KR102126318B1 - 돌연변이된 시스타티오닌 감마 신타제를 이용한 o-포스포-l-호모세린 및 메탄티올로부터 l-메티오닌의 제조 방법 - Google Patents

돌연변이된 시스타티오닌 감마 신타제를 이용한 o-포스포-l-호모세린 및 메탄티올로부터 l-메티오닌의 제조 방법 Download PDF

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KR102126318B1
KR102126318B1 KR1020157009704A KR20157009704A KR102126318B1 KR 102126318 B1 KR102126318 B1 KR 102126318B1 KR 1020157009704 A KR1020157009704 A KR 1020157009704A KR 20157009704 A KR20157009704 A KR 20157009704A KR 102126318 B1 KR102126318 B1 KR 102126318B1
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KR20150076159A (ko
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뮈리엘 메르캄므
도미니끄 루이스
카린 자일라흐동
도미니끄 토마스
필립 마리에르
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아디쎄오 프랑스 에스에이에스
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1085—Transferases (2.) transferring alkyl or aryl groups other than methyl groups (2.5)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P11/00—Preparation of sulfur-containing organic compounds
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/02—Amides, e.g. chloramphenicol or polyamides; Imides or polyimides; Urethanes, i.e. compounds comprising N-C=O structural element or polyurethanes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C12P13/12—Methionine; Cysteine; Cystine
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/26—Preparation of nitrogen-containing carbohydrates
    • C12P19/28—N-glycosides
    • C12P19/38—Nucleosides
    • C12P19/40—Nucleosides having a condensed ring system containing a six-membered ring having two nitrogen atoms in the same ring, e.g. purine nucleosides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y201/00—Transferases transferring one-carbon groups (2.1)
    • C12Y201/01—Methyltransferases (2.1.1)
    • C12Y201/01013—Methionine synthase (2.1.1.13)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y205/00—Transferases transferring alkyl or aryl groups, other than methyl groups (2.5)
    • C12Y205/01—Transferases transferring alkyl or aryl groups, other than methyl groups (2.5) transferring alkyl or aryl groups, other than methyl groups (2.5.1)
    • C12Y205/01048—Cystathionine gamma-synthase (2.5.1.48)

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
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  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
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  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
KR1020157009704A 2012-10-26 2013-10-25 돌연변이된 시스타티오닌 감마 신타제를 이용한 o-포스포-l-호모세린 및 메탄티올로부터 l-메티오닌의 제조 방법 Active KR102126318B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP12190150.8 2012-10-26
EP12190150 2012-10-26
PCT/EP2013/072380 WO2014064244A2 (en) 2012-10-26 2013-10-25 Means and methods for the enzymatic production of l-methionine from o-phospho-l-homoserine and methanethiol

Publications (2)

Publication Number Publication Date
KR20150076159A KR20150076159A (ko) 2015-07-06
KR102126318B1 true KR102126318B1 (ko) 2020-06-25

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KR1020157009704A Active KR102126318B1 (ko) 2012-10-26 2013-10-25 돌연변이된 시스타티오닌 감마 신타제를 이용한 o-포스포-l-호모세린 및 메탄티올로부터 l-메티오닌의 제조 방법

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Country Link
US (1) US9803225B2 (https=)
EP (1) EP2912185A2 (https=)
JP (1) JP6438402B2 (https=)
KR (1) KR102126318B1 (https=)
CN (1) CN104755625B (https=)
BR (1) BR112015007212B1 (https=)
IN (1) IN2015DN02439A (https=)
MY (1) MY176164A (https=)
RU (1) RU2650859C2 (https=)
WO (1) WO2014064244A2 (https=)

Families Citing this family (8)

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US10382927B2 (en) * 2015-08-20 2019-08-13 Samsung Electronics Co., Ltd. Method of text input for wearable devices
EP3330380A1 (en) * 2016-12-05 2018-06-06 Evonik Degussa GmbH Process for producing l-methionine from methional
WO2019011942A1 (en) 2017-07-11 2019-01-17 Adisseo France S.A.S. YEAST PRODUCING METHIONINE
KR102025867B1 (ko) * 2017-07-13 2019-09-27 씨제이제일제당 주식회사 인산을 발효액 또는 발효 폐액으로부터 회수 및 재사용하는 방법
JP6894650B2 (ja) * 2018-10-30 2021-06-30 ＧｒｅｅｎＥａｒｔｈＩｎｓｔｉｔｕｔｅ株式会社 有機化合物の製造方法およびコリネ型細菌
US20220315965A1 (en) * 2019-06-25 2022-10-06 Zymergen Inc. Engineered biosynthetic pathways for production of cystathionine by fermentation
KR102744891B1 (ko) 2022-03-24 2024-12-19 씨제이제일제당 주식회사 인산을 발효액 또는 발효 폐액으로부터 회수 및 재사용하는 방법
JP2026508194A (ja) * 2023-03-01 2026-03-10 フーナン リアー バイオテック カンパニー リミテッド Ｌ－メチオニンをｌ－ホモセリンから直接調製するプロセス

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011031285A1 (en) 2009-09-08 2011-03-17 Shai Ufaz Improving essential amino acid content in algae and cyanobacteria for animal feed

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Publication number Priority date Publication date Assignee Title
JPH07503855A (ja) * 1992-02-20 1995-04-27 ジェネンコア　インターナショナル　インコーポレーテッド 硫黄の還元源を用いたメチオニンの生合成
WO2006082254A2 (en) * 2005-02-07 2006-08-10 Metabolic Explorer Microorganisms comprising enzymes expressed with low gamma-elimination activity
CA2615416A1 (en) * 2005-07-18 2007-01-25 Basf Aktiengesellschaft Methionine producing recombinant microorganisms

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011031285A1 (en) 2009-09-08 2011-03-17 Shai Ufaz Improving essential amino acid content in algae and cyanobacteria for animal feed

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
Journal of Biological Chemistry, Vol. 277, pp. 36380-36386 (2002.)
Nucleic Acid Research, Vol. 24, pp. 2627-2631 (1996.)
Plant Physiology, Vol. 128, pp. 454-462 (2002.)

Also Published As

Publication number Publication date
BR112015007212A2 (pt) 2018-01-30
IN2015DN02439A (https=) 2015-09-04
BR112015007212B1 (pt) 2022-07-05
MY176164A (en) 2020-07-24
CN104755625A (zh) 2015-07-01
KR20150076159A (ko) 2015-07-06
WO2014064244A2 (en) 2014-05-01
JP2015533280A (ja) 2015-11-24
JP6438402B2 (ja) 2018-12-12
US9803225B2 (en) 2017-10-31
WO2014064244A3 (en) 2014-08-14
EP2912185A2 (en) 2015-09-02
RU2015119400A (ru) 2016-12-20
US20150275247A1 (en) 2015-10-01
RU2650859C2 (ru) 2018-04-17
CN104755625B (zh) 2020-02-07

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