CN116966247B - Traditional Chinese medicine composition and medicine for treating cerebral edema - Google Patents
Traditional Chinese medicine composition and medicine for treating cerebral edema Download PDFInfo
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- CN116966247B CN116966247B CN202310514027.1A CN202310514027A CN116966247B CN 116966247 B CN116966247 B CN 116966247B CN 202310514027 A CN202310514027 A CN 202310514027A CN 116966247 B CN116966247 B CN 116966247B
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Abstract
The invention provides a traditional Chinese medicine composition for treating cerebral edema, which is prepared from the following raw materials in parts by weight: 0.03-0.06 part of musk, 0.03-0.1 part of borneol, 1-3 parts of vinegar-baked euphorbia kansui, 1-3 parts of vinegar-baked euphorbia pekinensis, 1-3 parts of white mustard seed, 10-15 parts of cogongrass rhizome, 3-6 parts of amber, 10-15 parts of motherwort, 10-15 parts of medicinal cyathula root, 15-20 parts of poria cocos, 6-10 parts of ephedra herb, 10-12 parts of almond and 5-10 parts of baked licorice. The traditional Chinese medicine composition can effectively relieve common pathological mechanism-cerebral edema of diseases such as stroke, cerebral trauma and encephalitis, can relieve cerebral edema, reduce intracranial hypertension, improve nerve function and reduce death rate, has no obvious side effect and has wide application prospect.
Description
Technical Field
The invention belongs to the technical field of traditional Chinese medicines, and particularly relates to a traditional Chinese medicine composition and a medicine for treating cerebral edema.
Background
Cerebral edema is a nonspecific pathological swelling of the brain, and any type of nerve injury may develop gradually in a focal or diffuse manner, such as cerebral infarction, cerebral hemorrhage, encephalitis, brain tumor, hepatic encephalopathy, traumatic brain injury, etc. Commonly accepted cerebral oedema is defined as: the excessive accumulation of cerebral parenchymal fluid caused by various intracranial lesions and systemic diseases leads to increased brain volume and weight, and is classified into angiogenic cerebral edema, cytotoxic cerebral edema, interstitial cerebral edema and osmotic cerebral edema according to the pathogenesis and pathological changes. The development and progression of cerebral edema is a key factor in the deterioration of the patient's condition. In the early stages of cerebral edema formation, the patient's symptoms are mild and compensatory adjustments can be made in the brain, such as balancing the increase in water in the brain by reducing cerebrospinal fluid and blood volume. However, if the water content increases sharply due to the presence of the skull, cerebral edema progresses more rapidly than the maximum extent that can be compensated, resulting in increased intracranial pressure, eventually forming a cerebral hernia, causing damage to brain tissue and even leading to death of the patient. Cerebral edema is a powerful predictor of prognosis, accounting for 50% of mortality from severe traumatic brain injury, 80% of mortality from large-area cerebral infarction, and one third of hepatic encephalopathy patients die from cerebral edema and cerebral hemorrhage with consequent rise in intracranial pressure.
Cerebral edema belongs to critical clinical symptoms, and how to control the progress of cerebral edema in time is particularly critical for patients to get the golden opportunity for rescue. Current strategies for treating cerebral edema have not progressed as rapidly as other areas of the nervous system. The common method for controlling cerebral edema in modern medicine is surgical bone flap decompression, which can reduce mortality, but is limited in application by reasons such as increased long-term severe disability rate, critical illness, incapability of implementing patients with life-threatening complications, and the like. In addition, the recent emerging cryotherapy may improve neurological prognosis for controlling cerebral edema, but lacks central, large-sample clinical study support, and has a higher risk of adverse events during treatment. The application of osmotic therapy in the clinical treatment of cerebral edema is wide, however, the effectiveness thereof mainly depends on whether the blood-brain barrier is complete, the reflection coefficient of osmotic drugs and whether osmotic gradients are generated, and contraindications and adverse reactions exist in the use of such drugs, such as mannitol can cause hypovolemia and kidney injury, and hypertonic saline can cause ion metabolic disorder, volume overload, phlebitis, hypertension and the like. Other treatments such as analgesia sedation, elevation of bedside 30 °, hyperventilation, and the lack of high quality studies of the novel targeted drugs glibenclamide, bumetanide, fingolimod, etc. confirm their effectiveness.
The traditional Chinese medicine does not directly record and know 'cerebral edema', and according to symptoms after brain injury and pathophysiology of modern medicine, the modern traditional Chinese medicine proposes that the formation of cerebral edema is mostly caused by qi movement disorder, unsmooth blood circulation in brain and abnormal body fluid distribution, so that the cerebral vessels are overflowed with water; or qi deficiency and blood stasis in brain, unsmooth blood circulation and unfavorable distribution of body fluids; or overstrain, improper diet, long-term wetland, spleen deficiency and dampness stagnation, which can cause excessive water dampness and cover brain orifices; or qi and blood dysfunction, which results in stagnant blood in brain vessels or blood overflows to the brain, finally stagnant blood stays in the brain, water and fluid seeps out, and water stasis is mutually accumulated in the brain. The academic world of traditional Chinese medicine mainly expands some discussions around the pathogenesis typing of cerebral edema and the independent prescription of the pathogenesis typing of cerebral edema, but no traditional Chinese medicine preparation specially aiming at cerebral edema is marketed yet, and no significant breakthrough in clinical treatment, theory and the like can be generated.
Disclosure of Invention
Based on the above, the invention aims to provide a traditional Chinese medicine composition for treating cerebral edema, which can effectively relieve cerebral edema, reduce intracranial hypertension, improve nerve function and reduce the death rate.
In order to achieve the above purpose, the present invention adopts the following technical scheme.
The traditional Chinese medicine composition for treating cerebral edema is prepared from the following raw materials in parts by weight: 0.03-0.06 part of musk, 0.03-0.1 part of borneol, 1-3 parts of vinegar-baked euphorbia kansui, 1-3 parts of vinegar-baked euphorbia pekinensis, 1-3 parts of white mustard seed, 10-15 parts of cogongrass rhizome, 3-6 parts of amber, 10-15 parts of motherwort, 10-15 parts of medicinal cyathula root, 15-20 parts of poria cocos, 6-10 parts of ephedra herb, 10-12 parts of almond and 5-10 parts of baked licorice.
In some preferred embodiments, the active ingredients of the traditional Chinese medicine composition for treating cerebral edema are prepared from the following raw materials in parts by weight: 0.03-0.05 part of musk, 0.05-0.1 part of borneol, 1-3 parts of vinegar-baked euphorbia kansui, 1-3 parts of vinegar-baked euphorbia pekinensis, 1-3 parts of white mustard seed, 12-15 parts of cogongrass rhizome, 3-5 parts of amber, 12-15 parts of motherwort, 10-12 parts of medicinal cyathula root, 15-18 parts of poria cocos, 8-10 parts of ephedra herb, 10-12 parts of almond and 5-8 parts of baked licorice.
More preferably, the active ingredients of the traditional Chinese medicine composition for treating cerebral edema are prepared from the following raw materials in parts by weight: musk 0.03, borneol 0.1, vinegar-baked euphorbia kansui 3, vinegar-baked euphorbia pekinensis 3, white mustard seed 3, cogongrass rhizome 15, amber 3, motherwort 15, medicinal cyathula root 10, poria cocos 15, ephedra 8, almond 10 and baked licorice 5.
In some embodiments, the musk is an artificial musk.
The invention also provides a traditional Chinese medicine preparation for treating cerebral edema, which comprises the traditional Chinese medicine composition.
In some embodiments, the dosage form of the traditional Chinese medicine preparation is honeyed pills, granules, tablets, powder and capsules.
In some preferred embodiments, the dosage form of the traditional Chinese medicine preparation is a honeyed pill.
In some embodiments, the method for preparing the traditional Chinese medicine preparation comprises the following steps: (1) Pulverizing radix kansui Preparata with vinegar, semen Sinapis Albae, lalang grass rhizome, succinum, herba Leonuri, radix Cyathulae, poria, herba Ephedrae, semen Armeniacae amarum, radix Glycyrrhizae Preparata and radix Knoxiae Preparata with vinegar, and sterilizing; (2) Grinding musk and borneol, and then adding the ground musk and borneol into the sterilized product in the step (1) to obtain medicinal powder; (3) Adding refined honey into the medicinal powder, and making into pill to obtain the Chinese medicinal preparation.
In some embodiments, the weight ratio of the powder to refined honey is 1: (1-1.5).
The invention also provides a preparation method of the traditional Chinese medicine composition, which comprises the following steps: (1) Pulverizing radix kansui Preparata with vinegar, semen Sinapis Albae, lalang grass rhizome, succinum, herba Leonuri, radix Cyathulae, poria, herba Ephedrae, semen Armeniacae amarum, radix Glycyrrhizae Preparata and radix Knoxiae Preparata with vinegar, and sterilizing; (2) Grinding musk and borneol, and then adding the ground musk and borneol into the sterilized product obtained in the step (1) to obtain the traditional Chinese medicine composition.
The invention also provides application of the traditional Chinese medicine composition in preparing a traditional Chinese medicine preparation for treating cerebral edema.
The invention provides a traditional Chinese medicine composition for treating cerebral edema, which comprises musk, borneol, vinegar-baked kansui root, white mustard seed, cogongrass rhizome, amber, motherwort, medicinal cyathula root, poria cocos, ephedra, almond, baked licorice root and vinegar-baked euphorbia pekinensis. The traditional Chinese medicine composition mainly comprises 'son Long Miao pills' and 'Cantonese decoction', and is composed of drugs for inducing resuscitation and restoring consciousness and promoting blood circulation and inducing diuresis, and has the effects of 'drastic draining water, promoting blood circulation and removing blood stasis, restoring consciousness and restoring spirit'. Wherein, the 'ZI Long Miao Yingwan' is taken as a monarch drug: white mustard seed is taken to enter the lung to reach upper jiao, vinegar-baked euphorbia kansui is yellow to enter the spleen to move middle jiao, vinegar-baked euphorbia kansui is black to enter the kidney to move lower jiao, white mustard seed is taken to move water decoction outside the inner membrane of the skin, euphorbia kansui is taken to move through tunnel water decoction, vinegar-baked euphorbia kansui is taken to move through viscera, and the three are led to be different, so that water is removed under drastic action, and cerebral edema is eliminated from urination and defecation. The ministerial drugs comprise motherwort herb and cogongrass rhizome, which can promote blood circulation and induce diuresis, and can promote the brain to open, and can promote the water passage to remove blood stasis and promote tissue regeneration; succinum has effects of promoting blood circulation for removing blood stasis, inducing diuresis for treating stranguria, and can induce pathogenic factors to descend; radix Cyathulae has effects of inducing fire and descending blood, promoting blood circulation and removing water retention, and tonifying liver and kidney. With the assistance of 'Cannabis decoction', the ephedra can ventilate the lung and the boiled water can be added into the lung to ventilate the souls; the almond enters collaterals to reduce the adverse flow of the almond; prepared licorice root, radix Glycyrrhizae Praeparata goes into the fu organs to slow down its sudden and violent adverse reaction to dissipate the power and to tranquilize the mind. The medicine is musk, fragrant and pungent in smell, good in dredging the orifices, and small in dosage, the medicine is used for inducing resuscitation, promoting blood circulation, promoting diuresis, ascending the clear and descending the turbid; borneol has aromatic effect for inducing resuscitation.
The inventor has clinical research experience of treating various cerebral oedemas by years of engaged in traditional Chinese medicine, combines modern pharmacological research results, is based on the theory of 'cerebral water stasis', combines clinical practice, and can quickly and effectively reduce cerebral oedema and intracranial pressure by continuously optimizing a formula, thereby improving nerve function, reducing death rate, having no obvious side effect and having wide application prospect.
Drawings
FIG. 1 is a graph showing the results of a 3 month mRS patient ratio analysis for the treatment group and the control group.
Detailed Description
The experimental methods of the present invention, in which specific conditions are not specified in the following examples, are generally conducted under conventional conditions or under conditions recommended by the manufacturer. The various chemicals commonly used in the examples are commercially available.
Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs. The terminology used in the description of the invention herein is for the purpose of describing particular embodiments only and is not intended to be limiting of the invention.
The terms "comprising" and "having" and any variations thereof, are intended to cover a non-exclusive inclusion. For example, a process, method, apparatus, article, or device that comprises a list of steps is not limited to the elements or modules listed but may alternatively include additional steps not listed or inherent to such process, method, article, or device.
Cerebral edema is a neurologic emergency, and is a peak of cerebral edema 3-5 days after acute brain injury, and if the cerebral edema is not cured in time, the cerebral edema becomes herniated, so that coma and respiratory heartbeat stop are caused. Modern traditional Chinese medicine holds that the 'water stasis inter-junction intracranial' caused by various causes is a core pathogenesis of cerebral edema, and blood stasis and water drink are mutually influenced and mutually cemented, so that brain spirit is malnourished, and brain orifices are not led to be led to the communication. The brain is the house of the spirit, the place of the spirit of people and the place of clearing the orifices, and the precious place of clearing the smart. The inventor combines abundant clinical experience and a large amount of basic research results, and considers that the treatment of cerebral edema is critical in removing the evil of cerebral water stasis as soon as possible, and the medicine can be directly introduced into brain orifices to break malignant circulation so as to recover qing ling. In the treatment of the symptom of cerebral water stasis, the single treatment of the symptom of cerebral water stasis is that the water is not removed, the water is not dispersed, the orifice is not communicated, and the treatment of the symptom of the cerebral water stasis is that only the symptom of removing the water stasis and inducing diuresis, and the restoration of consciousness are positive. Therefore, the medicine prescription with great special effect and quick effect can relieve the danger, the medicine with drastic water-expelling effect can rapidly discharge excessive water in brain tissues in a short period, and simultaneously does not forget to remove blood stasis and detoxify, open brain orifices, and has no toxic or side effect on human bodies, so that the traditional Chinese medicine composition is continuously optimized and obtained on the basis.
The following description is made with reference to specific embodiments.
Example 1
The embodiment provides a traditional Chinese medicine composition for treating cerebral edema, which is prepared from the following raw materials in parts by weight: musk 0.03, borneol 0.1, vinegar-baked euphorbia kansui 3, vinegar-baked euphorbia pekinensis 3, white mustard seed 3, cogongrass rhizome 15, amber 3, motherwort 15, medicinal cyathula root 10, poria cocos 15, ephedra 8, almond 10 and baked licorice 5.
The invention also provides a traditional Chinese medicine preparation for treating cerebral edema, which is a honeyed pill, and the preparation method comprises the following steps: (1) Pulverizing radix kansui Preparata with vinegar, semen Sinapis Albae, lalang grass rhizome, succinum, herba Leonuri, radix Cyathulae, poria, herba Ephedrae, semen Armeniacae amarum, radix Glycyrrhizae Preparata and radix Knoxiae Preparata with vinegar, and sterilizing; (2) Grinding artificial musk, crushing borneol, and then adding the crushed musk into the sterilized product in the step (1) to obtain medicinal powder; (3) Adding 100-150 g refined honey (medium honey) into 100g of the medicinal powder, and making into big honeyed pill with 9 g pill weight.
Example 2
This example uses the honeyed pill of example 1 to treat patients with cerebral infarction and cerebral edema.
The clinical efficacy and safety of the honeyed pill described in example 1 in treating large area cerebral infarction were observed by prospective, randomized controlled, blind endpoint study.
The key points of syndrome differentiation are as follows: (1) the blindness is manifested by distending head, headache, excessive phlegm and saliva, dizziness, emesis, absentmindedness, amnesia, insomnia, or even confusion, dull expression, and slow reaction. Or epilepsy and convulsion; the people can cry and laugh, lose the calculation and act strangely; or see language reversal, word shortages, etc. (2) The loss of the limbs manifests as numbness, swelling, heavy stagnation, weakness, and muscle and tendon loss . Or hand and foot shake, or limb disuse, or even hemiplegia. (3) Loss of seven orifices is manifested as slurred speech, even loss of speech, stiff tongue root, choking and cough with drinking water, excessive mouth and saliva, excessive eyes and tears, excessive nose and nasal discharge, blurred vision or blurred vision, facial distortion, tinnitus and deafness, and incontinence of urination and urination. (4) The tongue pulse is manifested as a plurality of reddish or purple or bluish-purple tongue; the tongue body has blood stasis points and blood stasis spots, or the tongue body is fat and has tooth marks; coarse and dark color of sublingual venation; the tongue coating is watery or greasy. Its pulse condition is usually wiry and slippery, wiry and hard or deep, thready and astringent.
Patients were enrolled in 60 cases and randomized into 2 groups (treatment and control) of 30 cases each. Wherein, the honeyed pill described in example 1 is added to the Western basic treatment scheme, and the dosage is as follows: 9 g each time, twice daily, and nasal feeding after warming and melting; the control group used only the western medicine basal treatment regimen. The western medicine base treatment regimen was performed with reference to the on-screen large area cerebral infarction (Large hemispheric infarction, LHI) guidelines issued together on Neurocrit Care by the national institute of neurological intensive Care and emergency medical society (NCS).
The relevant efficacy index and laboratory data index at day 4, day 7, day 14 and month 3 after treatment were analyzed separately, the comparison between the two groups of the normal distribution was made using the independent sample T test for the metric data, the comparison between the two groups of the normal distribution was made using the mann-whitty rank sum test for the non-compliance, and the comparison between the count data groups was made using the X2 test, with P <0.05 being considered statistically different. The results are shown in Table 1:
TABLE 1 analysis of efficacy
Complications and bowel movements of both groups of patients during treatment are shown in table 2:
TABLE 2 complications and bowel movement conditions for two groups of patients
Project | Treatment group (n=30) | Control group (n=30) | P |
Complications of the invention | |||
Bleeding conversion [ n (%)] | 6(20.0) | 3(10.0) | 0.278 |
Epilepsy [ n (%)] | 2(6.7) | 2(6.67) | 1.000 |
Venous thrombosis [ n (%)] | 3(10.0) | 6(20.0) | 0.278 |
Acute heart failure [ n (%)] | 0(0.0) | 1(3.3) | 0.313 |
Pneumonia [ n (%)] | 18(60.0) | 18(60.0) | 1.000 |
Constipation of stool | |||
Diarrhea [ n (%)] | 8(26.7) | 3(10.0) | 0.068 |
Average number of stool/day M [ IQR ]] | 0.75(0.6-1.3) | 0.5(0.3-0.7) | 0.001* |
The results of the 3 month mRS patient ratio analysis for the treatment and control groups are shown in figure 1. Mortality in the treatment and control groups was 26.7% (8/30) and 53.3% (16/30) at 3 months, respectively; the severe disability rate of surviving patients was 36.4% (8/22) and 64.3% (9/14), respectively; the median severe disability rate in surviving patients was 86.4% (19/22) and 92.9% (13/14), respectively; the prognosis is good (mRS.ltoreq.3 min.) at 16.6% (5/30) and 3.3% (1/30), respectively. Mortality in the treatment group was significantly reduced, statistically significant (p=0.035).
The results show that the traditional Chinese medicine composition provided by the invention is safe for treating large-area cerebral infarction, and can reduce mortality (the death rate of a treatment group and a control group is respectively 26.7% and 53.3%, and P is less than 0.05), and cerebral edema (the midline shift of a skull CT display is carried out for 7 days, and the death rate of the treatment group is obviously lower than that of the control group, and P is less than 0.05). The secondary outcome measures were further analyzed, NIHSS score at day 7, central line shift shown by cranium CT was significantly lower in the treatment group than in the control group, blood osmolarity level at day 7 was significantly higher than in the control group (P < 0.05), and stool average number/day was significantly greater than in the control group (P < 0.05).
We analyze that the mechanism by which the Chinese medicinal composition of the present invention acts may be: by relieving cerebral edema, the nerve function of the patient is improved, and the death rate of large-area cerebral infarction is reduced. The cerebral edema of large-area cerebral infarction usually rapidly progresses to peak within 5 days of onset, patients within 48 hours of onset are involved, and the early intervention by using the traditional Chinese medicine composition also shows that the NIHSS score on the 7 th day of a treatment group and the midline shift of the skull CT display are obviously lower than those of a control group, so that the cerebral edema can be relieved after the traditional Chinese medicine is dried. The blood osmotic pressure level on the 7 th day is obviously higher than that of a control group, and the average number of times of stool during treatment is obviously increased, so that the traditional Chinese medicine composition can achieve the effect similar to that of osmotic therapy by promoting diuresis and reducing turbidity, so as to relieve cerebral edema, alleviate intracranial hypertension and improve nerve function.
In previous studies, the inventors have created other formulations for treating cerebral oedema, such as a formulation with better efficacy: 15-30g of red sage root, 15-30g of motherwort herb, 10-12g of szechuan lovage rhizome, 10-15g of red paeony root, 10-15g of peach seed, safflower and medicinal cyathula root, 15-24g of Indian buead, 0.1-0.2g of musk (taken after being infused with water) and 6-10g of amber. When musk is absent, 10-12g of angelica dahurica or 0.1-0.2g of borneol can be used for replacing (taking with water). In the recipe, musk and borneol are prepared by dissolving decoction for inducing resuscitation and activating blood, and musk and borneol are fragrant in smell, induce resuscitation and activating blood, induce yin to reach yang, and fragrance to channel away, so the recipe is suitable for treating hydrocephalus and blood accumulation, and is a monarch drug; chuan Xiong is pungent and warm in nature and moves away, moves qi and activates blood, is a qi-flowing herb in blood, and is combined with she Xiang to increase its action of inducing resuscitation; the salvia miltiorrhiza has the same function as four substances, and is used for activating blood and dissolving stasis without hurting the healthy energy; peach kernel and safflower activate blood and remove stasis; the red paeony root has the effects of promoting qi and blood circulation and strengthening the blood stasis and is taken as a ministerial drug; motherwort herb and tuckahoe, herba Leonuri and tuckahoe, poria have the effect of promoting blood circulation and removing water retention, and can be used for inducing resuscitation and water retention to help remove blood stasis and promote tissue regeneration; radix Cyathulae has effects of inducing fire and descending blood, promoting blood circulation and promoting diuresis, tonifying liver and kidney, promoting diuresis and relieving constipation, and semen Persicae has effects of loosening bowel and relieving constipation, and can be used as adjuvant drug for eliminating pathogenic factors from the front and back of the patient; succinum has effects of promoting blood circulation for removing blood stasis, inducing diuresis for treating stranguria, and can induce pathogenic factors to act downwards to treat severe cerebral edema, and often has effects of dewatering and lowering intracranial pressure. However, in clinical practice, the prescription has the important effects of activating blood and removing stasis, inducing resuscitation and dredging collaterals, but has insufficient blood-activating and diuresis-promoting effects, and from the modern medical point of view, "cerebral edema-intracranial hypertension-cerebral hernia-central respiratory circulatory failure" is a pathological process of worsening of the condition. The key point of the treatment is that the pathogenic factor of the craniocerebral water stasis is removed as soon as possible, and the medicine can be directly introduced into brain orifices to break the malignant circulation so as to recover the qingling. In the treatment of the symptom of cerebral water stasis, the single treatment of the symptom of cerebral water stasis is that the water is not removed, the water is not dispersed, the orifice is not communicated, and the treatment of the symptom of the cerebral water stasis is that only the symptom of removing the water stasis and inducing diuresis, and the restoration of consciousness are positive. Therefore, the medicine has the advantages of great special effect, quick response, capability of draining excessive water of brain tissues in a short period to eliminate edema, no forgetting to remove blood stasis and detoxify, opening brain orifices, and no toxic or side effect on human bodies. Based on the above formula, the Zilong Miao pill is added to remove water and eliminate phlegm, so that the craniocerebral water evil can go out from the urination and defecation, and the effect of promoting diuresis is enhanced; adding herba Ephedrae into lung to make it calm; the almond enters collaterals to reduce the adverse flow of the almond; prepared licorice root, radix Glycyrrhizae Praeparata goes into the fu organs to slow down its sudden and violent, will be dispersed in the adverse reaction and soul will be enough to assist musk and borneol to refresh the brain and induce resuscitation. Thus, the defects of the above formula are overcome, the treatment effect is further improved, and the mortality and disability rate are reduced.
In conclusion, the traditional Chinese medicine composition disclosed by the invention can effectively relieve common pathological mechanisms of diseases such as stroke, cerebral trauma and encephalitis, namely cerebral edema, relieve cerebral edema, reduce intracranial hypertension, improve nerve function and reduce death rate, and has a wide application prospect.
The technical features of the above embodiments may be arbitrarily combined, and all possible combinations of the technical features in the above embodiments are not described for brevity of description, however, as long as there is no contradiction between the combinations of the technical features, they should be considered as the scope of the description.
The foregoing examples illustrate only a few embodiments of the invention and are described in detail herein without thereby limiting the scope of the invention. It should be noted that it will be apparent to those skilled in the art that several variations and modifications can be made without departing from the spirit of the invention, which are all within the scope of the invention. Accordingly, the scope of protection of the present invention is to be determined by the appended claims.
Claims (10)
1. The traditional Chinese medicine composition for treating cerebral edema is characterized in that the active ingredients of the traditional Chinese medicine composition are prepared from the following raw materials in parts by weight: 0.03-0.06 part of musk, 0.03-0.1 part of borneol, 1-3 parts of vinegar-baked euphorbia kansui, 1-3 parts of vinegar-baked euphorbia pekinensis, 1-3 parts of white mustard seed, 10-15 parts of cogongrass rhizome, 3-6 parts of amber, 10-15 parts of motherwort, 10-15 parts of medicinal cyathula root, 15-20 parts of poria cocos, 6-10 parts of ephedra herb, 10-12 parts of almond and 5-10 parts of baked licorice.
2. The traditional Chinese medicine composition for treating cerebral edema according to claim 1, wherein the active ingredients of the traditional Chinese medicine composition are prepared from the following raw materials in parts by weight: 0.03-0.05 part of musk, 0.05-0.1 part of borneol, 1-3 parts of vinegar-baked euphorbia kansui, 1-3 parts of vinegar-baked euphorbia pekinensis, 1-3 parts of white mustard seed, 12-15 parts of cogongrass rhizome, 3-5 parts of amber, 12-15 parts of motherwort, 10-12 parts of medicinal cyathula root, 15-18 parts of poria cocos, 8-10 parts of ephedra herb, 10-12 parts of almond and 5-8 parts of baked licorice.
3. The traditional Chinese medicine composition for treating cerebral edema according to claim 1, wherein the active ingredients of the traditional Chinese medicine composition are prepared from the following raw materials in parts by weight: musk 0.03, borneol 0.1, vinegar-baked euphorbia kansui 3, vinegar-baked euphorbia pekinensis 3, white mustard seed 3, cogongrass rhizome 15, amber 3, motherwort 15, medicinal cyathula root 10, poria cocos 15, ephedra 8, almond 10 and baked licorice 5.
4. A traditional Chinese medicine preparation for treating cerebral edema, characterized in that the active ingredient of the traditional Chinese medicine preparation is the traditional Chinese medicine composition according to any one of claims 1-3.
5. The traditional Chinese medicine preparation for treating cerebral edema according to claim 4, wherein the dosage form of the traditional Chinese medicine preparation is honeyed pills, granules, tablets, powder and capsules.
6. The traditional Chinese medicine preparation for treating cerebral edema according to claim 5, wherein the dosage form of the traditional Chinese medicine preparation is a honeyed pill.
7. The method for preparing a traditional Chinese medicine preparation for treating cerebral edema according to claim 6, comprising the following steps: (1) Pulverizing radix kansui Preparata with vinegar, semen Sinapis Albae, lalang grass rhizome, succinum, herba Leonuri, radix Cyathulae, poria, herba Ephedrae, semen Armeniacae amarum, radix Glycyrrhizae Preparata and radix Knoxiae Preparata with vinegar, and sterilizing; (2) Grinding musk and borneol, and then adding the ground musk and borneol into the sterilized product in the step (1) to obtain medicinal powder; (3) Adding refined honey into the medicinal powder, and making into pill to obtain the Chinese medicinal preparation.
8. The method for preparing a traditional Chinese medicine preparation for treating cerebral edema according to claim 7, wherein the weight ratio of the medicinal powder to refined honey is 1: (1-1.5).
9. A method for preparing a Chinese medicinal composition according to any one of claims 1 to 3, comprising the steps of: (1) Pulverizing radix kansui Preparata with vinegar, semen Sinapis Albae, lalang grass rhizome, succinum, herba Leonuri, radix Cyathulae, poria, herba Ephedrae, semen Armeniacae amarum, radix Glycyrrhizae Preparata and radix Knoxiae Preparata with vinegar, and sterilizing; (2) Grinding musk and borneol, and then adding the ground musk and borneol into the sterilized product obtained in the step (1) to obtain the traditional Chinese medicine composition.
10. Use of a Chinese medicinal composition according to any one of claims 1 to 3 for the preparation of a Chinese medicinal preparation for the treatment of cerebral oedema.
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