CN104688974A - Traditional Chinese medicine electuary for treating alzheimer disease - Google Patents
Traditional Chinese medicine electuary for treating alzheimer disease Download PDFInfo
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Abstract
The invention relates to traditional Chinese medicine electuary for treating alzheimer disease. The traditional Chinese medicine electuary for treating alzheimer disease can effectively solve the therapeutic problem of alzheimer disease. According to the technical scheme, the traditional Chinese medicine electuary is composed of, by weight, 12-18 g of manyprickle acanthopanax roots, 12-18 g of acorus tatarinowii, 12-18 g of prepared rehmannia roots and 2-4 g of pseudo-ginseng. The raw materials only need to be made into electuaries according to a conventional preparation method. The raw materials of the traditional Chinese medicine electuary for treating alzheimer disease are abundant, low in cost, scientific in component and reasonable in compatibility, support each other, and jointly achieve the functions of reinforcing kidney to replenish essence, promoting blood circulation to remove blood stasis and dissipating phlegm for resuscitation, and the traditional Chinese medicine electuary is effectively used for treating alzheimer disease, the curative effect is good, the medication safety is achieved, and the traditional Chinese medicine electuary is innovation for treating alzheimer disease.
Description
Technical field
The present invention relates to field of medicaments, particularly a kind of instant particles as Chinese medicine for the treatment of senile dementia.
Background technology
Dementia has been called as one of current in the world " epidemic diseases ", is classified as the 4th the modal cause of death in developed country by estimation.So-called alzheimer disease, modal is Alzheimer (Alzheimer's disease, AD).Alzheimer is a kind of PDCD occurring in Senectitude and presenium, refer to a kind of persistence higher nerve functional activity obstacle, namely under the state not having disturbance of consciousness, the obstacle of the aspects such as memory, thinking, analysis judgement, visual space identification, emotion.Its characteristic pathological is changed to atrophy of cerebral cortex, and with amyloid-beta deposition, neurofibrillary tangles, mass memory neuron number reduces, and the formation of senile plaque.The treatment of senile dementia be there is no at present to the medicine of specific treatment or reverse disease progression.The medicines such as clinical conventional vasodilation, the agent of brain metabolic activation, glutamate receptor adjusting control agent, clinical effectiveness is not good, and toxic and side effects is larger; Therefore, the improvement for the treatment of on the medicine of senile dementia is the problem needing solution at present badly.
Summary of the invention
For above-mentioned situation, for solving the defect of prior art, the object of the present invention is just to provide a kind of instant particles as Chinese medicine for the treatment of senile dementia, effectively can solve the medication problem of senile dementia.
The traditional Chinese medical science is thought, senile dementia belongs to categories such as " dementia, moronism, dementias ".Its sick position is at brain, and have substantial connection with the visceral dysfunction such as the heart, liver,spleen,kidney, disease is not quite similar.Pathogenesis is deficiency in origin and excess in superficiality, and deficiency in origin is then all dirty losss, insufficiency of vital energy and blood; Mark is that blood stasis, essential resistance of turbid phlegm are in brain key actually.Although the cause of disease of primary disease is more, be all occur in old people, this and year high deficiency of kidney-essence, the blood vessels stasis of blood is stagnant relevant.Therefore tonify deficiency righting is to effect a permanent cure in treatment, promoting blood circulation, removing blood stasis resurrects is to take stopgap measures.Accordingly, the technical scheme that the present invention solves is that this Chinese medicine is made up of the material medicine of following weighing scale: Radix Et Caulis Acanthopanacis Senticosi 12-18g, Rhizoma Acori Graminei 12-18g, Radix Rehmanniae Preparata 12-18g and Radix Notoginseng 2-4g, preparation method makes electuary routinely.
Abundant raw material of the present invention, cheap, component science, reasonable compatibility, mutual support, all medicines share plays kidney tonifying, essence replenishing, blood circulation promoting and blood stasis dispelling altogether, effect of waking up the patient from unconsciousness by dissipating phlegm, being effective to treat senile dementia, good effect, drug safety, is the innovation on treatment senile dementia.
Detailed description of the invention
Below in conjunction with embodiment, the specific embodiment of the present invention is described in further detail.
Embodiment 1
The present invention in the specific implementation, can be made up of the material medicine of following weighing scale: Radix Et Caulis Acanthopanacis Senticosi 12g, Rhizoma Acori Graminei 12g, Radix Rehmanniae Preparata 12g and Radix Notoginseng 2g, preparation method makes electuary routinely.
Embodiment 2
The present invention in the specific implementation, also can be made up of the material medicine of following weighing scale: Radix Et Caulis Acanthopanacis Senticosi 15g, Rhizoma Acori Graminei 15g, Radix Rehmanniae Preparata 15g and Radix Notoginseng 3g, preparation method makes electuary routinely.
Embodiment 3
The present invention in the specific implementation, also can be made up of the material medicine of following weighing scale: Radix Et Caulis Acanthopanacis Senticosi 18g, Rhizoma Acori Graminei 18g, Radix Rehmanniae Preparata 18g and Radix Notoginseng 4g, preparation method makes electuary routinely.
Embodiment 4
The present invention in the specific implementation, also can be made up of the material medicine of following weighing scale: Radix Et Caulis Acanthopanacis Senticosi 12g, Rhizoma Acori Graminei 18g, Radix Rehmanniae Preparata 12g and Radix Notoginseng 4g, preparation method makes electuary routinely.
Embodiment 5
The present invention in the specific implementation, also can be made up of the material medicine of following weighing scale: Radix Et Caulis Acanthopanacis Senticosi 18g, Rhizoma Acori Graminei 12g, Radix Rehmanniae Preparata 18g and Radix Notoginseng 2g, preparation method makes electuary routinely.
Described customary preparation methods can be: Radix Et Caulis Acanthopanacis Senticosi, Rhizoma Acori Graminei, Radix Rehmanniae Preparata and Radix Notoginseng are prepared granulating through grinding, warm boiled water.
Also can be: get Radix Et Caulis Acanthopanacis Senticosi, Rhizoma Acori Graminei, Radix Rehmanniae Preparata and Radix Notoginseng pulverize, put and decoct in container, add water to submerge medical material, soak 30-60min, decoct 2-3 time, each 1-2h, collecting decoction, after centrifugalize or sedimentation filter, when 80-90 DEG C, be concentrated into the thick paste that relative density is 1.30-1.35, add thick paste 0.5-2 sucrose doubly, 1-3 dextrin doubly, stir, granulate, dry.
Can also be: first Radix Et Caulis Acanthopanacis Senticosi, Rhizoma Acori Graminei, Radix Rehmanniae Preparata and Radix Notoginseng are placed in container with lid, then after adding medical material amount 4-8 leaching solvent uniform wet doubly, airtight, place 15 minutes to a few hours, medical material is fully expanded in order to avoid expand in percolator.In percolation process, supplementing solvent at any time, makes effective ingredient in medical material fully leach.Collect percolate, be concentrated into clear paste, add the adjuvant of the 20%-60% of clear paste weight, granulate, dry.
In a word, what instant particles as Chinese medicine request of the present invention was protected is Chinese medicine composition (component invention), and does not lie in preparation method, and therefore, the electuary that all employing the application Chinese prescriptions are made, and the medicine being used for the treatment of senile dementia, all belong to the scope of the application's protection.
In prescription of the present invention, Rhizoma Acori Graminei is had one's ideas straightened out refreshment, the mind calming and mentality promoting; Pungently open bitter dry temperature and lead to, fragrance is walked to alter, and not only has the merit of refreshment of having one's ideas straightened out, and has concurrently and reduce phlegm, eliminating phlegm, wards off dirty removing dampness to restore normal function of the stomach, the effect of beneficial will of allaying excitement.As Shennong's Herbal is recorded: " tonifying five ZANG-organs, logical nine orifices, improve visual and auditory acuity, goes out speech.Clothes of a specified duration are made light of one's life by commiting suicide, and do not forget, and do not confuse, and prolong life." Rhizoma Acori Graminei main chemical compositions is volatile oil, sekishone, asaricin etc., and containing aminoacid, organic acid and saccharide etc.Volatile oil has sedation to mice; Rhizoma Acori Graminei is for oral administration can be secreted by facilitating digestion liquid, alleviates intestinal tube smooth muscle spasm, has inhibitory action in vitro to Common Pathogenic dermatophytes.
Radix Et Caulis Acanthopanacis Senticosi replenishing QI to invigorate the spleen, tonifying the kidney for tranquilization, the gas of energy reinforcing the heart spleen, and QI invigorating is to nourish blood, beneficial will of calming the nerves; Modern study is thought, Radix Et Caulis Acanthopanacis Senticosi, containing multiple glucosides, is its principle active component.Radix Et Caulis Acanthopanacis Senticosi and glycoside extracts thereof, have the effects such as obvious resisting fatigue, anti-stress, anoxia enduring; Corticocerebral excitement, process of inhibition can also be improved, improve blood supply in brain amount, improve mental work usefulness.
Radix Rehmanniae Preparata is enriched blood yin nourishing, life essence-filling, marrow-benefitting; Have angst resistance effect, modern study show that it has and reduces cerebral tissue cholinesterase activity, the accumulation of suppression aluminium ion in cerebral tissue, thus Improving memory obstacle.
Pseudo-ginseng blood-circulation-invigovating disperse blood stasis and dredge collateral, energy blood stasis dispersing and fresh blood promoting, have hemostasis not stay the stasis of blood, positive feature is not hindered in blood stasis dispelling; The main component arasaponin of Radix Notoginseng is improved microcirculation and reduces the effect that secondary ischemia pays close attention to damage again; protective effect is had to neurocyte; and can promote that nervous function is recovered, and improves prognosis, reduce disability rate; this product can shorten hemorrhage and clotting time; there is antiplatelet aggregation and thrombolytic effect, myocardial oxygen consumption and coefficient of oxygen utilization can be reduced, expansion of cerebral vascular; strengthen cerebrovascular flow, promote brain cell metabolism.
All medicines share plays kidney tonifying, essence replenishing, blood circulation promoting and blood stasis dispelling altogether, the merit of waking up the patient from unconsciousness by dissipating phlegm.Can reach that inducing resuscitation and resolving phlegmization is turbid to be taken into account, QI invigorating nourishing kidney benefit brain is joined mutually, take human righteousness into account constantly, be conducive to the physiological activity of marrow brain, improve the quality of life of patient, thus reach therapeutic purposes, be effective to treat senile dementia, good effect, drug safety, and obtain sufficient proof through clinical experiment, pertinent clinical experimental data is as follows:
1, clinical data
1.1 physical data are chosen from out-patient 52 example in year July in January, 2012 to 2014, adopt method of drawing lots to be divided into treatment group and matched group each 26 routine at random with the ratio of 1:1.Wherein treatment group man 20 example, female 6 example; Age 60 ~ 85(68.3 ± 6.4) year; The course of disease 1 ~ 15(5.4 ± 2.3) year; Symptom score 10 ~ 28(17.1 ± 2.6) point.Matched group man 20 example, female 6 example; Age 60 ~ 83(67.9 ± 6.5); The course of disease 1 ~ 15(5.2 ± 2.4) year; Symptom score 11 ~ 28(16.2 ± 2.7) point.Two groups of patients the physical data such as sex, age, the course of disease, the state of an illness through statistical analysis there was no significant difference (
p>0.05), there is comparability.
2, diagnostic criteria
The diagnostic criteria of American Psychiatry disease association the 4th edition " psychotic diagnostic and statistical manual (DSM--IV) " person in middle and old age's property dementia.
1. there is many-sided cognitive defect, cash as following two sides person
A. memory defects (capability deteriorates of study fresh information maybe can not recall the information acquired in the past)
B. one of following cognitive disorder is had at least: (1) aphasia (2) agnosia (3) apraxia (4) performs the obstacle of operating capability
2. above-mentioned performance causes the defect of social activity or occupational function, and can find these functions obviously not as in the past;
3. the onset feature of the course of disease is onset gradually, continuous downturn
4. above-mentioned cognitive defect is not caused by underlying cause
A causes other remembering or central nervous system's situation of cognitive Progressive symmetric erythrokeratodermia defect, as: cerebrovascular etc.
What B reason was bright causes dull-witted general disease
5. not due to caused by delirium
6. not due to caused by Serious depression and schizophrenia
3, inclusive criteria:
1. meet Americanism obstacle to dull-witted clinical criteria, MMSE scoring is all between 10 ~ 24 points, and schooling, all more than junior middle school, belongs to light moderate senile dementia, will with seriousness patient with nervous system disease, seriousness cardiopulmonary, and hepatorenal disease is all got rid of; 2. all with dysmnesia, the symptoms such as apraxia and judgment obstacle; .2. the age was at 60 ~ 85 years old; 3. agree to participate in the experiment, signature Informed Consent Form.
Exclusion standard: 1. the age is below 60 one full year of life or 85 one full year of life above person; 2. other group of influential medicine of cognitive function is cut out in therapeutic process; 3. the severe primary disease patients such as cardiovascular, lung, liver, kidney and hemopoietic system are associated with; 4. psychotic; 5. all not by regulation medication or the not congruent judgement person that affects the treatment of data
4, therapeutic scheme
4.1 matched group patients all give donepezil hydrochloride (Tianjin Lik-Sang pharmaceutcal corporation, Ltd produces, every sheet 5mg) 5mg, and before sleeping, 10min is oral.
4.2 treatment groups coordinate instant particles as Chinese medicine of the present invention on matched group basis, and when taking, with warm boiled water, therefore claim electuary, each 6 grams, every day 3 times 60 days is a course for the treatment of;
Treatments period avoids strong tea, coffee, pungent stimulation food.Two groups of curative effects are added up after the course for the treatment of.
4.3 curative effect determinate standards are according to " diagnosis of senile dementia, differentiation of symptoms and signs for classification of syndrome and efficacy assessment standard ":
Effective: cardinal symptom is recovered substantially, sanity, accurate positioning, answers a question correct, is quick on the draw, takes care of oneself, can carry out mass society activity;
Effective: main spirits symptom alleviates or partial disappearance to some extent, life is taken care of oneself substantially, answers a question and is in the main true, but bradykinesia, intelligence, personality still have obstacle; Control: main spirits state is without increasing the weight of, and situation of taking care of oneself change is not obvious, bradykinesia, intelligence, personality still have obstacle but nothing increases the weight of;
Invalid: cardinal symptom is without change, and the state of an illness has development can't take care of oneself, and answers a question incorrect, mental dementia.Treatment is/total number of persons always effectively=(effective+effective).
5, statistical procedures
5.1 efficacy evaluations: adopt traditional Chinese medical science intelligent comprehensive point system, (1) memory (6 points); (2) orientation force (4 points); (3) ability of thinking (4 points); (4) computing power (4 points); (5) affective activity (3 points); (6) two just function (3 points) (7) activity of daily living (4 points).
5.2 result efficacy assessment standards carry out efficacy evaluation according to MMSE scoring increase and decrease situation after treatment before patient treatment.Therapeutic index: front integration × 100% of (amassing integration before dividing – to treat after treatment)/treatment.
Effective therapeutic index >=20%
Effective therapeutic index >=12%
Futile treatment index < 12%
Worsen therapeutic index <-12%
Therapeutic effect of syndrome criterion
Effective integration increases >8 and divides or reach 28 points;
Effective integral increases by 4 ~ 7 points;
Invalid integration increases <3 and divides.
All cases is a course for the treatment of of main treatment through instant particles as Chinese medicine of the present invention, carries out comparing, to judge curative effect before and after treatment by above-mentioned standard.In table 1:
Table 1 liang group Clinical efficacy comparison example (%)
Note: compare with matched group,
?p < 0.05
6, conclusion
Component science of the present invention, abundant raw material, cheap, reasonable compatibility, supports mutually, and all medicines share plays kidney tonifying, essence replenishing, blood circulation promoting and blood stasis dispelling altogether, effect of waking up the patient from unconsciousness by dissipating phlegm.Be effective to treat senile dementia, good effect, drug safety, there is actual clinical meaning.
Claims (6)
1. treat an instant particles as Chinese medicine for senile dementia, it is characterized in that, be made up of the material medicine of following weighing scale: Radix Et Caulis Acanthopanacis Senticosi 12-18g, Rhizoma Acori Graminei 12-18g, Radix Rehmanniae Preparata 12-18g and Radix Notoginseng 2-4g, preparation method makes electuary routinely.
2. the instant particles as Chinese medicine for the treatment of senile dementia according to claim 1, is characterized in that, is made up of the material medicine of following weighing scale: Radix Et Caulis Acanthopanacis Senticosi 13g, Rhizoma Acori Graminei 13g, Radix Rehmanniae Preparata 13g and Radix Notoginseng 2.5g, preparation method makes electuary routinely.
3. the instant particles as Chinese medicine for the treatment of senile dementia according to claim 1, is characterized in that, is made up of the material medicine of following weighing scale: Radix Et Caulis Acanthopanacis Senticosi 15g, Rhizoma Acori Graminei 15g, Radix Rehmanniae Preparata 15g and Radix Notoginseng 3g, preparation method makes electuary routinely.
4. the instant particles as Chinese medicine for the treatment of senile dementia according to claim 1, is characterized in that, is made up of the material medicine of following weighing scale: Radix Et Caulis Acanthopanacis Senticosi 17g, Rhizoma Acori Graminei 17g, Radix Rehmanniae Preparata 17g and Radix Notoginseng 3.5g, preparation method makes electuary routinely.
5. the instant particles as Chinese medicine for the treatment of senile dementia according to claim 1, is characterized in that, is made up of the material medicine of following weighing scale: Radix Et Caulis Acanthopanacis Senticosi 12g, Rhizoma Acori Graminei 18g, Radix Rehmanniae Preparata 12g and Radix Notoginseng 4g, preparation method makes electuary routinely.
6. the instant particles as Chinese medicine for the treatment of senile dementia according to claim 1, is characterized in that, is made up of the material medicine of following weighing scale: Radix Et Caulis Acanthopanacis Senticosi 18g, Rhizoma Acori Graminei 12g, Radix Rehmanniae Preparata 18g and Radix Notoginseng 2g, preparation method makes electuary routinely.
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN105287985A (en) * | 2015-11-27 | 2016-02-03 | 广州白云山医药集团股份有限公司白云山制药总厂 | Application of composition to preparation of medicines for preventing and treating senile dementia |
| CN105287990A (en) * | 2015-10-10 | 2016-02-03 | 南京中医药大学 | Traditional Chinese medicinal preparation for preventing and treating senile dementia and preparation method of traditional Chinese medicinal preparation |
| CN113144105A (en) * | 2021-03-01 | 2021-07-23 | 湖南鹍廷科技开发有限责任公司 | Traditional Chinese medicine preparation for treating senile dementia and preparation method thereof |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105287990A (en) * | 2015-10-10 | 2016-02-03 | 南京中医药大学 | Traditional Chinese medicinal preparation for preventing and treating senile dementia and preparation method of traditional Chinese medicinal preparation |
| CN105287990B (en) * | 2015-10-10 | 2020-02-07 | 南京中医药大学 | Traditional Chinese medicine preparation for preventing and treating senile dementia and preparation method thereof |
| CN105287985A (en) * | 2015-11-27 | 2016-02-03 | 广州白云山医药集团股份有限公司白云山制药总厂 | Application of composition to preparation of medicines for preventing and treating senile dementia |
| CN105287985B (en) * | 2015-11-27 | 2020-05-01 | 广州白云山医药集团股份有限公司白云山制药总厂 | Application of pharmaceutical composition in preparing medicine for preventing and treating senile dementia |
| CN113144105A (en) * | 2021-03-01 | 2021-07-23 | 湖南鹍廷科技开发有限责任公司 | Traditional Chinese medicine preparation for treating senile dementia and preparation method thereof |
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