CN105232976B - Composition for preventing or/and treating sub-health - Google Patents
Composition for preventing or/and treating sub-health Download PDFInfo
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Abstract
The invention provides a composition for preventing or/and treating sub-health, which is prepared from the following raw materials in parts by weight: 15-55 parts of pilose antler, 140 parts of turtle shell glue, 80-120 parts of American ginseng, 170 parts of lucid ganoderma, 170 parts of pseudo-ginseng, 30-70 parts of pearl, 80-120 parts of chicken's gizzard-membrane and 40-80 parts of bletilla striata. The invention also provides a preparation method and application of the composition. The composition prepared by the invention has obvious curative effect on sub-health, the total effective rate reaches 91.94%, and the composition provides a new medicament which is high-efficiency, safe, free from toxic and side effects, suitable for long-term administration and wide in market prospect for clinical treatment of sub-health.
Description
Technical Field
The invention relates to a composition for preventing or/and treating sub-health, a preparation method and application thereof, belonging to the field of medicines.
Background
Sub-health is a state between health and disease, and its high incidence parallels the progress of society, causing serious social burden, and has become a health problem that cannot be ignored. According to related researches, the number of people in sub-health state in China exceeds 7 hundred million, and accounts for 60-70% of the total population in China. The young and middle-aged people are sub-healthy high-incidence people, and the proportion is close to 50%.
The symptoms of sub-health include fatigue, decreased immunity, constipation, insomnia, anorexia, irritability, postprandial drowsiness, canker sores, weakness, repeated colds, etc., with fatigue being the most prominent and common manifestation of sub-health. The sub-health fatigue is not defined relatively uniformly at present, and domestic scholars think that the fatigue which cannot be relieved by rest and sleep and is difficult to be diagnosed clearly through clinical physicochemical examination is called the sub-health fatigue.
Modern medicine has made many attempts to treat sub-health, but since sub-health is mainly a change in function, characterized by a decrease in quality of life, involving no substantial pathology, and lacking in clear physicochemical index changes, it is difficult to establish a specific diagnostic standard from the current laboratory examination. Relatively speaking, the traditional Chinese medicine has remarkable advantages in the aspect of preventive treatment, has more methods, has the advantages of oral administration, traditional Chinese medicine medicated diet and paste prescription, acupuncture, cupping, massage, scraping and the like, is generally superior to western medicines in the aspect of symptom improvement, has small toxic and side effects, is suitable for long-term administration and the like.
At present, the traditional Chinese medicines for treating sub-health are fewer and cannot meet the requirements of patients on medication and treatment, so that the method explains the pathogenesis of sub-health from the perspective of traditional Chinese medicine, and has very important significance for finding a treatment medicine which is efficient, safe, free from toxic and side effects and suitable for long-term administration.
Disclosure of Invention
The technical scheme of the invention provides a composition for preventing or/and treating sub-health, a preparation method and application thereof.
The invention provides a composition for preventing or/and treating sub-health, which is characterized by comprising the following components in parts by weight: the medicine is prepared from the following raw materials in parts by weight:
15-55 parts of pilose antler, 140 parts of turtle shell glue, 80-120 parts of American ginseng, 170 parts of lucid ganoderma, 170 parts of pseudo-ginseng, 30-70 parts of pearl, 80-120 parts of chicken's gizzard-membrane and 40-80 parts of bletilla striata.
Preferably, the composition is prepared from the following raw materials in parts by weight:
35 parts of pilose antler, 120 parts of turtle shell glue, 100 parts of American ginseng, 150 parts of lucid ganoderma, 150 parts of pseudo-ginseng, 50 parts of pearl, 100 parts of chicken's gizzard-membrane and 60 parts of bletilla striata.
Wherein the composition is a health food or a medicine prepared by taking crude medicinal powder or water or organic solvent extract of pilose antler, turtle shell gelatin, American ginseng, lucid ganoderma, pseudo-ginseng, pearl, chicken's gizzard-membrane and bletilla striata as active ingredients and adding auxiliary materials or auxiliary ingredients acceptable in food or medicine.
Wherein the health food is flour product, bread, cake, biscuit, beverage or wine; the medicine preparation is tablet, pill, hard capsule, soft capsule, granule or oral liquid preparation.
The invention provides a method for preparing the composition, which comprises the following steps:
weighing the raw materials, directly pulverizing into powder or extracting with water or organic solvent, filtering, concentrating, adding adjuvant or adjuvant ingredients acceptable in food or medicine, and making into health food or medicine.
Preferably, the preparation method comprises the following steps:
a. pulverizing cornu Cervi Pantotrichum, colla carapax Trionycis, Ganoderma, Margarita, endothelium corneum Gigeriae Galli, and rhizoma Bletillae into fine powder, and sieving;
b. extracting radix Panacis Quinquefolii and Notoginseng radix with ethanol, filtering, mixing filtrates, and recovering ethanol to obtain fluid extract with relative density of 1.25-1.30;
c. mixing the fine powder of step a and the fluid extract of step b, adding adjuvant or auxiliary components acceptable in food or medicine, and making into health food or medicine.
The invention provides application of the composition in preparing health-care food or medicine for preventing or/and treating sub-health.
Wherein the health food or the medicine is the health food or the medicine for preventing or/and treating the sub-health fatigue state; or the health food or the medicine is the health food or the medicine for relieving the sub-health symptoms.
The invention also provides application of the composition in preparing a medicine for improving immunity.
Wherein, the medicine is used for increasing the content of immunoglobulin IgA, IgM and IgG and/or increasing the activity of natural killer cells.
The theory of traditional Chinese medicine considers that sub-health is mainly related to spleen, liver and kidney. The spleen governs transportation and transformation, transporting and transforming food and water, and the spleen is the source of qi and blood. Dysfunction of the spleen can cause emaciation, mental fatigue, lassitude, dizziness and other phenomena; liver governing fascia, human strength comes from fascia. Liver dysfunction can cause unsmooth circulation of qi and blood, and the body is easy to fatigue; kidneys govern growth and development, so people with kidney deficiency often have dizziness, soreness of waist and legs, hypomnesis, listlessness, etc.
The composition is prepared from eight medicinal and edible medicinal materials of pilose antler, turtle shell glue, American ginseng, lucid ganoderma, pseudo-ginseng, pearl, chicken's gizzard-membrane and bletilla striata according to a specific ratio, wherein the pilose antler and the turtle shell glue are products with love in blood and have the effects of strengthening the primordial yang and tonifying qi and blood, the effect of tonifying yang is biased, the turtle shell glue has the effects of nourishing yin and suppressing yang, the effect of nourishing yin and supplementing marrow are biased, the effect of combining two medicines is that one yang and one yin are combined, the yin and yang are supplemented, the essence is supplemented, and the yang is contained in the yang tonifying, and the Chinese medicinal composition; the American ginseng and the lucid ganoderma have the effects of tonifying qi and nourishing yin, nourishing blood and soothing nerves and tonifying qi and blood together, and are ministerial drugs; pseudo-ginseng and bletilla striata promote blood circulation to remove blood stasis, pearl calm the nerves and relieve convulsion, and chicken's gizzard-membrane invigorate the stomach and promote digestion, are assistant and guiding drugs, are used in the meaning of ' tonifying and dredging ' and ' tonifying and reducing ' to prevent the nourishing product from producing the disadvantage of greasy food, and are actually mainly used for tonifying. The medicines are combined to have the effects of tonifying five internal organs, tonifying yang and yin, tonifying qi and producing sperm, nourishing blood and soothing nerves, activating blood and resolving masses, consolidating foundation and cultivating vigor, retaining youthful looks and blackening hair and relieving fatigue. At present, no report is found on a pharmaceutical composition taking pilose antler and turtle shell glue as monarch drugs.
The health food or the medicine prepared by the invention can effectively prevent or/and treat sub-health, and has the following effects on sub-health symptoms: the medicine has obvious relieving effects on fatigue (including drowsiness, weakness, poor sleeping quality, amnesia, fatigue which cannot be relieved after rest, fatigue after activity and fatigue after brain use), immunity reduction, constipation, insomnia, anorexia, irritability, drowsiness after meals, oral ulcer, repeated cold and the like, provides a novel medicine which is efficient, safe, free of toxic and side effects and suitable for long-term administration for clinical treatment of sub-health, and has wide market prospect.
The present invention is described in further detail below by way of specific embodiments, but the present invention is not limited thereto, and various changes and substitutions may be made by those skilled in the art without departing from the spirit of the present invention within the scope of the appended claims.
Detailed Description
EXAMPLE 1 preparation of the medicament of the invention
Weighing the following raw materials in parts by weight:
35g of pilose antler, 120g of turtle shell glue, 100g of American ginseng, 150g of artificial lucid ganoderma, 150g of pseudo-ginseng, 50g of pearl, 100g of chicken's gizzard-membrane and 60g of bletilla striata
The preparation method comprises the following steps:
pulverizing the raw materials into fine powder, sieving, mixing, adding adjuvant, granulating, tabletting, and coating.
EXAMPLE 2 preparation of the medicament of the invention
Weighing the following raw materials in parts by weight:
35g of pilose antler, 120g of turtle shell glue, 100g of American ginseng, 150g of artificial lucid ganoderma, 150g of pseudo-ginseng, 50g of pearl, 100g of chicken's gizzard-membrane and 60g of bletilla striata
The preparation method comprises the following steps:
pulverizing cornu Cervi Pantotrichum, colla carapax Trionycis, artificial Ganoderma, Margarita, endothelium corneum Gigeriae Galli, and rhizoma Bletillae into fine powder, and sieving; extracting radix Panacis Quinquefolii and Notoginseng radix with 70% v/v ethanol for 3 times, each for 1 hr, filtering, mixing filtrates, recovering ethanol to obtain fluid extract with relative density of 1.25-1.30(60 deg.C), mixing with above fine powder, adding appropriate amount of adjuvants, granulating, tabletting, and coating with film.
EXAMPLE 3 preparation of the medicament of the invention
Weighing the following raw materials in parts by weight:
15g of pilose antler, 100g of turtle shell glue, 80g of American ginseng, 130g of artificial lucid ganoderma, 130g of pseudo-ginseng, 30g of pearl, 80g of chicken's gizzard-membrane and 40g of bletilla striata
The preparation method comprises the following steps:
pulverizing cornu Cervi Pantotrichum, colla carapax Trionycis, artificial Ganoderma, Margarita, endothelium corneum Gigeriae Galli, and rhizoma Bletillae into fine powder, and sieving; extracting radix Panacis Quinquefolii and Notoginseng radix with 70% ethanol for 3 times (each time for 1 hr), filtering, mixing filtrates, recovering ethanol to obtain fluid extract with relative density of 1.25-1.30(60 deg.C), mixing with above fine powder, adding appropriate amount of adjuvants, granulating, tabletting, and coating with film.
EXAMPLE 4 preparation of the inventive Agents
Weighing the following raw materials in parts by weight:
55g of pilose antler, 140g of turtle shell glue, 120g of American ginseng, 170g of artificial lucid ganoderma, 170g of pseudo-ginseng, 70g of pearl, 120g of chicken's gizzard-membrane and 80g of bletilla striata
The preparation method comprises the following steps:
pulverizing cornu Cervi Pantotrichum, colla carapax Trionycis, artificial Ganoderma, Margarita, endothelium corneum Gigeriae Galli, and rhizoma Bletillae into fine powder, and sieving; extracting radix Panacis Quinquefolii and Notoginseng radix with 70% ethanol for 3 times (each time for 1 hr), filtering, mixing filtrates, recovering ethanol to obtain fluid extract with relative density of 1.25-1.30(60 deg.C), mixing with above fine powder, adding appropriate amount of adjuvants, granulating, tabletting, and coating with film.
The beneficial effects of the present invention are demonstrated by specific experiments below.
Experimental example 1 clinical experiment of the drug of the present invention for treating sub-health
1 data and method
1.1 general data Collection 226 sub-healthy patients who mainly complain of fatigue, several random numbers are sequentially extracted from a random number table, and are respectively sealed in envelopes, patients are randomly extracted, and all the patients with the random numbers of odd numbers are listed in a control group, and the patients with the even numbers are listed in a treatment group. 124 of the treatment groups, 52 men and 72 women, the age of 25-55 years, and the average age of 42.6 years; the control group 102, male 45, female 57, age 25-55, mean 41.9 years, had no significant difference from the treatment group.
1.2 diagnostic criteria for sub-health fatigue state refer to the TCM society of China, "clinical guidelines for sub-health TCM".
1.3 the standard of the judgment of the therapeutic effect is according to the guidance of clinical research on new drugs in Chinese medicine published by the pharmaceutical technology Press in 2002.
And (3) healing: the fatigue state and the accompanying symptoms completely disappear, and the health care wine can adapt to normal social life and work rhythm; the effect is shown: the fatigue state and the accompanying symptoms disappear, or the total integral reduction rate of the symptoms is more than or equal to 2/3; the method has the following advantages: the fatigue state and the accompanying symptoms disappear, or the total integral reduction rate of the symptoms is more than or equal to 1/3 and is less than 2/3: and (4) invalidation: the fatigue state and the accompanying symptoms disappear, or the total integral reduction rate of the symptoms is less than 1/3, or no improvement is caused.
1.4 methods of treatment group: the medicine (prepared according to example 2 and developed by Shanxi Chinese medicine institute traditional Chinese medicine preparation room) is 3 tablets each time and 2 times a day. Control group: 6g of pill for tonifying middle-jiao and qi (pharmaceutical factory, national standard of medicine: Z11020244, manufactured by Beijing Tongrentang scientific and technological development GmbH) is administered orally 2 times a day. The administration time of both groups was 8 weeks, and the disease condition and various reactions were recorded during the treatment period.
1.5 Observation indicators clinical symptom improvement rate: the improvement of related symptoms before and after two groups of treatments are analyzed, such as: fatigue, drowsiness, decreased endurance, weakness, poor sleep quality, amnesia, failure of fatigue to relieve after rest, fatigue after activity, fatigue after brain use, and other symptoms. Immunological indexes: detecting the content of immunoglobulin (Ig) A, IgG and IgM and the activity of natural killer cells (NK) in blood of a subject before and after treatment.
1.6 statistical treatment the comparison of the before and after treatment averages in each group was tested using paired sample t test, and the comparison of the averages between the two groups was tested using independent sample t test.
3 results
3.1 comparison of clinical effects of the two groups, see Table 1
TABLE 1 comparison of the clinical efficacy of the two groups
The results show that: the total effective rate of the treatment group is 91.94 percent, and the cure rate is 76.61 percent; the total effective rate of the control group is 72.55 percent, and the curative rate is 49.02 percent. The two groups of differences have significant statistical significance (P is less than 0.0001), which shows that the medicine has significant curative effect on sub-health, and even better than the positive medicine tonifying middle-jiao qi-tonifying pill.
3.2 comparison of the clinical symptom improvement rates of two groups of patients
After treatment, all symptom scores of the treatment group are obviously reduced compared with those before treatment (P is less than 0.01), which indicates that the treatment group obviously improves clinical symptoms (fatigue, drowsiness, endurance loss, weakness, poor sleep quality, amnesia, fatigue which cannot be relieved after rest, fatigue after activity and fatigue after brain use) better than the control group.
3.3 comparison of immunological indices of two groups of patients
TABLE 2 comparison of immunological indices of two groups of patients: (g/L)
Note that the difference between the treatment group and the group before treatment, and the difference between △ and the control group at the same time.
After treatment, the IgA, IgM and IgG contents and NK cell activity of two groups of patients are increased to a certain extent. Compared with the control group, the differences of the IgA, IgM and IgG contents and NK cell activities of the patients in the treatment group after treatment have significant statistical significance (P is less than 0.01), and the medicine has a good improvement effect on the organism immunity of the sub-health patients and can effectively improve the immunity.
3.4 there is no obvious adverse reaction.
In conclusion, the health food or the medicine prepared by the invention can effectively prevent or/and treat sub-health, and has the following effects on sub-health symptoms: the medicine has obvious relieving effects on fatigue (including drowsiness, weakness, poor sleep quality, amnesia, fatigue which cannot be relieved after rest, fatigue after activity and fatigue after brain use), immunity reduction, constipation, insomnia, anorexia, irritability, drowsiness after meals, oral ulcer, repeated cold and the like, and can also improve the immunoglobulin IgA, IgM and IgG content and NK cell activity of sub-health patients. The medicine has obvious curative effect on sub-health, the total effective rate reaches 91.94%, the cure rate is 76.61%, and the medicine provides a new medicine which is high-efficiency, safe, free of toxic and side effects, suitable for long-term administration and wide in market prospect for clinical treatment of sub-health.
Claims (7)
1. A composition for the prevention or/and treatment of sub-health, characterized in that: the traditional Chinese medicine is prepared from the following raw materials in parts by weight:
35 parts of pilose antler, 120 parts of turtle shell glue, 100 parts of American ginseng, 150 parts of lucid ganoderma, 150 parts of pseudo-ginseng, 50 parts of pearl, 100 parts of chicken's gizzard-membrane and 60 parts of bletilla striata;
the preparation method of the composition comprises the following steps:
a. pulverizing cornu Cervi Pantotrichum, colla carapax Trionycis, Ganoderma, Margarita, endothelium corneum Gigeriae Galli, and rhizoma Bletillae into fine powder,
sieving for later use;
b. extracting radix Panacis Quinquefolii and Notoginseng radix with ethanol, filtering, mixing filtrates, and recovering ethanol to obtain fluid extract with relative density of 1.25-1.30;
c. mixing the fine powder of step a and the fluid extract of step b, adding pharmaceutically acceptable adjuvants or auxiliary components, and making into medicine.
2. The composition of claim 1, wherein: the medicine is tablet, pill, hard capsule, soft capsule, granule or oral liquid.
3. A process for preparing the composition of any of claims 1-2, characterized in that: it comprises the following steps:
a. pulverizing cornu Cervi Pantotrichum, colla carapax Trionycis, Ganoderma, Margarita, endothelium corneum Gigeriae Galli, and rhizoma Bletillae into fine powder,
sieving for later use;
b. extracting radix Panacis Quinquefolii and Notoginseng radix with ethanol, filtering, mixing filtrates, and recovering ethanol to obtain fluid extract with relative density of 1.25-1.30;
c. mixing the fine powder of step a and the fluid extract of step b, adding pharmaceutically acceptable adjuvants or auxiliary components, and making into medicine.
4. Use of a composition according to any one of claims 1-2 for the manufacture of a medicament for the prevention or/and treatment of sub-health.
5. Use according to claim 4, characterized in that: the medicine is used for preventing or/and treating sub-health fatigue state; or the medicament is a medicament for relieving sub-health symptoms.
6. Use of a composition according to any one of claims 1-2 for the manufacture of a medicament for enhancing immunity.
7. Use according to claim 6, characterized in that: the medicine is used for improving the content of immunoglobulin IgA, IgM and IgG and/or improving the activity of natural killer cells.
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN106177585A (en) * | 2016-08-31 | 2016-12-07 | 周毅 | A kind of prevention and the Chinese herbal and crude drugs preparations for the treatment of subhealth state |
| CN106266951A (en) * | 2016-08-31 | 2017-01-04 | 周毅 | A kind of subhealth state of alleviating causes the Chinese herbal and crude drugs preparations of insomnia and dreamful sleep |
| CN106177208A (en) * | 2016-08-31 | 2016-12-07 | 周毅 | A kind of subhealth state that regulates causes the Chinese herbal and crude drugs preparations of insomnia agitation |
| CN106417522A (en) * | 2016-09-30 | 2017-02-22 | 刘贵雪 | Biscuit for tonifying qi, nourishing stomach and protecting fetus and preparation method thereof |
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| CN104605357A (en) * | 2015-02-12 | 2015-05-13 | 董广鹏 | Functional health product capable of conditioning sub-health |
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