CN105267656A

CN105267656A - Traditional Chinese medicine composition for treating constipation occurring after malignant neoplasm chemotherapy

Info

Publication number: CN105267656A
Application number: CN201510670046.9A
Authority: CN
Inventors: 王春峰
Original assignee: Individual
Current assignee: Individual
Priority date: 2015-10-09
Filing date: 2015-10-09
Publication date: 2016-01-27

Abstract

The invention discloses a traditional Chinese medicine composition for treating constipation occurring after malignant neoplasm chemotherapy. Traditional Chinese medicine holds that constipation due to intestinal dryness can occurs to people with cancer due to yin injury caused by prolonged illness, internal heat caused by yin deficiency and body fluid deficiency. A decoction is made by decocting herbs: Basella alba leaf or herb, flower of hollyhock, woody-rhizomed Fimbristylis herb, Henry Clematis root or leaf, Fructus Cannabis, Semen Pruni Japonica, common flax seed, smallflower Seaberry herb, sorrel Rhubarb stem, pedunculate Acronychia wood or root, Radix Polygonati Officinalis and adhesive rehmannia dried root, and clinical experiments show that the total effective rate is 95%, obviously superior to 75% of a control, and the side effect is low.

Description

A kind of Chinese medicine composition for the treatment of constipation after malignant tumor chemotherapy

Technical field

The present invention relates to a kind of Chinese medicine composition, particularly relate to a kind of Chinese medicine composition for the treatment of constipation after malignant tumor chemotherapy

Background technology

Along with the aggravation of China's the aging process of the society and the impact of the factor such as environmental pollution, unhealthy life style, cancer presents the trend constantly risen at the sickness rate of China, the life and health of serious threat patient, brings white elephant to family and society.At present, clinically there is no the method for curing cancer completely, one of chemotherapy main method being still clinical cancer therapy.Cancer patient is when accepting chemotherapeutic treatment, himself is not only subject to the torment of disease, the side effect of chemotherapy process Chinese medicine, such as constipation, Nausea and vomiting etc., the body and mind of patient is usually made to be in the unbalance passive state of painful anxiety, the serious life quality reducing patient.One of side effect the most common during constipation is chemotherapy, doctor trained in Western medicine mainly adopts the medicine improving gastrointestinal motility ability, and such as the method such as cathartic, coloclysis, carries out symptomatic treatment, its treatment easily causes people digest road Flora Disturbance, and easily occurs aggravation after drug withdrawal.Clinical research confirmation, differentiation of tcm has obvious advantage to the constipation side effect that cancer chemotherapy causes, and obviously can alleviate the pain of patient, improves the life quality of patient.Applicant through years'experiences, the Chinese medicine composition of constipation during developing a kind of Therapeutic cancer Chemotherapy in Patients, and achieve satisfied curative effect.

Summary of the invention

The object of this invention is to provide a kind of Chinese medicine composition for the treatment of constipation after malignant tumor chemotherapy.The traditional Chinese medical science is thought: cancer patient can cause dryness of the intestine constipation because of prolonged illness impairment of YIN, yin asthenia generating intrinsic heat, deficiency of body fluid.Chemotherapeutics is impairing the spleen and stomach more, and transporting and transforming function of the spleen and stomach is not normal, and body fluid must not four cloth, the withered large intestine that can not make moist in Tianjin, the withered accumulation of heat in Tianjin, and intestinal loses and makes moist, therefore constipation.Control and work as clearing away heat and moistening the bowels, purging FU-organs of regulating the flow of vital energy.

The object of the invention is to be achieved through the following technical solutions, after this treatment malignant tumor chemotherapy, the Chinese medicine composition of constipation is made up of the Chinese medicine of following weight: Herba basellae rubrae 5-10 part, Flos althaeae roseae 5-10 part, Radix Fimbristylis rigidulae 8-12 part, Radix Clematidis Henryi 8-12 part, Fructus Cannabis 7-13 part, Semen Pruni 7-13 part, Semen Lini 7-13 part, Herba Haloragidis Micranthae 10-15 part, Caulis Rhei 10-15 part, Lignum seu Radix Acronychiae 10-15 part, Rhizoma Polygonati Odorati 7-12 part, Radix Rehmanniae 7-12 part.

Preferably: Herba basellae rubrae 7 parts, Flos althaeae roseae 7 parts, Radix Fimbristylis rigidulae 10 parts, Radix Clematidis Henryi 10 parts, Fructus Cannabis 10 parts, Semen Pruni 10 parts, Semen Lini 10 parts, Herba Haloragidis Micranthae 13 parts, Caulis Rhei 13 parts, Lignum seu Radix Acronychiae 13 parts, Rhizoma Polygonati Odorati 9 parts, Radix Rehmanniae 9 parts.

Preparation method: traditionally make decoction.

Fang Zhong: Herba basellae rubrae heat clearing away laxation, removing pathogenic heat from blood and toxic substance from the body; Flos althaeae roseae and blood are moisturized, smoothening secretion; Radix Fimbristylis rigidulae is nourshing Yin and drynsessmoistening prescription, the beneficial damage of tonify deficiency; Radix Clematidis Henryi promoting flow of QI and blood, anti-inflammation; Fructus Cannabis is moisturized laxation, treating strangurialy to be invigorated blood circulation; Semen Pruni moisturizes laxation, therapeutic method to keep the adverse QI flowing downwards diuretic; Semen Lini leads to intestine and small intestine, suppressing the hyperactive liver is pleasant; Herba Haloragidis Micranthae heat clearing and blood circulation promoting, removing toxic substances, relieving constipation; The logical stool of Caulis Rhei, bowel relieving heat; Lignum seu Radix Acronychiae promoting flow of QI and blood, spleen invigorating cough-relieving; Rhizoma Polygonati Odorati nourishing YIN to relieve dryness, relieving restlessness; Radix Rehmanniae nourishing YIN and benefiting blood.

Clinical data

1, physical data: full group 80 example, all through proved by pathology be malignant tumor.Man 40 example, female 40 example; Age 30-68 year, the median age 57 years old.Wherein pulmonary carcinoma 20 example, hepatocarcinoma 10 example, gastric cancer 20 example, mammary cancer 10 example, colorectal cancer 10 example, malignant lymphoma 5 example, multiple myeloma 5 example.The course of disease 2 months-4 years is not etc.All patient KPS scoring > 60 points.Patient gets rid of gut region property blocks, or previously has habitual constipation medical history, and all patients all accept intravenous chemotherapy, the equal preventive use 5-HT of all patients ₃receptor antagonist granisetron emesis, treatments period generation constipation.

2, evaluation criterion: constipation diagnostic criteria: (1) defecation frequency reduces; (2) difficult defecation or have row to feel not to the utmost; (3) feces is dry and hard hard.If 1-3 item possess wherein 1 or combination can be diagnosed as constipation.Usually be reduced to master with stool, general every 2-3 days or longer time defecation be constipation 1 time.

3, Therapeutic Method: patient is divided into two groups, treatment group and matched group, the sex of case selected by two groups, age, the tumor course of disease, tumor class and stadium, tumor histology's typing, previously treat situation, in the recent period chemotherapeutics kind and consumption, through statistical procedures there are no significant difference.Treatment group 40 example, take Chinese medicine of the present invention, prescription is: Herba basellae rubrae 7 grams, Flos althaeae roseae 7 grams, Radix Fimbristylis rigidulae 10 grams, Radix Clematidis Henryi 10 grams, Fructus Cannabis 10 grams, Semen Pruni 10 grams, Semen Lini 10 grams, Herba Haloragidis Micranthae 13 grams, Caulis Rhei 13 grams, Lignum seu Radix Acronychiae 13 grams, Rhizoma Polygonati Odorati 9 grams, Radix Rehmanniae 9 grams, decocting extracting juice 300ml, point early, evening is oral; 1 dose/d, 5 doses/week, to illumination group 40 example, phenolphthalein (phenolphthalein tablets) 100mg per os hora somni.

4, criterion of therapeutical effect, effective by " Chinese medical disease Standardization of diagnosis and curative effect ": defecation 1 time in 2 days, just matter turns profit, and defecation is unobstructed, and short-term is without recurrence; Effective: defecation 1 time in 3 days, just matter turns profit, and defecation owes unobstructed; Invalid: symptom is without improvement; Effective adding is effectively total effective rate.

5, therapeutic outcome: effective 30 examples for the treatment of group, effective 8 examples, invalid 2 examples, total effective rate 95%; Effective 20 examples of matched group, effective 10 examples, invalid 10 examples, total effective rate 75%.Two groups of comparing differences have significance, and treatment group is obviously better than illumination.

Untoward reaction: treatment group loose stool 1 side, stomachache 1 example, mild symptoms; Matched group: stomachache 7 example, loose stool 6 example, mild symptoms, does not all affect continuation medication.

Detailed description of the invention

Embodiment one: take Herba basellae rubrae 7 grams, Flos althaeae roseae 7 grams, Radix Fimbristylis rigidulae 10 grams, Radix Clematidis Henryi 10 grams, Fructus Cannabis 10 grams, Semen Pruni 10 grams, Semen Lini 10 grams, Herba Haloragidis Micranthae 13 grams, Caulis Rhei 13 grams, Lignum seu Radix Acronychiae 13 grams, Rhizoma Polygonati Odorati 9 grams, Radix Rehmanniae 9 grams, decocting extracting juice 300ml, point early, evening is oral.

Embodiment two: take Herba basellae rubrae 10 grams, Flos althaeae roseae 5 grams, Radix Fimbristylis rigidulae 8 grams, Radix Clematidis Henryi 12 grams, Fructus Cannabis 7 grams, Semen Pruni 13 grams, Semen Lini 7 grams, Herba Haloragidis Micranthae 10 grams, Caulis Rhei 15 grams, Lignum seu Radix Acronychiae 10 grams, Rhizoma Polygonati Odorati 7 grams, Radix Rehmanniae 12 grams, decocting extracting juice 300ml, point early, evening is oral.

Embodiment three: take Herba basellae rubrae 5 grams, Flos althaeae roseae 10 grams, Radix Fimbristylis rigidulae 12 grams, Radix Clematidis Henryi 8 grams, Fructus Cannabis 13 grams, Semen Pruni 7 grams, Semen Lini 13 grams, Herba Haloragidis Micranthae 15 grams, Caulis Rhei 10 grams, Lignum seu Radix Acronychiae 15 grams, Rhizoma Polygonati Odorati 12 grams, Radix Rehmanniae 7 grams, decocting extracting juice 300ml, point early, evening is oral.

Claims

1. treat a Chinese medicine composition for constipation after malignant tumor chemotherapy, it is characterized in that this Chinese medicine composition is made up of the Chinese medicine of following weight: Herba basellae rubrae 5-10 part, Flos althaeae roseae 5-10 part, Radix Fimbristylis rigidulae 8-12 part, Radix Clematidis Henryi 8-12 part, Fructus Cannabis 7-13 part, Semen Pruni 7-13 part, Semen Lini 7-13 part, Herba Haloragidis Micranthae 10-15 part, Caulis Rhei 10-15 part, Lignum seu Radix Acronychiae 10-15 part, Rhizoma Polygonati Odorati 7-12 part, Radix Rehmanniae 7-12 part.

2. a kind of Chinese medicine composition for the treatment of constipation after malignant tumor chemotherapy as claimed in claim 1, is characterized in that this Chinese medicine composition is made up of the Chinese medicine of following weight: Herba basellae rubrae 7 parts, Flos althaeae roseae 7 parts, Radix Fimbristylis rigidulae 10 parts, Radix Clematidis Henryi 10 parts, Fructus Cannabis 10 parts, Semen Pruni 10 parts, Semen Lini 10 parts, Herba Haloragidis Micranthae 13 parts, Caulis Rhei 13 parts, Lignum seu Radix Acronychiae 13 parts, Rhizoma Polygonati Odorati 9 parts, Radix Rehmanniae 9 parts.