn Innovations, Llc. Methods and systems for nourishment refinement using psychiatric markers
JP2024534233A (ja) * 2021-09-17 2024-09-18 ソシエテ・デ・プロデュイ・ネスレ・エス・アー バイオマーカーとしてブチレートを使用して気分障害及び／又は気分障害の状態の改善を検出及び／又は定量する方法、並びにその改善された方法及び組成物
US20240393304A1 (en) * 2021-09-28 2024-11-28 Societe Des Produits Nestle S.A. Method for detecting and/or quantifying mood disorder and/or improvements of the mood disorder status using trigonelline as biomarker and improved methods and compositions thereof
US12100484B2 (en) 2021-11-01 2024-09-24 Matterworks Inc Methods and compositions for analyte quantification
US20230137741A1 (en) 2021-11-01 2023-05-04 Matterworks Inc Methods and compositions for analyte quantification
JP7819901B2 (ja) * 2021-11-04 2026-02-25 国立大学法人九州大学 ひきこもりのバイオマーカー、ひきこもり識別支援方法
CN114176581A (zh) * 2021-12-06 2022-03-15 重庆邮电大学 基于体液中l-酪氨酸含量的抑郁情绪检测装置
CN116429952B (zh) * 2023-03-27 2024-02-02 深圳市第二人民医院(深圳市转化医学研究院) 一种抑郁症标志物及其在抑郁症诊断中的应用、评估装置
CN116809027B (zh) * 2023-05-18 2026-01-27 复旦大学附属中山医院 一种用于捕获外泌体的异质性复合材料及其制备方法和应用
CN116990498B (zh) * 2023-09-28 2024-08-09 山东大学齐鲁医院 血浆色氨酸代谢物在儿童偏头痛诊断中的应用
CN117590005A (zh) * 2024-01-15 2024-02-23 中国疾病预防控制中心环境与健康相关产品安全所 空气污染致抑郁的代谢标志物组合及其筛选方法和应用
WO2025163640A1 (en) * 2024-01-31 2025-08-07 Sheba Impact Ltd. Ai based clinical decision support system (cdss) for mental health
CN118566488B (zh) * 2024-04-10 2026-02-27 合肥歆智医疗器械有限公司 抑郁症检测用试剂组合、制造方法、检测系统及其应用

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1215472A (zh) * 1996-02-02 1999-04-28 史密丝克莱恩比彻姆公司 识别具有不良健康后果风险的患者的方法和系统
WO2000034791A1 (en) * 1998-12-08 2000-06-15 Knoll Aktiengesellschaft Assays for compounds which increase phospholipase a2 activity
CN101336372A (zh) * 2005-12-02 2008-12-31 剑桥企业有限公司 监测、诊断和鉴定精神障碍的生物标记的方法
CN101338337A (zh) * 2007-07-04 2009-01-07 北京华安佛医药研究中心有限公司 多态性位点基因型预测抑郁症及药效的用途、方法和试剂盒
WO2009006338A1 (en) * 2007-06-29 2009-01-08 Quest Diagnostics Investments Incorporated Analysis of amino acids in body fluid by liquid chromatography-mass spectrometry

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPWO2004080312A1 (ja) 2003-03-14 2006-06-08 清三郎 有田 うつ病の診断方法
DK1866650T3 (da) 2005-04-06 2010-09-06 Univ Maastricht Neurodegenerative markører for depression
JP2007024822A (ja) 2005-07-21 2007-02-01 Aska Pharmaceutical Co Ltd 男性の更年期又はうつ病の鑑別方法
US7606622B2 (en) 2006-01-24 2009-10-20 Cardiac Pacemakers, Inc. Method and device for detecting and treating depression
US20080281531A1 (en) 2007-03-15 2008-11-13 Kazuhito Rokutan Method for Diagnosing Depression
JP2009092550A (ja) 2007-10-10 2009-04-30 Japan Health Science Foundation うつ病またはうつ状態の同定方法
JP2009187521A (ja) 2008-01-08 2009-08-20 Yaskawa Electric Corp 位置指令作成方法及び位置指令作成装置
JP2009291029A (ja) 2008-05-30 2009-12-10 Yazaki Corp コルゲートチューブ配索部材

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1215472A (zh) * 1996-02-02 1999-04-28 史密丝克莱恩比彻姆公司 识别具有不良健康后果风险的患者的方法和系统
WO2000034791A1 (en) * 1998-12-08 2000-06-15 Knoll Aktiengesellschaft Assays for compounds which increase phospholipase a2 activity
CN101336372A (zh) * 2005-12-02 2008-12-31 剑桥企业有限公司 监测、诊断和鉴定精神障碍的生物标记的方法
WO2009006338A1 (en) * 2007-06-29 2009-01-08 Quest Diagnostics Investments Incorporated Analysis of amino acids in body fluid by liquid chromatography-mass spectrometry
CN101338337A (zh) * 2007-07-04 2009-01-07 北京华安佛医药研究中心有限公司 多态性位点基因型预测抑郁症及药效的用途、方法和试剂盒

Also Published As

Publication number Publication date
JP5372213B2 (ja) 2013-12-18
EP2466312A1 (en) 2012-06-20
EP2466312A4 (en) 2013-03-13
US9442121B2 (en) 2016-09-13
JP5859502B2 (ja) 2016-02-10
JP2014013257A (ja) 2014-01-23
CN104777314A (zh) 2015-07-15
US8951739B2 (en) 2015-02-10
US20150126623A1 (en) 2015-05-07
EP2466312B1 (en) 2019-10-16
JPWO2011019072A1 (ja) 2013-01-17
DK2466312T3 (da) 2020-01-13
CN102667485B (zh) 2015-04-22
CN102667485A (zh) 2012-09-12
WO2011019072A1 (ja) 2011-02-17
JP2012211908A (ja) 2012-11-01
US20120282592A1 (en) 2012-11-08

Similar Documents

Publication Publication Date Title
CN102667485B (zh) 抑郁症的生物标记物、抑郁症的生物标记物的测定方法、计算机程序及记录介质
JP6927212B2 (ja) 軽度認知障害又はアルツハイマー型認知症の評価方法
US20150141528A1 (en) Neural specific s100b for biomarker assays and devices for detection of a neurological condition
EP3028049B1 (en) Diagnostic tools for alzheimer's disease
US20180275144A1 (en) Diagnostic tools for alzheimer's disease
JP6870679B2 (ja) アルツハイマー型認知症の将来の発症リスクの評価方法
CN102933966A (zh) 阿尔茨海默病的新型诊断制剂
Zhu et al. Serum high-sensitivity C-reactive protein levels are positively associated with cognitive impairments in patients with first-episode schizophrenia
Siddique et al. Estimation of alpha-synuclein monomer and oligomer levels in the saliva of the children with autism spectrum disorder: a possibility for an early diagnosis
US20240142471A1 (en) Test for mild cognitive impairment
US20210278405A1 (en) Identification of metabolomic signatures in urine samples for tuberculosis diagnosis
WO2018117064A1 (ja) うつ状態を呈する疾患を検査する方法
JP7531068B2 (ja) 認知症又はそのリスクの検査方法
WO2013080917A1 (ja) 統合失調症の客観的評価法
CN118112253A (zh) 血浆神经丝轻链蛋白在帕金森病日间过度嗜睡相关产品制备或筛选中的应用
RU2835349C1 (ru) Способ дифференциальной диагностики болезни Паркинсона и болезни диффузных телец Леви
CN121816502A (zh) 双相障碍的生物标志物
Yaplito-Lee et al. Correlation between dried blood spot thin layer chromatography and plasma high performance liquid chromatography of leucine/isoleucine levels among Filipino patients with maple syrup urine disease (MSUD) seen at the Institute of Human Genetics, National Institutes of Health
JP2013528802A (ja) 筋萎縮性側索硬化症の診断方法

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
EXSB Decision made by sipo to initiate substantive examination
SE01 Entry into force of request for substantive examination
C14 Grant of patent or utility model
GR01 Patent grant
CF01 Termination of patent right due to non-payment of annual fee
CF01 Termination of patent right due to non-payment of annual fee

Granted publication date: 20170104