CN104704130A - 借助隧道电流分析用于核酸-测序的装置 - Google Patents

借助隧道电流分析用于核酸-测序的装置 Download PDF

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Publication number
CN104704130A
CN104704130A CN201380050219.6A CN201380050219A CN104704130A CN 104704130 A CN104704130 A CN 104704130A CN 201380050219 A CN201380050219 A CN 201380050219A CN 104704130 A CN104704130 A CN 104704130A
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China
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particles
particle
aforementioned
conductive
recess
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CN201380050219.6A
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English (en)
Chinese (zh)
Inventor
W.甘布雷希特
O.海登
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Siemens Corp
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Siemens Corp
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Publication of CN104704130A publication Critical patent/CN104704130A/zh
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483—Physical analysis of biological material
    • G01N33/487—Physical analysis of biological material of liquid biological material
    • G01N33/48707—Physical analysis of biological material of liquid biological material by electrical means
    • G01N33/48721—Investigating individual macromolecules, e.g. by translocation through nanopores
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6869—Methods for sequencing
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/416—Systems
    • G01N27/447—Systems using electrophoresis
    • G01N27/453—Cells therefor

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biophysics (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Nanotechnology (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • General Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Electrochemistry (AREA)
  • Investigating Or Analyzing Materials By The Use Of Electric Means (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
CN201380050219.6A 2012-09-27 2013-09-18 借助隧道电流分析用于核酸-测序的装置 Pending CN104704130A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE102012217603.9 2012-09-27
DE102012217603.9A DE102012217603A1 (de) 2012-09-27 2012-09-27 Anordnung zur Nukleinsäure-Sequenzierung mittels Tunnelstromanalyse
PCT/EP2013/069384 WO2014048816A1 (de) 2012-09-27 2013-09-18 Anordnung zur nukleinsäure-sequenzierung mittels tunnelstromanalyse

Publications (1)

Publication Number Publication Date
CN104704130A true CN104704130A (zh) 2015-06-10

Family

ID=49301440

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201380050219.6A Pending CN104704130A (zh) 2012-09-27 2013-09-18 借助隧道电流分析用于核酸-测序的装置

Country Status (7)

Country Link
US (1) US9804146B2 (https=)
EP (1) EP2880183B1 (https=)
JP (1) JP6033448B2 (https=)
CN (1) CN104704130A (https=)
DE (1) DE102012217603A1 (https=)
IN (1) IN2015DN01996A (https=)
WO (1) WO2014048816A1 (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113221200A (zh) * 2021-04-15 2021-08-06 哈尔滨工程大学 一种适用于堆芯颗粒分布不确定性分析的三维高效随机排布方法

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102013214341A1 (de) * 2013-07-23 2015-01-29 Siemens Aktiengesellschaft Verfahren zum Herstellen einer Nanopore zum Sequenzieren eines Biopolymers
DE102014213814A1 (de) * 2014-07-16 2016-01-21 Siemens Aktiengesellschaft Sequenziervorrichtung und Sequenzierverfahren zur Analyse von Nukleotidsequenzen
DE102014217014A1 (de) * 2014-08-27 2016-03-03 Siemens Aktiengesellschaft Sequenzierung von Nukleinsäuren mittels Tunnelstrommessungen
WO2019000158A1 (zh) * 2017-06-26 2019-01-03 武汉科技大学 一种基于隧道识别技术的纳米检测装置及方法
EP3456414A1 (en) 2017-09-19 2019-03-20 Siemens Healthcare GmbH Setup and method for the capture of a biopolymer and its controlled translocation through a nanoporous network

Citations (3)

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WO2000015844A1 (en) * 1998-09-16 2000-03-23 Incyte Pharmaceuticals, Inc. Nucleic acid sequencing with solid phase capturable terminators
WO2008043426A2 (de) * 2006-09-20 2008-04-17 Genovoxx Gmbh Komponenten und verfahren zur enzymatischen synthese von nukleinsäuren
CN101605910A (zh) * 2006-12-15 2009-12-16 帝国改革有限公司 电极系统及其在分子表征中的用途

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US6261469B1 (en) * 1998-10-13 2001-07-17 Honeywell International Inc. Three dimensionally periodic structural assemblies on nanometer and longer scales
US6541539B1 (en) * 1998-11-04 2003-04-01 President And Fellows Of Harvard College Hierarchically ordered porous oxides
DE10112778A1 (de) 2001-03-16 2002-10-02 Infineon Technologies Ag Biosensor, Vorrichtung und Verfahren zum Erfassen von Nukleinsäuren mittels mindestens zwei Einheiten zum Immobilisieren von Nukleinsäuren
US20060019259A1 (en) * 2004-07-22 2006-01-26 Joyce Timothy H Characterization of biopolymers by resonance tunneling and fluorescence quenching
US20060086626A1 (en) * 2004-10-22 2006-04-27 Joyce Timothy H Nanostructure resonant tunneling with a gate voltage source
US7525194B2 (en) * 2005-07-27 2009-04-28 Palo Alto Research Center Incorporated System including self-assembled interconnections
US20070190542A1 (en) * 2005-10-03 2007-08-16 Ling Xinsheng S Hybridization assisted nanopore sequencing
US20070127164A1 (en) * 2005-11-21 2007-06-07 Physical Logic Ag Nanoscale Sensor
JP5628690B2 (ja) * 2008-02-29 2014-11-19 アイメックＩｍｅｃ 導電性ナノシェルの作製
JP5264585B2 (ja) * 2009-03-24 2013-08-14 パナソニック株式会社 電子部品接合方法および電子部品
JP4880740B2 (ja) 2009-12-01 2012-02-22 シャープ株式会社 電子放出素子及びその製造方法、並びに、電子放出装置、帯電装置、画像形成装置、電子線硬化装置、自発光デバイス、画像表示装置、送風装置、冷却装置
JP5838474B2 (ja) * 2010-02-02 2016-01-06 アリゾナ ボード オブ リージェンツ オン ビハーフ オブ アリゾナ ステート ユニバーシティ ポリマーの配列を決定するための制御されたトンネルギャップデバイス
CN102822471B (zh) 2010-02-05 2015-12-16 万迪尼苏珀特宝公司 具有高速牵引驱动和连续可变变速箱的超级涡轮增压器
US20120193231A1 (en) * 2011-01-28 2012-08-02 International Business Machines Corporation Dna sequencing using multiple metal layer structure with organic coatings forming transient bonding to dna bases
US8852407B2 (en) * 2011-01-28 2014-10-07 International Business Machines Corporation Electron beam sculpting of tunneling junction for nanopore DNA sequencing
US8986524B2 (en) * 2011-01-28 2015-03-24 International Business Machines Corporation DNA sequence using multiple metal layer structure with different organic coatings forming different transient bondings to DNA

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000015844A1 (en) * 1998-09-16 2000-03-23 Incyte Pharmaceuticals, Inc. Nucleic acid sequencing with solid phase capturable terminators
WO2008043426A2 (de) * 2006-09-20 2008-04-17 Genovoxx Gmbh Komponenten und verfahren zur enzymatischen synthese von nukleinsäuren
CN101605910A (zh) * 2006-12-15 2009-12-16 帝国改革有限公司 电极系统及其在分子表征中的用途

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113221200A (zh) * 2021-04-15 2021-08-06 哈尔滨工程大学 一种适用于堆芯颗粒分布不确定性分析的三维高效随机排布方法

Also Published As

Publication number Publication date
US9804146B2 (en) 2017-10-31
JP2015532089A (ja) 2015-11-09
JP6033448B2 (ja) 2016-11-30
US20150268220A1 (en) 2015-09-24
EP2880183A1 (de) 2015-06-10
EP2880183B1 (de) 2018-04-11
WO2014048816A1 (de) 2014-04-03
DE102012217603A1 (de) 2014-03-27
IN2015DN01996A (https=) 2015-08-14

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