CN104758793A - Chinese medicine preparation used for acute intermittent porphyria and preparation method thereof - Google Patents

Abstract

The invention discloses a Chinese medicine preparation used for acute intermittent porphyria and belongs to the field of Chinese medicine invention. The Chinese medicine preparation comprises the raw materials of radix curcumae, peach kernels, rhizoma chuanxiong, cassia twigs, rhubarb, mirabilite, milkvetch roots, radix codonopsis, prepared rehmannia roots, Chinese angelica, tree peony parks, white peony roots, rhizoma corydalis, Szechwan Chinaberry fruits, ground beetles, red sage roots, capillary wormwood herbs, longhairy antenoron herbs, fiveleaf akebia fruits, fructus aurantii, officinal magnolia bark and senna leaves. According to different characteristics of all the herbs, the herbs are cleaned, cut into blocks, pre-treated, proportioned and manufactured into the Chinese medicine preparation through a specific method, and the Chinese medicine preparation has the effects of soothing the liver, relieving depression, dispelling wind, removing obstruction in the meridians, nourishing the blood for tranquilization, clearing away heat and removing toxicity. The combination and manufacturing method is specific, and through clinical verifications, the Chinese medicine preparation is remarkable in therapy effect, low in price and capable of relieving the illness state of patients, and has broad market application prospects.

Description

A kind of Chinese medicine preparation for hepatic porphyria and preparation method thereof

Technical field

The present invention relates to a kind of Chinese medicine preparation, be specifically related to a kind of Chinese medicine preparation for hepatic porphyria, the invention still further relates to the preparation method of this Chinese medicine preparation.

Background technology

Hepatic porphyria is also known as Waldenstrom syndrome, acute intemittent porphyria (AIP).Primary disease is due to a series of syndromes such as the ictal stomachache of the interval in liver caused by porphyrin metabolism disorder, vomiting, constipation and neuropsychic symptoms.With between twenty and fifty people's morbidity for many.Primary disease is autosomal dominant disease.In porphyrin metabolism synthesis of hematoidin process, because the former synzyme of porphin gallbladder lacks, the former not energy metabolism of porphin gallbladder and gathering in vivo, bilirubin is synthesized reduce, by feedback effect, δ-aminolevulinic acid synthase activity is increased, result δ-aminolevulinic acid and porphin gallbladder originality produce in vivo and increase, and increasing of they plays toxic action by directly or indirectly machine-processed in neurotransmission function, and then causes the outbreak of primary disease.Primary disease is autosomal dominant disease.In porphyrin metabolism synthesis of hematoidin process, because the former synzyme of porphin gallbladder lacks, the former not energy metabolism of porphin gallbladder and gathering in vivo, bilirubin is synthesized reduce, by feedback effect, δ-aminolevulinic acid synthase activity is increased, result δ-aminolevulinic acid and porphin gallbladder originality produce in vivo and increase, and increasing of they plays toxic action by directly or indirectly machine-processed in neurotransmission function, and then causes the outbreak of primary disease.Primary disease clinical manifestation is widely different, and the interval outbreak of lower abdomen angor and neuropsychic symptom is feature.Brought out by taking barbiturates, sulfa drugs or stress state.Abdominal part shows as violent angor, companion's constipation, nausea and vomiting, similar acute abdomen performance, but stomachache is without fixed position, also without abdominal rebound pain and muscle tonus.The performance of peripheric movement neurological disorder has tetraparesis unable, and paresis, even collapses from physical exhaustion.Mental symptom can have depression, mental disorder, hallucination etc.Symptom Chang Fanfu acute attack, the sustainable a few days to tens day.In addition, autonomic nervous dysfunction can be had to show, as tachycardia, hypertension, urine retention.Because δ-aminolevulinic acid and former to discharge from kidney of porphin gallbladder increase, can change into red or dark brown under Urine in Patients being exposed to daylight, be the very important feature of primary disease one.

Summary of the invention

The object of the present invention is to provide a kind of Chinese medicine preparation for hepatic porphyria, this Chinese medicine preparation is for alleviation hepatic porphyria symptom, and have therapeutic effect remarkable, healing time is short, cheap, has no adverse reaction and the feature of secondary toxic action.

Inventor is in clinical treatment practice for many years, and according to the law of development of this disease, and the combination principle of Chinese medicine, and by a large amount of clinical verifications, Exploration and conclusion goes out to be used for the treatment of the new formula of the Chinese medicine preparation of hepatic porphyria repeatedly.The present invention has that therapeutic effect is remarkable, and healing time is short, cheap, has no adverse reaction and the feature of secondary toxic action.

The effect of Chinese medicine of the present invention:

Wherein:

Radix Curcumae: be the dried root of zingiberaceous plant RADIX CURCUMAE Curcuma wenyujin Y. H. Chen et C. Ling, Rhizoma Curcumae Longae Curcuma longa L., Guangxi zedoary Curcuma kwangsiensis S. G. Lee et C. F. Liang or Rhizoma Curcumae Curcuma phaeocaulis Val..Nature and flavor: pungent, bitter, cold.Return liver, the heart, lung meridian.Effect: regulating qi to disperse stagnation, heart fire-clearing upset-relieving, promoting the function of the gallbladder to alleviate jaundice.For amenorrhea dysmenorrhea, chest and abdomen swelling and pain, twinge, calentura coma, epilepsy is gone mad, jaundice dark coloured urine.Record in essentials of Matea Medica: " circulation of qi promoting, resolving depression; Let out blood, removing blood stasis with potent drugs.Cool heat in the heart, loose stagnation of liver-QI.

Semen Persicae: be the dry mature seed of rosaceous plant Fructus Persicae Prunus persica (L.) Batsch or Prunus davidiana Prunus davidiana (Carr.) Franch..Nature and flavor: bitter, sweet, flat.GUIXIN, liver, large intestine channel.Effect: blood circulation promoting and blood stasis dispelling, loosening bowel to relieve constipation.For amenorrhea, dysmenorrhea ， WEIJIA mass in the abdomen, injury from falling down, dryness of the intestine constipation.Record in " herbal classic ": main blood stasis, blood closes lump in the abdomen, pathogen, kills small worm." not Lu ": only cough with dyspnea, disappear hardness in the epigastrium, and except soldier hits blood cruelly, broken lump in the abdomen, promotes blood circulation, pain relieving.

Rhizoma Chuanxiong: be samphire Rhizoma Chuanxiong Ligusticum chuanxiong Hort.(or Ligusticum wallichii Franch.) dry rhizome.Nature and flavor: pungent, temperature.Return liver, gallbladder, pericardium channel.Effect: blood-activating and qi-promoting, wind-expelling pain-stopping.For menoxenia, amenorrhea dysmenorrhea, lump in the abdomen is suffered from abdominal pain, the twinge of the breast side of body, tumbling and swelling, headache, rheumatic arthralgia.Record in " Japan hanako materia medica ": control a wind cutting, all gas, all strains, all blood, mend five kinds of over strain, strengthening bone and muscle, adjusts many arteries and veins, and broken Disorder ties stagnated blood, supports fresh blood, puts on flesh, serious epistaxis, spits blood and hematuria, hemorrhoid complicated by anal fistula, brain carbuncle carbuncle on the back, and scrofula wart is gone to live in the household of one's in-laws on getting married, skin ulcer scabies, and evacuation of pus repercussive blood.

Ramulus Cinnamomi: be the dry twig of canella Cortex Cinnamomi Cinnamomum cassia Presl.Spring, Xia Erji gather, and except defoliation, dry, or section is dried.Nature and flavor: acrid, sweet, warm.GUIXIN, lung, urinary bladder channel.Cure mainly diaphoresis expelling pathogenic factors from muscles, promoting the flow of QI-blood by warming the meridian, supporing yang activating QI, the flat gas that spins.For anemofrigid cold, coldness and pain in the epigastrium, cold in blood amenorrhea, arthralgia, phlegm retention, edema, cardiopalmus, renal mass.

Radix Et Rhizoma Rhei: be polygonum rheum palmatum Rheum palmatum L., Rheum tanguticum Rheum tanguticum Maxim.ex Balf。Or Rheum officinale Rheum officinale Baill.Dry root and rhizome.Nature and flavor: bitter, cold.Return spleen, stomach, large intestine, liver, pericardium channel.Effect: purging heat and dredging bowels, removing pathogenic heat from blood and toxic substance from the body, eliminating blood stasis and inducing menstruation.For excess-heat constipation, stagnant stomachache, dysentery is not well, jaundice due to damp-heat, and heat in blood tells nosebleed, conjunctival congestion, pharyngeal swelling, abdominalgia with intestinal abscess, carbuncle furuncle, blood stasis amenorrhea, traumatic injury, external treatment burn due to hot liquid or fire; Upper gastrointestinal hemorrhage.Radix et Rhizoma Rhei (stir-fried with wine) is apt to clear part of the body cavity above the diaphragm housing the heart and lungs noxious heat in the blood system.For conjunctival congestion pharyngeal swelling, gingivitis.Radix Et Rhizoma Rhei rushes down exerts oneself to delay, eliminating fire and detoxication.For pathogenic fire,toxin and furuncles.Charred Radix Et Rhizoma Rhei cooling blood and removing stasis stops blooding.Stasis of blood hemorrhage is had for heat in blood.Record in " Japan hanako materia medica ": logical all gas of a surname, blood circulation regulating, sharp joint, lets out and moulds stagnant, aqueous vapor, extremity unbalanced cold and heat, warm miasma heat-phlegm, sharp defecation, and applies-Qie furuncle carbuncle poison.

Natrii Sulfas: be Sulfates mineral Natrii Sulfas race Natrii Sulfas, through the crystalline solid of processing and refining.Nature and flavor: salty, bitter, cold.Return stomach, large intestine channel.Effect: purging heat to relax the bowels, moistening for dryness and softening hard mass, detumescence of relieving inflammation or internal heat.For excess-heat constipation, constipation due to dry stool, stagnant stomachache, acute appendicitis swells and ache; External treatment acute mastitis, swelling and pain of hemorrhoid.Record in " not Lu ": main the five internal organs gather, and hot stomach of a specified duration closes, except pathogen, broken stagnant blood, in abdomen, the real knot of expectorant is fought, qualcomm meridian, and sharp defecation and Yue Shui, the fifth day of the first lunar month drenches, and pushes away Chen Zhixin.

The Radix Astragali: be the dry root of leguminous plant Radix Astagali Astragalus membranaceus (Fisch.) Bge. var. mongholicus (Bge.) Hsiao or Radix Astragali Astragalus membranaceus (Fisch.) Bge..Nature and flavor: sweet, temperature.Return lung, spleen channel.Effect: invigorating QI to consolidate the body surface resistance, diuresis poison holding, evacuation of pus, expelling pus and promoting granulation.Weak for the deficiency of vital energy, anorexia and loose stool, sinking of QI of middle-JIAO, chronic diarrhea proctoptosis, metrorrhagia of having blood in stool, exterior deficiency spontaneous perspiration, deficiency of vital energy edema, carbuncle difficulty is burst, and burst for a long time and do not hold back, blood deficiency dull yellowish colored skin, interior-heat is quenched one's thirst; Chronic nephritis proteinuria, diabetes.

Radix Codonopsis: be the dry root of Campanulaceae Radix Codonopsis Codonopsis pilosula (Franch.) Nannf., element flower Radix Codonopsis (RADIX CODONOPSIS PILOSULAE from Northwest of China) Codonopsis pilosula Nannf. var. modesta (Nannf.) L. T. Shen or radix codonpsis tangshen Codonopsis tangshen Oliv..Nature and flavor: sweet are flat.Return spleen, lung meridian.Effect: invigorating the spleen and replenishing QI, spleen invigorating lung benefiting.For deficiency of the spleen and lung, cardiopalmus of breathing hard, anorexia and loose stool, dyspnea due to deficiency is coughed, and interior-heat is quenched one's thirst.Record in " Bencao Congxin ": invigorating the spleen and replenishing QI, and taste, relieving thirst and restlessness.

Radix Rehmanniae Preparata: be the Preparation process product of Radix Rehmanniae.Nature and flavor: sweet, tepor.Return liver, kidney channel.Function cures mainly: nourishing YIN and supplementing blood, and beneficial essence fills out marrow.For the hepatic and renal YIN deficiency, soreness of the waist and knees, osteopyrexia and fever, night sweat is passed out semen, and interior-heat is quenched one's thirst, blood deficiency and yellow complexion, severe palpitation, menoxenia, and metrostaxis is dizzy, tinnitus, early whitening of beard and hair.Record in " pearl sac ": enrich blood greatly empty not enough, promoting blood circulation, physical strength profiting.

Radix Angelicae Sinensis: be the dry root of umbelliferae angelica Angelica sinensis (Oliv.) Diels.Nature and flavor: sweet, acrid, warm.Return liver, the heart, spleen channel.Effect: enrich blood and invigorate blood circulation, menstruction regulating and pain relieving, loosening bowel to relieve constipation.For blood deficiency and yellow complexion, dizzy cardiopalmus, menoxenia, amenorrhea dysmenorrhea, asthenia cold abdominalgia, dryness of the intestine constipation, rheumatic arthralgia, injury from falling down, ulcer sores.Radix Angelicae Sinensis (processed with wine) promoting blood circulation to restore menstrual flow.For amenorrhea dysmenorrhea, rheumatic arthralgia, injury from falling down.Record in " not Lu ": " warming middle-JIAO to relieve pain, fills in except in objective blood, middle puerperal tetanus, no sweating, arthralgia chiefly caused by damp pathogen, and attacked by pestiferous factors is courteous, cold caused by deficiency, mends five and hides, granulation promoting meat."

Cortex Moutan: be the dry root bark of ranunculaceae peony Paeonia suffruticosa Andr..Nature and flavor: bitter, pungent, are slightly cold.GUIXIN, liver, kidney channel.Effect: clearing away heat and cooling blood, blood circulation promoting and blood stasis dispelling.For maculae caused by violent heat pathogen, hematemesis and epistaxis, night fever abating at dawn, lossless hectic fever due to YIN-deficiency, amenorrhea dysmenorrhea, carbuncle sore tumefacting virus, falls and flutters the pain of injury.Record in " property of medicine opinion ": control cold air, loose all pains, control woman's passages through which vital energy circulates obstructed, blood drop pain in the lumbar region.

The Radix Paeoniae Alba: be the dry root of ranunculaceae plant Radix Paeoniae Paeonia lactiflora Pall..Nature and flavor: bitter, sour, are slightly cold.Return liver, spleen channel.Effect: suppressing the hyperactive liver pain relieving, nourishing blood for regulating menstruation, astringing YIN to stop sweating.Dizzy for having a headache, hypochondriac pain, stomachache, limb pain twin, blood deficiency and yellow complexion, menoxenia, spontaneous perspiration, night sweat.Record in " herbal classic ": main pathogen stomachache, except arthralgia due to stagnation of blood, broken hard long-pending, control cold and heat hernia abdominal mass, pain relieving, diuresis, QI invigorating.

Rhizoma Corydalis: be the dry tuber of papaveraceae plant corydalis Corydalis yanhusuo W. T. Wang.Nature and flavor: pungent, bitter, temperature.Return liver, spleen channel.Effect: invigorate blood circulation, promoting the circulation of QI, pain relieving.For the breast side of body, epigastric pain, amenorrhea dysmenorrhea, postpartum stagnation, tumbling and swelling.Record in " Japan hanako materia medica ": except wind, control gas, warm waist knee joint, broken disease addiction, flutter damage blood stasis, fall tire, and sudden and violent lumbago.

Fructus Toosendan: be the dry mature fruit of Meliaceae plant Fructus Toosendan Melia toosendan Sieb. et Zucc..Nature and flavor: bitter, cold; Slightly poisonous.Return liver, small intestinal, urinary bladder channel.Effect: soothing liver-QI promoting the circulation of QI to relieve pain, anthelmintic.For the breast side of body, abdominal distention, colic, abdominal pain due to worm stagnation.Record in " medical center bun is wanted ": eliminating heart-fire, hard kidney water, lung heat clearing gold, clearing away liver-fire.Core: happy hernia, removes syndrome of aversion to cold lasting day and night with cold limbs.

Eupolyphaga Seu Steleophaga: be Corydiidae insecticide eupolyphoge sinensis Eupolyphaga sinensis Walker or Ji eupolyphoge sinensis Steleophaga plancyi(Boleny) female worm dry body.Nature and flavor: salty, cold; Slightly poisonous.Return Liver Channel.Effect: removing blood stasis with potent drugs blood, reuniting the fractured tendons and bones.For injured bone, blood stasis amenorrhea, lump in the abdomen mass in the abdomen.

Radix Salviae Miltiorrhizae: be the dry root and rhizome of labiate Radix Salviae Miltiorrhizae Salvia miltiorrhiza Bunge..Nature and flavor: bitter, are slightly cold.GUIXIN, Liver Channel.Effect: stasis-dispelling and pain-killing, promoting blood circulation to restore menstrual flow, clear away heart-fire relieving restlessness.For menoxenia, amenorrhea dysmenorrhea, lump in the abdomen, breast ventral spine pain, pyretic arthralgia pain, skin infection swells and ache, dysphoria and insomnia; Hepatosplenomegaly, angina pectoris.Record in " the southern regions of the Yunnan Province book on Chinese herbal medicine ": reinforcing the heart sedate, calming heart and tranquilizing mind.Control forgetful punching seized with terror, palpitation with fear is insomnia.

Herba Artemisiae Scopariae: be the dry aerial parts of feverfew Artemisia scoparia Waldst. et Kit. Artemisia scoparia Waldst. et Kit. or Herba Artemisiae Scopariae Artemisia capillaris Thunb..Nature and flavor: bitter, pungent, are slightly cold.Return spleen, stomach, liver, gallbladder meridian.Effect: clearing away damp-heat, jaundice eliminating subcutaneous ulcer.For jaundice oliguria, eczema pruritus; Infectious jaundice type hepatitis.

Herba Lysimachiae: be the dry herb of Ofthe Primulaceae Lysimachia christinae Hance Lysimachia christinae Hance.Nature and flavor: sweet, salty, are slightly cold.Return liver, gallbladder, kidney, urinary bladder channel.Effect: eliminating damp-heat, treating stranguria, detumescence.For pyretic stranguria, Sha Lin, urinates and puckeryly to have a pain, jaundice dark coloured urine, carbuncle furuncle, venom; Liver and bile stone, lithangiuria.Record in " Traditional Chinese Medicine in Sichuan will ": dispelling the wind and dampness pathogens is numb, bones and muscles pain, jaundice, lung abscess.

Fructus Akebiae: be the fruit of BENTONG section plant Caulis Akebiae, threeleaf akebia, white BENTONG.Nature and flavor: sweet, cold.Effect: liver-smoothing, qi-regulating, promoting blood circulation and stopping pain, relieving restlessness diuresis.Treating the liver peratodynia, gastric heat food is slow-witted, excessive thirst, also Hakuri, lumbago, hypochondriac pain, hernia, cave warp, and uterus drops.Record in " Shaanxi Chinese herbal medicine ": Shugan Yishen, invigorating the spleen and regulating the stomach.

Fructus Aurantii: be the dry immature fruit of rutaceae Citrus aurantium Linn. Citrus aurantium L. and variety thereof.Nature and flavor: bitter, pungent, sour, temperature.Return spleen, stomach warp.Function cures mainly: regulating the flow of QI to ease the stomach, the stagnant relieving distension of row.For the breast side of body stagnation of QI, distension pain, accumulation of food in the stomach and intes tine due to indigestion, stops in phlegm retention; Gastroptosis, proctoptosis, sub-official's prolapsus.Record in " Japan hanako materia medica ": spleen benefiting and stimulating the appetite, adjust the five internal organs, the therapeutic method to keep the adverse QI flowing downwards, preventing or arresting vomiting is inverse, expectorant.

Cortex Magnoliae Officinalis: be the dry dried bark of Magnoliacea plant Cortex Magnoliae Officinalis Magnolia officinalis Rehd. et Wils. or magnolia officinalis rehd.et wils.var.biloba rehd.et wils. Magnolia officinalis Rehd. et Wils. var. biloba Rehd. et Wils., root bark and branch skin.Nature and flavor: bitter, pungent, temperature.Return spleen, stomach, lung, large intestine channel.Effect: dampness expectorant, the therapeutic method to keep the adverse QI flowing downwards is except full.For humidity hysteresis damaging the spleen and stomach, gastral cavity painful abdominal mass is vomited and diarrhoea, and stagnation of QI due to dyspepsia, abdominal distention constipation, phlegm retention is breathed with cough.Record in " not Lu ": warming middle-JIAO QI invigorating, the expectorant therapeutic method to keep the adverse QI flowing downwards.Treat cholera and stomachache distension, cold in the stomach is inverse and vomit more than in the heart, lets out dysentery and drenches dew, except frightened, and earnest stuffy sensation with restlessness of going or staying, thick the intestines and stomach.

Folium Sennae: be the dry lobule of leguminous plant narrow leaf Senna fruit Cassia angustifolia Vahl or cassia acutifolia Delile Cassia acutifolia Delile.Nature and flavor: sweet, bitter, cold.Return large intestine channel.Effect: the row that purges heat is stagnant, relieving constipation, diuretic.Stagnate for accumulation of heat, constipation is suffered from abdominal pain, edema distension.

Side's solution of the present invention is: in side, Radix Rehmanniae Preparata, Cortex Moutan, the Radix Paeoniae Alba, Rhizoma Corydalis, Fructus Toosendan, Eupolyphaga Seu Steleophaga, Herba Artemisiae Scopariae, Herba Lysimachiae, Fructus Akebiae return Liver Channel, have dispersing liver and promoting blood circulation, dispelling wind and removing obstruction in the collateral effect.Hepatic porphyria pathological changes endogenous cause of ill is a series of diseases such as the ictal stomachache of interval in self liver caused by porphyrin metabolism disorder, vomiting, constipation and neuropsychic symptom, all returns Liver Channel, unclog and readjust liver function function from endogenous cause of ill to add medicine to, and strengthens the promoting blood circulation to remove obstruction in the collateral function of liver function.So tonifying liver is the basis of hepatic porphyria, above nine taste medicines are monarch drug, and first fundamentally dispersing liver and promoting blood circulation, dispelling wind and removing obstruction in the collateral is that disease is controlled effectively.Radix Curcumae, Semen Persicae, Rhizoma Chuanxiong, Radix Et Rhizoma Rhei, Radix Angelicae Sinensis, return liver, heart channel.Liver governing tendons, the main blood of the heart and gods, above five kinds of Chinese medicine, as ministerial drug, is assisted on the one hand and is returned Liver Channel to assist monarch drug dispersing liver and promoting blood circulation, dispelling wind and removing obstruction in the collateral; GUIXIN warp on the other hand, nourishing blood to tranquillize the mind, reducing the asthenic fever, alleviates affected part disease pain, promotes health blood circulation.Ramulus Cinnamomi, Natrii Sulfas, the Radix Astragali, Radix Codonopsis, Fructus Aurantii, Cortex Magnoliae Officinalis, Folium Sennae return spleen, stomach warp, above seven flavor medicine is as adjuvant drug, control from pathology the inducement causing hepatic porphyria, the main transporting of taste, diet water paddy is through the effect of QI of the spleen and stomach, turn to foodstuff essence, foodstuff essence turns to ying-qi and body fluid again, and ying-qi and body fluid enter arteries and veins, turns to the blood of redness of the skin or complexion through heart-yang effect, the nourishing liver heart, dredging collateral is invigorated blood circulation.The all medicines of this side share, and the monarch and his subjects pull together, and assistant makes auxiliary altogether, have effect of effect of dispersing the stagnated live-QI to relieve the stagnation of QI, dispelling wind and removing obstruction in the collateral, nourishing blood to tranquillize the mind, heat-clearing and toxic substances removing, can effectively alleviate hepatic porphyria disease.

Medicine material consumption of the present invention is groped to sum up to draw through inventor in a large number, each raw material dosage is for all to have good curative effect in following weight parts scope: Radix Curcumae 13-17 part, Semen Persicae 10-14 part, Rhizoma Chuanxiong 13-17 part, Ramulus Cinnamomi 10-14 part, Radix Et Rhizoma Rhei 8-12 part, Natrii Sulfas 7-11 part, Radix Astragali 28-32 part, Radix Codonopsis 13-17 part, Radix Rehmanniae Preparata 16-20 part, Radix Angelicae Sinensis 16-20 part, Cortex Moutan 10-14 part, Radix Paeoniae Alba 13-17 part, Rhizoma Corydalis 16-20 part, Fructus Toosendan 13-17 part, Eupolyphaga Seu Steleophaga 7-11 part, Radix Salviae Miltiorrhizae 18-22 part, Herba Artemisiae Scopariae 18-22 part, Herba Lysimachiae 22-26 part, Fructus Akebiae 10-14 part, Fructus Aurantii 10-14 part, Cortex Magnoliae Officinalis 10-14 part, Folium Sennae 4-8 part.

Wherein be preferably: Radix Curcumae 15 parts, 12 parts, Semen Persicae, Rhizoma Chuanxiong 15 parts, Ramulus Cinnamomi 12 parts, Radix Et Rhizoma Rhei 10 parts, 9 parts, Natrii Sulfas, the Radix Astragali 30 parts, Radix Codonopsis 15 parts, Radix Rehmanniae Preparata 18 parts, Radix Angelicae Sinensis 18 parts, Cortex Moutan 12 parts, the Radix Paeoniae Alba 15 parts, Rhizoma Corydalis 18 parts, Fructus Toosendan 15 parts, Eupolyphaga Seu Steleophaga 9 parts, Radix Salviae Miltiorrhizae 20 parts, Herba Artemisiae Scopariae 20 parts, Herba Lysimachiae 24 parts, Fructus Akebiae 12 parts, Fructus Aurantii 12 parts, Cortex Magnoliae Officinalis 12 parts, Folium Sennae 6 parts.

Medicine of the present invention can adopt the conventional method of Chinese medicine preparation to be prepared into any conventional oral preparations, as pill, powder, tablet, oral liquid etc.Such as these crude drug pulverize mix homogeneously can be made powder to take after mixing it with water; Can decocting be used, obtain filtrate after filtration, add antiseptic and make oral liquid; Also directly decoction can be taken if desired.

A kind of preparation method of the Chinese medicine preparation for hepatic porphyria is as follows:

Step one: by weight of the present invention, gets Radix Rehmanniae Preparata, Natrii Sulfas respectively, grinding, crosses 120 mesh sieves, for subsequent use;

Step 2: by weight of the present invention, by Semen Persicae, Fructus Akebiae, Fructus Toosendan respectively with gauze wrapping, for subsequent use;

Step 3: by weight proportion of the present invention, get Radix Curcumae, Rhizoma Chuanxiong, Ramulus Cinnamomi, Radix Et Rhizoma Rhei, the Radix Astragali, Radix Codonopsis, Radix Angelicae Sinensis, Cortex Moutan, the Radix Paeoniae Alba, Rhizoma Corydalis, Eupolyphaga Seu Steleophaga, Radix Salviae Miltiorrhizae, magnolia medicament is placed in marmite, add the water of 8 times of volumes, intense fire infusion 15 ~ 20 minutes, fiery infusion of larding speech with literary allusions is filtered for 30 ~ 40 minutes, add the water of 2 times of volumes again, by Herba Artemisiae Scopariae, Herba Lysimachiae, Fructus Aurantii, Folium Sennae is dropped in marmite, slow fire infusion obtains filtrate in 20 ~ 30 minutes, add monoploid hydrops again, by Semen Persicae in step 2, Fructus Akebiae, Fructus Toosendan drops in marmite, slow fire infusion 20 ~ 30 minutes, infusion merges gained filtrate three times repeatedly, for subsequent use,

Step 4: by step one gained medicated powder, drops in step 3 gained filtrate, stirs evenly, both Chinese medicine decoction of the present invention.

Using method of the present invention: get decoction warm, one after each meal, every day 3 times.It within 10 days, is a course for the treatment of.

Medicine of the present invention has dispersing the stagnated live-QI to relieve the stagnation of QI, dispelling wind and removing obstruction in the collateral, nourishing blood to tranquillize the mind, antipyretic and antidote functions, and good analgesic effect, cheap, have no side effect, easy to use, the mode that this Chinese medicine preparation adopts is treated and can be reduced the injury of Western medicine to patient body, alleviates the slight illness of patient.

Detailed description of the invention

Embodiment one: Radix Curcumae 15 parts, 12 parts, Semen Persicae, Rhizoma Chuanxiong 15 parts, Ramulus Cinnamomi 12 parts, Radix Et Rhizoma Rhei 10 parts, 9 parts, Natrii Sulfas, the Radix Astragali 30 parts, Radix Codonopsis 15 parts, Radix Rehmanniae Preparata 18 parts, Radix Angelicae Sinensis 18 parts, Cortex Moutan 12 parts, the Radix Paeoniae Alba 15 parts, Rhizoma Corydalis 18 parts, Fructus Toosendan 15 parts, Eupolyphaga Seu Steleophaga 9 parts, Radix Salviae Miltiorrhizae 20 parts, Herba Artemisiae Scopariae 20 parts, Herba Lysimachiae 24 parts, Fructus Akebiae 12 parts, Fructus Aurantii 12 parts, Cortex Magnoliae Officinalis 12 parts, Folium Sennae 6 parts.

Embodiment two: Radix Curcumae 16 parts, 11 parts, Semen Persicae, Rhizoma Chuanxiong 16 parts, Ramulus Cinnamomi 12 parts, Radix Et Rhizoma Rhei 10 parts, 9 parts, Natrii Sulfas, the Radix Astragali 30 parts, Radix Codonopsis 15 parts, Radix Rehmanniae Preparata 20 parts, Radix Angelicae Sinensis 18 parts, Cortex Moutan 11 parts, the Radix Paeoniae Alba 16 parts, Rhizoma Corydalis 18 parts, Fructus Toosendan 16 parts, Eupolyphaga Seu Steleophaga 9 parts, Radix Salviae Miltiorrhizae 20 parts, Herba Artemisiae Scopariae 21 parts, Herba Lysimachiae 24 parts, Fructus Akebiae 12 parts, Fructus Aurantii 12 parts, Cortex Magnoliae Officinalis 12 parts, Folium Sennae 7 parts.

Embodiment three: Radix Curcumae 14 parts, 12 parts, Semen Persicae, Rhizoma Chuanxiong 15 parts, Ramulus Cinnamomi 12 parts, Radix Et Rhizoma Rhei 10 parts, 10 parts, Natrii Sulfas, the Radix Astragali 30 parts, Radix Codonopsis 16 parts, Radix Rehmanniae Preparata 18 parts, Radix Angelicae Sinensis 18 parts, Cortex Moutan 11 parts, the Radix Paeoniae Alba 16 parts, Rhizoma Corydalis 18 parts, Fructus Toosendan 15 parts, Eupolyphaga Seu Steleophaga 9 parts, Radix Salviae Miltiorrhizae 21 parts, Herba Artemisiae Scopariae 21 parts, Herba Lysimachiae 25 parts, Fructus Akebiae 13 parts, Fructus Aurantii 12 parts, Cortex Magnoliae Officinalis 11 parts, Folium Sennae 7 parts.

Model case and curative effect:

Case one, patient Wang, man, 36 years old, people from Qingdao City, came here and goes to a doctor on January 18th, 2011.Check: the violent angor of abdominal part, companion's constipation, nausea and vomiting, tetraparesis is unable, paresis, spirit depressing.Symptom Chang Fanfu acute attack, tachycardia, hypertension, urine retention, can change redness under Urine in Patients being exposed to daylight, be diagnosed as hepatic porphyria.Adopt made preparation in the embodiment of the present invention one, and selected preparation method, after a course for the treatment of of treatment, effect is very good.

Case three: Song, female, 32 years old, family's Yishui, Shandong, JIUYUE in 2013 first visit on the 22nd.Diagnosis: abdominal colic, companion's constipation, nausea and vomiting, paresis, there is hallucination in spirit.Chang Fanfu acute attack, can change into dark brown under Urine in Patients being exposed to daylight.Confirm as hepatic porphyria.Adopt made preparation in the embodiment of the present invention one, and selected preparation method, after two courses for the treatment of of treatment, effect is very good.

Claims (4)

1. the Chinese medicine preparation for hepatic porphyria, it is characterized in that, this Chinese medicine preparation is made up of the medicine of following weight portion: Radix Curcumae 13-17 part, Semen Persicae 10-14 part, Rhizoma Chuanxiong 13-17 part, Ramulus Cinnamomi 10-14 part, Radix Et Rhizoma Rhei 8-12 part, Natrii Sulfas 7-11 part, Radix Astragali 28-32 part, Radix Codonopsis 13-17 part, Radix Rehmanniae Preparata 16-20 part, Radix Angelicae Sinensis 16-20 part, Cortex Moutan 10-14 part, Radix Paeoniae Alba 13-17 part, Rhizoma Corydalis 16-20 part, Fructus Toosendan 13-17 part, Eupolyphaga Seu Steleophaga 7-11 part, Radix Salviae Miltiorrhizae 18-22 part, Herba Artemisiae Scopariae 18-22 part, Herba Lysimachiae 22-26 part, Fructus Akebiae 10-14 part, Fructus Aurantii 10-14 part, Cortex Magnoliae Officinalis 10-14 part, Folium Sennae 4-8 part.

2. the Chinese medicine preparation for hepatic porphyria according to claim 1, it is characterized in that, be made up of the medicine of following weight portion: Radix Curcumae 15 parts, 12 parts, Semen Persicae, Rhizoma Chuanxiong 15 parts, Ramulus Cinnamomi 12 parts, Radix Et Rhizoma Rhei 10 parts, 9 parts, Natrii Sulfas, the Radix Astragali 30 parts, Radix Codonopsis 15 parts, Radix Rehmanniae Preparata 18 parts, Radix Angelicae Sinensis 18 parts, Cortex Moutan 12 parts, the Radix Paeoniae Alba 15 parts, Rhizoma Corydalis 18 parts, Fructus Toosendan 15 parts, Eupolyphaga Seu Steleophaga 9 parts, Radix Salviae Miltiorrhizae 20 parts, Herba Artemisiae Scopariae 20 parts, Herba Lysimachiae 24 parts, Fructus Akebiae 12 parts, Fructus Aurantii 12 parts, Cortex Magnoliae Officinalis 12 parts, Folium Sennae 6 parts.

3. the Chinese medicine preparation for hepatic porphyria according to claim 1 and 2, is characterized in that: described Chinese medicine preparation is decoction.

4. for a preparation method for the Chinese medicine preparation of hepatic porphyria, it is characterized in that, preparation method is as follows: step one: by weight of the present invention, gets Radix Rehmanniae Preparata, Natrii Sulfas respectively, grinding, crosses 120 mesh sieves, for subsequent use, step 2: by weight of the present invention, by Semen Persicae, Fructus Akebiae, Fructus Toosendan respectively with gauze wrapping, for subsequent use, step 3: by weight proportion of the present invention, get Radix Curcumae, Rhizoma Chuanxiong, Ramulus Cinnamomi, Radix Et Rhizoma Rhei, the Radix Astragali, Radix Codonopsis, Radix Angelicae Sinensis, Cortex Moutan, the Radix Paeoniae Alba, Rhizoma Corydalis, Eupolyphaga Seu Steleophaga, Radix Salviae Miltiorrhizae, magnolia medicament is placed in marmite, add the water of 8 times of volumes, intense fire infusion 15 ~ 20 minutes, fiery infusion of larding speech with literary allusions is filtered for 30 ~ 40 minutes, add the water of 2 times of volumes again, by Herba Artemisiae Scopariae, Herba Lysimachiae, Fructus Aurantii, Folium Sennae is dropped in marmite, slow fire infusion obtains filtrate in 20 ~ 30 minutes, add monoploid hydrops again, by Semen Persicae in step 2, Fructus Akebiae, Fructus Toosendan drops in marmite, slow fire infusion 20 ~ 30 minutes, infusion merges gained filtrate three times repeatedly, for subsequent use, step 4: by step one gained medicated powder, drops in step 3 gained filtrate, stirs evenly, both Chinese medicine decoction of the present invention.