CN103251848B - Pharmaceutical composition for preventing and treating gastric cancer and precursor lesion of gastric cancer - Google Patents
Pharmaceutical composition for preventing and treating gastric cancer and precursor lesion of gastric cancer Download PDFInfo
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- CN103251848B CN103251848B CN201310185026.3A CN201310185026A CN103251848B CN 103251848 B CN103251848 B CN 103251848B CN 201310185026 A CN201310185026 A CN 201310185026A CN 103251848 B CN103251848 B CN 103251848B
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- gastric cancer
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Abstract
The invention discloses a pharmaceutical composition for preventing and treating gastric cancer and precursor lesion of gastric cancer. The composition comprises the main effective components of river deer milk, Codonopsis pilosula, Rhizoma Atractylodis Macrocephalae, Poria cocos, semen coicis, Chinese yam and tangerine pith. The composition integrates functions of several effective components of traditional Chinese medicines which have the synergetic and supplementary effect, and has good effect for improving the function of the digestive system and preventing and treating gastric cancer and precursor lesion of gastric cancer.
Description
Technical field
The invention belongs to compound Chinese medicinal preparation and field of health care products, is take Chinese medicine as the pharmaceutical composition for improving digestive system function and prevention, treatment gastric cancer and cercinoma prophase pathologic change thereof prepared by raw material.
Background technology
Various chronic gastritis, gastric and duodenal ulcers are common frequently-occurring diseases, and according to investigations, that within more than 50 years old, suffers from chronic gastritis reaches 50% and gastric and duodenal ulcers is sick, have the people of 10% to suffer from this disease in life at it, and easily recur, can cancerate in the course of time.Gastric cancer is one of common malignant tumor, and its sickness rate and mortality rate all occupy the prostatitis of malignant tumor in China.The canceration of gastric epithelial cell is a progressive process, and in the normal experience lasting preventing precancerous lesion of stomach cancer stage for many years, some patient finally can develop into gastric cancer.Therefore prevention or treatment gastric precancerous lesion, stoping precancerous lesion, to be converted into pernicious gastric cancer be the important channel preventing and treating gastric cancer, for reduction China's cancer morbidity and patient death rate significant.At present mainly with this type of gastroenteropathy of western medicine, lay particular emphasis on gastrointestinal local patholoic change, the globality of body of having slipped, and drug price is expensive, toxic and side effects is large, and relapse rate is high.
The present inventor is through studying with keen determination; especially by the therapeutical effect of deer treasure to gastric precancerous lesion and the research of cure mechanism; based on the effect that deer treasure can protect gastric mucosa function and control gastric precancerous lesion and then prevention gastric cancer to occur well; the invigorating the spleen and benefiting QI of comprehensive Radix Codonopsis, the Rhizoma Atractylodis Macrocephalae, Poria, Semen Coicis, Rhizoma Dioscoreae, vascular aurantii again; improve the Chinese medicine composition of gastrointestinal function, for the control of gastrotherapy and gastric cancer provides new therapeutic scheme.
Summary of the invention
The invention provides a kind of pharmaceutical composition for improving digestive system function and prevention, treatment gastric cancer and cercinoma prophase pathologic change thereof.
This pharmaceutical composition is under the guidance of theory of Chinese medical science, optimize and select Chinese medicine formula obtain, each component comprehensively plays a role, and has good treatment and preventive effect for above-mentioned disease.
Pharmaceutical composition of the present invention is made up of the raw material of following weight: deer treasure 20-35 part, peeling Radix Codonopsis 6-10 part, peeling Rhizoma Atractylodis Macrocephalae 5-10 part, peeling Poria 8-12 part, peeling Rhizoma Dioscoreae 8-12 part, Semen Coicis 8-12 part, vascular aurantii 2-5 part, compound vitamin B 0.5-1 part, vitamin D 0.5-1 part, calcium 0.5-1 part, ferrum 0.5-1 part, zinc 0.5-1 part, Fructus Hordei Germinatus lactose 15-20 part, starch 10-15 part.Said components is dry, pulverizing, grinds rear mistake 200 mesh sieve altogether, makes granule or make tablet in conventional manner or be optionally prepared into clinical other conventional dosage form.
In compositions of the present invention, each composition all has the effect of certain strengthening the spleen and nourishing the stomach, wherein:
Deer treasure: invigorating the spleen and replenishing QI, building body, food stagnation removing appetizing;
Radix Codonopsis: gas in replenishing QI to invigorate the spleen, the lung moistening and production of body fluid promoting, strong fortune;
The Rhizoma Atractylodis Macrocephalae: spleen invigorating helps in fortune, removing dampness freely, stomach function regulating helps digestion;
Poria: burnt in spleen invigorating eliminating dampness by diuresis, transporting, help digestion stomach function regulating;
Semen Coicis: spleen benefiting and stimulating the appetite, transmitting and distributing the fluids, clear middle cuticula;
Rhizoma Dioscoreae: spleen invigorating helps fortune, stomach reinforcing tonify deficiency, holds concurrently and adjust lung kidney;
Vascular aurantii: fragrant is amusing, circulation of qi promoting is whetted the appetite, help digestion smooth in;
Fructus Hordei Germinatus lactose: strengthening the spleen to promote digestion stomach reinforcing also increases sweet taste, is in harmonious proportion all product;
Vitamin B, D and calcium, ferrum, zinc etc.: vitimin supplement and trace element, be conducive to helping gastrointestinal function recovery and building body etc.
Starch: excipient and filler.
Above-mentioned active component is combined through special ratios, plays invigorating spleen and reinforcing stomach, the comprehensive function of building body.
The consumption of raw material components of the present invention is also through inventor and gropes in a large number to sum up and draw, each amounts of components all has good therapeutic effect within the scope of following portions by weight.
The invention provides pharmaceutical composition, be made up of the raw material of following weight portion:
Preferably be made up of the raw material of following weight portion:
Various customary adjuvant required when preparing different dosage form can be added in pharmaceutical composition of the present invention, peroral dosage form is commonly used, as granule, pill, powder, tablet, capsule, oral liquid etc. as disintegrating agent, lubricant, binding agent etc. are prepared into any one with the method for Chinese medicinal of routine.
Detailed description of the invention
Effective ingredient deer treasure in the present invention can adopt method well known in the art to obtain, such as, more than chartering cost three generations newborn river deer is stomach after sucking river deer milk, especially form Off-white solid or semi-solid mass thing in abomasum (glandular stomach) meeting, underwent operative is drying to obtain after taking out.
Particularly: 1. select the newborn river deer of more than the chartering cost three generations of 12 ages in days to raise with river deer breast bottlefeeding.After three hours, this newborn river deer glandular stomach position can touch lump;
2., by newborn river deer anesthesia sterilization, bring aseptic operating room into, be fixed on operating-table, carry out live body operation, cut glandular stomach open, take out Off-white solid or semi-solid mass thing, dry, pulverizing, namely obtaining can for the deer treasure of the present invention.
Certainly, the present invention also can adopt commercially available deer treasure raw material medicine, and the deer treasure that following examples specifically adopt is commercially available prod.
Embodiment 1:
Each raw material is taken: deer treasure 25, peeling Radix Codonopsis 8, the peeling Rhizoma Atractylodis Macrocephalae 6, peeling Poria 10, Semen Coicis 10, peeling Rhizoma Dioscoreae 10, vascular aurantii 4, compound vitamin B 0.5, vitamin D 0.5, calcium 0.5, ferrum 0.5, zinc 0.5, Fructus Hordei Germinatus lactose 15 by following parts by weight; Drying, pulverizing, mixing, and with starch 15 parts of figurations, filling, grind superfine end altogether, cross 200 mesh sieves, make granule altogether, be pressed into tablet, hereinafter referred to as deer treasure tabellae stomachicus, in every sheet, deer treasure content amounts to 30 milligrams.
Set forth the beneficial effect of pharmaceutical composition of the present invention further below by way of test example, test example includes the clinical research effect of the present composition for pathological changes before reversing stomach.
Test example 1:
Year March in March, 2010 to 2013, the outpatient service of my the spleen-stomach disease section of institute is according to the tentative suggestion of digestive endoscopy branch of Chinese Medical Association chronic gastritis endoscopic classification grade scales in 2003 and treatment, through pathological diagnosis be chronic atrophic gastritis (CAG) accompany mucosa intestinal epithelial metaplasia (Im) and (or) dysplasia (Dys) patient 200 example, man 116 example, female 84 example, age 25-83 year.Be divided into treatment group 100 example (man 53 example, female 47 example) at random, matched group 100 example (man 63 example, female 37 example).Wherein positive 148 examples of helicobacter pylori (Hp), negative 52 examples of Hp.Merge bile reflux 38 example, have gastric cancer family history 32 example.The aspect comparing differences such as two groups of ages, sex, severity extents are without significance (P > 0.05).
Exclusion standard: 1, with other gastrointestinal distress person, as malignant tumor of digestive tract, peptic ulcer etc.; 2, with systemic disease person, as severe cardiac liver renal failure, diabetes, autoimmune disease etc.; 3, gestation or women breast-feeding their children; 4, allergic constitution or to this test medication allergy sufferers; 5, can not further consultation or the person of following up a case by regular visits on schedule.
One, Therapeutic Method
The deer treasure tabellae stomachicus of the oral embodiment 1 for the treatment of group, 2 pieces/times, every day 3 times.Matched group takes WEIFUCHUN PIAN (being produced by Hu Qingyu Pharmaceutical Workshop, Hangzhou pharmaceutical factory), 4 pieces/times, every day 3 times.Two groups was all a course for the treatment of with 3 months, serve on 2 courses for the treatment of.Treatments period withdraws the medicine that all affect this research.
Two, Testing index
Clinical symptoms (upper abdominal pain, abdominal distention, acid regurgitation, belch, poor appetite, nausea and vomiting) before and after treating selected patients is marked; Before and after treatment, row gastroscopy and pathological biopsy, Hp check respectively.
Three, curative effect judging standard
(1) clinical efficacy diagnostic criteria
Cure: clinical symptom disappearance or substantially disappear;
Effective: clinical symptoms is obviously improved;
Effective: clinical symptoms makes moderate progress;
Invalid: clinical symptoms is not improved or increased the weight of.
Total effective rate=(cure+effective+effectively)/total number of cases * 100%.
(2) gastroscope, pathological diagnosis standard
Gastric mucosal lesion degree evaluation is as follows with reference to the whole nation, digestive endoscopy branch of Chinese Medical Association Dalian in 2003 chronic gastritis thematic classification standard:
The classification of chronic gastritis endoscopic classification
Gastric mucosa Histopathologic change evaluation criteria adopts the standard in national chronic gastritis meeting in 2000.
(3) anti-Hp curative effect diagnostic criteria
Hp is positive: RUT experiment is positive;
Hp is negative: RUT experiment is negative.
Four, statistical procedures
Adopt SPSS11.5 statistical software to carry out statistical disposition, enumeration data compares employing X
2inspection.
Five, result
(1) two group of Clinical efficacy comparison
Clinical efficacy comparison after two groups of treatments, difference has significance (X
2=9.072, P < 0.05).See the following form.
Two groups of patients clinical comparitive study (example) after treatment
(2) two groups of gastroscopes, pathology comparitive study
The display for the treatment of group gastroscope result is effective 83 examples, invalid 17 examples always, total effective rate 83.00%, and matched group is respectively 66 examples, 34 examples, and total effective rate 66.00%, two groups of comparing differences have significance (X
2=7.606, P < 0.05); Treatment group pathology (CAG, Im, Dys) result shows total efficiently individual quantity and is respectively 80,72 and 31 examples, invalid number is respectively 20,10 and 4 examples, total effective rate is respectively 80.00%, 87.80%, 88.57%, matched group pathology (CAG, Im, Dys) result shows total efficiently individual quantity and is respectively 64,49 and 18 examples, invalid number is respectively 36,20,10 examples, its total effective rate is respectively 64.00%, 71.01% and 64.29%, and two groups of comparing differences have statistical significance (X
2=5.308-6.349, P < 0.05).
(3) anti-Hp comparitive study
After 2 course of therapy, positive 59 examples for the treatment of group Hp, negative 24 examples, matched group is respectively 58,7 examples, and two groups of comparing differences have significance (X
2=7.249, P < 0.05)
Conclusion
Deer treasure tabellae stomachicus significantly can improve the clinical symptoms of patient CAG, and gastroscope, pathology and Hp assay are obviously better than matched group, and therefore compositions of the present invention is the active drug of current gastric precancerous lesion patient reversal therapies.
Claims (2)
1. a pharmaceutical composition for prevention or treatment gastric precancerous lesion, be made up of the raw material of following weight portion:
Described pharmaceutical composition is prepared to granule, pill, powder, tablet, capsule or oral liquid.
2. pharmaceutical composition according to claim 1, be made up of the raw material of following weight portion:
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| Application Number | Priority Date | Filing Date | Title |
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| CN201310185026.3A CN103251848B (en) | 2013-05-20 | 2013-05-20 | Pharmaceutical composition for preventing and treating gastric cancer and precursor lesion of gastric cancer |
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| CN201310185026.3A CN103251848B (en) | 2013-05-20 | 2013-05-20 | Pharmaceutical composition for preventing and treating gastric cancer and precursor lesion of gastric cancer |
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| CN103251848B true CN103251848B (en) | 2015-03-11 |
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102038883A (en) * | 2009-10-15 | 2011-05-04 | 张红旗 | Traditional Chinese medicine formulation for treating gastric cancer |
| CN102188641A (en) * | 2010-03-18 | 2011-09-21 | 罗红英 | Medicament for treating stomach diseases |
| CN102342418A (en) * | 2011-08-30 | 2012-02-08 | 马松江 | Food composition with functions of tonifying spleen and nourishing stomach and preparation method thereof |
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2013
- 2013-05-20 CN CN201310185026.3A patent/CN103251848B/en not_active Expired - Fee Related
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102038883A (en) * | 2009-10-15 | 2011-05-04 | 张红旗 | Traditional Chinese medicine formulation for treating gastric cancer |
| CN102188641A (en) * | 2010-03-18 | 2011-09-21 | 罗红英 | Medicament for treating stomach diseases |
| CN102342418A (en) * | 2011-08-30 | 2012-02-08 | 马松江 | Food composition with functions of tonifying spleen and nourishing stomach and preparation method thereof |
Non-Patent Citations (3)
| Title |
|---|
| 獐宝促进消化作用的实验研究;夏勇等;《中国预防医学杂志》;20071220(第06期) * |
| 獐宝治疗小儿厌食症60 例临床观察;黄对忠等;《药学实践杂志》;20000229;第18卷(第2期);第68-69页 * |
| 看似糟粕的抗癌一族;张意;《湖南农业》;20040730(第07期);第28页 * |
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