JP6033448B2 - トンネル電流解析を用いた核酸シークエンシングのための装置 - Google Patents

トンネル電流解析を用いた核酸シークエンシングのための装置 Download PDF

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JP6033448B2
JP6033448B2 JP2015533535A JP2015533535A JP6033448B2 JP 6033448 B2 JP6033448 B2 JP 6033448B2 JP 2015533535 A JP2015533535 A JP 2015533535A JP 2015533535 A JP2015533535 A JP 2015533535A JP 6033448 B2 JP6033448 B2 JP 6033448B2
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particles
conductive particles
conductive
electrodes
diameter
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JP2015532089A (ja
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グンブレヒト ヴァルター
グンブレヒト ヴァルター
ハイデン オリヴァー
ハイデン オリヴァー
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Siemens AG
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483—Physical analysis of biological material
    • G01N33/487—Physical analysis of biological material of liquid biological material
    • G01N33/48707—Physical analysis of biological material of liquid biological material by electrical means
    • G01N33/48721—Investigating individual macromolecules, e.g. by translocation through nanopores
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6869—Methods for sequencing
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/416—Systems
    • G01N27/447—Systems using electrophoresis
    • G01N27/453—Cells therefor

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biophysics (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Nanotechnology (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • General Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Electrochemistry (AREA)
  • Investigating Or Analyzing Materials By The Use Of Electric Means (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
JP2015533535A 2012-09-27 2013-09-18 トンネル電流解析を用いた核酸シークエンシングのための装置 Expired - Fee Related JP6033448B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE102012217603.9 2012-09-27
DE102012217603.9A DE102012217603A1 (de) 2012-09-27 2012-09-27 Anordnung zur Nukleinsäure-Sequenzierung mittels Tunnelstromanalyse
PCT/EP2013/069384 WO2014048816A1 (de) 2012-09-27 2013-09-18 Anordnung zur nukleinsäure-sequenzierung mittels tunnelstromanalyse

Publications (2)

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JP2015532089A JP2015532089A (ja) 2015-11-09
JP6033448B2 true JP6033448B2 (ja) 2016-11-30

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JP2015533535A Expired - Fee Related JP6033448B2 (ja) 2012-09-27 2013-09-18 トンネル電流解析を用いた核酸シークエンシングのための装置

Country Status (7)

Country Link
US (1) US9804146B2 (https=)
EP (1) EP2880183B1 (https=)
JP (1) JP6033448B2 (https=)
CN (1) CN104704130A (https=)
DE (1) DE102012217603A1 (https=)
IN (1) IN2015DN01996A (https=)
WO (1) WO2014048816A1 (https=)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102013214341A1 (de) * 2013-07-23 2015-01-29 Siemens Aktiengesellschaft Verfahren zum Herstellen einer Nanopore zum Sequenzieren eines Biopolymers
DE102014213814A1 (de) * 2014-07-16 2016-01-21 Siemens Aktiengesellschaft Sequenziervorrichtung und Sequenzierverfahren zur Analyse von Nukleotidsequenzen
DE102014217014A1 (de) * 2014-08-27 2016-03-03 Siemens Aktiengesellschaft Sequenzierung von Nukleinsäuren mittels Tunnelstrommessungen
WO2019000158A1 (zh) * 2017-06-26 2019-01-03 武汉科技大学 一种基于隧道识别技术的纳米检测装置及方法
EP3456414A1 (en) 2017-09-19 2019-03-20 Siemens Healthcare GmbH Setup and method for the capture of a biopolymer and its controlled translocation through a nanoporous network
CN113221200B (zh) * 2021-04-15 2022-10-25 哈尔滨工程大学 一种适用于堆芯颗粒分布不确定性分析的三维高效随机排布方法

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6046005A (en) 1997-01-15 2000-04-04 Incyte Pharmaceuticals, Inc. Nucleic acid sequencing with solid phase capturable terminators comprising a cleavable linking group
US6261469B1 (en) * 1998-10-13 2001-07-17 Honeywell International Inc. Three dimensionally periodic structural assemblies on nanometer and longer scales
US6541539B1 (en) * 1998-11-04 2003-04-01 President And Fellows Of Harvard College Hierarchically ordered porous oxides
DE10112778A1 (de) 2001-03-16 2002-10-02 Infineon Technologies Ag Biosensor, Vorrichtung und Verfahren zum Erfassen von Nukleinsäuren mittels mindestens zwei Einheiten zum Immobilisieren von Nukleinsäuren
US20060019259A1 (en) * 2004-07-22 2006-01-26 Joyce Timothy H Characterization of biopolymers by resonance tunneling and fluorescence quenching
US20060086626A1 (en) * 2004-10-22 2006-04-27 Joyce Timothy H Nanostructure resonant tunneling with a gate voltage source
US7525194B2 (en) * 2005-07-27 2009-04-28 Palo Alto Research Center Incorporated System including self-assembled interconnections
US20070190542A1 (en) * 2005-10-03 2007-08-16 Ling Xinsheng S Hybridization assisted nanopore sequencing
US20070127164A1 (en) * 2005-11-21 2007-06-07 Physical Logic Ag Nanoscale Sensor
EP2074133A2 (de) * 2006-09-20 2009-07-01 Genovoxx GmbH Komponenten und verfahren zur enzymatischen synthese von nukleinsäuren
GB0625070D0 (en) * 2006-12-15 2007-01-24 Imp Innovations Ltd Characterization of molecules
JP5628690B2 (ja) * 2008-02-29 2014-11-19 アイメックＩｍｅｃ 導電性ナノシェルの作製
JP5264585B2 (ja) * 2009-03-24 2013-08-14 パナソニック株式会社 電子部品接合方法および電子部品
JP4880740B2 (ja) 2009-12-01 2012-02-22 シャープ株式会社 電子放出素子及びその製造方法、並びに、電子放出装置、帯電装置、画像形成装置、電子線硬化装置、自発光デバイス、画像表示装置、送風装置、冷却装置
JP5838474B2 (ja) * 2010-02-02 2016-01-06 アリゾナ ボード オブ リージェンツ オン ビハーフ オブ アリゾナ ステート ユニバーシティ ポリマーの配列を決定するための制御されたトンネルギャップデバイス
CN102822471B (zh) 2010-02-05 2015-12-16 万迪尼苏珀特宝公司 具有高速牵引驱动和连续可变变速箱的超级涡轮增压器
US20120193231A1 (en) * 2011-01-28 2012-08-02 International Business Machines Corporation Dna sequencing using multiple metal layer structure with organic coatings forming transient bonding to dna bases
US8852407B2 (en) * 2011-01-28 2014-10-07 International Business Machines Corporation Electron beam sculpting of tunneling junction for nanopore DNA sequencing
US8986524B2 (en) * 2011-01-28 2015-03-24 International Business Machines Corporation DNA sequence using multiple metal layer structure with different organic coatings forming different transient bondings to DNA

Also Published As

Publication number Publication date
US9804146B2 (en) 2017-10-31
JP2015532089A (ja) 2015-11-09
CN104704130A (zh) 2015-06-10
US20150268220A1 (en) 2015-09-24
EP2880183A1 (de) 2015-06-10
EP2880183B1 (de) 2018-04-11
WO2014048816A1 (de) 2014-04-03
DE102012217603A1 (de) 2014-03-27
IN2015DN01996A (https=) 2015-08-14

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