CN106139035B - Traditional Chinese medicine for treating encephalatrophy, senile dementia and cerebral infarction and preparation and application thereof - Google Patents

Abstract

The invention discloses a Chinese medicament for treating encephalatrophy, senile dementia and cerebral infarction and preparation and application thereof; the traditional Chinese medicine comprises the following raw materials in parts by weight: 4-12 parts of uncaria, 3-9 parts of scorpion, 4-12 parts of gastrodia elata, 5-15 parts of salvia miltiorrhiza bunge, 4-12 parts of pseudo-ginseng, 4-12 parts of clematis root, 3-9 parts of fructus alpiniae oxyphyllae, 4-12 parts of tuber fleeceflower stem, 3-9 parts of radix curcumae, 5-15 parts of astragalus membranaceus, 4-12 parts of mulberry twig, 4-12 parts of rehmannia, 3-9 parts of jujube peel, 3-9 parts of dendrobium, 3-9 parts of radix ophiopogonis, 3-9 parts of rhizoma acori graminei, 3-9 parts of herba cistanches, 3-9 parts of morinda officinalis and 5-15 parts of rhizoma polygonati. The traditional Chinese medicine composition is prepared into decoction or pills for administration, has the effects of replenishing essence and marrow, nourishing yin and tonifying kidney, calming liver to stop wind, resolving depression and soothing nerves, strengthening spleen and nourishing heart, and promoting blood circulation to remove blood stasis, and has particularly obvious treatment effects on senile dementia, encephalatrophy and cerebral infarction.

Description

Traditional Chinese medicine for treating encephalatrophy, senile dementia and cerebral infarction and preparation and application thereof

Technical Field

The invention relates to the technical field of traditional Chinese medicines, in particular to a traditional Chinese medicine for treating encephalatrophy, senile dementia and cerebral infarction, and a preparation method and application thereof.

Background

Senile dementia is clinically divided into three stages according to deterioration degree of cognitive ability and physical function: mild dementia, moderate dementia, and severe dementia. The clinical manifestations of brain atrophy are classified into two categories, i.e., brain hypofunction and cognitive hypofunction, which are mainly related to the location and extent of brain atrophy. Cerebral infarction is a general term of ischemic stroke, including cerebral thrombosis, lacunar infarction, cerebral embolism and the like, accounts for about 70% of all cerebral apoplexy, and is a cerebral lesion caused by cerebral blood supply disorder.

There is no special treatment for senile dementia. The currently used treatment methods mainly try to alleviate various symptoms including mental symptoms appearing in the course of the disease and delay the further development of dementia. If the patient exhibits agitation and aggressive behavior, the antipsychotic is administered for treatment. Patients with mood depression can be treated with antidepressants, such as those with poor drug control or significant suicidal tendencies can be treated under close observation with modified electrical tics. Because most of patients with senile dementia have poor constitution and renal function, the medicine is easy to accumulate in the body and serious side effect is generated.

At present, no specific therapy exists for treating the encephalatrophy, and the symptomatic therapy is mainly used. Including drug therapy to improve cognitive function and memory impairment; symptomatic treatment improves mental symptoms; good nursing and disease progress delaying. The medicine and rehabilitation therapy aim at improving cognition and memory function, maintaining independent living ability of patients and improving living quality

The best method for treating cerebral infarction at present is to clean thrombus as early as possible, expand and dredge blood vessels, improve cerebral blood supply, reduce necrosis caused by cerebral cell hypoxia as far as possible, recover corresponding functions, reduce sequelae and improve the quality of daily life later.

The traditional Chinese medicine considers that: the kidney is the innate foundation, the kidney stores essence, and is mainly used for growth, development and reproduction, the kidney governs bones, marrow generation, brain stimulation, the kidney governs qi absorption, the kidney governs water solution, the kidney opens into ears, the kidney drives stool, the waist is the house of the kidney and the like. In summary, kidney health indicates the growth, development and viability of the reproductive system of the human body. If the kidney is deficient, a series of aging phenomena will appear. The book Huangdi's classic of internal classic of medicine, Ling Shu (treatise on the sea) says: "the brain is the marrow sea … … the excess of marrow sea, so it is strong and mild and can pass its strength; if the marrow sea is insufficient, the brain turns to tinnitus, the shank is sour and dizzy, the eyes are not seen, and the patient is difficult to lie down at night. This proves that the brain is the nerve center, and all the seas belong to the brain, so the neurasthenia of the hearing, the joints and the vision, the general nerve decline and the uneasiness even in sleeping can occur due to the insufficient mental force. The Chinese medicinal preparation is completely applied to clinic, has the effects of replenishing essence and marrow, nourishing yin and tonifying kidney, calming liver to stop wind, relieving depression and soothing nerves, strengthening spleen and nourishing heart, and promoting blood circulation to remove blood stasis, and has obvious clinical effects on improving cerebral blood circulation, softening blood vessels, clearing thrombus, regulating emotion of patients and enhancing human body free function. In addition, the medicine is cheap in clinical application, so that patients can bear the medicine economically and completely, and hardly have any adverse reaction, and the medicine is more suitable for long-term administration and treatment of the patients.

Disclosure of Invention

The invention aims to provide a traditional Chinese medicine for treating encephalatrophy, senile dementia and cerebral infarction, and preparation and application thereof.

In order to solve the technical problems, the technical scheme adopted by the invention is as follows: a traditional Chinese medicine for treating encephalatrophy, senile dementia and cerebral infarction comprises the following raw materials in parts by weight: 4-12 parts of uncaria, 3-9 parts of scorpion, 4-12 parts of gastrodia elata, 5-15 parts of salvia miltiorrhiza bunge, 4-12 parts of pseudo-ginseng, 4-12 parts of clematis root, 3-9 parts of fructus alpiniae oxyphyllae, 4-12 parts of tuber fleeceflower stem, 3-9 parts of radix curcumae, 5-15 parts of astragalus membranaceus, 4-12 parts of mulberry twig, 4-12 parts of rehmannia, 3-9 parts of jujube peel, 3-9 parts of dendrobium, 3-9 parts of radix ophiopogonis, 3-9 parts of rhizoma acori graminei, 3-9 parts of herba cistanches, 3-9 parts of morinda officinalis and 5-15 parts of rhizoma polygonati.

In a preferred scheme, the feed comprises the following raw materials in parts by weight: 10 parts of uncaria, 6 parts of scorpion, 10 parts of gastrodia elata, 12 parts of salvia miltiorrhiza, 6 parts of pseudo-ginseng, 6 parts of radix clematidis, 8 parts of fructus alpiniae oxyphyllae, 6 parts of caulis polygoni multiflori, 8 parts of radix curcumae, 11 parts of radix astragali, 9 parts of mulberry twig, 9 parts of rehmannia, 8 parts of jujube peel, 8 parts of dendrobe, 7 parts of radix ophiopogonis, 7 parts of rhizoma acori graminei, 6 parts of herba cistanches, 5 parts of morinda officinalis and 11 parts of rhizoma polygonati.

In the preferred scheme, 8 parts of uncaria, 5 parts of scorpion, 8 parts of gastrodia elata, 12 parts of salvia miltiorrhiza bunge, 8 parts of pseudo-ginseng, 8 parts of clematis root, 8 parts of sharpleaf galangal fruit, 10 parts of tuber fleeceflower stem, 5 parts of curcuma aromatica, 15 parts of astragalus mongholicus, 5 parts of mulberry twig, 10 parts of rehmannia glutinosa, 8 parts of Chinese date peel, 8 parts of dendrobe, 8 parts of radix ophiopogonis, 8 parts of rhizoma acori graminei, 8 parts of herba cistanches, 8 parts of morinda officinalis and 15 parts of rhizoma.

Further, the rehmannia is prepared rehmannia root, and the rhizoma polygonati is roasted rhizoma polygonati.

Further comprises 3-9 parts of first-root pearl and 2-6 parts of centipede.

Further comprises 6 parts of first-root pearl and 4 parts of centipede.

The invention also relates to a method for preparing the traditional Chinese medicine, which comprises the following steps: weighing the raw materials according to a certain proportion, adding water which is 4-6 times of the total weight of the raw medicinal materials, soaking for more than half an hour, decocting with strong fire until the medicine is boiled, then decocting with slow fire for 20-40min, filtering out medicine residues, and taking out liquid medicine, namely the traditional Chinese medicine for treating encephalatrophy, senile dementia and cerebral infarction.

The invention also relates to a method for preparing the traditional Chinese medicine, which comprises the following steps: weighing the raw materials in proportion, drying, pulverizing, sieving, adding Mel into the obtained medicinal powder, making into pill, and oven drying to obtain the Chinese medicinal composition for treating encephalatrophy, senile dementia and cerebral infarction.

The invention also relates to the application of the traditional Chinese medicine in preparing medicines for treating encephalatrophy, senile dementia or cerebral infarction.

The respective pharmacological effects of the raw materials in the formula of the invention are as follows:

uncaria: clear heat and calm liver, extinguish wind and relieve convulsion. It can be used for treating infantile convulsion, hypertension, dizziness, and female eclampsia. The compendium records that: dizziness due to rotation of the head of the adult, calming liver wind, removing heart heat, abdominal pain during fishing in children, and macula.

Scorpion: extinguish wind and relieve spasm, counteract toxic pathogen and dissipate nodulation, dredge meridians to stop pain. Can be used for treating infantile convulsion, spasm, facial distortion due to apoplexy, hemiplegia, tetanus, rheumatism, headache, pyocutaneous disease, and lymphoid tuberculosis.

Gastrodia elata: the traditional Chinese medicine composition has the effects of dispelling wind and dispersing phlegm, arresting and relieving epilepsy, headache and dizziness, limb numbness, infantile convulsion, epilepsy, convulsion, tetanus and the like, so that the traditional Chinese medicine composition has the effects of treating dizziness and headache caused by hyperactivity of liver-yang, limb numbness and ache caused by rheumatism, stroke paralysis, nervous migraine, neurasthenia, dizziness, headache, insomnia and the like.

Centipede: dispel wind, arresting convulsion, counteracting toxic pathogen, dissipating nodulation. It is used to treat apoplexy, epilepsy, tetanus, pertussis, scrofula, tuberculosis, tumor, skin and external diseases, tinea, alopecia areata, anal fistula and scald.

Radix salviae miltiorrhizae: promoting blood circulation, dispelling blood stasis, tranquilizing mind, calming heart, expelling pus, and relieving pain. Treating angina pectoris, menoxenia, dysmenorrhea, amenorrhea, metrorrhagia, leukorrhagia, abdominal mass, blood stasis, abdominal pain, arthralgia, palpitation, insomnia, skin ulcer, and toxic swelling.

Pseudo-ginseng: stop bleeding, dissipate blood stasis, resolve swelling and alleviate pain. It is used to treat hematemesis, hemoptysis, epistaxis, hematochezia, dysentery, metrorrhagia, abdominal mass, puerperal dizziness, lochiorrhea, traumatic hemorrhage, carbuncle, swelling, and pain.

Clematis root: dispel wind-damp, unblock meridians, resolve phlegm and saliva, disperse accumulation of pathogen. It can be used for treating gout, obstinate arthralgia, cold pain of waist and knee, tinea pedis, malaria, abdominal mass, tetanus, tonsillitis, and bone sticking throat. It also has the effect of softening bone spur and promoting thrombosis.

Fructus alpiniae oxyphyllae: warm spleen, warm kidney, secure qi and astringe essence. It is indicated for cold-wind with abdominal pain, vomiting and diarrhea, excessive saliva, seminal emission, dribbling urine and frequent urination at night. Materia Medica Shi Yi: there are records of vomiting and retch, seminal emission and asthenic discharge treatment, dribbling urination, qi-tonifying and tranquilization, deficiency tonifying, triple energizer benefiting, qi regulation and frequent urination at night.

Caulis Polygoni Multiflori: has effects in nourishing heart, tranquilizing mind, dredging collaterals, and dispelling pathogenic wind, and can be used for treating insomnia, fatigue, hyperhidrosis, blood deficiency, general pain, carbuncle, lymphoid tuberculosis, sore, and scabies. The herb Renzhen, carrying caulis Polygoni Multiflori, can tonify qi of middle-jiao, move meridians and collaterals, promote blood circulation and treat overstrain injury. The 'decoction piece Xinshen' carries the herb to nourish liver and kidney, stop sweating due to debility, tranquilize and hypnotize.

Turmeric root-tuber: promoting blood circulation, relieving energy, promoting qi circulation, relieving depression, clearing away heart-fire, cooling blood, dispersing depressed liver-energy, and promoting bile flow. Treating pain in chest, abdomen and hypochondriac area, dysmenorrhea, amenorrhea, mass, coma, mania, epilepsy, hematemesis, epistaxis, stranguria with blood, sand stranguria and jaundice.

Astragalus root: tonify qi, strengthen superficies, expel toxin, expel pus, induce diuresis, promote sore and promote tissue regeneration. Can be used for treating deficiency of vital energy, asthenia, spontaneous perspiration, chronic diarrhea, proctoptosis, edema, uterine prolapse, chronic nephritis, albuminuria, diabetes, and unhealed wound.

Mulberry twig: dispel wind-damp, benefit joints and move water and dampness. It is indicated for arthralgia due to wind-cold-dampness, spasm of limbs, edema of beriberi, and wind itching of body. The book Yu catalpa Yao Ji (Jade mountain ash Yao Jie) (explanation): for apoplexy, facial paralysis and cough. The book Ben Cao Xin (herbal medicine renewal) contains: strengthening lung qi, eliminating dampness, nourishing kidney water, dredging channels, relieving cough and restlessness, and relieving swelling and pain. "

Rehmannia root: to nourish yin, enrich blood, replenish essence and replenish marrow. Can be used for treating deficiency of liver-yin and kidney-yin, soreness of waist and knees, hectic fever, night sweat, nocturnal emission, internal heat, diabetes, blood deficiency, sallow complexion, cardiopalmus, severe palpitation, menoxenia, metrorrhagia, metrostaxis, hemorrhage, giddiness, tinnitus, and early white beard and hair.

Jujube peel: tonify liver and kidney, astringe essence and qi, and strengthen deficiency. It is used to treat soreness of waist and knees, vertigo, tinnitus, sexual impotence, spermatorrhea, frequent micturition, liver deficiency, cold and heat, sweating, and heart shaking pulse powder.

Dendrobe: promote the production of body fluid, benefit stomach, clear heat and nourish yin. It is indicated for dry mouth with polydipsia due to fluid damage by febrile disease, and deficiency heat after illness, yin damaging dark eyes. The "treatise on herb properties" contains: to replenish qi and remove heat. The traditional Chinese medicine composition is mainly used for treating male waist and foot weakness, yang strengthening, skin muscle rheumatism, long-term cold in bones, deficiency, kidney tonifying, essence accumulation, lumbago, kidney qi nourishing and force benefiting. "

Radix ophiopogonis: nourish yin and moisten lung, clear heart and relieve restlessness, nourish stomach and promote fluid production. It is indicated for dry cough due to lung dryness, hematemesis, hemoptysis, consumptive lung disease, lung abscess, consumptive disease with dysphoria, thirst, heat disease with fluid consumption, dry throat and mouth, constipation.

Grassleaf sweelflag rhizome: resolving dampness and promoting appetite, inducing resuscitation and eliminating phlegm, refreshing mind and improving intelligence, regulating qi-flowing and promoting blood circulation, dispelling pathogenic wind and removing dampness. It can be used for treating epilepsy, phlegm syncope, fever, coma, amnesia, qi block, deafness, vexation, gastralgia, abdominal pain, arthralgia due to wind-cold-dampness, superficial infection, toxic swelling, traumatic injury, coma, epilepsy, amnesia, and deafness.

One bead at the top of the head: replenishing qi to alleviate pain, removing blood stasis to stop bleeding, removing dampness to expel wind. It can be used for treating cough, hematemesis, neurasthenia, rheumatic lumbago, amenorrhea, abdominal pain, lymphoid tuberculosis, sore, damp toxin, traumatic injury, and tetanus.

Herba cistanches: tonify kidney yang, replenish essence and blood, moisten intestines to relieve constipation. Can be used for treating kidney deficiency, sexual impotence, spermatorrhea, premature ejaculation, infertility, psychroalgia of waist and knees, spasm of muscles and bones, constipation due to intestinal dryness.

Morinda officinalis: tonify kidney yang, strengthen tendons and bones, dispel wind-damp. It is used to treat impotence, cold pain in the lower abdomen, urinary incontinence, cold uterus, arthralgia due to wind-cold-dampness, and soreness of waist and knees. The book Jing records that: it is effective in strengthening tendons and bones, calming five internal organs, strengthening middle-jiao, strengthening will, and invigorating qi. "

Rhizoma polygonati: moistening dryness, nourishing yin, nourishing kidney yin, moistening lung, relieving cough, replenishing essence, nourishing marrow, invigorating spleen, invigorating qi, nourishing yin, and quenching thirst. Mainly treats yin deficiency cough; cough due to dryness of the lung; asthenia due to spleen deficiency; eating less and dry mouth; quenching thirst; soreness and weakness of the waist and knees due to kidney deficiency; impotence and spermatorrhea; tinnitus and dark eyes; the beard and hair are early white; the body is weak and thin; tinea diseases.

In the formula of the health-care beverage, rhizoma polygonati, rehmannia, fructus alpiniae oxyphyllae, dendrobium, herba cistanches, morinda officinalis and astragalus membranaceus are added with essence and marrow, so that yin and yang balance in a body is achieved, and the immunity of the human body is improved; pseudo-ginseng, radix curcumae, radix clematidis, mulberry twig and salvia miltiorrhiza, has the effects of activating blood and dissolving stasis, clearing and activating the channels and collaterals, softening blood vessels and removing thrombus. Scorpio, rhizoma Gastrodiae, Scolopendra, ramulus Uncariae cum uncis, and herba Berberidis Amurensis, and has effects in calming endogenous wind and stopping dizziness; caulis Polygoni Multiflori, rhizoma Acori Tatarinowii, radix Ophiopogonis, and fructus Jujubae peel, with effects of dispersing stagnated liver qi for relieving qi stagnation, nourishing heart, and tranquilizing mind. The Chinese medicinal composition has the effects of replenishing essence and marrow, nourishing yin and tonifying kidney, calming liver to stop wind, relieving depression and calming nerves, strengthening spleen and nourishing heart, and activating blood and dissolving stasis, and has obvious clinical effects of improving cerebral blood circulation, softening blood vessels, clearing thrombus, regulating emotion of a patient, and enhancing human body immunity.

Detailed Description

The invention will be further elucidated with reference to the following specific examples. These examples are to be construed as merely illustrative and not limitative of the remainder of the disclosure. After reading the description of the invention, one skilled in the art can make various changes and modifications to the invention, and such equivalent changes and modifications also fall into the scope of the invention defined by the claims.

Example 1: a traditional Chinese medicine for treating encephalatrophy, senile dementia and cerebral infarction comprises the following raw materials in parts by weight: 4 parts of uncaria, 3 parts of scorpion, 4 parts of gastrodia elata, 2 parts of centipede, 5 parts of salvia miltiorrhiza, 4 parts of pseudo-ginseng, 4 parts of radix clematidis, 3 parts of fructus alpiniae oxyphyllae, 4 parts of caulis polygoni multiflori, 3 parts of radix curcumae, 5 parts of radix astragali, 4 parts of mulberry twig, 4 parts of rehmannia, 3 parts of jujube peel, 3 parts of dendrobe, 3 parts of radix ophiopogonis, 3 parts of rhizoma acori graminei, 3 parts of parietal barberry, 3 parts of herba cistanches, 3 parts of morinda officinalis and 5-15 parts of rhizoma polygonati.

Example 2: a traditional Chinese medicine for treating encephalatrophy, senile dementia and cerebral infarction comprises the following raw materials in parts by weight: 12 parts of uncaria, 9 parts of scorpion, 12 parts of gastrodia elata, 6 parts of centipede, 15 parts of salvia miltiorrhiza bunge, 12 parts of pseudo-ginseng, 12 parts of radix clematidis, 9 parts of fructus alpiniae oxyphyllae, 12 parts of tuber fleeceflower stem, 9 parts of radix curcumae, 15 parts of astragalus mongholicus, 12 parts of mulberry twig, 12 parts of rehmannia glutinosa, 9 parts of Chinese date peel, 9 parts of dendrobe, 9 parts of radix ophiopogonis, 9 parts of rhizoma acori graminei, 9 parts of parietal barberry, 9 parts of herba cistanches, 9 parts of morinda officinalis and 15.

Example 3: a traditional Chinese medicine for treating encephalatrophy, senile dementia and cerebral infarction comprises the following raw materials in parts by weight: 10 parts of uncaria, 6 parts of scorpion, 10 parts of gastrodia elata, 12 parts of salvia miltiorrhiza, 6 parts of pseudo-ginseng, 6 parts of radix clematidis, 8 parts of fructus alpiniae oxyphyllae, 6 parts of caulis polygoni multiflori, 8 parts of radix curcumae, 11 parts of radix astragali, 9 parts of mulberry twig, 9 parts of rehmannia, 8 parts of jujube peel, 8 parts of dendrobe, 7 parts of radix ophiopogonis, 7 parts of rhizoma acori graminei, 6 parts of herba cistanches, 5 parts of morinda officinalis and 11 parts of rhizoma polygonati.

Example 4: a traditional Chinese medicine for treating encephalatrophy, senile dementia and cerebral infarction comprises the following raw materials in parts by weight: 6 parts of uncaria, 5 parts of scorpion, 6 parts of gastrodia elata, 15 parts of salvia miltiorrhiza, 8 parts of pseudo-ginseng, 8 parts of radix clematidis, 8 parts of fructus alpiniae oxyphyllae, 10 parts of tuber fleeceflower stem, 5 parts of radix curcumae, 15 parts of radix astragali, 5 parts of mulberry twig, 10 parts of rehmannia, 8 parts of jujube peel, 9 parts of dendrobe, 6 parts of radix ophiopogonis, 8 parts of rhizoma acori graminei, 7 parts of herba cistanches, 7 parts of morinda officinalis and 15 parts of rhizoma polygonati.

Example 5: a traditional Chinese medicine for treating encephalatrophy, senile dementia and cerebral infarction comprises the following raw materials in parts by weight: 8 parts of uncaria, 5 parts of scorpion, 8 parts of gastrodia elata, 12 parts of salvia miltiorrhiza, 8 parts of pseudo-ginseng, 8 parts of radix clematidis, 8 parts of fructus alpiniae oxyphyllae, 10 parts of caulis polygoni multiflori, 5 parts of radix curcumae, 15 parts of radix astragali, 5 parts of ramulus mori, 10 parts of prepared rehmannia root, 8 parts of jujube peel, 8 parts of dendrobe, 8 parts of radix ophiopogonis, 8 parts of rhizoma acori graminei, 8 parts of herba cistanches, 8 parts of morinda officinalis and 15 parts of rhizoma polygonati preparata.

Example 6: a traditional Chinese medicine for treating encephalatrophy, senile dementia and cerebral infarction comprises the following raw materials in parts by weight: 10 parts of uncaria, 4 parts of scorpion, 8 parts of gastrodia elata, 10 parts of salvia miltiorrhiza, 10 parts of pseudo-ginseng, 10 parts of radix clematidis, 10 parts of fructus alpiniae oxyphyllae, 12 parts of caulis polygoni multiflori, 6 parts of radix curcumae, 15 parts of radix astragali, 5 parts of ramulus mori, 10 parts of prepared rehmannia root, 8 parts of jujube peel, 8 parts of dendrobe, 8 parts of radix ophiopogonis, 8 parts of rhizoma acori graminei, 8 parts of herba cistanches, 8 parts of morinda officinalis and 15 parts of rhizoma polygonati preparata.

The preparation method of the traditional Chinese medicine comprises the following steps:

can be made into decoction or pill for administration.

When the traditional Chinese medicine is prepared into decoction, the raw materials are weighed according to the proportion, water which is 4-6 times of the total weight of the raw medicinal materials is added, the raw medicinal materials are soaked for more than half an hour, the mixture is decocted with strong fire until the medicine is boiled, then the mixture is decocted with slow fire for 20-40min, medicine residues are filtered, and medicine liquid is taken, namely the traditional Chinese medicine for treating encephalatrophy, senile dementia and cerebral infarction.

When the traditional Chinese medicine is prepared into pills, the raw materials are weighed according to a proportion, dried, crushed and sieved, the obtained medicine powder is added with honey to prepare pills, and the pills are dried to obtain the traditional Chinese medicine for treating encephalatrophy, senile dementia and cerebral infarction.

The application method and the dosage are as follows: the liquid medicine is taken 100 ml before meals according to the condition of the patient, and taken three times a day. Or taking the pill 6-9g before meals three times a day, and avoiding uncooked and cold diet with low salt and low fat.

1. Diagnostic criteria for brain atrophy

Traditional Chinese medicine diagnosis: A. memory: memory, including the ability to remember recent and distant events, is diminished. B. And (3) judging: and judging the decline of the abilities of the cognitive people, the articles, the time and the places. C. And (3) calculating: and 4, calculating the number, and reversing the capacity of the number to decline. D. Identification: the ability to identify spatial locations and structures diminishes. E. Language: spoken language skills, including the ability to understand someone else's language skills and to systematically answer questions. Those with high culture degree have difficulty in reading and writing. F. Personality: the facial expression is lonely marked, the expression is indifferent, the language is verbose and repetitive, the self is narrow, stubborn, firm or unconscious, and the facial expression is easy to excite or rage, etc. G. Thinking: the abstract thinking ability is reduced, for example, the proverb cannot be explained, the same point and different point of the words cannot be distinguished, and the definition of things cannot be given. H. Personality: the character change, ethical deficiency, agnostic to the pubic.

Age: this is often seen in those over 60 years old. The course of the disease is as follows: the onset of disease is slow and the course of disease is long.

Western diagnostic criteria: (1993 American psychiatric society DSM-M standard): A. the mental retardation affects social and occupational activities. B. Memory impairment. C. There is 1 of the following 4: (a) abstract thinking ability disorders cannot be defined for things, etc. (b) And (6) judging the obstacle. (c) Other advanced cortical dysfunctions: such as loss of speech, misuse, disapproval, structural misuse. (d) Personality change: alteration or enhancement of the original personality characteristics. D. An unconscious disorder. E. One of the following: (a) the medical history, physical examination and laboratory suggest the discovery of the etiology. (b) If there is no evidence, the behavior change belongs to various recognition dysfunctions, which can reasonably exclude functional psychosis and make some inference about organic disease cause. F. Further comprehensive diagnosis of skull CT or nuclear magnetic resonance is carried out.

2. Diagnostic criteria for senile dementia

International diagnostic criteria for senile dementia, revised the tenth time in 1992 (ICD-10):

(1) dementia exists.

(2) Latent onset of disease, a slow change, often makes it difficult to indicate the time of onset, but others suddenly perceive the presence of symptoms. During progressive development, a relatively stationary phase may occur.

(3) The results of no clinical evidence or special examination can indicate that the mental disorder is due to other systemic diseases that can cause dementia or diseases of the brain (e.g., hypothyroidism, hypercalcemia, vitamin B12 deficiency, niacin deficiency, neurosyphilis, normal pressure hydrocephalus, or subdural hematoma).

(4) Lack of sudden, stroke-like attacks, no signs of focal nervous system damage in the early stages of the disease, such as paraplegia, loss of sensation, visual field loss, and motor coordination (but these symptoms occur in the later stages of the disease).

The Chinese medical society also established the diagnosis standard of senile dementia in 1989;

(1) meeting the diagnosis standard of brain organic mental disorder;

(2) compliance with diagnostic criteria for dementia;

(3) the onset is slow, the development of dementia is also slow, and the dementia can not be worsened for a period of time but is irreversible;

(4) dementia not due to cerebrovascular disease;

(5) the dementia caused by other specific reasons is eliminated through medical history, physical examination or laboratory examination;

(6) pseudo-organic dementia caused by depression was excluded by medical history and mental examination.

3. Diagnostic criteria for cerebral infarction

(1) The disease is usually caused by sudden onset;

(2) most are without prodrome symptoms;

(3) clear general consciousness or transient disturbance of consciousness;

(4) symptoms and signs of the carotid and/or vertebro-basilar systems;

(5) cerebrospinal fluid generally contains no blood in lumbar puncture;

(6) simultaneously, the medicine is accompanied with embolism symptoms such as other organs, skin, mucosa and the like;

in order to better verify the curative effect of the traditional Chinese medicine composition provided by the invention, the beneficial effect of the traditional Chinese medicine composition on the gastric bleeding is illustrated by the following typical cases.

Examples of brain atrophy:

case 1: senior, female, 56 years old, farmer. The patient is initially diagnosed 24 days after 7 months in 2010, dizziness appears before one year, the patient is determined to be encephalatrophy by CT examination in a hospital, the condition of the patient is slightly improved after transfusion treatment (the transfusion medication is unknown), and the treatment is stopped after the patient is slightly improved due to economic and family environmental factors. At present, the doctor is seen by family members, and the family members complain: the patient begins to complain of dizziness and dizziness in 2 months, but is unconscious due to the household environment, the patient is forgetful and sleepless in the next month, occasionally stands unstably, cries and laughs at home alone, a home-returning path is not known after going out, the patient can not sit at a dining table to eat by oneself if the patient does not call, the patient needs to know to eat and eat by a loud voice, the appetite is still enough, and the patient is worried about ten minutes, so the patient can see a doctor at present. The patients are checked to be in a poor expression, the question-answer response is slow, the blood pressure is 132/84cmHg, the tongue fur is thin and white, the pulse is thin and weak, and the traditional Chinese medicine diagnoses that the patients are poor memory due to kidney essence deficiency and qi and blood deficiency. The western medicine diagnosis is brain atrophy. For treatment, it can tonify kidney, supplement qi, activate blood, strengthen brain, eliminate phlegm and induce resuscitation.

Prescription: 80g of uncaria, 50g of scorpion, 80g of centipede, 30g of salvia miltiorrhiza, 120g of pseudo-ginseng, 80g of radix clematidis, 80g of fructus alpiniae oxyphyllae, 80g of tuber fleeceflower stem, 100g of radix curcumae, 50g of radix astragali, 150g of ramulus mori, 50g of rehmannia, 100g of Chinese date peel, 80g of dendrobe, 80g of radix ophiopogonis, 80g of rhizoma acori graminei, 80g of radix berberidis, 80g of herba cistanches, 60.

The traditional Chinese medicine is applied, pulverized and sieved by a sieve of 80 meshes, the mixture is refined into pills, the pills are taken three times a day, 6g each time, after meals, uncooked and cold foods are forbidden to be eaten, low-salt and low-fat foods are eaten, families are advised to do outdoor exercise for many patients at ordinary times, the mood of the patients is kept pleasant, the patients are guided to do language function exercise for many times, and the patients are subjected to a double-diagnosis after three months.

The 10 th and 10 th reexamination in 2010, family complaints: after the patient takes the medicine for three months, the treatment effect is particularly good, only slight amnesia symptoms exist, the rest symptoms do not exist, and the patient can be cooked at home. The patient is asked to have pleasurable expression, ask for words to be answered as if they were, have clear spirit and no more effect, and take three months after taking the pill in front.

Case 2: the male is aged for 58 years, farmers and 2010.7.5 are diagnosed for the first time, the patient suffers from headache and dizziness, memory loss and reaction retardation before one year, the brain atrophy is diagnosed in a large hospital, the effect is not obvious after one month of hospitalization, the patient is diagnosed by introducing the doctor at present, the clinical symptoms of the patient are obviously improved after the doctor takes the traditional Chinese medicine honey pill for one month, the doctor takes 2010.8.6 for two times, the patient is observed to recover to be normal after taking the honey pill for five months, and the patient is visited at 2011.6 for follow-up, so the patient can participate in normal work.

Case 3: wangzhi, male. After 60 years old, farmers, 2010..8.3 make an initial diagnosis, patients have dizziness and vertigo and slow response half a year ago, the patients are determined to have encephalatrophy after CT examination in hospitals, the patients take the decoction to treat more than one month, the symptoms are obviously improved, the patients take the honey pills for three months, and the patients complain and recover after visiting 2011.8 telephones.

Case 4: zhangqi, male, age 58, crew. 2010.8.4. In the initial diagnosis, patients have dizziness, memory deterioration and slow response before one year, and certain hospitals have confirmed brain atrophy. After the traditional Chinese medicine honey pill is taken for one month and the diagnosis is carried out for 2010.9.3 two times, the symptom is obviously improved, the patient returns to normal after the honey pill is taken for three months and the 2011.9 telephone follow-up visit, and the patient is on work at present.

Cerebral infarction cases:

case 5: the patient is initially diagnosed in 5 months 6 and 2011 in 5 months 5 and suddenly suffers from left hand-foot hemiplegia in 1 month 5 and 2011 in a Zhou-chi period, is sent to a hospital for examination, is confirmed to be cerebral infarction through brain CT examination, is treated for the rest of the month in hospital, and is required to be treated by the traditional Chinese medicine at the present time of discharge. The patients are examined to be dark in body and face, hemiplegic in left hand and feet, unclear speaking and spitting words, 1 grade of left hand muscle strength, 2 grade of left hand muscle strength, 140/86mmHg of blood pressure, red tongue with white fur, extending tongue to right side, and wiry and smooth pulse, the traditional Chinese medicine diagnosis refers to liver-kidney yin deficiency, middle-stroke of the external deficient yang, and the western medicine diagnosis of cerebral infarction treats the diseases by nourishing yin and tonifying kidney, calming endogenous wind and astringing yang, activating blood and dissolving stasis, and clearing and activating the channels and collaterals.

Prescription: 100g of uncaria, 80g of scorpion, 100g of centipede, 30g of salvia miltiorrhiza, 120g of pseudo-ginseng, 80g of radix clematidis, 80g of fructus alpiniae oxyphyllae, 30g of tuber fleeceflower stem, 80g of radix curcumae, 50g of radix astragali, 100g of ramulus mori, 100g of rehmannia, 80g of Chinese date peel, 80g of dendrobe, 60g of radix ophiopogonis, 50g of rhizoma acori graminei, 80g of berberis kusnezoffii, 50g of herba cis.

The medicine is applied, pulverized and sieved by a sieve of 80 meshes, and water-honeyed pills are taken after meals for three times a day, 9g each time, and uncooked and cold foods, low-salt and low-fat foods are forbidden to be eaten. Order the patient to do more functional exercises at home, and keep the mood comfortable.

8-month and 8-day double-diagnosis in 2011, patients arrive at our clinic independently, the effect is good after self-complaint of taking the medicine, the walking stick can be abandoned, the speaking mouth and teeth are clear, the life can be taken by oneself completely, and the patient is required to continue taking the medicine for three months. The patients are examined to see that the patients have fresh and cool spirit and pleasant mood, the blood pressure is 132/82mmHg, the left hand muscle strength can reach 4 grade, the left foot muscle strength is 4 grade, the tongue is stretched and centered, the tongue is red and the coating is white, the pulse is wiry, the effect is not more square, and the pill and the medicine are taken for three months after the dosage of the former formula. The call was followed up after 9 months.

Case 6: the patient complains about intermittent dizziness and headache, memory decline and reaction retardation before five years, takes the medicine such as 'pain relieving tablet', 'fenbide' and 'flunarizine' each time, can temporarily relieve pain symptoms, and dizziness and headache aggravate since 2010, and can not relieve pain and dizziness after taking the medicine. After 7/3 days in 2010 to the remaining treatment months of hospitalization in a large hospital, the hospital is diagnosed as 'multiple lumen peduncles' by brain CT examination, the symptoms are relieved after treatment, and the hospital is discharged and returned to home for rest. The symptoms of mental fatigue, headache and dizziness are in three days before the onset, and the medicines such as the gastrodia elata pill, the xuesaitong, the flunarizine and the like are taken at home without effect, so the diagnosis is specially seen at present. The patients with emaciation, abstinence and white face, low voice, 120/76mmHg blood pressure, thin and white tongue coating and thready and weak pulse are diagnosed as vertigo due to liver-kidney yin deficiency, qi stagnation and blood stasis by traditional Chinese medicine. The western medicine diagnosis is cerebral infarction. For treatment, it can nourish yin, tonify kidney, tonify qi, activate blood, remove blood stasis and dredge vessels.

Prescription: 50g of uncaria, 50g of scorpion, 100g of centipede, 30g of salvia miltiorrhiza, 100g of pseudo-ginseng, 100g of clematis root, 50g of sharpleaf galangal fruit, 100g of tuber fleeceflower stem, 80g of curcuma root, 50g of astragalus, 150g of mulberry twig, 80g of rehmannia, 120g of Chinese date peel, 80g of dendrobium, 100g of dwarf lilyturf tuber, 80g of grassleaf sweelflag rhizome, 100g of berba kephalaeae, 80g of dandelion

The medicine is applied, pulverized and sieved by a sieve of 80 meshes, and water-honeyed pills are taken after meals for three times a day, 9g each time, and uncooked and cold foods, low-salt and low-fat foods are forbidden to be eaten. And advocate to keep the mood pleasant and not to ascend the critical risk.

The patient is retested in 7-month and 10-day 2011, the effect is obvious after the patient self-complains about taking the pill, the effect is not better, one dose of the pill is taken in front, and the taking method is the same as that before.

In 2011, 12 and 25 days, the patient is happy to notice the recovery of the disease after telephone follow-up.

Case 7: the patient declines for something, male, 60 years old, worker. 2011.9.4 the medicine is used for initial diagnosis, the patient complains about intermittent dizziness and headache three years ago, the patient has been diagnosed with cerebral infarction (multiple lumen infarction) in a certain hospital, the patient has suffered from mild hemiplegia, hemiparesis and hypoesthesia, unstable gait and limb weakness when getting up in the morning yesterday, the patient has been diagnosed in the place of the medicine, the decoction is taken for 6 days, the patient has been diagnosed with the medicine for 2011.9.11 two times, the patient has better effect after self-complaint, the patient is required to take the medicine for three months, and the patient is treated with the honeyed pill for 2012.6 telephone follow-up and has recovered.

Case 8: zhai, woman, age 54, teacher. 2011.8.6 the diagnosis of diabetes is confirmed by self-complaints of cerebral infarction (multiple lumen infarction) in a certain hospital. The decoction is automatically required to be taken, the water pills are taken after effective fruits are taken, the decoction is decocted for 7 days, and the decoction is used for 2011.8.14 second diagnosis, so that the effect is obvious, the former symptoms basically disappear, and the water pills are taken after three months, three times a day and meal. 2012, 10 telephone follow-up, patient was happy to tell that he had recovered and had no relapse.

Senile dementia cases:

case 9: wangzhi, male, age 78, retirement worker. Initial diagnosis in 2011, 4 and 5 days, and home complaints: patients show amnesia and insomnia two years ago, suffer from three and four times of daily life, are occasionally lost in the familiar environment near villages, are in a gradually-aggravated state in nearly two years, are undeveloped in speaking words, have the grippers of flocculus, are low in emotion and self-closed, do not know families, are diagnosed in a certain hospital from 2 months this year, are diagnosed with senile dementia (the laboratory sheet is not detailed), are treated home with medicine, are taken for two months, are not obvious in effect, are diagnosed in our clinic at present, are examined for patient's bland expression and dementia, are meaningless in questions, are ill in mouth, have dark tongue quality and silted points, thin and white fur, and thin and numerous veins. The traditional Chinese medicine diagnosis is as follows: malnutrition of the heart and kidney, empty marrow sea, malnutrition of the brain and stagnation of blood in the meridians, senile dementia in western medicine. For treatment, it can tonify kidney and nourish heart, nourish essence and marrow, dredge meridians and remove blood stasis.

Prescription: 80g of uncaria, 60g of scorpion, 30g of centipede, 30g of salvia miltiorrhiza, 120g of pseudo-ginseng, 80g of radix clematidis, 80g of fructus alpiniae oxyphyllae, 90g of tuber fleeceflower stem, 100g of radix curcumae, 60g of radix astragali, 150g of ramulus mori, 80g of rehmannia, 100g of Chinese date peel, 80g of dendrobe, 80g of radix ophiopogonis, 80g of rhizoma acori graminei, 60g of berberis capitata, 80g of herba cistanches.

The medicine is applied, pulverized and sieved by a sieve of 80 meshes, and water-honeyed pills are taken after meals for three times a day, 9g each time, and uncooked and cold foods, low-salt and low-fat foods are forbidden to be eaten. Advising family members to supervise the patient to do physical function and language function exercise at home, keeping the patient happy, and making a double-visit after three months.

And B, diagnosis: in 7/8/2011, the effect is obvious after the family members of the patients complain about the patients to take the medicine, the dosage of the pills is required to be increased, the pills are taken half a year later, the effect is not better, the dosage of the pills is increased in the former formula, the family members are advised to keep communication, and the patients are uncomfortable to take the medicine at any time.

Three diagnosis, 2 month and 11 days in 2012, the patients are informed by clinics of family members, the patients are gradually cured, the life can be self-managed, and the patients are required to take pills next half a year for economic reasons.

Case 10: zhangzhi, male. The patient is in early diagnosis for 2011.10.5 and mainly suffers from the complaints of family members at the age of 70 years, the patient gradually becomes amnesia and apathy after the rest before 8 years, the speaking is not fluent, the later period is gradually aggravated to cause the unknown family members, the patient is diagnosed with the Alzheimer disease by a certain hospital 2 years ago, and the patient is diagnosed with the senile dementia by traditional Chinese medicine. According to the introduction, the pill preparation is required to be used for home treatment, and the honeyed pill is temporarily taken for 5 months after being matched with the family. 2012, 3.9 and two diagnoses, the patient is brought by family, the patient is observed to be bright and clear, the eyes are clear, the answer is fluent, the pronunciation is slightly less clear, the family substitutes for complaints, the patient can take care of himself now, the effect is not more square, the honey pill is taken after 6 months, 2012.10 is followed, the patient basically recovers, the patient can take care of himself now, and the square morning can be started every day.

Case 11: senior, male, 72 years old, retired teacher. 2011.6.6 early diagnosis, home complaints of patients 3 years ago showing amnesia and insomnia, gradually aggravated state, depressed emotion and self-closure, often chatting and self-language, and even unconsciousness, diagnosis in certain hospitals 5 months, and diagnosis of senile dementia and diabetes. The hospitalization treatment is unattended and the economic burden is heavy, so that the patients are treated from our places, the water-bindered pill preparation disclosed by the invention is used for 6 months to go home for treatment, the patients are diagnosed with 2011..12.10 twice, the clinical symptoms of the patients after taking the water-bindered pill are obviously improved, the patients can communicate with the neighboring old people, the patients can take a self-care diet and take a daily life, the curative effect is consolidated after the patients take the pill for half a year, and the patients are basically recovered after 2012..6 telephone follow-up.

Case 12: tan Shi in certain age, male, 68 years old, farmer. 2012.2.2 the early diagnosis is that the patient suffers from mental depression and apathy after a family accident 4 years ago, is untreated or not checked for various reasons, speaks for oneself in the daytime, is afraid of staying at home alone, and is diagnosed with senile dementia by the fact that the family brings a doctor to a large hospital before one month. The treatment with the honey pill of the invention is required by introducing to our doctor, and the treatment with the honey pill of the invention for 6 months is recommended by consulting with family members, so that the curative effect is observed and the doctor is not suitable for follow-up treatment. 2012.8.10 the patients have obvious effect after taking the medicine, and take the medicine for 6 months. 2013.6.15 the telephone follow-up is carried out, the patient reports the recovery in the telephone, and the life is self-care and can help bring grandchildren.

Claims (1)

1. The application of a traditional Chinese medicine in preparing a medicine for treating senile dementia is characterized in that: the traditional Chinese medicine is prepared from the following raw materials in parts by weight: 4-12 parts of uncaria, 3-9 parts of scorpion, 4-12 parts of gastrodia elata, 5-15 parts of salvia miltiorrhiza bunge, 4-12 parts of pseudo-ginseng, 4-12 parts of clematis root, 3-9 parts of fructus alpiniae oxyphyllae, 4-12 parts of tuber fleeceflower stem, 3-9 parts of radix curcumae, 5-15 parts of astragalus membranaceus, 4-12 parts of mulberry twig, 4-12 parts of rehmannia, 3-9 parts of jujube peel, 3-9 parts of dendrobium, 3-9 parts of radix ophiopogonis, 3-9 parts of rhizoma acori graminei, 3-9 parts of herba cistanches, 3-9 parts of morinda officinalis, 5-15 parts of rhizoma polygonati, 3-9 parts of berberis poiretii and 2-6 parts of; the rehmanniae radix is radix rehmanniae Preparata, and the rhizoma Polygonati is processed rhizoma Polygonati.