CN105213991B - Traditional Chinese medicine composition for treating gastroesophageal reflux disease - Google Patents
Traditional Chinese medicine composition for treating gastroesophageal reflux disease Download PDFInfo
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Abstract
The invention relates to the field of medicament formulas, in particular to a traditional Chinese medicine composition for treating gastroesophageal reflux disease, which is characterized by being prepared from the following raw material medicines in parts by weight: 5-9 parts of radix bupleuri, 4-7 parts of radix paeoniae alba, 4-8 parts of fructus aurantii, 4-7 parts of fructus toosendan, 4-8 parts of rhizoma corydalis, 5-8 parts of coptis chinensis, 6-9 parts of fructus evodiae, 6-9 parts of radix curcumae, 7-9 parts of endothelium corneum gigeriae galli, 6-9 parts of radix clematidis, 2-5 parts of pseudo-ginseng, 6-9 parts of rhizoma bletillae, 2-5 parts of cuttle bone, 4-6 parts of thunberg fritillary bulb, 2-4 parts of concha arcae, 4-6 parts of oyster, 2-4 parts of radix glycyrrhizae preparata and.
Description
Technical Field
The invention relates to a Chinese patent medicine preparation, in particular to a traditional Chinese medicine composition for treating gastroesophageal reflux disease.
Background
It is known that gastroesophageal reflux disease refers to a condition in which the contents of the gastroduodenal tract reversely flow into the esophagus, causing heartburn, etc., and may cause reflux esophagitis and tissue damage in the vicinity of the esophagus, such as the throat and trachea. More men have more gastro-esophageal reflux diseases than women, and the prevalence rate of gastro-esophageal reflux disease in Beijing and Shanghai is 5.77%. Heartburn and reflux are the most common symptoms of the disease, and in addition, chest pain, dysphagia, cough and other discomforts can occur. There is no record of gastroesophageal reflux disease in traditional Chinese medicine, but the disease can be roughly classified into the category of acid regurgitation according to its clinical manifestations. The pathogenesis of the disease is that the liver and stomach are disharmony, the stomach is disharmony and descending, and the stomach qi and the gastric juice are reversed to cause the disease.
At present, the treatment by medicines mainly aims at controlling symptoms, improving the state of illness, inhibiting gastric acid secretion, protecting gastric mucosa and the like, mainly inhibits acid and protects gastric mucosa, and clinically mainly treats proton pump inhibitors, so that the medicines can relieve inflammation and relieve discomfort such as heartburn and pantothenic acid, but are easy to attack repeatedly, and the medicines are large in harm to the body and have a plurality of side effects after being applied for a long time.
Disclosure of Invention
The invention aims to overcome the defects of the prior art and provide the traditional Chinese medicine for treating the gastroesophageal reflux disease, which has the advantages of obvious curative effect, low cost and no toxic or side effect.
The technical scheme adopted by the invention for solving the technical problems is as follows: a traditional Chinese medicine composition for treating gastroesophageal reflux disease is characterized by being prepared from the following raw material medicines in parts by weight: 5-9 parts of radix bupleuri, 4-7 parts of radix paeoniae alba, 4-8 parts of fructus aurantii, 4-7 parts of fructus toosendan, 4-8 parts of rhizoma corydalis, 5-8 parts of coptis chinensis, 6-9 parts of fructus evodiae, 6-9 parts of radix curcumae, 7-9 parts of endothelium corneum gigeriae galli, 6-9 parts of radix clematidis, 2-5 parts of pseudo-ginseng, 6-9 parts of rhizoma bletillae, 2-5 parts of cuttle bone, 4-6 parts of thunberg fritillary bulb, 2-4 parts of concha arcae, 4-6 parts of oyster, 2-4 parts of radix glycyrrhizae preparata and.
The invention has the advantages of obvious curative effect, low cost and no toxic or side effect.
Detailed Description
The invention is further described with reference to the following examples:
example 1:
is prepared from radix bupleuri, radix paeoniae alba, fructus aurantii, fructus toosendan, rhizoma corydalis, rhizoma coptidis, fructus evodiae, radix curcumae, endothelium corneum gigeriae galli, radix clematidis, radix notoginseng, rhizoma bletillae, cuttle bone, thunberg fritillary bulb, concha arcae, oyster, radix glycyrrhizae preparata and nacre. Each side of the ingredients (by weight) is 7 portions of bupleurum, 6 portions of white peony root, 6 portions of bitter orange, 5 portions of toosendan fruit, 6 portions of rhizoma corydalis, 6 portions of coptis root, 7 portions of evodia fruit, 7 portions of curcuma aromatica, 8 portions of endothelium corneum gigeriae galli, 7 portions of clematis root, 4 portions of pseudo-ginseng, 8 portions of bletilla, 3 portions of cuttle bone, 5 portions of thunberg fritillary bulb, 3 portions of concha arcae, 5 portions. Taking the 18 raw materials, adding 800-900 ml of water into 176 g of the total weight, soaking for 5-6 hours at room temperature, decocting with slow fire for 60-80 minutes, removing residues to obtain about 150 ml of filtrate, adding 200-300 ml of water into the residues, decocting for 20-30 minutes, removing residues to obtain 50-70 ml of filtrate, and obtaining about 200-220 ml of decoction in total, thus obtaining the decoction. The mixture is put into a sterile glass bottle, the bottle cap is sealed for standby, 1 dose is taken orally 2 times a day, and 100-110 ml of the mixture is taken once in the morning and at night in an empty stomach each time.
The radix bupleuri has the functions of relieving exterior syndrome and fever, soothing liver-qi stagnation and lifting yang, and has good effect on treating the pathogenesis of pantothenic acid caused by liver qi stagnation and liver qi stagnation by pungent and bitter discharge and good property; radix Paeoniae alba has effects of nourishing blood, astringing yin, relieving pain of flesh crown, and suppressing liver yang, and it is often combined with bupleuri radix clinically for its actions of astringing liver yin, nourishing blood, softening liver and relieving pain; the fructus aurantii has the functions of breaking qi, removing food retention, reducing phlegm and removing mass, and has good effects on liver qi discomfort and liver and stomach disharmony with pantothenic acid; fructus Toosendan and rhizoma corydalis are combined to form the fructus Toosendan powder, which has the functions of soothing liver-qi stagnation, dredging channels and promoting qi circulation, and can cut the pathogenesis of liver-stomach disharmony; the coptis and the evodia are matched to form a Zuojin pill, which is a special prescription for treating pantothenic acid in the traditional Chinese medicine and has great effect on pantothenic acid and heartburn caused by disharmony between the liver and the stomach; the turmeric root-tuber and the chicken's gizzard-membrane are matched into the Erjin powder, and the Erjin powder has the effects of dispersing liver qi and promoting stomach qi to play the role of dispersing liver and harmonizing stomach; the clematis root can pass through twelve meridians and has the effect on qi stagnation of all meridians; the combination of notoginseng and bletilla tuber has the functions of stopping bleeding, promoting granulation, reducing swelling and relieving pain, and is effective for patients with liver-stomach disharmony and blood collateral internal injury; the four medicines of the cuttle bone, the thunberg fritillary bulb, the concha arcae and the oyster pearl shell can prepare acid and relieve pain, and are necessary products for clinically treating heartburn and pantothenic acid; prepared licorice root, radix Glycyrrhizae Praeparata coordinates the effects of the other drugs in the recipe.
The invention can also be realized by mixing the raw materials in the proportions (parts by weight) shown in the following table. The processing technique is the same as in example 1.
The invention is described in further detail below in connection with clinical trials conducted in my hospital:
1. general data
Of the 100 patients, the age was 25-71 years, the course of disease was mostly 3 months to 10 years, and the average age was 62 years.
2. Diagnostic criteria
Refer to the Chinese gastroesophageal reflux disease consensus expert group of the digestive diseases division of the Chinese medical society, "Chinese gastroesophageal reflux disease consensus opinion" (2006, III).
(1) Clinical symptoms
Gastroesophageal reflux disease is considered when the patient exhibits typical symptoms including acid regurgitation, heartburn, pain or discomfort behind the sternum, belching and the like, or simultaneously exhibits extra-esophageal symptoms such as throat discomfort, cough and the like. If the presence of esophageal mucosal inflammation and/or reflux can be confirmed, a definitive diagnosis can be made.
(2) Endoscopy
Endoscopy revealed the presence or absence of Reflux Esophagitis (RE) and Barrett's Esophagus (BE).
RE was ranked according to LA classification by the world gastroenteropathy university of los Angeles, 1994.
A level: one or more mucosal lesions of the esophagus mucosa are smaller than 5mm in diameter;
b stage: one or more mucous membrane lesions with diameter larger than 5mm but no fusion phenomenon among lesions;
c level: (ii) mucosal fusogenic lesions over 2 folds, but less than 75% of the esophageal circumference;
d stage: the range of mucosal lesions fused to each other accumulates at least 75% of the esophageal circumference.
BE is diagnosed mainly according to endoscopy and esophageal mucosa biopsy, and can BE diagnosed as BE when the endoscopy finds that the far end of the esophagus has obvious columnar epithelialization and obtains pathological examination and verification.
3. Method of treatment
The decoction of the embodiment is taken 1 dose per day by 2 times, once in the morning and evening, and 100-110 ml of the decoction is taken for 10 days each time with empty stomach as 1 course of treatment.
4. The treatment results are as follows:
4.1 treatment evaluation standard, refer to the spleen and stomach disease division of the Chinese medical society of China-treatise on the consensus opinion of traditional Chinese medicine diagnosis and treatment of gastroesophageal reflux disease 2009 for evaluation.
And (3) healing: the symptoms disappear.
The effect is shown: the symptom improvement percentage is more than or equal to 80 percent.
The improvement is as follows: the symptom improving percentage is more than or equal to 50 percent and less than 80 percent.
And (4) invalidation: the percentage improvement in symptoms was < 50%.
Deterioration: percent improvement of symptoms was negative.
The total effective rate is calculated according to the number of cure and significant cases.
4.2 results: of 100 patients, 56 patients (56.00%) were cured clinically, 32 patients (32.00%) had significant effects, 12 patients (12.00%) were advanced, 0 patient (0%) was worsened, and the total effective rate was 88.00%.
Typical cases
1. Zhou Zhi, male, 39 years old, heartburn and pantothenic acid for more than 3 years, patients have repeated heartburn and pantothenic acid attacks in nearly 3 years, have been subjected to electronic gastroscopy for many times to prompt gastroesophageal reflux disease, have been subjected to proton pump inhibitor oral administration for many times, and have symptoms relieved during administration and relapse after stopping administration. The patient has heartburn and acid regurgitation, belching with uncomfortable feeling, abdominal distension and discomfort, bitter taste and peculiar smell in the mouth. And (4) checking: the abdomen is soft, the abdomen has no tenderness and rebound pain, and the liver and kidney regions have no percussion pain. And (3) diagnosis: gastroesophageal reflux disease. After the medicine is taken for 3 treatment courses, heartburn and pantothenic acid are obviously relieved, other symptoms are relieved, the medicine is continuously taken for 3 treatment courses, the disease is healed, and no relapse occurs after half a year follow-up visit.
2. Wan Zhi, female, 60 years old, has heart burn and pantothenic acid attack repeatedly for more than 8 years. The discomfort of heartburn, pantothenic acid and the like repeatedly appears in nearly 8 years, the patient does not pay attention to enough and does not have systematic treatment, local traditional Chinese medicine is taken at home, the effect is not ideal, and the gastroesophageal reflux disease is prompted by the electronic gastroscopy in hospital. Patients are at present heartburn and acid regurgitation, with uncomfortable belching, distending and uncomfortable upper abdomen, bitter taste and discomfort feeling of fullness and distention of the ribs on both sides. And (4) checking: the abdomen is soft, the abdomen has no tenderness and rebound pain, and the liver and kidney regions have no percussion pain. And (3) diagnosis: gastroesophageal reflux disease. After the medicine is taken 1 dose a day and 3 treatment courses, the heartburn and pantothenic acid are relieved, the swelling disappears, and other symptoms are relieved. The patient can be cured after continuously taking the medicine for 4 courses of treatment, and the disease does not relapse after one year of follow-up.
Claims (1)
1. A traditional Chinese medicine composition for treating gastroesophageal reflux disease is characterized by being prepared from the following raw material medicines in parts by weight: 5-9 parts of radix bupleuri, 4-7 parts of radix paeoniae alba, 4-8 parts of fructus aurantii, 4-7 parts of fructus toosendan, 4-8 parts of rhizoma corydalis, 5-8 parts of coptis chinensis, 6-9 parts of fructus evodiae, 6-9 parts of radix curcumae, 7-9 parts of endothelium corneum gigeriae galli, 6-9 parts of radix clematidis, 2-5 parts of pseudo-ginseng, 6-9 parts of rhizoma bletillae, 2-5 parts of cuttle bone, 4-6 parts of thunberg fritillary bulb, 2-4 parts of concha arcae, 4-6 parts of oyster, 2-4 parts of radix glycyrrhizae preparata and.
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| CN113713073A (en) * | 2021-08-26 | 2021-11-30 | 朱伟宁 | Traditional Chinese medicine composition for treating spleen and stomach damp-heat type chronic atrophic gastritis |
| CN114470092A (en) * | 2022-03-10 | 2022-05-13 | 徐英剑 | Pharmaceutical composition for treating upper gastrointestinal hemorrhage and powder thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN104306941A (en) * | 2014-10-30 | 2015-01-28 | 上海中医药大学附属岳阳中西医结合医院 | Medicament for treating non-erosive gastro-oesophageal reflux disease and application of medicament |
| CN104906554A (en) * | 2015-07-16 | 2015-09-16 | 上海中医药大学附属岳阳中西医结合医院 | Traditional Chinese medicine composition for treating refractory gastroesophageal reflux disease and application thereof |
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| CN104306941A (en) * | 2014-10-30 | 2015-01-28 | 上海中医药大学附属岳阳中西医结合医院 | Medicament for treating non-erosive gastro-oesophageal reflux disease and application of medicament |
| CN104906554A (en) * | 2015-07-16 | 2015-09-16 | 上海中医药大学附属岳阳中西医结合医院 | Traditional Chinese medicine composition for treating refractory gastroesophageal reflux disease and application thereof |
Non-Patent Citations (1)
| Title |
|---|
| 健脾疏肝汤治疗胆汁反流性胃炎60例临床观察;毕卫珍;《山东中医杂志》;20090531(第5期) * |
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