CN101828703B - Product for enhancing organic immunity and improving sleeping quality and preparation method thereof - Google Patents
Product for enhancing organic immunity and improving sleeping quality and preparation method thereof Download PDFInfo
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Abstract
The invention relates to a product for enhancing organic immunity and improving sleeping quality and a preparation method thereof, which belong to the field of functional health foods. The active components of the product comprise panaxoside, pueraria isoflavone, stevioside, a glossy ganoderma extract and an inonotus obliquus extract, and the active components thereof comprise the following used raw materials in proportion by weight: 30-80 parts of glossy ganoderma, 20-50 parts of inonotus obliquus, 5-12 parts of pueraria isoflavone, 2-8 parts of panaxoside and 2-8 parts of stevioside. The product has an integral conditioning action for crowds with low immunity and susceptibility, can improve subhealthy conditions, performs an antifatigue curative effect and has certain improving efficacy for people with poor sleeping quality.
Description
Technical field
The present invention relates to functional health care food, specifically describe and relate to a kind of herbaceous plant composition and method of making the same that strengthens immunity of organisms and can improve sleep quality that has.
Background technology
The intensified competition of modern society, rhythm is accelerated, the modern is in nervous living environment for a long time, operating pressure reaches overtired greatly, add abnormal living and diet custom, cause immunity generally to weaken and cause endocrine, nervous system, digestive system imbalance, immunity reduces gradually, and sleep quality worse and worse.
Along with science and technology development, the pollution in the life has produced various harmful substances, as the peroxide of releases such as medicine, food additives; The radiation that mobile phone, TV, computer etc. produce etc., the integrality of these factors disrupt human body cells, stability, it medically is referred to as " oxidative damage " to the injury of human body, and in addition, the intrusion of bacterium, virus also can produce oxidative damage.Oxidative damage causes the pathology of human internal organ easily, as tumour, cardiovascular and cerebrovascular disease, enterogastric diseases, diabetes, hepatopathy, cataract etc.How to strengthen immunity, improve the human body oxidation resistance, become the problem that the whole society all pays close attention to.
Poor sleeping quality causes the state of mind dispirited, directly causes operating efficiency low.
Genseng is the dry root of Araliaceae genseng, be China's tradition rare Chinese medicine, has the strengthening by means of tonics effect, can reinforce vital energy, allay excitement intelligence development, strengthening the spleen and replenishing qi, effect such as promote the production of body fluid, mainly containing active ingredients such as saponin, each seed amino acid, vitamin, polysaccharide, is the article that can be used for health food that the Ministry of Public Health determines.Carry out mouse anti anoxic gas ability, the experiment of swimming with a load attached to the body antifatigue with panaxoside, the result proves that mouse time-to-live and swimming time obviously prolong, and shows that genseng has antifatigue effect.Effect to panaxoside is studied, the result shows that panaxoside can reduce mouse brain and myocardium lactic acid content under the severe depletion of oxygen situation, the reduction of cardiac muscle CANP '/CGMP ratio shows that panaxoside can improve the energetic supersession when being organized in anoxic in the time of recovering anoxic.
Glossy ganoderma is Basidiomycetes, Polyporus, Ganoderma fungi.Glossy ganoderma is the famous medicinal bacterium of China, and the Shennong's Herbal record " red sesame master ties in the heart, the beneficial motive, and bowl spares increases wisdom and does not forget.For a long time food is made light of one's life by commiting suicide and is not prolonged life always ", among the people have saying of " having eaten polyporus lucidus, alive for evermore ".Modern medicine study is found, is mainly contained two class material, polysaccharide and triterpene compounds in the glossy ganoderma.The contained macromolecule polysaccharide of glossy ganoderma can promote the synthetic of body protein DNA, RNA, promotes the division growth of body, stimulates the human body nospecific immunity and suppresses tumour, body immune system.Human body void declines, and shows as body mobility deficiency, and multiple physiology, biochemical function weaken or be disorderly, especially immunologic function, marrow hemopoiesis function, E﹠M dysfunction, and body resistance against diseases is low.Glossy ganoderma has anti-oxidant, promotes protein, nucleic acid to synthesize delaying senility function.Glossy ganoderma strengthens resisting stress capability, strengthens adrenal cortex function, improves the resistivity to the body destructive stimulus.The immunoloregulation function disorder of body also is old and feeble, weak feature, and glossy ganoderma and GL-B can be regulated immunologic function from many aspects.Glossy ganoderma promotes the biosynthesis of bone marrow cell bone marrow cell protein and nucleic acid, can strengthen the marrow hemopoiesis function, but and radioresistance damage.
The root of kudzu vine is the dry root of legume Pueraria lobata (Willd.) Ohwi.Practise and claim elegant jessamine.It is sweet to distinguish the flavor of, and spleen, stomach warp are returned in property suffering, cold.Be good at relieving muscles to expel heat, the promoting eruption of promoting the production of body fluid rises positive antidiarrheal.Be mainly used in the headache of treatment fever caused by exogenous pathogens, stiff nape and back, thirsty, quench one's thirst, measles without adequate eruption, hot dysentery is had loose bowels; The hypertension neck pain.The active component of kudzuvine root for treating cardiovascular and cerebrovascular disease is a kudzuvine root isoflavone, and active ingredient mainly contains Puerarin, daidzein, daidzin, seven material lignin etc.That the pharmacological action of the root of kudzu vine has is analgesic, hypoglycemic, intelligence development, improve brain circulation, anti-arrhythmia, resist myocardial ischemia, reduce MCO and do not have obvious negative inotropic action, also have antithrombotic, improve effects such as HDL, vasospasm and reduction platelet aggregation.The clinical illnesss such as treatment retinal arterial obstruction, sudden deafness, coronary heart disease, angina pectoris, hypertension, cerebral arteriovenous malformation, antimigraine, high fat of blood that are mainly used in.
16-17 is since century, Eastern Europe, Russia, Poland, Finland etc. are among the people to be CHAGA (Inonotus obliquus with regard to extensively utilizing the precious medicinal fungi of a kind of Chaga of crying, its formal name used at school is: Phaeoporus obliquus (Pers.:Fr.) J.Schroet. is in foreign language datum, its formal name used at school often occurs with Inonotus obliquus or Fuscoporia obliqua, its another name also has Black birchtuchwood, Malalon mushroon) prevent and treat as diabetes.It is said that the smart powder of Inonotus obliquus that the Muscovite Suo Molesiji of bearing (Komsomlski) drugmaker produces reaches 93% to the cure rate of diabetes.But use the effect of CHAGA extract reduction hyperglycaemia slow merely through clinical observation, need long-term (the 3-6 month) take just and produce effect.
Summary of the invention
Prior art has extensively adopted the product that comprises Chinese medicines such as genseng, glossy ganoderma, the root of kudzu vine to be used to strengthen immunity of organisms, and for example CN1355039A discloses the preparation that the reparation Gene regulation that contains multiple Chinese herbal medicines such as comprising genseng, glossy ganoderma improves immunity; CN101040713A discloses the health food of the enhancing immunity function of multiple extracts such as comprising ginseng extract, kudzu root extract and Ganodenna Lucidum P.E.
Steviol glycoside, food and medicine field have been widely used in as sweetener, CHAGA now also only finds to have effect in reducing blood glucose, the inventor finds through long-term experimental study, on the basis of panaxoside, kudzuvine root isoflavone and Ganodenna Lucidum P.E, add steviol glycoside and CHAGA extract, not only can improve mouthfeel, and than the better effects if of single enhancing immunity during with panaxoside, kudzuvine root isoflavone and Ganodenna Lucidum P.E, find also that simultaneously said composition also has the effect of improving sleep quality.
A kind of product that strengthens immunity of organisms and can improve sleep quality, its active component is made up of panaxoside, kudzuvine root isoflavone, steviol glycoside, Ganodenna Lucidum P.E and CHAGA extract, the raw materials used weight ratio of its active component is: glossy ganoderma 30-80 part, CHAGA 20-50 part, kudzuvine root isoflavone 5-12 part, panaxoside 2-8 part, steviol glycoside 2-8 part.
Preferably: the raw materials used weight ratio of described active component is: glossy ganoderma 50-60 part, CHAGA 20-30 part, kudzuvine root isoflavone 8-10 part, panaxoside 3-6 part, steviol glycoside 2-5 part.
Preferably: the raw materials used weight ratio of described active component is: 50 parts of glossy ganodermas, 30 parts of CHAGAs, 10 parts of kudzuvine root isoflavones, 5 parts of panaxosides, 5 parts of steviol glycosides.
Its dosage form of described product is tablet, capsule, granule, oral liquid, perhaps beverage, tea in bag.
The preparation method of the said goods, it is characterized in that: glossy ganoderma is adopted solvent refluxing extraction, the concentrated Ganodenna Lucidum P.E that obtains, CHAGA adopts normal-temperature water to soak the concentrated CHAGA extract that obtains of back decompression, again with panaxoside, kudzuvine root isoflavone and steviol glycoside mixed product activity composition of the present invention, add auxiliary material by dosage form again and make.
Described solvent is water, ethanol or its mixture.
Described product strengthens immunity of organisms and can improve application in the sleep quality product in preparation.
Ganodenna Lucidum P.E dry powder of the present invention, CHAGA extract dry powder, panaxoside, kudzuvine root isoflavone and steviol glycoside also can directly mix to incapsulate to be taken, perhaps the glossy ganoderma in the above-mentioned composition can be with The suitable solvent respectively or mix to extract processing and obtain its extract, CHAGA obtains the soak at room temperature extract, and extract is made preparation with the pharmaceutical excipient hybrid process again.Described solvent is meant solvent pharmaceutically commonly used, preferred water, ethanol or its combination, and extracting method can be extracted with pharmaceutically conventional method, as decocting method, percolation, reflux extraction, continuous extraction etc.
When being used for oral administration, conventional solid pharmaceutical preparation be can be made into, tablet, capsule, granule, pill and oral solution etc. comprised.Tablet means the disk shape that medicine and suitable auxiliary materials and mixing compacting form or the solid pharmaceutical preparation of special-shaped sheet; Tablet is based on oral ordinary tablet, and other has lozenge, sublingual tablet, mouth paster, chewable tablets, dispersing tablet, fuse, effervescent tablet, sustained release tablets, controlled release tablet and enteric coatel tablets etc.Capsule means medicine or is added with the auxiliary material filling in Capsules or be sealed in solid pharmaceutical preparation in the soft capsule material; Capsule can be divided into hard shell capsules (being commonly referred to as capsule), soft capsule (capsule and pill), spansule, controlled release capsule and capsulae enterosolubilis according to its dissolving and release characteristics.Granule means that medicine and suitable auxiliary material make the dried particles shape preparation with certain particle size; Granule can be divided into soluble particles (being commonly referred to as particle), mix suspension grain, effervescence granular, enteric coated particles, slow-releasing granules and controlled release granule etc.Pill means that medicine evenly mixes with suitable auxiliary material, the spherical or near-spherical solid pharmaceutical preparation made from proper method; Pill comprises dripping pill, sugar-pill, piller etc.Oral solution means that medicine is dissolved in the supernatant liquid preparation of making in the suitable solvent for oral.
The preparation of herbaceous plant composition of the present invention can adopt the conventional method production in the existing pharmaceutical field, can add various pharmaceutically acceptable carriers when needing.Described carrier comprises osmotic pressure regulator, pH value conditioning agent, solubilizer, antioxidant, bacteriostatic agent, emulsifying agent, suspending agent, filler, adhesive, disintegrant, lubricant of pharmaceutical field routine etc.
Herbaceous plant composition of the present invention can add suitable filler, adhesive, disintegrant, lubricant etc. when making oral formulations.Filler comprises starch, Icing Sugar, calcium phosphate, calcium sulfate two water things, dextrin, microcrystalline cellulose, lactose, pregelatinized starch, sweet mellow wine etc.; Adhesive comprises sodium carboxymethylcellulose, PVP-K30, hydroxypropyl cellulose, starch slurry, methylcellulose, ethyl cellulose, Hydroxypropyl methylcellulose, gelling starch etc.; Disintegrant comprises dried starch, PVPP, Ac-Di-Sol, sodium carboxymethyl starch, low-substituted hydroxypropyl cellulose etc.; Lubricant comprises dolomol, talcum powder, lauryl sodium sulfate, superfine silica gel powder etc.
The present invention adds steviol glycoside and CHAGA extract in Ganodenna Lucidum P.E, panaxoside, kudzuvine root isoflavone, not only improved mouthfeel, find that also the function of said composition enhancing immunity of organisms obviously exceeds the effect of Ganodenna Lucidum P.E, panaxoside, kudzuvine root isoflavone composition, but also has the effect of improving sleep, component is simple, effect is significantly various, is the functional health product that is worthy to be popularized.
The specific embodiment
The concrete content of the operation of the active ingredient of Chinese herbs water extract that carries out among the embodiment and the excipient of adding all is ordinary skill in the art, is that the those skilled in the art realizes easily, does not have the inadequate problem that discloses.The purpose of embodiment is that explanation composition of the present invention can be made regular dosage form, rather than is used to limit its protection domain or influences it openly fully.
Raw material: CHAGA, glossy ganoderma, panaxoside, kudzuvine root isoflavone, steviol glycoside and auxiliary material are the commercially available prod.Glossy ganoderma is extracted the Ganodenna Lucidum P.E that obtains by water, ethanol or its mixture, this process using be heating and refluxing extraction method conventional on the Chinese pharmacology, CHAGA is soaked by normal-temperature water and obtains the CHAGA extract, the water yield was not as the criterion there not to be raw material, once soak about 24 hours, three immersions are advisable.
Embodiment 1
Get glossy ganoderma 800g spray-drying after poach extracts, concentrates, get Ganodenna Lucidum P.E dry powder, the frequent emerge in worm water of CHAGA 300g extracts, decompression concentrates the back drying and obtains the CHAGA extract, add ginsenoside 20 g, kudzuvine root isoflavone 50g and steviol glycoside 30g again, mixing, granulation, oven dry, whole grain, adding dolomol, compressing tablet.
Embodiment 2
Get glossy ganoderma 300g spray-drying after water-ethanol (9: 1) refluxing extraction concentrates, get Ganodenna Lucidum P.E dry powder, the frequent emerge in worm water of CHAGA 200g extracts, decompression concentrates the back drying and obtains the CHAGA extract, add panaxoside 60g, kudzuvine root isoflavone 80g and steviol glycoside 20g, again will an amount of microcrystalline cellulose, pregelatinized starch, CMS-Na add Chinese herbal medicine and extract mixing in the dry powder, granulation, oven dry, whole, add dolomol, compressing tablet at last.
Embodiment 3
Get glossy ganoderma 700g spray-drying after water-ethanol (4: 6) refluxing extraction concentrates, get Ganodenna Lucidum P.E dry powder, the frequent emerge in worm water of CHAGA 400g extracts, decompression concentrates the back drying and obtains the CHAGA extract, add panaxoside 70g, kudzuvine root isoflavone 90g and steviol glycoside 60g, directly mixing, direct filled hard capsules.
Embodiment 4
Get glossy ganoderma 600g spray-drying after the alcohol reflux extraction concentrates, the frequent emerge in worm water of CHAGA 500g extracts, decompression concentrates the back drying and obtains the CHAGA extract, add panaxoside 80g, kudzuvine root isoflavone 120g and steviol glycoside 80g, mix, granulate, oven dry adds dolomol and talcum powder, filled hard capsules.
Embodiment 5
Get glossy ganoderma 500g after the poach extraction concentrates, get concentrate, the frequent emerge in worm water of CHAGA 300g extracts, the concentrated CHAGA that obtains of decompression extracts concentrate, add panaxoside 50g, kudzuvine root isoflavone 100g and steviol glycoside 50g, be mixed with soup, can, oral liquid is made in sterilization.
Reference examples 1 (carrying out) according to implementing 1
Get glossy ganoderma 800g spray-drying after the poach extraction concentrates,, add ginsenoside 20 g, kudzuvine root isoflavone 50g, mix, granulate, dry, add dolomol and talcum powder, filled hard capsules.
Reference examples 2 (carrying out) according to implementing 3
Get glossy ganoderma 700g spray-drying after water-ethanol (4: 6) refluxing extraction concentrates, get Ganodenna Lucidum P.E dry powder, add panaxoside 70g, kudzuvine root isoflavone 100g, directly mixing, direct filled hard capsules.
The present invention is to provide a kind of food that strengthens immunity of organisms and can improve sleep quality that has, have immunologic function, realize according to " health food check and assessment technique standard " version (function assessment evaluation test method) in 2003 for proving it.To improving the criterion of sleep function health food, show that through zoopery and human experimentation health food of the present invention has the tangible sleep function that improves according to " health food check and assessment technique standard " (2003 editions).
1, strengthens the experiment of immunity of organisms function assessment
1.1 material
1.1.1 animal and raising
80 of cleaning level Male Kunming strain mice, 40 of female mices, body weight 18-24g is provided by animal technical college animal used as test plant of Agricultural University Of Hunan.
1.1.2 main agents
Sheep red blood cell (SRBC) (SRBC), HankShi liquid (pH7.2-7.4), RPMI RPMI-1640, calf serum, blue or green strepto-rope, concanavalin A (ConA), MTT, complement (GPS), SA buffer solution, india ink, Dou Shi reagent, YAC-1 cell, 3H-TdR etc.
1.2 method
Cellular immune function assay: high, medium and low three dosage groups of sample of the present invention all can obviously strengthen immunosuppressed mice delayed allergy value, and the cellular immunity positive as a result is described; In the SPL transformation experiment, the cell in vitro cultivation results shows, during more than or equal to 0.01562mg/ml, sample of the present invention all has three the value-added effect of tangible enhancing SPL is arranged more than the concentration in the concentration of sample.
The humoral immunity measuring: high, medium and low three dosage groups of sample of the present invention all can obviously strengthen immunosuppressed mice HC50 value, and this product humoral immune function positive as a result is described.
Monokaryon-macrophage function is measured: three dosage groups of sample of the present invention all can obviously increase immunosuppressed mice phagocytic index K, increase peritoneal macrophage and engulf chicken red blood cell percentage and phagocytic index; Three dosage groups of sample of the present invention all can obviously strengthen mouse carbon and clean up ability.Monokaryon-macrophage function positive as a result is described.
The NK cytoactive is measured: the cell in vitro experiment shows, when the concentration of capsule of the present invention can obviously increase the NK cytoactive greater than 4 concentration of 1.0mg/ml.The NK cytoactive measurement result positive is described.
1) strengthen immunologic function zoopery result:
Sample of the present invention is to effect of immunologic function overall assessment table
Annotate: " * " expression contrast high dose group relatively has conspicuousness to influence with the blank group, * P＜0.05 wherein, * * P＜0.01; The no conspicuousness influence of "-" expression;
Each dosage group of " △ " expression sample of the present invention relatively has significant difference with the contrast high dose group, wherein △ P＜0.05; △ △ P＜0.01.
Blank: distilled water
The product that sample: embodiment 1 obtains
The product that reference examples 1 makes.
2) anti-oxidation function experimental result:
Three dosage groups of sample of the present invention and contrast high dose group all can significantly improve the TAC (T-AOC) of D-galactolipin induced mice aging model, improve superoxide dismutase (SOD) vigor, reduce MDA (MDA) content, illustrate that sample of the present invention and contrast all have anti-oxidation function, and the anti-oxidant effectiveness of sample also is better than contrast.
Sample of the present invention and contrast antioxidation overall assessment table
Annotate: the contrast of " * " expression high dose relatively has the conspicuousness influence with the blank group, * P＜0.05 wherein, * * P＜0.01; The no conspicuousness influence of "-" expression;
" △ " expression each dosage group of sample of the present invention and high dose have been compared significant difference, wherein △ P＜0.05; △ △ P＜0.01.
Blank: distilled water
The product that sample: embodiment 3 obtains
The product that reference examples 2 makes.
2 improve sleep function learns zoopery
2.1 materials and methods
2.1.1 the health food of the present invention of instrument and reagent embodiment 4 preparations is for being tried thing, electronic balance, stopwatch, spontaneous activity counter, yellow Jackets.
2.1.2 animal used as test ICR kind mouse, ablactation SD rat, the cleaning level is provided by medical animal experiment center, Wuhan City, the animal quality certification number: Hubei Province doctor's examination 0708. occupancy permit number: EYS0805.
2.2 method
2.2.1 to spontaneous activity influence 48 male and female half and half of mouse, be divided into four groups at random.The high, medium and low dosage group of the embodiment of the invention 4 health foods gives 10.0ml/Kg, 5.0ml/Kg, this health food of 2.5ml/kg respectively, and control group gives with volume physiological saline.Continuous irrigation stomach 30d, 30min after the last administration puts into spontaneous activity counter endoadaptation 5min with mouse, writes down the means of activity of mouse in the 5min then.
2.2.2 to the yellow Jackets influence of the length of one's sleep, 60 of mouse, the male and female dual-purpose is divided into 4 groups at random.The high, medium and low dosage group of this health food gives 10.0ml/Kg, 5.0ml/Kg, this health food of 2.5ml/kg respectively, and control group gives with volume physiological saline.Continuous irrigation stomach 30d, 30min after the last administration, every group of mouse peritoneal injection yellow Jackets 40mg/kg.The length of one's sleep (with the righting reflex loss is time for falling asleep, is sleep time from righting reflex loss to recovery time) of record mouse
2.2.3 sleep dosage under the yellow Jackets threshold is influenced mice group to be reached to the same 1.3.2 of this health food, continuous irrigation stomach 30d, 30min after the last administration, each treated animal lumbar injection yellow Jackets 30mg/kg, the number of animals (to be index more than the righting reflex loss 1min) that observation is slept to each group generation in the 30min behind the yellow Jackets
2.3 the sleep function experimental result of improving of this health food sees Table 1,2,3,4
2.3.1 the influence to spontaneous activity sees Table the spontaneous activity number of times that 1 health food high dose group can obviously reduce mouse, with control group significant difference (P＜0.05) is arranged relatively
This health food of table 1 is to the influence of mouse 5min spontaneous activity
This health food sees Table 2 to the influence of yellow Jackets induced hypnotic time
This health food of table 2 to the influence of the length of one's sleep of yellow Jackets inducing mouse (
)
* compared significant difference (P＜0.05) with the blank group.
This health food sees Table 3 to the influence of yellow Jackets sub-threshold dose hypnosis experiment
This health food of table 3 to the influence of the sleeping incidence of yellow Jackets sub-threshold dose mouse (
)
* compared significant difference (P＜0.05) with the blank group.
The preclinical influence of sleeping sees Table 4 to this health food to yellow Jackets
This health food of table 4 to the mouse yellow Jackets sleep preclinical influence (
)
* compared significant difference (P＜0.05) with the blank group.
* has compared with the blank group than significant difference (P＜0.01).
Per os gives this health food 32d of mouse various dose, and control group and three dosage groups all find no direct sleep phenomenon in being tried thing 60min.With the blank group relatively, this health food can prolong mouse sleep time (P＜0.05) that yellow Jackets induce in middle dosage group, shorten barbital sodium sleep incubation period (P＜0.05); Can prolong mouse sleep time (P＜0.05) that yellow Jackets induce in high dose group, improve the sleeping animal incidence (P＜0.05) of yellow Jackets sub-threshold dose mouse, shorten barbital sodium sleep incubation period (P＜0.01).This health food has no adverse effects to weight of mice.To improving the criterion of sleep function health food, can determine that this health food zoopery result shows to have the sleep function of improvement according to " health food check and assessment technique standard " (2003 editions).
3 improve sleep function learns zooperal clinical observation
(1) suitable crowd's situation
The suitable crowd volunteer who participates in the experiment is totally 50 examples, wherein male 29 examples, and women 21 examples, the men and women was than 1.38: 1.Age 30-40 year 5 examples, 41-50 year 19 examples, 51-60 year 16 examples, 10 examples more than 60 years old.Wherein professional cadre 25 people, teacher 10 people, workman 7 people, student 6 people, other 2 people.
(2) experiment situation
Dosage grouping and this health food give the time experiment and establish 3 dosage groups of basic, normal, high dosage and 1 blank group, this health food of embodiment 5 preparations is with adult's recommended amounts oral 700mg/d every day, by adult 60kg batheroom scale, promptly 12mg/ (kg body weight) control group adopts blank.This health food gives time totally 4 all 30d.Take this health food after one week, suitable crowd is under quiet resting state, and the groups of people feel that 89% needs improve sleep can enter the state of sleeping soundly very soon, and sleep generally is no less than 8 hours continuously.The centre person of getting up in the night to urinate accounts for 21%, after continuing to take, all enters normal condition generally speaking.
Conclusion: the overall process of taking health food improvement sleep of the present invention is an incremental process, the Chinese herbal medicine effect, and haste brings no success.After date when drinking 1, sleep is fluctuation status, continues to drink when crest.Drinking generally speaking slept after 1 period tends towards stability gradually, drinks in one month, and sleep is basic to recover normal, holds on to drink the back and just do not had the situation of dyssomnia again.Effectively: various need improve the sleep crowd through period of edible this health food, and sleep is stabilized in the normal range (NR), does not generally need to stop using, because this health food has multinomial health care simultaneously, can continue to take.We are by clinical verification, health food of the present invention except having the effect of improving sleep, can also balancing blood pressure, alleviating physical fatigue, delay senility, reduce headache incidence, improve one's memory, effect that the somebody also has the increase working strength.Take the without any side effects and bad reaction of this health food for a long time.
Claims (7)
1. one kind strengthens the food that immunity of organisms also can improve sleep quality, its active component is made up of panaxoside, kudzuvine root isoflavone, steviol glycoside, Ganodenna Lucidum P.E and CHAGA extract, the raw materials used weight ratio of its active component is: glossy ganoderma 30-80 part, CHAGA 20-50 part, kudzuvine root isoflavone 5-12 part, panaxoside 2-8 part, steviol glycoside 2-8 part.
2. food according to claim 1, the raw materials used weight ratio of described active component is: glossy ganoderma 50-60 part, CHAGA 20-30 part, kudzuvine root isoflavone 8-10 part, panaxoside 3-6 part, steviol glycoside 2-5 part.
3. food according to claim 2, the raw materials used weight ratio of described active component is: 50 parts of glossy ganodermas, 30 parts of CHAGAs, 10 parts of kudzuvine root isoflavones, 5 parts of panaxosides, 5 parts of steviol glycosides.
4. according to the arbitrary described food of claim 1-3, its dosage form is tablet, capsule, granule, oral liquid, perhaps beverage, tea in bag.
5. according to the preparation method of the described food of claim 4, it is characterized in that: glossy ganoderma is adopted solvent refluxing extraction, the concentrated Ganodenna Lucidum P.E that obtains, CHAGA adopts normal-temperature water to soak the concentrated CHAGA extract that obtains of back decompression, with the mixed active component that gets of panaxoside, kudzuvine root isoflavone and steviol glycoside, add auxiliary material by dosage form again and make again.
6. preparation method according to claim 5, described solvent is water, ethanol or its mixture.
7. strengthen the Application in Food that immunity of organisms also can improve sleep quality according to the arbitrary described food of claim 1-4 in preparation.
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| CN107029080A (en) * | 2017-04-26 | 2017-08-11 | 杭州敦和科技有限公司 | The medicine and preparation method of immunity of organisms are slept and can strengthened to a kind of improve |
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