CN104706690A - Ching's briggsia extract and application thereof in medicament for treating gastric ulcer - Google Patents
Ching's briggsia extract and application thereof in medicament for treating gastric ulcer Download PDFInfo
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- CN104706690A CN104706690A CN201510077512.2A CN201510077512A CN104706690A CN 104706690 A CN104706690 A CN 104706690A CN 201510077512 A CN201510077512 A CN 201510077512A CN 104706690 A CN104706690 A CN 104706690A
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Abstract
The invention relates to the technical field of medicine, in particular to a ching's briggsia extract and application thereof in a medicament for treating gastric ulcer. The ching's briggsia extract is prepared by extracting a raw material ching's briggsia. The extract is prepared by the following steps: drying and crushing the raw material ching's briggsia; adding ching's briggsia powder obtained by crushing into water with an amount which is 5 to 15 times to that of the ching's briggsia powder, adding 1,000 to 2,000 units of trypsin and 3,000 to 5,000 units of superoxide dismutase into every gram of the raw material, heating the mixture to 36 to 38 DEG C, and performing reaction for 2 to 4 hours with stirring; after reaction, performing distillation and concentration under reduced pressure to obtain extract, adding chloroform with an amount which is 3 to 5 times to that of the extract, performing stirring and filtering to obtain filtrate, and performing distillation and concentration on the filtrate under reduced pressure to obtain the extract. According to the ching's briggsia extract and the application thereof in the medicament for treating gastric ulcer, the ching's briggsia extract has the characteristics of low cost and convenience in use, and gastric ulcer can be effectively treated.
Description
Technical field
The present invention relates to medical art, be specifically related to a kind of Herba Briggsiae Chienii extract and the application in treatment Gastric Ulcer Treatment thereof.
Background technology
Chronic ulcer between cardia to pylorus is referred to as gastric ulcer (gastric ulcer, GU), is the one of peptic ulcer.Peptic ulcer (peptic ulcer) can occur in Stomach duodenum, also can occur in lower esophageal, near stomach-intestinal anastomosis mouth and in your diverticulum of Meike on Ectopic Gastric Mucosa.The formation of these ulcer is all relevant with pepsic Digestion with gastric acid, therefore is called peptic ulcer.The primary disease overwhelming majority is positioned at harmonization of the stomach duodenum (98% ~ 99%).In crowd, about there is the people of 10% may suffer from this disease in the middle of all one's life, be therefore a frequently-occurring disease and commonly encountered diseases, occupy an important position in Gastroenterology dept..
Gastric ulcer is that inflammation causes gastric gland atrophy to gastric mucosa repeatedly, mucous layer is the change of special reproducibility, belong to Chinese medicine stomach painful abdominal mass category, referring to gastral cavilty painful abdominal mass plug, fullly vexedly not relax, is main manifestations without stomachache and the swollen urgency of profile, spleen not transporting, stomach lose along falling, raw, poly-and be trouble in phlegm-damp.Tcm clinical practice adopting regulates the flow of vital energy disappears the ruling by law treatment gastric ulcer of stagnant, normalizing the stomach by guiding QI downward, achieves good curative effect.
Herba Briggsiae Chienii is herb or the root of Gesneriaceae Herba Briggsiae Chienii, another name: Rhizoma Seu Herba Bergeniae, Budgerigar, little lotus grass.Nature and flavor: micro-hardship are flat.Although prior art reports the pharmaceutical effect of some Herba Briggsiae Chieniis, how improving the drug action of Herba Briggsiae Chienii, the pharmaceutical active particularly in treatment gastric ulcer, is those skilled in the art's technical problems urgently to be resolved hurrily.
Summary of the invention
The present invention is directed to the deficiencies in the prior art, by the screening of several years with repeatedly test, a kind of Herba Briggsiae Chienii extract and the application in treatment Gastric Ulcer Treatment thereof are provided, are characterized in that cost is low, easy to use, effectively can treat gastric ulcer.In order to realize object of the present invention, intend adopting following technical scheme:
One aspect of the present invention relates to a kind of Herba Briggsiae Chienii extract, it is characterized in that described extract Herba Briggsiae Chienii is that raw material is prepared from by extraction.
In a preferred embodiment of the present invention, described extract is prepared from as follows:
A () gets Herba Briggsiae Chienii is raw material, dry, pulverize;
(b) pulverize after Herba Briggsiae Chienii powder add in the water of 5-15 times of weight and every gram of raw material and add 1000-2000 unit pepsin and 3000-5000 unit superoxide dismutase, be heated to 36-38 DEG C, under stirring state, react 2-4 hour;
C () reaction terminates after, distilling under reduced pressure is concentrated obtains extractum, and add the chloroform of extractum 3-5 times weight, filter to get filtrate after stirring, namely filtrate decompression distillation and concentration obtains extract.
The present invention also relates to the application of above-mentioned Chinese medicine extract in preparation treatment Gastric Ulcer Treatment on the other hand; Preferably, described medicine does not comprise other Chinese medicine or western medicine component.
In a preferred embodiment of the present invention, described medicine is oral formulations.
The Chinese medicine extract for the treatment of treatment gastric ulcer of the present invention by clinical research, treatment gastric ulcer determined curative effect, obviously.
Detailed description of the invention
If not specified, the conventional means that technological means used in embodiment is well known to those skilled in the art.
Embodiment 1:
1 clinical data
Choose 2 ~ October in 2013 because of gastric ulcer be in hospital patient 100 example, wherein male 69 example, women 31 example, age 21-70 year, average 46 years old, course of disease l-15, average 7.5 years.Wherein merge atrophic gastritis 6 example.Gastric Ulcer standard during all patients all meet " in two doctor clinical disease for digest ", and make a definite diagnosis through gastroscopy.100 routine patients are divided at random treatment group 50 example, observation group 50 example.Two groups are compared in sex, age, the course of disease, no significant difference.
2 Therapeutic Method
Matched group 15 minutes after the meal oral ranitidine+Amoxicillin Capsules 0.15 g, 2 weeks are 1 course for the treatment of, are used in conjunction 2-3 courses for the treatment of.；
Treatment group adopts Chinese medicine extract.Medicine forms: Herba Briggsiae Chienii extract, is prepared from as follows:
A () gets Herba Briggsiae Chienii is raw material, dry, pulverize;
(b) pulverize after Herba Briggsiae Chienii powder add in the water of 10 times of weight and every gram of raw material and add 1500 unit pepsin and 4000 unit superoxide dismutases, be heated to 37 DEG C, react 3 hours under stirring state;
C () reaction terminates after, distilling under reduced pressure is concentrated obtains extractum, and add the chloroform of extractum 4 times of weight, filter to get filtrate after stirring, namely filtrate decompression distillation and concentration obtains extract.
Get 0.5g extract, warm water is taken at every turn, and sooner or later respectively take 1 time, serveing on 15 days is a course for the treatment of, totally 1 course for the treatment of.
3 results
3.1 efficacy determination
Recovery from illness: stomachache transference cure, check under gastroscope and see cicatrization ulcer healing, Hp eradicates;
Effective: clinical symptom remission, check under gastroscope and see part cicatrization >50%, enter healing stage, Hp elimination factor >=50%;
Invalid: clinical symptoms, substantially without alleviation, is shown in a small amount of or produces ulcer, Hp elimination factor <50% without cicatrization under gastroscope.
Total effectively for recovery from illness adds effectively.
4 statistical results
| Group | N | Recovery from illness | Effectively | Invalid | Total effective rate |
| Treatment group | 50 | 30 | 10 | 10 | 80% |
| Matched group | 50 | 20 | 14 | 16 | 68% |
As can be seen from the above table, after the treatment of a course for the treatment of, the curative effect for the treatment of group patient is obviously better than the curative effect of matched group patient.
The above is the preferred embodiments of the present invention; it should be pointed out that for those skilled in the art, under the prerequisite not departing from principle of the present invention; can also make some improvements and modifications, these improvements and modifications also should be considered as protection scope of the present invention.
Claims (4)
1. a Herba Briggsiae Chienii extract, is characterized in that described extract Herba Briggsiae Chienii is that raw material is prepared from by extraction.
2. a Herba Briggsiae Chienii extract, is characterized in that described extract is prepared from as follows:
A () gets Herba Briggsiae Chienii is raw material, dry, pulverize;
(b) pulverize after Herba Briggsiae Chienii powder add in the water of 5-15 times of weight and every gram of raw material and add 1000-2000 unit pepsin and 3000-5000 unit superoxide dismutase, be heated to 36-38 DEG C, under stirring state, react 2-4 hour;
C () reaction terminates after, distilling under reduced pressure is concentrated obtains extractum, and add the chloroform of extractum 3-5 times weight, filter to get filtrate after stirring, namely filtrate decompression distillation and concentration obtains extract.
3. the application of above-mentioned Chinese medicine extract in preparation treatment Gastric Ulcer Treatment; Preferably, described medicine does not comprise other Chinese medicine or western medicine component.
4. application according to claim 3, described medicine is oral formulations.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510077512.2A CN104706690B (en) | 2015-02-13 | 2015-02-13 | A kind of chien briggsia herb extract and its application in Gastric Ulcer Treatment is treated |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201510077512.2A CN104706690B (en) | 2015-02-13 | 2015-02-13 | A kind of chien briggsia herb extract and its application in Gastric Ulcer Treatment is treated |
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| CN104706690A true CN104706690A (en) | 2015-06-17 |
| CN104706690B CN104706690B (en) | 2018-04-27 |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109172645A (en) * | 2018-11-21 | 2019-01-11 | 思南县人民医院 | A kind of Chinese medicine composition and preparation method thereof for treating gastric ulcer |
| CN109200102A (en) * | 2018-11-21 | 2019-01-15 | 思南县人民医院 | It is a kind of to treat helicobacter pylori Chinese medicinal composition preparation and preparation method thereof |
| CN109288944A (en) * | 2018-11-21 | 2019-02-01 | 思南县人民医院 | A kind of rhizoma cyperi prepares Eradication Therapy of Helicobacter pylori Infection preparation and preparation method thereof |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103585460A (en) * | 2013-11-06 | 2014-02-19 | 周慧 | Packing agent for gingival hemostasis |
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Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103585460A (en) * | 2013-11-06 | 2014-02-19 | 周慧 | Packing agent for gingival hemostasis |
Non-Patent Citations (3)
| Title |
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| 中医内科眼科治验集: "《中医内科眼科治验集》", 31 August 1995, 中医古籍出版社 * |
| 南京中医药大学: "《中药大辞典》", 31 March 2006, 上海科学技术出版社 * |
| 高文远: "《中药生物工程》", 31 January 2014, 上海科学技术出版社 * |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109172645A (en) * | 2018-11-21 | 2019-01-11 | 思南县人民医院 | A kind of Chinese medicine composition and preparation method thereof for treating gastric ulcer |
| CN109200102A (en) * | 2018-11-21 | 2019-01-15 | 思南县人民医院 | It is a kind of to treat helicobacter pylori Chinese medicinal composition preparation and preparation method thereof |
| CN109288944A (en) * | 2018-11-21 | 2019-02-01 | 思南县人民医院 | A kind of rhizoma cyperi prepares Eradication Therapy of Helicobacter pylori Infection preparation and preparation method thereof |
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| CN104706690B (en) | 2018-04-27 |
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