CN112316102A - Traditional Chinese medicine composition for preventing or treating colitis - Google Patents
Traditional Chinese medicine composition for preventing or treating colitis Download PDFInfo
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Abstract
The invention relates to the technical field of traditional Chinese medicines, in particular to a traditional Chinese medicine composition for preventing or treating colitis. The traditional Chinese medicine composition is suitable for treating the colitis, is particularly suitable for spleen-kidney deficiency cold type chronic colitis, and can effectively solve the problem that chronic colitis is difficult to cure due to chronic diarrhea. The medicines are combined to play the roles of invigorating spleen and warming, eliminating dampness and stopping diarrhea. The prescription is strict, the compatibility is precise and appropriate, and the medicinal threads are screwed according to the characteristics of pathogenesis. Has the advantages of treating both principal and secondary aspect of disease, obvious curative effect, small side effect, convenient administration, low price and the like. The production process is advanced and is beneficial to industrial production.
Description
Technical Field
The invention relates to the technical field of traditional Chinese medicines, in particular to a traditional Chinese medicine composition for preventing or treating colitis.
Background
Colitis is an intestinal inflammatory disease with uncertain etiology, is clinically mainly manifested by abdominal pain, diarrhea and bloody pus, is easy to repeatedly attack, is continuous in winding, and can seriously trouble the quality of life of people. Modern medicine generally considers that the inflammatory response of the gut is associated with infections caused by bacteria, viruses, parasites, etc. The treatment strategies of inflammation reaction control, such as inflammation diminishing, pain relieving, infection resistance and the like are mainly adopted, but the treatment is not permanent, the clinical curative effect is not good, the adverse reaction is large, and the recurrence rate is high.
According to the clinical symptoms of colitis, it can be classified into diarrhea and dysentery in traditional Chinese medicine. The pathogenesis of the disease is mainly related to the weakness of the spleen and the stomach, and the course of the disease is indicated as mixed deficiency and excess. Among them, chronic colitis due to cold-type deficiency of the spleen and kidney is common in clinic. Often, such colitis is characterized by a long course of disease and presents certain difficulties in treatment. Therefore, the discovery of traditional Chinese medicines with effects of treating colitis, especially chronic colitis due to deficiency of spleen and kidney cold is a problem to be solved urgently at present.
Disclosure of Invention
In view of the above situation, in order to solve the defects of the prior art, the invention aims to provide a traditional Chinese medicine composition for treating chronic colitis due to spleen-kidney deficiency cold, which can effectively solve the problem of chronic colitis and chronic diarrhea which is difficult to cure.
In order to achieve the purpose, the invention adopts the following technical scheme:
a Chinese medicinal composition for preventing and/or treating colitis is prepared from Ginseng radix, Poria, rhizoma Atractylodis, Zingiberis rhizoma, Halloysitum rubrum, Limonitum, fructus Psoraleae and radix Glycyrrhizae Preparata. Preferably, the raw materials of the traditional Chinese medicine composition also comprise agrimony and platycodon grandiflorum.
Wherein, the ginseng, the tuckahoe, the rhizoma atractylodis and the honey-fried licorice root have the effects of tonifying qi and spleen, eliminating dampness and regulating the middle warmer, and reinforcing the middle warmer to take care of acquired constitution; gan Jiang and Bu Gu Zhi can warm and tonify spleen and kidney, strengthen yang and resolve dampness, so it is good at treating chronic diarrhea due to spleen and kidney yang deficiency failing to consolidate; halloysitum rubrum and Limonitum have effects of astringing intestine to relieve depletion, and can be used for treating continuous urination, and has good therapeutic effect on diarrhea; the agrimony has the effects of tonifying in the middle-jiao and dredging in the middle-jiao, can help the ginseng and the tuckahoe to exert the effect of tonifying qi, and can be matched with the red halloysite and the limonite to enhance the convergence; radix Platycodi regulates qi movement, raises qi and clears yang, thus helping to check diarrhea.
The traditional Chinese medicine composition is prepared from the following medicinal materials in parts by weight: the traditional Chinese medicine composition comprises, by weight, 5-12 parts of ginseng, 15-22 parts of poria cocos, 15-22 parts of rhizoma atractylodis, 5-12 parts of dried ginger, 25-35 parts of red halloysite, 25-35 parts of limonite, 15-22 parts of fructus psoraleae and 5-10 parts of honey-fried licorice root; preferably, the traditional Chinese medicine composition also comprises 25-35 parts of hairyvein agrimony and 5-12 parts of platycodon grandiflorum.
Preferably, the traditional Chinese medicine composition comprises, by weight, 8-12 parts of ginseng, 18-22 parts of poria cocos, 18-22 parts of rhizoma atractylodis, 8-12 parts of rhizoma zingiberis, 27-33 parts of halloysite, 27-33 parts of limonite, 27-33 parts of hairyvein agrimonia herb and bud, 8-12 parts of platycodon grandiflorum, 18-22 parts of fructus psoraleae and 5-8 parts of radix glycyrrhizae preparata.
Further preferably, the traditional Chinese medicine composition comprises, by weight, 10 parts of ginseng, 20 parts of poria cocos, 20 parts of rhizoma atractylodis, 10 parts of rhizoma zingiberis, 30 parts of red halloysite, 30 parts of limonite, 30 parts of hairyvein agrimony, 10 parts of platycodon grandiflorum, 20 parts of fructus psoraleae and 6 parts of radix glycyrrhizae preparata.
The invention also provides a traditional Chinese medicine preparation for treating colitis, which is prepared by directly or indirectly adding pharmaceutically acceptable auxiliary materials into the traditional Chinese medicine composition through conventional processing to prepare granules, tablets, pills, powder, capsules, solutions, suspensions or emulsions. The preferred dosage form of the traditional Chinese medicine composition is granules.
According to the traditional Chinese medicine, the pathogenesis of chronic colitis is mainly deficiency of origin and excess of superficiality, spleen-kidney yang deficiency, internal cold-dampness resistance, spleen deficiency and weakness, and cold-yang deficiency and yang deficiency, so that the chronic colitis is easy to cause the disease. If the patient prefers to eat raw cold, fat and sweet, and drink alcohol, the condition will be aggravated if the patient has abnormal daily life and causes the interior abundance of cold and dampness. Therefore, starting from the regulation of spleen and kidney, the spleen and kidney are treated simultaneously, and the curative effects of warming kidney, strengthening spleen, reinforcing intestine and relieving diarrhea are always achieved fundamentally. The traditional Chinese medicine composition is suitable for treating the colitis, is particularly suitable for spleen-kidney deficiency cold type chronic colitis, and can effectively solve the problem that chronic colitis is difficult to cure due to chronic diarrhea. The medicines are combined to play the roles of invigorating spleen and warming, eliminating dampness and stopping diarrhea. The prescription is strict, the compatibility is precise and appropriate, and the medicinal threads are screwed according to the characteristics of pathogenesis. Has the advantages of treating both principal and secondary aspect of disease, obvious curative effect, small side effect, convenient administration, low price and the like. The production process is advanced and is beneficial to industrial production.
Detailed Description
The invention discloses a traditional Chinese medicine composition for preventing or treating colitis, which can be realized by appropriately improving process parameters by the technical personnel in the field with reference to the content. It is expressly intended that all such similar substitutes and modifications which would be obvious to one skilled in the art are deemed to be included in the invention. While the invention has been described in terms of preferred embodiments, it will be apparent to those skilled in the art that the techniques of the invention can be implemented and practiced with modification, or with appropriate modification, and combinations of the methods and applications described herein without departing from the spirit, scope, and spirit of the invention.
Example 1
Respectively taking 5-12 parts of ginseng, 15-22 parts of poria cocos, 15-22 parts of rhizoma atractylodis, 5-12 parts of rhizoma zingiberis, 25-35 parts of red halloysite, 25-35 parts of limonite, 15-22 parts of fructus psoraleae and 5-10 parts of radix glycyrrhizae preparata; mixing the above materials, placing into a medicinal pot, soaking in water for 30-60 min, decocting with strong fire to boil, decocting with slow fire for 20-30 min, filtering to obtain filtrate, adding water into the residue, repeating above steps, mixing the filtrates, and mixing.
Example 2
Respectively taking 5-12 parts of ginseng, 15-22 parts of poria cocos, 15-22 parts of rhizoma atractylodis, 5-12 parts of rhizoma zingiberis, 25-35 parts of red halloysite, 25-35 parts of limonite, 25-35 parts of hairyvein agrimony, 5-12 parts of platycodon grandiflorum, 15-22 parts of fructus psoraleae and 5-10 parts of radix glycyrrhizae preparata; mixing the above materials, placing into a medicinal pot, soaking in water for 30-60 min, decocting with strong fire to boil, decocting with slow fire for 20-30 min, filtering to obtain filtrate, adding water into the residue, repeating above steps, and mixing the filtrates. Concentrating, drying, adding dextrin and correctant, and granulating according to conventional method in the art.
Example 3
Respectively taking 8-12 parts of ginseng, 18-22 parts of poria cocos, 18-22 parts of rhizoma atractylodis, 8-12 parts of rhizoma zingiberis, 27-33 parts of red halloysite, 27-33 parts of limonite, 27-33 parts of hairyvein agrimony, 8-12 parts of platycodon grandiflorum, 18-22 parts of fructus psoraleae and 5-8 parts of radix glycyrrhizae preparata; mixing the above materials, placing into a medicinal pot, soaking in water for 30-60 min, decocting with strong fire to boil, decocting with slow fire for 20-30 min, filtering to obtain filtrate, adding water into the residue, repeating above steps, and mixing the filtrates. Concentrating, drying, adding dextrin and correctant, and granulating according to conventional method in the art.
Example 4
Mixing 10 g of ginseng, 20 g of poria cocos, 20 g of rhizoma atractylodis, 10 g of rhizoma zingiberis, 30 g of red halloysite, 30 g of limonite, 30 g of hairyvein agrimony, 10 g of platycodon grandiflorum, 20 g of fructus psoraleae and 6 g of radix glycyrrhizae preparata, putting the mixture into a medicine pot, adding water to immerse the mixture, soaking the mixture for 30 to 60 min, decocting the mixture with strong fire until the mixture is boiled, then decocting the mixture with slow fire for 20 to 30 min, filtering the mixture to obtain filtrate, adding water into filter residues, repeating the steps. Concentrating, adding adjuvant such as appropriate correctant, and filtering and refining according to conventional process in the art to obtain solution with dosage of 1 day for normal adult.
Example 5
Respectively taking 8-12 parts of ginseng, 18-22 parts of poria cocos, 18-22 parts of rhizoma atractylodis, 8-12 parts of rhizoma zingiberis, 27-33 parts of red halloysite, 27-33 parts of limonite, 27-33 parts of hairyvein agrimony, 8-12 parts of platycodon grandiflorum, 18-22 parts of fructus psoraleae and 5-8 parts of honey-fried licorice root, crushing the raw materials, adding 75% ethanol in an amount which is 10 times that of the raw materials, and performing reflux extraction for 1 hour to obtain a traditional Chinese medicine composition extract solution; filtering the extract solution twice, centrifuging the filtrate at 10000rpm, collecting supernatant, evaporating the solvent under reduced pressure, and drying to obtain total extract of the Chinese medicinal composition; can be prepared into oral preparations such as granules, tablets, pills, powder, capsules, solutions, suspensions or emulsions by adopting a conventional method according to requirements; the adjuvants added in the preparation of tablet and capsule are starch, dextrin and magnesium stearate. The adjuvants added during preparation of granule are sucrose, dextrin or other sweetener.
Example 6: clinical efficacy data
Medical record data: 62 patients with spleen-kidney deficiency cold type chronic colitis were collected between 5 months in 2018 and 8 months in 2020, wherein 43 patients were male and 19 patients were female. The age is 20-70 years.
The treatment scheme comprises the following steps: the traditional Chinese medicine is orally taken twice in the morning and at night every day after meals. The treatment course is 4 weeks, and the treatment effect is counted after 3 treatment courses. During the treatment period, uncooked, cold, greasy and spicy food is prohibited.
The curative effect standard is as follows: according to the comprehensive treatment effect evaluation standard in the clinical research guiding principle of new traditional Chinese medicines, the specific standard contents are as follows:
(1) significant effect (or complete remission): clinical symptoms disappeared and colonoscopy reviewed mucosal normality. No relapse was observed after 6 months with drug withdrawal or maintenance dose alone.
(2) The method has the following advantages: clinical symptoms basically disappear, and the colonoscope reviews the mucosa for mild inflammatory reaction and part of pseudopolyp formation.
(3) And (4) invalidation: no improvement in clinical symptoms, endoscopy and pathological examination.
As shown in Table 1, the results of statistical treatment show that 34 patients with obvious effect, 25 patients with effective effect and 3 patients with ineffective effect have a total effective rate of 95.2% and no obvious adverse reaction is observed in the total 62 patients. Therefore, the traditional Chinese medicine composition has good effect and wide clinical application prospect.
TABLE 1 statistics of clinical efficacy
| Number of examples | Show effect | Is effective | Invalidation | Total effective rate (%) | Adverse reaction Rate (%) |
| 62 | 34 | 25 | 3 | 95.2 | 0 |
Example 7: classic case
To demonstrate the good efficacy of the present invention for chronic colitis, the following typical cases are exemplified:
1. li Shi, female, 67 years old, first diagnosis in 2018, 6 months and 15 days. Chronic colitis was confirmed by enteroscopy in hospital for over ten years, and many treatments were not cured. Diarrhea is treated 5-6 times per day, and the type 6 is determined according to the Bristol stool classification. Accompanied by abdominal pain, cold and diarrhea, aversion to cold, pale tongue with thin and white coating, deep and soft pulse. The traditional Chinese medicine composition is used for carrying out traditional Chinese medicine treatment, after the traditional Chinese medicine composition is taken for 1 course of treatment, the defecation frequency is reduced to 3-4 times per day, and after the traditional Chinese medicine composition is treated for 3 courses of treatment, the defecation is recovered to a Bristol 4 type, so that the disease condition is recovered.
2. Liu Jie, male, 26 years old, first diagnosis in 2019, 10 and 11 days. Abdominal distension and diarrhea were diagnosed as colitis accompanied by colonic polyps in 5 years by enteroscopy for 7 months in 2019. Diarrhea, 2-3 times daily, with singultus, asthenia, borborborygmus, emaciation, 173cm height, 60kg weight, and yellowish complexion. Pale and swollen with teeth marks, thin and white coating and thready and smooth pulse. Many treatments are ineffective and are specific to the diagnosis. After the traditional Chinese medicine composition is used for carrying out traditional Chinese medicine treatment, diarrhea, abdominal distension, hiccup and the like are recovered after 2 treatment courses of administration, and the diarrhea, abdominal distension, hiccup and the like are not relapsed.
3. Suzhong, male, 65 years old, 9 months and 7 days in 2019. Colitis has been diagnosed by enteroscopy for over 30 years. Diarrhea is caused 4-5 times per day, stool is urgent, with sticky jelly, and the tendency of aggravation is in near 3 years. Plain aversion to eating cold, fond of warm or even scalding food, had poor subjective digestion, and was prone to abdominal distension and pain after eating, and diarrhea aggravated when eating cold or uncooked food. The traditional Chinese medicine composition is used for traditional Chinese medicine treatment, after the traditional Chinese medicine composition is taken for 1 treatment course, the defecation frequency is reduced, 3-4 times a day, the sticking and freezing are reduced, and the abdominal pain and the abdominal distension are not caused; after taking the medicine for 3 courses, the state of illness is recovered, the excrement is recovered to be a Bristol 4 type, 1 to 2 times per day, and the disease is not relapsed until now through follow-up.
The foregoing is only a preferred embodiment of the present invention, and it should be noted that, for those skilled in the art, various modifications and decorations can be made without departing from the principle of the present invention, and these modifications and decorations should also be regarded as the protection scope of the present invention.
Claims (9)
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| CN101757591A (en) * | 2008-12-26 | 2010-06-30 | 徐仁辉 | Traditional Chinese medicine composition for treating chronic colitis and protitis |
| US20150231163A1 (en) * | 2012-08-17 | 2015-08-20 | University-Industry Cooperation Group Of Kyung Hee University | Composition for preventing or treating colitis |
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| US20150231163A1 (en) * | 2012-08-17 | 2015-08-20 | University-Industry Cooperation Group Of Kyung Hee University | Composition for preventing or treating colitis |
| CN105106913A (en) * | 2015-09-26 | 2015-12-02 | 冷国玉 | Traditional Chinese medicine composition for treating spleen-kidney yang deficiency type chronic colitis |
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