CN104755625B - 使用突变的胱硫醇γ-合酶从O-磷酸-L-高丝氨酸和甲硫醇制备L-甲硫氨酸的方法 - Google Patents

使用突变的胱硫醇γ-合酶从O-磷酸-L-高丝氨酸和甲硫醇制备L-甲硫氨酸的方法 Download PDF

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CN104755625B
CN104755625B CN201380055160.XA CN201380055160A CN104755625B CN 104755625 B CN104755625 B CN 104755625B CN 201380055160 A CN201380055160 A CN 201380055160A CN 104755625 B CN104755625 B CN 104755625B
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methionine
homoserine
phospho
amino acid
seq
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CN104755625A (zh
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缪里·梅尔卡姆
多米尼克·路易斯
卡琳·加拉尔东
多米尼克·托马斯
菲力浦·马利尔
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Andy Sue French Union Co Ltd
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C12P13/12—Methionine; Cysteine; Cystine
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1085—Transferases (2.) transferring alkyl or aryl groups other than methyl groups (2.5)
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    • C12P11/00—Preparation of sulfur-containing organic compounds
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    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/02—Amides, e.g. chloramphenicol or polyamides; Imides or polyimides; Urethanes, i.e. compounds comprising N-C=O structural element or polyurethanes
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/26—Preparation of nitrogen-containing carbohydrates
    • C12P19/28—N-glycosides
    • C12P19/38—Nucleosides
    • C12P19/40—Nucleosides having a condensed ring system containing a six-membered ring having two nitrogen atoms in the same ring, e.g. purine nucleosides
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    • C12P21/00—Preparation of peptides or proteins
    • C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y205/00—Transferases transferring alkyl or aryl groups, other than methyl groups (2.5)
    • C12Y205/01—Transferases transferring alkyl or aryl groups, other than methyl groups (2.5) transferring alkyl or aryl groups, other than methyl groups (2.5.1)
    • C12Y205/01048—Cystathionine gamma-synthase (2.5.1.48)

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  • Proteomics, Peptides & Aminoacids (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
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CN201380055160.XA 2012-10-26 2013-10-25 使用突变的胱硫醇γ-合酶从O-磷酸-L-高丝氨酸和甲硫醇制备L-甲硫氨酸的方法 Active CN104755625B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP12190150.8 2012-10-26
EP12190150 2012-10-26
PCT/EP2013/072380 WO2014064244A2 (en) 2012-10-26 2013-10-25 Means and methods for the enzymatic production of l-methionine from o-phospho-l-homoserine and methanethiol

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CN104755625A CN104755625A (zh) 2015-07-01
CN104755625B true CN104755625B (zh) 2020-02-07

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US (1) US9803225B2 (https=)
EP (1) EP2912185A2 (https=)
JP (1) JP6438402B2 (https=)
KR (1) KR102126318B1 (https=)
CN (1) CN104755625B (https=)
BR (1) BR112015007212B1 (https=)
IN (1) IN2015DN02439A (https=)
MY (1) MY176164A (https=)
RU (1) RU2650859C2 (https=)
WO (1) WO2014064244A2 (https=)

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US10382927B2 (en) * 2015-08-20 2019-08-13 Samsung Electronics Co., Ltd. Method of text input for wearable devices
EP3330380A1 (en) * 2016-12-05 2018-06-06 Evonik Degussa GmbH Process for producing l-methionine from methional
WO2019011942A1 (en) 2017-07-11 2019-01-17 Adisseo France S.A.S. YEAST PRODUCING METHIONINE
KR102025867B1 (ko) * 2017-07-13 2019-09-27 씨제이제일제당 주식회사 인산을 발효액 또는 발효 폐액으로부터 회수 및 재사용하는 방법
JP6894650B2 (ja) * 2018-10-30 2021-06-30 ＧｒｅｅｎＥａｒｔｈＩｎｓｔｉｔｕｔｅ株式会社 有機化合物の製造方法およびコリネ型細菌
US20220315965A1 (en) * 2019-06-25 2022-10-06 Zymergen Inc. Engineered biosynthetic pathways for production of cystathionine by fermentation
KR102744891B1 (ko) 2022-03-24 2024-12-19 씨제이제일제당 주식회사 인산을 발효액 또는 발효 폐액으로부터 회수 및 재사용하는 방법
JP2026508194A (ja) * 2023-03-01 2026-03-10 フーナン リアー バイオテック カンパニー リミテッド Ｌ－メチオニンをｌ－ホモセリンから直接調製するプロセス

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993017112A1 (en) * 1992-02-20 1993-09-02 Genencor International, Inc. Biosynthesis of methionine using a reduced source of sulfur
WO2011031285A1 (en) * 2009-09-08 2011-03-17 Shai Ufaz Improving essential amino acid content in algae and cyanobacteria for animal feed

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006082254A2 (en) * 2005-02-07 2006-08-10 Metabolic Explorer Microorganisms comprising enzymes expressed with low gamma-elimination activity
CA2615416A1 (en) * 2005-07-18 2007-01-25 Basf Aktiengesellschaft Methionine producing recombinant microorganisms

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993017112A1 (en) * 1992-02-20 1993-09-02 Genencor International, Inc. Biosynthesis of methionine using a reduced source of sulfur
WO2011031285A1 (en) * 2009-09-08 2011-03-17 Shai Ufaz Improving essential amino acid content in algae and cyanobacteria for animal feed

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
Hypermutagenic PCR involving all four transitions and a sizeable proportion of transversions;Vartanian J P et al;《Nucleic Acids Research》;19961231;2627-2631 *
Purification and properties of cystathionine gamma-synthase from wheat(Triticum aestivum L);Kreft B D et al;《Plant Physiology》;19941231;1215-1220 *
代谢途径分析在S－腺苷甲硫氨酸生产中的应用;郑荣勤;《广西轻工业》;20090131;8－9 *

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BR112015007212A2 (pt) 2018-01-30
IN2015DN02439A (https=) 2015-09-04
BR112015007212B1 (pt) 2022-07-05
KR102126318B1 (ko) 2020-06-25
MY176164A (en) 2020-07-24
CN104755625A (zh) 2015-07-01
KR20150076159A (ko) 2015-07-06
WO2014064244A2 (en) 2014-05-01
JP2015533280A (ja) 2015-11-24
JP6438402B2 (ja) 2018-12-12
US9803225B2 (en) 2017-10-31
WO2014064244A3 (en) 2014-08-14
EP2912185A2 (en) 2015-09-02
RU2015119400A (ru) 2016-12-20
US20150275247A1 (en) 2015-10-01
RU2650859C2 (ru) 2018-04-17

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