CN101496603A - Health-care food with enhancing immunity and antioxidation functions - Google Patents
Health-care food with enhancing immunity and antioxidation functions Download PDFInfo
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- CN101496603A CN101496603A CNA2009100372573A CN200910037257A CN101496603A CN 101496603 A CN101496603 A CN 101496603A CN A2009100372573 A CNA2009100372573 A CN A2009100372573A CN 200910037257 A CN200910037257 A CN 200910037257A CN 101496603 A CN101496603 A CN 101496603A
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Abstract
The invention discloses a health care food with functions of enhancing the immunity and resisting the oxidation, which comprises the following active components in portion by weight: 30 to 150 portions of glossy ganoderma, 3 to 50 portions of astraolylis lancea formalyrata, 3 to 50 portions of tuckahoe, 3 to 50 portions of semen coicis, 3 to 50 portions of rhizoma polygonati, 3 to 50 portions of medlar, 3 to 35 portions of radix ophiopogonis, and 3 to 35 portions of radix codonopsitis. The health care food has the functions of enhancing the immunity, enhancing oxidation resistance, and improving the health condition. The health care food is prepared from natural Chinese herbal medicines as main raw materials and can be taken for a long time; and the results of functional tests prove that the health care food has the effects of enhancing the immunity and resisting the oxidation, and has remarkable effect.
Description
Technical field
The present invention relates to a kind of is the health food that strengthens immunity and anti-oxidation function that has of primary raw material preparation with the natural Chinese medicinal herb.
Background technology
The intensified competition of modern society, rhythm is accelerated, and the modern is in nervous living environment for a long time, operating pressure reaches overtired greatly, add abnormal living and diet custom, cause immunity generally to weaken and cause endocrine, nervous system, digestive system imbalance that immunity reduces gradually.Along with science and technology development, the pollution in the life has produced various harmful substances, as the peroxide of releases such as medicine, food additives; The radiation that mobile phone, TV, computer etc. produce etc., the integrality of these factors disrupt human body cells, stability, it medically is referred to as " oxidative damage " to the injury of human body, and in addition, the intrusion of bacterium, virus also can produce oxidative damage.Oxidative damage causes the pathology of human internal organ easily, as tumour, cardiovascular and cerebrovascular disease, enterogastric diseases, diabetes, hepatopathy, cataract etc.How to strengthen immunity, improve the human body oxidation resistance, become the problem that the whole society all pays close attention to.
Summary of the invention
The purpose of this invention is to provide a kind of is that the primary raw material preparation time possesses the health food that strengthens immunity and anti-oxidation function with the natural Chinese medicinal herb.
A kind of health food that strengthens immunity and anti-oxidation function that has provided by the invention, its active component and weight portion proportioning thereof are: glossy ganoderma 30～150, the bighead atractylodes rhizome 3～50, Poria cocos 3～50, coix seed 3～50, sealwort 3～50, the fruit of Chinese wolfberry 3～50, the tuber of dwarf lilyturf 3～35, Radix Codonopsis 3～35.
Preferred weight part proportioning of the active component of preparation health food of the present invention is: glossy ganoderma 50～90, the bighead atractylodes rhizome 10～30, Poria cocos 10～30, coix seed 10～30, sealwort 10～30, the fruit of Chinese wolfberry 8～30, the tuber of dwarf lilyturf 8～20, Radix Codonopsis 8～20.
Optimum weight part proportioning of the active component of preparation health food of the present invention is: glossy ganoderma 75, the bighead atractylodes rhizome 18, Poria cocos 18, coix seed 18, sealwort 18, the fruit of Chinese wolfberry 15, the tuber of dwarf lilyturf 15, Radix Codonopsis 15.
The above-mentioned health food that has enhancing immunity and anti-oxidation function simultaneously by common process, can be made said multiple formulation on the pharmacy, as tablet, capsule, granule or oral liquid etc.
The active component of health food of the present invention has following effect and characteristics:
Glossy ganoderma is Basidiomycetes, Polyporus, Ganoderma fungi.Glossy ganoderma is the famous medicinal bacterium of China, and the Shennong's Herbal record " red sesame master ties in the heart, the beneficial motive, and bowl spares increases wisdom and does not forget.Food is made light of one's life by commiting suicide and is not prolonged life always for a long time.", among the people have saying of " having eaten polyporus lucidus, alive for evermore ".Modern medicine study is found, is mainly contained two class material, polysaccharide and triterpene compounds in the glossy ganoderma.The contained macromolecule polysaccharide of glossy ganoderma can promote the synthetic of body protein DNA, RNA, promotes the division growth of body, stimulates the human body nospecific immunity and suppresses tumour, body immune system.Human body void declines, and shows as body mobility deficiency, and multiple physiology, biochemical function weaken or be disorderly, especially immunologic function, marrow hemopoiesis function, E﹠M dysfunction, and body resistance against diseases is low.Glossy ganoderma has anti-oxidant, promotes protein, nucleic acid to synthesize delaying senility function.Glossy ganoderma strengthens resisting stress capability, strengthens adrenal cortex function, improves the resistivity to the body destructive stimulus.The immunoloregulation function disorder of body also is old and feeble, weak feature, and glossy ganoderma and GL-B can be regulated immunologic function from many aspects.Glossy ganoderma promotes the biosynthesis of bone marrow cell protein and nucleic acid, can strengthen the marrow hemopoiesis function, but and radioresistance damage.
Bighead atractylodes rhizome flavor is sweet, bitter, warm in nature, is the key medicine of tonifying spleen." Bencao Jingshu " cloud: " art, its gas virtue is strong, and it distinguishes the flavor of sweet dense, and the pure sun of its property is the superb work of peace taste." " book on Chinese herbal medicine converge with speech " also cloud: " and the bighead atractylodes rhizome be foster taste key medicine also, insufficiency of the spleen strong, art can be mended it." bighead atractylodes rhizome can regulate gastrointestinal motility and secreting function, suppresses damage factor, effects such as protection gastric mucosa; Soluble polysaccharide can promote body cell immunity and humoral immune function, and the regulating action of intestines function and immunologic function is the valuable pharmacological basis of its air making-up and spleen enlivening, also is the main component of antioxidation.
Poria cocos has clearing damp and promoting diuresis, functions such as invigorating the spleen Ning Xin.Modern pharmacological research shows that the active component pachymaran in the Poria cocos passes through to strengthen immunologic function, and the activate immunity surveillance suppresses mechanism such as tumour cell DNA, RNA synthesize, the performance antitumor action.
The history of its medicine-food two-purpose of coix seed is of long duration, and is a kind of inexpensive, integrates the dietotherapy good merchantable brand of nutrition, health care.Along with deepening continuously of research, it is found that it not only contains rich nutrient substances, more have good antitumor, improve immunity of organisms, strengthen the tumor chemoradiotherapy effect, a series of medical values such as appearance, reducing pressure and sugar, antipyretic-antalgic anti-inflammatory are stayed in beauty treatment, are subjected to people's attention and favor just day by day.Just on the books in Shennong's Herbal, " main muscular contracture contraction is unable to flex and stretch the extremities, rheumatism numbness, and the therapeutic method to keep the adverse qi flowing downward is obeyed the beneficial gas of making light of one's life by commiting suicide for a long time." and classified as top gradely by this book, be rare simply, all good grain kind of food medicine.Tang's " dietitian's heart mirror " is Sino-Japan: " coix seed congee is controlled rheumatism numbness of a specified duration, revisal gas, sharp stomach, consumer edema removes perverse trend in the heart, the treating disorders in tendons and vessels contraction, coix seed be the end, cook congee with polished rice, day solar eclipse it, very." studies show that in recent years; coix seed has the effect that suppresses growth of cancer cells and propagation; its water decoction or alcohol extract all have the obvious suppression effect to kinds of tumors such as the EC of animal used as test, sarcoma 180s; improve body's immunity, control cancerous effusion, suppress the blood vessel generation, multiple efficacies such as high-energy nutrition is provided, and do not have obvious toxic and side effects.
The sealwort flavor is sweet, and property is flat, is used for the existing very long history of nourishing and fit keeping function, and Compendium of Material Medica is called it and can " be mended all void, end fever and chills, the replenishing essence marrow." modern study proof sealwort can improve fruit bat the ability of circling in the air, prolong life span, can reduce myocardium lipofuscin content, improve the liver SOD activity.The effect of promoting longevity of sealwort may delay senility relevant with antioxidation with it.
Matrimony vine is the traditional rare traditional Chinese medicine of China, have " red treasured " laudatory title, is rich in plant polyose, protein, vitamins and other nutritious components.In Shennong's Herbal, just point out: obey hard muscles and bones for a long time; " Mingyi Bielu " meaning matrimony vine is good at " nourishing the essence and strengthening QI "; " dietetic materia medica " also puts down in writing matrimony vine " the beneficial people of energy removes consumptive disease ".The merit of matrimony vine aspect nourishing liver and kidney, benefiting shrewd head also imitated not only and praised highly by ancient Chinese medicine doctor and dietotherapy scholar.LBP-X in the fruit of Chinese wolfberry is its important active ingredient, shows after deliberation, and LBP-X is the main active that the fruit of Chinese wolfberry is regulated immunity, delayed senility, and its prevention to malignant tumour, AIDS also can play a positive role with treatment.It has symptoms such as the fatiguability of improvement, poor appetite and eyesight in addition, has reducing blood lipid, AFL, antitumor, the anti-ageing effect of waiting for a long time.
Radix Codonopsis flavor is sweet, property flat, goes into spleen, lung two warps, has tonifying middle-Jiao and Qi, promotes the production of body fluid and the effect of stomach." book on Chinese herbal medicine justice " thought and particularly pointed out " Radix Codonopsis can the tonifying spleen nourishing the stomach, moistening lung is promoted the production of body fluid, strong fortune in gas ": Radix Codonopsis " invigorating the spleen and be dry is grown stomach-Yin and is wet, and moistening lung and do not violate is cold and coolly nourished blood and do not grown greasy partially ".Supplementary Amplifications of the Compendium of Materia Medica also has saying that Radix Codonopsis " controls the deficiency syndrome of the lung; beneficial lung qi ", Radix Codonopsis has multiple functions in clinical practice, and the several amino acids (lysine, methionine, leucine, valine, phenylalanine etc.), the multiple inorganic elements that contain polysaccharide and formation nutriment with Radix Codonopsis are relevant.These are Radix Codonopsis material bases as tonic, also are to replace genseng to be applied to the scientific evidence of general asthenic symptoms.
The tuber of dwarf lilyturf, Shennong's Herbal was classified it as top grade, and the successive dynasties book on Chinese herbal medicine is all on the books thereafter, was extensive use of clinically as enriching yin class Chinese medicine for a long time.The tuber of dwarf lilyturf, main chemical compositions was steroid saponin, polysaccharide, homoisoflavone class, amino acid etc.Wherein ophiopogonpolysaccharide has immunocompetence as one of main component of the tuber of dwarf lilyturf, can obviously increase mouse thymus and spleen weight, has the effect that impels T lymphocyte and bone-marrow-derived lymphocyte propagation.Body reticuloendothelial system (RES) phagocytic function is an important physiological Foundations of the traditional Chinese medical science " healthy tendency ".
Red ganoderma of the present invention is kind controls consumptive disease, and beneficial vital essence is protected spirit; Bighead atractylodes rhizome air making-up and spleen enlivening; Poria cocos, coix seed invigorating spleen to remove dampness are calmed the nerves; The sealwort boosting qi and nourishing yin; The fruit of Chinese wolfberry tonifies the liver and kidney, yin and blood nourishing.All medicines share, but the yin-nourishing of income gas, the effect that qi-restoratives is calmed the nerves.Be applicable to plain body weakness, body void after being ill, impairment of both QI and YIN, and the body of old body void is weak weak, refreshing tired body is tired, lassitude, insomnia forgetfulness, the few indigestion and loss of appetite disease of waiting of food.
Health products of the present invention are to be monarch drug in a prescription with the glossy ganoderma, according to the compound Chinese prescription theory, are aided with multiple traditional Chinese herbal medicines such as strengthening immunity, help, the anti-oxidant and delaying senility function bighead atractylodes rhizome, sealwort, the fruit of Chinese wolfberry, whole conditioning, the health-care efficacy of performance the best.Health food of the present invention shows that through the function assessment experimental study it has the immunity of enhancing and anti-oxidation function effect.
The invention will be further described below by the specific embodiment and function assessment result of study.
The specific embodiment
The present invention will be described to enumerate a part of specific embodiment below, is necessary to be pointed out that at this following specific embodiment only is used for that the invention will be further described, does not represent limiting the scope of the invention.Some nonessential modifications that other people make according to the present invention and adjustment still belong to protection scope of the present invention.
Embodiment 1
Get glossy ganoderma 300g, bighead atractylodes rhizome 500g, Poria cocos 500g, coix seed 300g, sealwort 300g, fruit of Chinese wolfberry 500g, tuber of dwarf lilyturf 300g, Radix Codonopsis 300g.
Above-mentioned raw materials is followed these steps to be prepared into tablet:
With glossy ganoderma, Radix Codonopsis, the bighead atractylodes rhizome, coix seed, sealwort, the tuber of dwarf lilyturf, Poria cocos, fruit of Chinese wolfberry spray-drying after the poach extraction concentrates, get Chinese herbal medicine and extract dry powder.Microcrystalline cellulose, pregelatinized starch, CMS-Na are added Chinese herbal medicine extract in the dry powder, mix, granulate, oven dry, whole grain adds dolomol, compressing tablet.
Embodiment 2
Get glossy ganoderma 500g, bighead atractylodes rhizome 300g, Poria cocos 300g, coix seed 300g, sealwort 250g, fruit of Chinese wolfberry 300g, tuber of dwarf lilyturf 200g, Radix Codonopsis 200g.
Above-mentioned raw materials is followed these steps to be prepared into capsule:
With glossy ganoderma, Radix Codonopsis, the bighead atractylodes rhizome, coix seed, sealwort, the tuber of dwarf lilyturf, Poria cocos, fruit of Chinese wolfberry spray-drying after the poach extraction concentrates, get Chinese herbal medicine and extract dry powder.Pregelatinized starch is added Chinese herbal medicine extract in the dry powder, mix, granulate, oven dry adds dolomol and talcum powder, filled hard capsules.
Embodiment 3
Get glossy ganoderma 750g, bighead atractylodes rhizome 180g, Poria cocos 180g, coix seed 180g, sealwort 180g, fruit of Chinese wolfberry 150g, tuber of dwarf lilyturf 150g, Radix Codonopsis 150g.
Above-mentioned raw materials is followed these steps to be prepared into capsule:
With glossy ganoderma, Radix Codonopsis, the bighead atractylodes rhizome, coix seed, sealwort, the tuber of dwarf lilyturf, Poria cocos, fruit of Chinese wolfberry spray-drying after the poach extraction concentrates, get Chinese herbal medicine and extract dry powder.Pregelatinized starch is added Chinese herbal medicine extract in the dry powder, mix, granulate, oven dry adds dolomol and talcum powder, filled hard capsules.
Embodiment 4
Get glossy ganoderma 1050g, bighead atractylodes rhizome 100g, Poria cocos 100g, coix seed 100g, sealwort 100g, fruit of Chinese wolfberry 80g, tuber of dwarf lilyturf 80g, Radix Codonopsis 80g.
Above-mentioned raw materials is followed these steps to be prepared into tablet:
With glossy ganoderma, Radix Codonopsis, the bighead atractylodes rhizome, coix seed, sealwort, the tuber of dwarf lilyturf, Poria cocos, fruit of Chinese wolfberry spray-drying after the poach extraction concentrates, get Chinese herbal medicine and extract dry powder.Microcrystalline cellulose, pregelatinized starch, CMS-Na are added Chinese herbal medicine extract in the dry powder, mix, granulate, oven dry, whole grain adds dolomol, compressing tablet.
Embodiment 5
Get glossy ganoderma 1500g, bighead atractylodes rhizome 50g, Poria cocos 50g, coix seed 50g, sealwort 50g, fruit of Chinese wolfberry 100g, tuber of dwarf lilyturf 100g, Radix Codonopsis 100g.
Above-mentioned raw materials is followed these steps to be prepared into tablet:
With glossy ganoderma, Radix Codonopsis, the bighead atractylodes rhizome, coix seed, sealwort, the tuber of dwarf lilyturf, Poria cocos, fruit of Chinese wolfberry spray-drying after the poach extraction concentrates, get Chinese herbal medicine and extract dry powder.Microcrystalline cellulose, pregelatinized starch, CMS-Na are added Chinese herbal medicine extract in the dry powder, mix, granulate, oven dry, whole grain adds dolomol, compressing tablet.
Function assessment research
The present invention is to provide a kind of health food that strengthens immunity, for proving that it has immunologic function, the inventor uses the capsule (hereinafter referred to as capsule of the present invention) for preparing by the foregoing description 3 to carry out the function assessment test, through the function assessment experimental study of Academy of Traditional Chinese Medicine, Guangdong Province, the result is as follows:
1, strengthen immunologic function zoopery result:
Cellular immune function assay: high, medium and low three dosage groups of capsule sample 1 of the present invention, sample 2 all can obviously strengthen immunosuppressed mice delayed allergy value, and the cellular immunity positive as a result is described; In the SPL transformation experiment, the cell in vitro cultivation results shows, during more than or equal to 0.01562mg/ml, capsule sample 1 of the present invention, sample 2 all have three the value-added effect of tangible enhancing SPL is arranged more than the concentration in the concentration of sample.
The humoral immunity measuring: high, medium and low three dosage groups of capsule sample 1 of the present invention, sample 2 all can obviously strengthen immunosuppressed mice HC50 value, and this product humoral immune function positive as a result is described.
Monokaryon-macrophage function is measured: capsule sample 1 of the present invention, 2 three dosage groups of sample all can obviously increase immunosuppressed mice phagocytic index K, increase peritoneal macrophage and engulf chicken red blood cell percentage and phagocytic index; Capsule sample 1 of the present invention, 2 three dosage groups of sample all can obviously strengthen mouse carbon and clean up ability.Monokaryon-macrophage function positive as a result is described.
The NK cytoactive is measured: the cell in vitro experiment shows, when the concentration of capsule of the present invention can obviously increase the NK cytoactive greater than 4 concentration of 1.0mg/ml.The NK cytoactive measurement result positive is described.
Capsule sample 1 of the present invention, 2 pairs of effect of immunologic function overall assessments of sample table
Annotate: " * " representation model control group and blank group relatively have the conspicuousness influence, wherein
*P＜0.05,
*P＜0.01;
The no conspicuousness influence of "-" expression;
" △ " expression glossy ganoderma each dosage group of emperor and model control group relatively have significant difference, wherein △ P＜0.05; △ △ P＜0.01.
2, anti-oxidation function experimental result:
Capsule sample 1 of the present invention and 2 three dosage groups of sample all can significantly improve the TAC (T-AOC) of D-galactolipin induced mice aging model, improve superoxide dismutase (SOD) vigor, reduce MDA (MDA) content, illustrate that capsule sample 1 of the present invention all has anti-oxidation function with sample 2.
Capsule sample 1 of the present invention, sample 2 antioxidation overall assessment tables
Annotate: " * " representation model control group and blank group relatively have the conspicuousness influence, wherein
*P＜0.05,
*P＜0.01;
The no conspicuousness influence of "-" expression;
" △ " expression each dosage group of capsule of the present invention and model control group relatively have significant difference, wherein △ P＜0.05; △ △ P＜0.01.
Claims (4)
1. one kind has the health food that strengthens immunity and anti-oxidation function, it is characterized in that the active component of described health food and weight portion proportioning thereof are: glossy ganoderma 30～150, the bighead atractylodes rhizome 3～50, Poria cocos 3～50, coix seed 3～50, sealwort 3～50, the fruit of Chinese wolfberry 3～50, the tuber of dwarf lilyturf 3～35, Radix Codonopsis 3～35.
2. the health food with enhancing immunity and anti-oxidation function according to claim 1, wherein the weight portion proportioning of each active component is: glossy ganoderma 50～90, the bighead atractylodes rhizome 10～30, Poria cocos 10～30, coix seed 10～30, sealwort 10～30, the fruit of Chinese wolfberry 8～30, the tuber of dwarf lilyturf 8～20, Radix Codonopsis 8～20.
3. the health food with enhancing immunity and anti-oxidation function according to claim 1, wherein the weight portion proportioning of each active component is: glossy ganoderma 75, the bighead atractylodes rhizome 18, Poria cocos 18, coix seed 18, sealwort 18, the fruit of Chinese wolfberry 15, the tuber of dwarf lilyturf 15, Radix Codonopsis 15.
4. according to claim 1,2 or 3 described health foods with enhancing immunity and anti-oxidation function, the formulation that it is characterized in that described health food is tablet, capsule, granule or oral liquid.
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| CN102293430A (en) * | 2011-06-24 | 2011-12-28 | 于光远 | Beverage with functions of antioxidation and immunity enhancing, and preparation method thereof |
| CN103445176A (en) * | 2013-09-17 | 2013-12-18 | 天津隆顺榕发展制药有限公司 | Health food for enhancing immunity and preparation method thereof |
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