CN101804133A - A kind ofly be used for the treatment of that development in children is slow, the Chinese medicine composition of mental retardation and preparation method thereof - Google Patents
A kind ofly be used for the treatment of that development in children is slow, the Chinese medicine composition of mental retardation and preparation method thereof Download PDFInfo
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Abstract
The present invention relates to field of medicaments, disclose a kind ofly be used for the treatment of that childhood development is slow, the Chinese medicine composition of mental retardation and preparation method thereof.Said composition is made up of raw materials such as Radix Rehmanniae Preparata, Caulis Polygoni Multiflori, Rhizoma Acori Graminei, the Cortex Eucommiae, Radix Notoginseng, Fructus Schisandrae Chinensis, has the effect of kidney tonifying and enriching blood, intelligence promoting and the mind tranquilizing.Be mainly used in treatment because of ischemia, the caused brain dysplasia in children of anoxia, brain injury, hypomnesis, development in children such as learning disorder are slow, the mental retardation symptom.
Description
Technical field
The invention belongs to the field of Chinese medicines, be that a kind of treatment is because of ischemia, the caused brain dysplasia in children of anoxia, brain injury specifically, hypomnesis, development in children such as learning disorder are slow, the Chinese medicine composition of mental retardation symptom, the invention still further relates to the preparation method of said composition.
Background technology
Mental retardation (MR) is a genesis and development in period, and intellectual function is starkly lower than level of the same age, simultaneously with a kind of disease of adaptive behavior defective.Its prevalence is 1% in China city, and the rural area is 2～3%.So high prevalence has brought greatest misery not only for patient and family, returns society and has caused heavy pressure, has directly reduced the population quality of China simultaneously.
The traditional Chinese medical science is thought, causes the cause of disease of children mental retardation mainly to comprise: the natural endowment deficiency: kidney storing essence, comprise congenital essence and acquired essence, and if deficiency of essence endowed from father, a little less than female vim and vigour, then fetus is congenital has thanks to.The heart controlling mental and emotional activities, liver the chief instigator omit, kidney master intelligence and store essential substances, the smart marrow of giving birth to, fill on the marrow in brain, people's growth promoter, if the vital essence that the growth that comprises brain all needs kidney is hidden is congenital deficiency of the liver and kindey, then brain is not filled, brain do not have support and mental retardation, mostly this type of mentally retarded child is inherent.Acquired disposition: acquired essence that kidney is hidden derives from the vital organs of the human body, if weak and sickly after the birth, or feeds imbalance, and malnutrition or terrified tumbling down damage in brain, all can cause the children's's deficiency day after tomorrow, and promptly kidney is hidden the acquired essence deficiency, is difficult to give birth to marrow and supports brain and stare blankly.
Modern study shows that the encephalopathy that is caused by Hypoxia and ischemia is a very harmful commonly encountered diseases in children's's period.Hypoxic ischemic encephalopathy can cause the irreversible damage of axoneure, both can cause the perinatal stage neonatal death, is again the one of the main reasons that neonatal period causes disabled children later on.
Give full play to the advantage of Chinese medicine at aspects such as the yin nourishing of enriching blood, nourishing the liver and kidney, further investigate and develop the medicine of the encephalopathy that causes because of Hypoxia and ischemia, can greatly improve mental retardation of children, late-blooming disease, improve patient and household's quality of life, produce great society and economic benefit.
The present invention develops at this clinical characters just, is formed by Radix Rehmanniae Preparata, Caulis Polygoni Multiflori, Rhizoma Acori Graminei, the Cortex Eucommiae, Radix Notoginseng, Fructus Schisandrae Chinensis prescription.Pharmacological testing shows that each medicinal substances extract of this prescription can alleviate cerebral edema, and the brain injury that ischemia, anoxia are caused has protective effect, cerebral ischemia, the inductive neuronal apoptosis of anoxia is had pick up anti-effect simultaneously, and cranial nerve cell is had protective effect.
Summary of the invention
The present invention is directed to present mental retardation of children problem incidence rate height, and this present situation of the encephalopathy that is mainly Hypoxia and ischemia and causes provides a kind of treatment because of ischemia, the caused brain dysplasia in children of anoxia, brain injury, hypomnesis, development in children such as learning disorder are slow, the Chinese medicine composition of mental retardation symptom.
Said composition is prepared from by the material medicine of following weight: Radix Rehmanniae Preparata 200g, Caulis Polygoni Multiflori 150g, Rhizoma Acori Graminei 60g, Cortex Eucommiae 100g, Radix Notoginseng 40g, Fructus Schisandrae Chinensis 25g.
The present invention also provides the preparation method of this Chinese medicine composition.Get Caulis Polygoni Multiflori and Radix Notoginseng and add 50% ethanol, reflux, extract, twice adds 8 times of amount 50% ethanol extractions 3 hours for the first time, add for the second time 5 times of amount 50% ethanol extractions 2 hours, gradation filters, merging filtrate, recovery ethanol to relative density in the time of 80 ℃ is 1.05 clear paste, and is standby.Residue adding Radix Rehmanniae Preparata, Rhizoma Acori Graminei, the Cortex Eucommiae, Fructus Schisandrae Chinensis decoct with water twice, add 10 times of amounts of water at every turn, decocted 2.5 hours for the first time, decocted 2 hours for the second time, gradation filters, merging filtrate, filtrate is concentrated into that relative density is the clear paste of 1.1-1.2 in the time of 80 ℃, merges drying with Caulis Polygoni Multiflori and Radix Notoginseng extractum, add proper auxiliary materials, make required dosage form.
In order to estimate the curative effect of Chinese medicine composition of the present invention; it has been carried out pharmacological testing research; result of the test shows that medicine of the present invention has certain oxygen lack resistant function; and can suppress cortex neuron apoptosis; cranial nerve cell is had protective effect, and the encephalopathy that causes at Hypoxia and ischemia has better therapeutic effect.
Now that test report is as follows:
Test example 1: to the influence of chmice acute cerebral ischemia
Get 60 of Kunming mouses, the male and female dual-purpose is divided into 5 groups by weight average.Be respectively sham operated rats: the only capable surgical pathway of mice does not connect and pricks vagus nerve and common carotid artery.Acute cerebral ischemia perfusion group again: mice is anaesthetized with 20% urethane, separate bilateral common carotid arteries and vagus nerve, wherein at a side vagus nerve and the other ligature of steel wire of putting a diameter 0.1mm of common carotid artery, thereafter extract steel wire out, the complete ligation of opposite side common carotid artery and vagus nerve causes the chmice acute cerebral ischemia, and ischemia pours into 30min again after 10 minutes, break end rapidly then, the record broken end is dehisced the time of breathing.Get brain immediately, claim its brain heavy (calculating cerebral index=brain weight/body weight), make 10% brain homogenate, survey MDA with sulfo-barbital method, xanthine oxidase is surveyed SOD, and nitrate reductase method is surveyed NO, quantification of protein biuret method.Nimodipine group (positive drug matched group): preceding 15 minutes of mouse anesthesia, lumbar injection nimodipine 2mg/kg operates same model group thereafter.Medicine small dose group of the present invention and heavy dose of group: mice is irritated stomach, every day 1 time, continuous 20 days, same thereafter model group with 0.1ml/10g and 0.2ml/10g medicine of the present invention respectively.
The result is as seen: MDA content obviously raises (P＜O.05) behind the acute cerebral ischemia, and the content of SOD, NO reduces to some extent; And nimodipine group and medicine group of the present invention all can make MDA content obviously reduce, and increase the content (P＜0.05) of SOD, NO simultaneously, and along with the increase of dosage, the effect of medicine of the present invention is all the more obvious.Simultaneously, medicine of the present invention shortened mice broken end visible ischemia group broken end time of breathing of snorting influence of dehiscing, and administration group significant prolongation (P＜0.05).Illustrate that this medicine has certain oxygen lack resistant function.
Table 1 medicine of the present invention is to the influence of mouse brain homogenate MDA, NO, SOD
*P＜0.05
**P＜0.01
Table 2 medicine of the present invention is to the snorting influence of dehiscing of mice broken end
**P＜0.01
Test example 2: to the influence of mice normal pressure anoxia enduring
Get 40 of mices, be divided into 4 groups at random: normal group, this medicine group 10,20mgkg-1 group, nimodipine 6mgkg-1 positive controls, 10 every group by body weight.This medicine group and positive control drug group are in experiment beginning in preceding 5 days gastric infusion, and the normal group mouse stomach gives equal volume 0.5%CMC-Na.1h after the last administration, the interior and sealing of 250mL wide mouthed bottle of containing the 20g sodica calx in every mice places.Is dead sign with the respiratory arrest, the time-to-live of record mice is also calculated the prolonged survival period rate, rate elongation=(experimental group time-to-live-matched group time-to-live)/matched group time-to-live * 100%.
The result as seen, each dosage group mice of this medicine anoxia and the dead time is a bit larger tham normal group under normal pressure, but there are no significant (P＞0.05) with the difference of normal group, shows that medicine of the present invention can prolong mice normal pressure hypoxia endurance time and not have significance.
Table 3 medicine of the present invention is to mice normal pressure anoxia enduring experimental result
*P＞0.05
**P＜0.05
Test example 3: to the influence of mice sodium nitrite poisoning anoxia enduring
Get 40 of mices, be divided into 4 groups at random: model group, this medicine group 10,20mgkg-1 group, nimodipine 6mgkg-1 positive controls, 10 every group by body weight.This medicine group and positive control drug group are in experiment beginning in preceding 5 days gastric infusion, and the model group mouse stomach gives equal volume 0.5%CMC-Na.1h after the last administration, each treated animal lumbar injection sodium nitrite 240mgkg-1 and timing immediately cease breathing up to animal, the time-to-live that record is respectively tried mice.
Table 4 medicine of the present invention is to the influence of poisoning time-to-live of mice sodium nitrite
Compare with model group
*P＜0.05
*P＜0.01
Test example 4: to cerebral ischemia-pour into the again influence of inductive neuronal apoptosis
30 of SD rats, body weight 200-300 gram is divided into 3 groups, 10 every group at random.Each treated animal is tested medicine with this respectively, XINGNAOJING ZHUSHEYE and normal saline gastric infusion 7 days.After the administration in the 7th day 1 hour, use the pentobarbital sodium intraperitoneal injection of anesthesia; Get dorsal position, separate the exposure bilateral carotid, close bilateral carotid with the bulldog clamp folder and unclamp after 60 minutes, sew up wound is put to death animal after observing 24 hours, get brain, get the brain sagittate section along the brain median line, paraffin embedding, serial section are done HE chromosome and the dyeing of apoptosis original position.The step of recommending by apoptosis original position TUNEL detection kit detects, and calculates number, the integral optical density of average every high power field apoptotic cell.
The result as seen, this medicine group can suppress cortex neuron apoptosis, and cranial nerve cell is had protective effect, can not only reduce the integral optical density of apoptotic cell, also can reduce the number of apoptotic cell.
Average every high power field apoptotic cell number of each experimental group of table 5 and integral optical density
Compare with the normal saline matched group
*P＜0.05,
The specific embodiment
By specific embodiment given below, can further be well understood to the present invention, but they not limitation of the invention.
Embodiment 1:
Prescription: Radix Rehmanniae Preparata 200g Caulis Polygoni Multiflori 150g Rhizoma Acori Graminei 60g
Cortex Eucommiae 100g Radix Notoginseng 40g Fructus Schisandrae Chinensis 25g
Get Caulis Polygoni Multiflori and Radix Notoginseng and add 50% ethanol, reflux, extract, twice adds 8 times of amount 50% ethanol extractions 3 hours for the first time, add for the second time 5 times of amount 50% ethanol extractions 2 hours, gradation filters, merging filtrate, recovery ethanol to relative density in the time of 80 ℃ is 1.05 clear paste, and is standby.Residue adding Radix Rehmanniae Preparata, Rhizoma Acori Graminei, the Cortex Eucommiae, Fructus Schisandrae Chinensis decoct with water twice, add 10 times of amounts of water at every turn, decoct 2.5 hours for the first time, decocted 2 hours for the second time, gradation filters, merging filtrate, filtrate is concentrated into that relative density is the clear paste of 1.1-1.2 in the time of 80 ℃, merge with Caulis Polygoni Multiflori and Radix Notoginseng extractum, add starch, granulate, dry, incapsulate, make 1000, promptly.
Embodiment 2:
Prescription: Radix Rehmanniae Preparata 200g Caulis Polygoni Multiflori 150g Rhizoma Acori Graminei 60g
Cortex Eucommiae 100g Radix Notoginseng 40g Fructus Schisandrae Chinensis 25g
Get Caulis Polygoni Multiflori and Radix Notoginseng and add 50% ethanol, reflux, extract, twice adds 8 times of amount 50% ethanol extractions 3 hours for the first time, add for the second time 5 times of amount 50% ethanol extractions 2 hours, gradation filters, merging filtrate, recovery ethanol to relative density in the time of 80 ℃ is 1.05 clear paste, and is standby.Residue adding Radix Rehmanniae Preparata, Rhizoma Acori Graminei, the Cortex Eucommiae, Fructus Schisandrae Chinensis decoct with water twice, add 10 times of amounts of water at every turn, decoct 2.5 hours for the first time, decocted 2 hours for the second time, gradation filters, merging filtrate, filtrate is concentrated into that relative density is the clear paste of 1.1-1.2 in the time of 80 ℃, merges with Caulis Polygoni Multiflori and Radix Notoginseng extractum, adds carboxymethyl starch sodium, starch, mixing, granulate granulate, tabletting, make 1000, promptly.
Embodiment 3:
Prescription: Radix Rehmanniae Preparata 200g Caulis Polygoni Multiflori 150g Rhizoma Acori Graminei 60g
Cortex Eucommiae 100g Radix Notoginseng 40g Fructus Schisandrae Chinensis 25g
Get Caulis Polygoni Multiflori and Radix Notoginseng and add 50% ethanol, reflux, extract, twice adds 8 times of amount 50% ethanol extractions 3 hours for the first time, add for the second time 5 times of amount 50% ethanol extractions 2 hours, gradation filters, merging filtrate, recovery ethanol to relative density in the time of 80 ℃ is 1.05 clear paste, and is standby.Residue adding Radix Rehmanniae Preparata, Rhizoma Acori Graminei, the Cortex Eucommiae, Fructus Schisandrae Chinensis decoct with water twice, add 10 times of amounts of water at every turn, decoct 2.5 hours for the first time, decocted 2 hours for the second time, gradation filters, merging filtrate, filtrate is concentrated into that relative density is the clear paste of 1.1-1.2 in the time of 80 ℃, merges with Caulis Polygoni Multiflori and Radix Notoginseng extractum, adds cyclamate 5g, sodium benzoate 3g, add water and be adjusted to 1000ml, cold preservation 24 hours filters packing, sterilization, promptly.
Embodiment 4:
Prescription: Radix Rehmanniae Preparata 200g Caulis Polygoni Multiflori 150g Rhizoma Acori Graminei 60g
Cortex Eucommiae 100g Radix Notoginseng 40g Fructus Schisandrae Chinensis 25g
Get Caulis Polygoni Multiflori and Radix Notoginseng and add 50% ethanol, reflux, extract, twice adds 8 times of amount 50% ethanol extractions 3 hours for the first time, add for the second time 5 times of amount 50% ethanol extractions 2 hours, gradation filters, merging filtrate, recovery ethanol to relative density in the time of 80 ℃ is 1.05 clear paste, and is standby.Residue adding Radix Rehmanniae Preparata, Rhizoma Acori Graminei, the Cortex Eucommiae, Fructus Schisandrae Chinensis decoct with water twice, add 10 times of amounts of water at every turn, decocted 2.5 hours for the first time, decocted 2 hours for the second time, gradation filters, merging filtrate, filtrate are concentrated into that relative density is the clear paste of 1.1-1.2 in the time of 80 ℃, merge with Caulis Polygoni Multiflori and Radix Notoginseng extractum, add lactose, dextrin, cyclamate, mixing, dry granulation, promptly.
Claims (4)
1. one kind is used for the treatment of that development in children is slow, the Chinese medicine composition of mental retardation, it is characterized in that being prepared from by the material medicine of following weight: Radix Rehmanniae Preparata 200g, Caulis Polygoni Multiflori 150g, Rhizoma Acori Graminei 60g, Cortex Eucommiae 100g, Radix Notoginseng 40g, Fructus Schisandrae Chinensis 25g.
2. as claims 1 described Chinese medicine composition, it is characterized in that said composition can make capsule, tablet, granule or oral liquid.
3. the preparation method of Chinese medicine composition as claimed in claim 2, it is characterized in that passing through following steps: get Caulis Polygoni Multiflori and Radix Notoginseng and add 50% ethanol, twice of reflux, extract,, add for the first time 8 times of amount 50% ethanol extractions 3 hours, add for the second time 5 times of amount 50% ethanol extractions 2 hours, gradation filters, merging filtrate, recovery ethanol to relative density in the time of 80 ℃ is 1.05 clear paste, and is standby.Residue adding Radix Rehmanniae Preparata, Rhizoma Acori Graminei, the Cortex Eucommiae, Fructus Schisandrae Chinensis decoct with water twice, add 10 times of amounts of water at every turn, decocted 2.5 hours for the first time, decocted 2 hours for the second time, gradation filters, merging filtrate, filtrate is concentrated into that relative density is the clear paste of 1.1-1.2 in the time of 80 ℃, merges drying with Caulis Polygoni Multiflori and Radix Notoginseng extractum, add proper auxiliary materials, make required dosage form.
As any one described Chinese medicine composition among the right 1-2 in treatment because of ischemia, the caused brain dysplasia in children of anoxia, brain injury, hypomnesis, development in children such as learning disorder are slow, the application in the mental retardation disease.
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104623051A (en) * | 2015-02-11 | 2015-05-20 | 郭如英 | Oral liquid suitable for congenitally mentally deficient children |
| CN104666997A (en) * | 2015-02-11 | 2015-06-03 | 郭如英 | Oral liquid for treating intellectual development retardation and preparation |
| CN104688974A (en) * | 2015-04-02 | 2015-06-10 | 河南中医学院 | Traditional Chinese medicine electuary for treating alzheimer disease |
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2010
- 2010-04-06 CN CN201010140515A patent/CN101804133A/en active Pending
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104623051A (en) * | 2015-02-11 | 2015-05-20 | 郭如英 | Oral liquid suitable for congenitally mentally deficient children |
| CN104666997A (en) * | 2015-02-11 | 2015-06-03 | 郭如英 | Oral liquid for treating intellectual development retardation and preparation |
| CN104688974A (en) * | 2015-04-02 | 2015-06-10 | 河南中医学院 | Traditional Chinese medicine electuary for treating alzheimer disease |
| CN104688974B (en) * | 2015-04-02 | 2018-08-14 | 河南中医学院 | A kind of instant particles as Chinese medicine for treating senile dementia |
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Application publication date: 20100818 |