CN104718004A - 新的氮杂苯并咪唑六氢呋喃并[3,2-b]呋喃衍生物 - Google Patents

新的氮杂苯并咪唑六氢呋喃并[3,2-b]呋喃衍生物 Download PDF

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Publication number
CN104718004A
CN104718004A CN201380055225.0A CN201380055225A CN104718004A CN 104718004 A CN104718004 A CN 104718004A CN 201380055225 A CN201380055225 A CN 201380055225A CN 104718004 A CN104718004 A CN 104718004A
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China
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alkyl
aryl
ring
heteroaryl
thiazolinyl
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Pending
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CN201380055225.0A
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Chinese (zh)
Inventor
J.M.阿普加
A.阿拉萨潘
T.比夫图
陈萍
冯丹青
E.圭德里
J.希克斯
A.克克奇
K.利维特
厉冰
T.麦克拉肯
I.塞巴特
X.钱
魏兰
R.维尔克宁
吴志才
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Merck Sharp and Dohme LLC
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Schering Corp
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Publication of CN104718004A publication Critical patent/CN104718004A/zh
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • A61K31/366—Lactones having six-membered rings, e.g. delta-lactones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/397—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having four-membered rings, e.g. azetidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/438—The ring being spiro-condensed with carbocyclic or heterocyclic ring systems
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
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    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/501—Pyridazines; Hydrogenated pyridazines not condensed and containing further heterocyclic rings
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/541—Non-condensed thiazines containing further heterocyclic rings
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    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CN201380055225.0A 2012-08-22 2013-08-19 新的氮杂苯并咪唑六氢呋喃并[3,2-b]呋喃衍生物 Pending CN104718004A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261692018P 2012-08-22 2012-08-22
US61/692018 2012-08-22
PCT/US2013/055528 WO2014031515A1 (en) 2012-08-22 2013-08-19 Novel azabenzimidazole hexahydrofuro[3,2-b]furan derivatives

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CN104718004A true CN104718004A (zh) 2015-06-17

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US (1) US9290517B2 (US07714131-20100511-C00038.png)
EP (1) EP2888005B1 (US07714131-20100511-C00038.png)
JP (1) JP2015526468A (US07714131-20100511-C00038.png)
KR (1) KR20150045436A (US07714131-20100511-C00038.png)
CN (1) CN104718004A (US07714131-20100511-C00038.png)
AR (1) AR092201A1 (US07714131-20100511-C00038.png)
AU (1) AU2013306030A1 (US07714131-20100511-C00038.png)
BR (1) BR112015003109A2 (US07714131-20100511-C00038.png)
CA (1) CA2881836A1 (US07714131-20100511-C00038.png)
RU (1) RU2015109706A (US07714131-20100511-C00038.png)
TW (1) TW201412751A (US07714131-20100511-C00038.png)
WO (1) WO2014031515A1 (US07714131-20100511-C00038.png)

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CN105503927A (zh) * 2016-01-11 2016-04-20 沧州普瑞东方科技有限公司 一种合成3,6-二氢-2h-吡(噻)喃-4-硼酸酯的方法
CN106478653A (zh) * 2016-10-16 2017-03-08 云南民族大学 异山梨醇—单咪唑盐类化合物及其制备方法
CN111423435A (zh) * 2020-03-30 2020-07-17 厦门大学 (1H-咪唑并[4,5-b]吡啶-6-基)吡啶衍生物及其应用
CN113891891A (zh) * 2019-03-05 2022-01-04 戒毒及精神健康中心 Ampa受体信号转导的调节剂
CN115944612A (zh) * 2022-12-23 2023-04-11 敖虎山 胰高血糖素拮抗剂阿度格列凡的新用途
CN117838690A (zh) * 2023-10-09 2024-04-09 中国药科大学 一种治疗以ampk激活为治疗靶点的疾病的复方药物及其应用

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US9540364B2 (en) 2012-08-22 2017-01-10 Merck Sharp & Dohme Corp. Benzimidazole tetrahydrofuran derivatives
EP2888006B1 (en) 2012-08-22 2019-04-24 Merck Sharp & Dohme Corp. Novel azabenzimidazole tetrahydropyran derivatives useful as ampk activators
EP2906040B1 (en) 2012-08-22 2021-02-17 Merck Sharp & Dohme Corp. Novel benzimidazole tetrahydropyran derivatives
US9556193B2 (en) 2012-08-22 2017-01-31 Merck Shapr & Dohme Corp. Benzimidazole hexahydrofuro[3,2-b]furan derivatives
WO2014031517A1 (en) 2012-08-22 2014-02-27 Merck Sharp & Dohme Corp. Novel azabenzimidazole tetrahydrofuran derivatives
EP2963013A4 (en) 2013-02-27 2016-09-14 Shionogi & Co INDOLE AND AZAINDOLE DERIVATIVES HAVING AMPK ACTIVATION ACTIVITY EACH
ES2669543T3 (es) * 2013-07-17 2018-05-28 Boehringer Ingelheim International Gmbh Nuevos derivados de azabenzimidazol
KR20170044184A (ko) 2014-08-27 2017-04-24 시오노기세야쿠 가부시키가이샤 Ampk 활성화 작용을 갖는 아자인돌 유도체
CN107108521A (zh) 2014-10-28 2017-08-29 盐野义制药株式会社 具有ampk活化作用的杂环衍生物
WO2016113300A1 (en) * 2015-01-16 2016-07-21 Boehringer Ingelheim International Gmbh New azabenzimidazole derivatives as agonists of the amp-activated protein kinase
AU2016280255A1 (en) 2015-06-18 2018-02-08 Cephalon, Inc. 1, 4-substituted piperidine derivatives
CA3014432C (en) 2015-06-18 2024-05-07 Cephalon, Inc. Substituted 4-benzyl and 4-benzoyl piperidine derivatives
EP3421467A4 (en) 2016-02-26 2019-08-07 Shionogi & Co., Ltd 5-PHENYLAZAINDOLE DERIVATIVE HAVING AMPK ACTIVATION EFFECT
WO2017200068A1 (ja) 2016-05-20 2017-11-23 塩野義製薬株式会社 Ａｍｐｋ活性化作用を有する５－置換ベンズイミダゾールおよび５－置換アザベンズイミダゾール誘導体
US11590161B2 (en) 2018-08-13 2023-02-28 Viscera Labs, Inc. Therapeutic composition and methods
US11524029B2 (en) 2018-08-13 2022-12-13 Viscera Labs, Inc. Therapeutic composition and methods
CN116323608A (zh) 2020-05-19 2023-06-23 卡尔优普公司 Ampk活化剂
AU2021297323A1 (en) 2020-06-26 2023-02-16 Kallyope, Inc. AMPK activators
US20240101563A1 (en) * 2022-07-28 2024-03-28 Ac Immune Sa Novel compounds
KR102638391B1 (ko) * 2023-05-30 2024-02-20 삼화페인트공업주식회사 다이알칸설포닐 아이소소바이드 화합물의 제조 방법, 리튬이차전지용 전해액 첨가제, 리튬이차전지용 전해액 및 리튬이차전지

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CN102361857A (zh) * 2008-09-26 2012-02-22 默沙东公司 可用作抗糖尿病剂的新颖的环状苯并咪唑衍生物
TW201217372A (en) * 2010-09-10 2012-05-01 Shionogi & Amp Co Ltd Heterocycle fused imidazole derivative having AMPK activating activity
CN103476258A (zh) * 2011-02-25 2013-12-25 默沙东公司 用作抗糖尿病药剂的新的环状氮杂苯并咪唑衍生物

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