DE102012217603A1 - Anordnung zur Nukleinsäure-Sequenzierung mittels Tunnelstromanalyse - Google Patents

Anordnung zur Nukleinsäure-Sequenzierung mittels Tunnelstromanalyse Download PDF

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Publication number
DE102012217603A1
DE102012217603A1 DE102012217603.9A DE102012217603A DE102012217603A1 DE 102012217603 A1 DE102012217603 A1 DE 102012217603A1 DE 102012217603 A DE102012217603 A DE 102012217603A DE 102012217603 A1 DE102012217603 A1 DE 102012217603A1
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DE
Germany
Prior art keywords
particles
electrically conductive
electrodes
arrangement according
conductive particles
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Ceased
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DE102012217603.9A
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German (de)
English (en)
Inventor
Walter Gumbrecht
Oliver Hayden
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Siemens Healthcare GmbH
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Siemens AG
Siemens Corp
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Application filed by Siemens AG, Siemens Corp filed Critical Siemens AG
Priority to DE102012217603.9A priority Critical patent/DE102012217603A1/de
Priority to CN201380050219.6A priority patent/CN104704130A/zh
Priority to US14/431,896 priority patent/US9804146B2/en
Priority to IN1996DEN2015 priority patent/IN2015DN01996A/en
Priority to EP13771414.3A priority patent/EP2880183B1/de
Priority to JP2015533535A priority patent/JP6033448B2/ja
Priority to PCT/EP2013/069384 priority patent/WO2014048816A1/de
Publication of DE102012217603A1 publication Critical patent/DE102012217603A1/de
Ceased legal-status Critical Current

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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483—Physical analysis of biological material
    • G01N33/487—Physical analysis of biological material of liquid biological material
    • G01N33/48707—Physical analysis of biological material of liquid biological material by electrical means
    • G01N33/48721—Investigating individual macromolecules, e.g. by translocation through nanopores
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6869—Methods for sequencing
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/416—Systems
    • G01N27/447—Systems using electrophoresis
    • G01N27/453—Cells therefor

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biophysics (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Nanotechnology (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • General Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Electrochemistry (AREA)
  • Investigating Or Analyzing Materials By The Use Of Electric Means (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
DE102012217603.9A 2012-09-27 2012-09-27 Anordnung zur Nukleinsäure-Sequenzierung mittels Tunnelstromanalyse Ceased DE102012217603A1 (de)

Priority Applications (7)

Application Number Priority Date Filing Date Title
DE102012217603.9A DE102012217603A1 (de) 2012-09-27 2012-09-27 Anordnung zur Nukleinsäure-Sequenzierung mittels Tunnelstromanalyse
CN201380050219.6A CN104704130A (zh) 2012-09-27 2013-09-18 借助隧道电流分析用于核酸-测序的装置
US14/431,896 US9804146B2 (en) 2012-09-27 2013-09-18 Assembly for nucleic acid sequencing by means of tunnel current analysis
IN1996DEN2015 IN2015DN01996A (https=) 2012-09-27 2013-09-18
EP13771414.3A EP2880183B1 (de) 2012-09-27 2013-09-18 Anordnung zur nukleinsäure-sequenzierung mittels tunnelstromanalyse
JP2015533535A JP6033448B2 (ja) 2012-09-27 2013-09-18 トンネル電流解析を用いた核酸シークエンシングのための装置
PCT/EP2013/069384 WO2014048816A1 (de) 2012-09-27 2013-09-18 Anordnung zur nukleinsäure-sequenzierung mittels tunnelstromanalyse

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE102012217603.9A DE102012217603A1 (de) 2012-09-27 2012-09-27 Anordnung zur Nukleinsäure-Sequenzierung mittels Tunnelstromanalyse

Publications (1)

Publication Number Publication Date
DE102012217603A1 true DE102012217603A1 (de) 2014-03-27

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DE102012217603.9A Ceased DE102012217603A1 (de) 2012-09-27 2012-09-27 Anordnung zur Nukleinsäure-Sequenzierung mittels Tunnelstromanalyse

Country Status (7)

Country Link
US (1) US9804146B2 (https=)
EP (1) EP2880183B1 (https=)
JP (1) JP6033448B2 (https=)
CN (1) CN104704130A (https=)
DE (1) DE102012217603A1 (https=)
IN (1) IN2015DN01996A (https=)
WO (1) WO2014048816A1 (https=)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102013214341A1 (de) 2013-07-23 2015-01-29 Siemens Aktiengesellschaft Verfahren zum Herstellen einer Nanopore zum Sequenzieren eines Biopolymers
DE102014213814A1 (de) * 2014-07-16 2016-01-21 Siemens Aktiengesellschaft Sequenziervorrichtung und Sequenzierverfahren zur Analyse von Nukleotidsequenzen
DE102014217014A1 (de) * 2014-08-27 2016-03-03 Siemens Aktiengesellschaft Sequenzierung von Nukleinsäuren mittels Tunnelstrommessungen
CN113221200A (zh) * 2021-04-15 2021-08-06 哈尔滨工程大学 一种适用于堆芯颗粒分布不确定性分析的三维高效随机排布方法

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2019000158A1 (zh) * 2017-06-26 2019-01-03 武汉科技大学 一种基于隧道识别技术的纳米检测装置及方法
EP3456414A1 (en) 2017-09-19 2019-03-20 Siemens Healthcare GmbH Setup and method for the capture of a biopolymer and its controlled translocation through a nanoporous network

Citations (8)

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US20010019037A1 (en) * 1998-10-13 2001-09-06 Anvar Zakhidov Three dimensionally periodic structural assemblies on nanometer and longer scales
US20020190415A1 (en) * 1998-11-04 2002-12-19 Peidong Yang Hierarchically ordered porous oxides
US20070023909A1 (en) * 2005-07-27 2007-02-01 Palo Alto Research Center Incorporated System including self-assembled interconnections
WO2007041621A2 (en) * 2005-10-03 2007-04-12 Xingsheng Sean Ling Hybridization assisted nanopore sequencing
US20070125181A1 (en) * 2005-11-21 2007-06-07 Physical Logic Ag Polymer Nanosensor Device
US20100244283A1 (en) * 2009-03-24 2010-09-30 Panasonic Corporation Method of joining electronic component and the electronic component
US20100323173A1 (en) * 2008-02-29 2010-12-23 Imec Fabrication of conducting open nanoshells
US20120193237A1 (en) * 2011-01-28 2012-08-02 International Business Machines Corporation Dna sequencing using multiple metal layer structure with different organic coatings forming different transient bondings to dna

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US6046005A (en) 1997-01-15 2000-04-04 Incyte Pharmaceuticals, Inc. Nucleic acid sequencing with solid phase capturable terminators comprising a cleavable linking group
DE10112778A1 (de) 2001-03-16 2002-10-02 Infineon Technologies Ag Biosensor, Vorrichtung und Verfahren zum Erfassen von Nukleinsäuren mittels mindestens zwei Einheiten zum Immobilisieren von Nukleinsäuren
US20060019259A1 (en) * 2004-07-22 2006-01-26 Joyce Timothy H Characterization of biopolymers by resonance tunneling and fluorescence quenching
US20060086626A1 (en) * 2004-10-22 2006-04-27 Joyce Timothy H Nanostructure resonant tunneling with a gate voltage source
EP2074133A2 (de) * 2006-09-20 2009-07-01 Genovoxx GmbH Komponenten und verfahren zur enzymatischen synthese von nukleinsäuren
GB0625070D0 (en) * 2006-12-15 2007-01-24 Imp Innovations Ltd Characterization of molecules
JP4880740B2 (ja) 2009-12-01 2012-02-22 シャープ株式会社 電子放出素子及びその製造方法、並びに、電子放出装置、帯電装置、画像形成装置、電子線硬化装置、自発光デバイス、画像表示装置、送風装置、冷却装置
JP5838474B2 (ja) * 2010-02-02 2016-01-06 アリゾナ ボード オブ リージェンツ オン ビハーフ オブ アリゾナ ステート ユニバーシティ ポリマーの配列を決定するための制御されたトンネルギャップデバイス
CN102822471B (zh) 2010-02-05 2015-12-16 万迪尼苏珀特宝公司 具有高速牵引驱动和连续可变变速箱的超级涡轮增压器
US20120193231A1 (en) * 2011-01-28 2012-08-02 International Business Machines Corporation Dna sequencing using multiple metal layer structure with organic coatings forming transient bonding to dna bases
US8852407B2 (en) * 2011-01-28 2014-10-07 International Business Machines Corporation Electron beam sculpting of tunneling junction for nanopore DNA sequencing

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20010019037A1 (en) * 1998-10-13 2001-09-06 Anvar Zakhidov Three dimensionally periodic structural assemblies on nanometer and longer scales
US20020190415A1 (en) * 1998-11-04 2002-12-19 Peidong Yang Hierarchically ordered porous oxides
US20070023909A1 (en) * 2005-07-27 2007-02-01 Palo Alto Research Center Incorporated System including self-assembled interconnections
WO2007041621A2 (en) * 2005-10-03 2007-04-12 Xingsheng Sean Ling Hybridization assisted nanopore sequencing
US20070125181A1 (en) * 2005-11-21 2007-06-07 Physical Logic Ag Polymer Nanosensor Device
US20100323173A1 (en) * 2008-02-29 2010-12-23 Imec Fabrication of conducting open nanoshells
US20100244283A1 (en) * 2009-03-24 2010-09-30 Panasonic Corporation Method of joining electronic component and the electronic component
US20120193237A1 (en) * 2011-01-28 2012-08-02 International Business Machines Corporation Dna sequencing using multiple metal layer structure with different organic coatings forming different transient bondings to dna

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Ivanov, A.P. [u.a.]: DNA Tunneling Detector Embedded in a Nanopore. In: Nano Letters (2011), Vol. 11, Seiten 279-285 *

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102013214341A1 (de) 2013-07-23 2015-01-29 Siemens Aktiengesellschaft Verfahren zum Herstellen einer Nanopore zum Sequenzieren eines Biopolymers
DE102014213814A1 (de) * 2014-07-16 2016-01-21 Siemens Aktiengesellschaft Sequenziervorrichtung und Sequenzierverfahren zur Analyse von Nukleotidsequenzen
DE102014217014A1 (de) * 2014-08-27 2016-03-03 Siemens Aktiengesellschaft Sequenzierung von Nukleinsäuren mittels Tunnelstrommessungen
CN113221200A (zh) * 2021-04-15 2021-08-06 哈尔滨工程大学 一种适用于堆芯颗粒分布不确定性分析的三维高效随机排布方法

Also Published As

Publication number Publication date
US9804146B2 (en) 2017-10-31
JP2015532089A (ja) 2015-11-09
CN104704130A (zh) 2015-06-10
JP6033448B2 (ja) 2016-11-30
US20150268220A1 (en) 2015-09-24
EP2880183A1 (de) 2015-06-10
EP2880183B1 (de) 2018-04-11
WO2014048816A1 (de) 2014-04-03
IN2015DN01996A (https=) 2015-08-14

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Owner name: SIEMENS HEALTHCARE GMBH, DE

Free format text: FORMER OWNER: SIEMENS AKTIENGESELLSCHAFT, 80333 MUENCHEN, DE

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