CN100386104C - Immunopotentiating drugs - Google Patents
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- CN100386104C CN100386104C CNB031183034A CN03118303A CN100386104C CN 100386104 C CN100386104 C CN 100386104C CN B031183034 A CNB031183034 A CN B031183034A CN 03118303 A CN03118303 A CN 03118303A CN 100386104 C CN100386104 C CN 100386104C
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Abstract
The present invention relates to an immunopotentiating medicine for treating cardio-cerebrovascular disease, some physique weakness, etc., which is composed of Chinese medicine with a main formula for recovering functions and strengthening physique, and Chinese medicine with an auxiliary formula for supplementing yin and qi, wherein the Chinese medicine for recovering functions and strengthening physique comprises the main formula composed of three or seven kinds of Chinese medicine of Chinese caterpillar fungus, pilose asiabell root, fleeceflower root, barbary wolfberry fruit, solomonseal rhizome, hairy antler and astragalus root; the Chinese medicine for supplementing yin and qi comprises the auxiliary formula composed of three to eight kinds of Chinese medicine of ginseng, human placenta, psoralea fruit, atractylodes, rhizome, ganoderma, radix asparagi and ophiopogon root; the Chinese medicine of the respective components of the main formula and the auxiliary formula is decocted, or prepared as tincture or pulverized and coarsely extracted into capsules and pills; after being prepared, the capsules and pills are respectively packaged, and the immunopotentiating medicine can be obtained. The medicine has the good function of strengthening the organism autoimmune function and improving the adaptive capacity in order to reach the purpose of fundamentally improving the organism capability to resist disease and has obvious treatment effect on immunological disease, such as rheumatoid arthritis, allergic purpura, etc., and functional disease, such as cardio-cerebrovascular disease, etc.
Description
Technical field
The present invention relates to a kind of immunostimulant, it is the immunostimulant that is used for the treatment of immune disease and diseases such as the heart, cerebrovascular.
Background technology
At present, the reduction of immunologic function is one of root of disease generation and development.The domestic and international in recent years medicine for difficult disease such as the heart, cerebrovascular has had remarkable progress, but treatment is to adopt benefiting qi and nourishing blood, blood circulation promoting and blood stasis dispelling, circulation of qi promoting path, this class medicine of expectorant softening the hard mass, and its effect is undesirable.And the medicament composing prescription that has raising immune organ function, raising immunocyte and immune molecule quantity at present is less.
Summary of the invention
The objective of the invention is to be to provide a kind of immunostimulant that improves the human immunity organ dysfunction.
Technical scheme of the present invention is: from improving human body premunition and adaptive capacity, and from improving immune organ (bone marrow, thymus, splenic lymph nodes) function and weight, improving immunocyte (I, bone-marrow-derived lymphocyte, macrophage, cytotoxic cell, the existing cell of antigen presentation etc.) and immune molecule (immunoglobulin, complement system molecule, histocompatibility antigen molecule, adhesion molecule etc.) quantity starts with, be equipped with Chinese medicine again, promote the effect of macrophage phagocytic function, enhancing cellular immunization and humoral immunization.The imbalance of the decline of immunity, the infection of pathogen, secretory function, the reduction of adaptive capacity are to cause that disease takes place and the basic reason of development, and body is subjected to the destruction of foeign element, and the regulatory function of body self, adaptive capacity are descending.The cause of disease of cardiovascular and cerebrovascular disease is decline and the sclerosis of blood vessel and the narrow vascular that comes from body constitution, just the position difference; As: coronary heart disease is that sclerosis and narrow, the sclerosis of cerebral vessels and the narrow disease that just causes cerebral thrombosis, cerebral hemorrhage and cerebral arteriosclerosis appear in coronary artery.Cause sclerosis of blood vessels and narrow reason be virus, antibacterial infection, cause the deposition of metabolite on blood vessel wall, or disorder, endocrine disturbance that body generation is penetrated function finally cause body disease-resistant and suitable ability drop or the like, so be that the Chinese medicine of assisting is prepared based on Chinese medicine and the nourishing YIN QI invigorating class of selecting restore funcitons, health invigorating class for use on treating.
The present invention is an immunostimulant by restore funcitons, health invigorating class is that the Chinese medicine of main formula and Chinese medicine two parts that nourishing YIN, QI invigorating class are auxilliary side are formed; The main formula that restore funcitons, health invigorating class Chinese medicine are made up of Cordyceps, Radix Codonopsis, Radix Polygoni Multiflori, Fructus Lycii, Rhizoma Polygonati, Cornu Cervi Pantotrichum, seven kinds of Chinese medicines of the Radix Astragali; Nourishing YIN, QI invigorating class Chinese medicine are by Radix Ginseng, Placenta Hominis, Fructus Psoraleae, the Rhizoma Atractylodis Macrocephalae, Rhizoma Dioscoreae, Ganoderma, Radix Asparagi, auxiliary formula that Radix Ophiopogonis, eight kinds of Chinese medicines were formed.
Restore funcitons, health invigorating class are that the weight proportion of main Chinese medicine component is as follows:
10～30 parts of 2～10 parts of Radix Codonopsis of Cordyceps
15～30 parts of 10～25 parts of Fructus Lycii of Radix Polygoni Multiflori
10～25 parts of 0.2～1 part of Radixs Astragali of Cornu Cervi Pantotrichum
15～30 parts of Rhizoma Polygonatis
Seven kinds of Chinese medicine is fried, make tincture or pulverize slightly obtain through refining into capsule, ball all can;
Nourishing YIN, QI invigorating class are that the weight proportion of component of auxilliary side is as follows:
10～30 parts of 10～15 parts of Placenta Hominiss of Radix Ginseng
15～30 parts of 10～20 parts of Rhizoma Atractylodis Macrocephalaes of Fructus Psoraleae
10～25 parts of 10～30 portions of Ganodermas of Rhizoma Dioscoreae
10～25 parts of Radix Asparagi 10～30 parts of Radix Ophiopogonis
Eight kinds of Chinese medicine is fried or make tinctures, or pulverize thick deduction capsule, ball all can.
Key of the present invention is to adopt nourishing YIN, QI invigorating and restore funcitons, constitutional Chinese medicine preparation, improves the immunity of self.Cordyceps in the main formula: to the influence of immune organ.Cordyceps and Cordyceps mycelium, the spleen that meticortelone and cyclophosphamide are caused heavily alleviate and have tangible antagonism.Show the speed that to quicken spleen nucleic acid and protein renewal, promote KNA synthetic, strengthen bone bone hemopoietic function.Strengthen monokaryon-macrophage system function.Strengthen hematid immunity function.Antitumor action is arranged.Radix Codonopsis: can strengthen the mononuclear phagocyte system phagocytic function, to lymphocytic influence, high concentration suppresses lymphocytic mitosis as a result, and low concentration then promotes its mitosis.To the effect of humoral immunization, the result obviously strengthens humoral immune reaction, and serum antibody titer improves.Improve organism adaptation.Calmness, antiulcer and anti-gastric mucosa injury, antiplatelet aggregation, function of resisting myocardial ischemia are arranged.
Radix Polygoni Multiflori: can delay the degeneration and the atrophy of old Mus thymus, improve thymus microenvironment.The mouse thymus weight and volume is obviously increased, and cortex significantly thickens, and the boundary of skin medullary substance is clear, and cell density obviously increases; The Radix Polygoni Multiflori and the Radix Astragali share, and can obviously promote the non-lymphocyte hypertrophy, help improving thymus microenvironment.Fructus Lycii: the function that can strengthen macrophage; Can promote that Turnover of Mouse Peritoneal Macrophages (M Φ) quantity increases, volume increases, pseudopodium increases, phagocytic rate and phagocytic index increase, and improves old people's cellular immune function.Structure Qi polysaccharide can be by increasing the lymphocytic quantity of T and increasing that it is active and immune system is produced regulating action.Fructus Lycii has the effect of obvious promotion normal mouse hemopoietic function, shows the propagation that can promote multipotency hemocytoblast (CFU-S); Increase grain-monosystem colony forming unit (CFU-GM) quantity.Cornu Cervi Pantotrichum: have the promotion macrophage phagocytic function.The lumbar injection pilose antler polysaccharides also can obviously strengthen the phagocytic function of the reticuloendothelial system of mice.Has the enhancing humoral immune function; Antler liquid can promote spleen T, bone-marrow-derived lymphocyte breeder reaction.Cornu Cervi Pantotrichum has synthetic, the antitumor of strong body, defying age, antioxidation, promotion nucleic acid and albumen.Particularly in the time of immunologic hypofunction, its mechanism of action can be relevant with excited hypophysis-adrenal cortex function.In addition pilose antler polysaccharides, antler polypeptide directly the immune stimulatory cell immunologic function is strengthened.The Radix Astragali: contain polysaccharide (APS), hemopoietic, astragalus decoction can significantly promote the synthetic of myeloid element DNA, accelerate the nucleated cell fission process, remove immune complex.The astragalin first not only can make mouse lymph knot M Φ volume increase, and the multiple parameters of the organelles such as phagosome, molten sugared body, endoplasmic reticulum, Golgi complex, mitochondrion and microfilament in the M Φ is obviously raise.Rhizoma Polygonati: polygonatum polysaccharide has the moderate excitation to normal person's lymphocyte transformation, the patient's of immunologic hypofunction lymphocyte transformation is then had the excitation of height.Can improve 3 the monthly age Mus the spleen hemolysis plaque form cell number.Blood pressure lowering, blood fat reducing, blood sugar lowering, arteriosclerosis, disease-resistant former, the tuberculosis disease.And the Radix Ginseng in the auxiliary formula: the ginsenoside can obviously improve the resistance that infects, and body is had significant protective effect.Increase natural killer cell, lymphokine activity, promote body growth, growth, weight increase, strengthen adaptive faculty, improve organism adaptation injurious factors such as external environment reason, change, biologies.Placenta Hominis: to the influence of immune organ.Promote the enhancing of macrophage.Improve cellular immune function.Improve fibrin and separate enzymatic activity deeply.After carrying out active immunity, can make mice obtain tangible immunoprotection effect, and have certain specificity.Fructus Psoraleae: have antiinflammatory action, principle is excited indirectly hypophysis---adrenal system by nervous system.Be to increase hypophysis ACTH secretion by the system that affects the nerves.Discharge adrenergic result.Rhizoma Dioscoreae: can strengthen the mononuclear phagocyte system phagocytic function.Influence to hemopoietic function: PM-2 can promote normal mouse marrow hemopoietic stem cells propagation.Strengthen macrophage function; Can significantly promote the phagocytic index of normal mouse peritoneal macrophage.This product also has blood fat reducing, anti peroxidation of lipid, removing oxygen-derived free radicals, defying age, decreased heart rate, increase coronary flow, hepatoprotective effect.The Rhizoma Atractylodis Macrocephalae: can promote cytophagous phagocytic function, so the Rhizoma Atractylodis Macrocephalae has the effect of adrenal cortex reinforcing function.The ratio (TH/TS) of raising and suppressor T lymphocyte is corrected T subsets distribution disturbance state.Ganoderma: strengthen cellular immune function.DNA's is synthetic in the short nearly immunocyte, to stopping the influence that has of liquid immunologic function.Inductive normal mouse antibody forming cell.Immunologic hypofunction immune function of mice due to the enhancing aging.Strengthen drug-induced immunologic hypofunction immune function of mice.Ganoderan fluorouracil and cytosine arabinoside be to the inhibition of mice mixed lymphocyte reaction, the enhancing non-specific immunity function.Radix Asparagi: promote macrophage (M Φ) phagocytic function.The protective effect that has to hemopoietic function.Hemopoietic function of bone marrow there is facilitation.Be used for pulmonary disease tuberculosis disease.Radix Ophiopogonis: strengthen the hematopoietic cell function.Strengthen the mononuclear phagocyte system phagocytic function.Antiinflammatory, anti-allergy, strengthening increases immune organ weight, improves myocardial contraction, the protection cardiac muscle, anti-arrhythmia is used for pulmonary disease, the sick diabetes of tuberculosis.
In sum, the present invention adopts restore funcitons, strengthen to stop matter class Chinese medicine and nourishing YIN, QI invigorating class Chinese medicine are made immunostimulant, the cardiovascular and cerebrovascular disease that immune disease and arteriosclerosis are caused and coronary heart disease, cerebral thrombosis, apoplexy sequela are had significant medical effect.Clinical observation, this medical instrument have blood fat reducing and blood pressure raising immunocyte numerical value preferably, and the effect of decreased heart rate, reduction oxygen consumption is applicable to all immune diseases such as rheumatoid arthritis.
The specific embodiment
Immunostimulant is that Chinese medicine and nourishing YIN, the QI invigorating class of main formula is that auxiliary Chinese medicine two parts are formed by restore funcitons, health invigorating class.
Restore funcitons, health invigorating class are that the weight proportion of Chinese medicine component of main formula is as follows:
18 parts of 0.4 part of Radix Codonopsis of 15 parts of Cornu Cervi Pantotrichums of 2 parts of Radix Polygoni Multiflori of Cordyceps
16 parts of 18 parts of Radixs Astragali of 15 parts of Rhizoma Polygonatis of Fructus Lycii
Nourishing YIN, QI invigorating class are that the weight proportion of Chinese medicine component of auxilliary side is as follows:
In order to make curative effect better, be equipped with nourishing YIN, QI invigorating class Chinese medicine again, the weight proportion of the Chinese medicine component of its nourishing YIN, QI invigorating class is as follows:
15 parts of 20 parts of Fructus Psoraleaes of 20 parts of Placenta Hominiss of 12 portions of Rhizoma Dioscoreaes of Radix Ginseng
18 parts of 20 parts of Rhizoma Atractylodis Macrocephalaes of Radix Asparagi, 18 portions of Ganodermas, 20 parts of Radix Ophiopogonis
With described Chinese medicine fried make tincture or pulverize slightly obtain through refining into capsule, ball all can, after the preparation, packing.
The present invention is through clinical observation, take this medicine after, the heart, cerebrovascular conditions of patients are alleviated greatly, can fully recover about a year and a half.
Below be the clinical model case of this medicine:
Case one: yellow XX, 82 years old, the women, zhuzhou,hunan county retired professor, 1979 are ill, and are unable to leave the bed, and nineteen eighty-two is taken the treatment of this medicine, and just can walk about end of the year nineteen eighty-three, and all not morbidities are healthy so far.
Case two:
Liu XX, 42 years old, the women, Li Jia village, Zhangshu City Yuan Du township, Jiangxi, 1997 are ill, are unable to leave the bed 3 years, take this medicine in 2000, are clearly better after 1 year, now can take care of oneself fully.
Claims (1)
1. immunostimulant is characterized in that:
A, described immunostimulant are that the Chinese medicine of main formula and Chinese medicine two parts that nourishing YIN, QI invigorating class are auxilliary side are formed by restore funcitons, health invigorating class;
The main formula that B, described restore funcitons, health invigorating class Chinese medicine are made up of Cordyceps, Radix Codonopsis, Radix Polygoni Multiflori, Fructus Lycii, Rhizoma Polygonati, Cornu Cervi Pantotrichum, seven kinds of Chinese medicines of the Radix Astragali;
C, described nourishing YIN, QI invigorating class Chinese medicine are by Radix Ginseng, Placenta Hominis, Fructus Psoraleae, the Rhizoma Atractylodis Macrocephalae, Rhizoma Dioscoreae, Ganoderma, Radix Asparagi, auxilliary side that Radix Ophiopogonis, eight kinds of Chinese medicines were formed;
D, described restore funcitons, health invigorating class are that the weight proportion of Chinese medicine component of main formula is as follows:
10～30 parts of 2～10 parts of Radix Codonopsis of Cordyceps
15～30 parts of 10～25 parts of Fructus Lycii of Radix Polygoni Multiflori
10～25 parts of 0.2～1 part of Radixs Astragali of Cornu Cervi Pantotrichum
15～30 parts of Rhizoma Polygonatis
Seven kinds of Chinese medicine is fried, make tincture or pulverizing or slightly obtain through refining into capsule, ball;
E, described nourishing YIN, QI invigorating class are that the component weight proportion of auxilliary side is as follows:
10～30 parts of 10～15 parts of Placenta Hominiss of Radix Ginseng
15～30 parts of 10～20 parts of Rhizoma Atractylodis Macrocephalaes of Fructus Psoraleae
10～25 parts of 10～30 portions of Ganodermas of Rhizoma Dioscoreae
10～25 parts of Radix Asparagi 10～30 parts of Radix Ophiopogonis
Eight kinds of Chinese medicine is fried, make tincture or pulverizing or slightly obtain through refining into capsule, ball.
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| Application Number | Priority Date | Filing Date | Title |
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| CNB031183034A CN100386104C (en) | 2003-04-22 | 2003-04-22 | Immunopotentiating drugs |
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| CNB031183034A CN100386104C (en) | 2003-04-22 | 2003-04-22 | Immunopotentiating drugs |
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| CN100386104C true CN100386104C (en) | 2008-05-07 |
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| CNB031183034A Expired - Fee Related CN100386104C (en) | 2003-04-22 | 2003-04-22 | Immunopotentiating drugs |
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Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100457158C (en) * | 2005-04-18 | 2009-02-04 | 潘文祥 | Medicine for fortifying human body immune function |
| CN101496603B (en) * | 2009-02-19 | 2012-05-09 | 无限极（中国）有限公司 | Health-care food with enhancing immunity and antioxidation functions |
| CN102226137A (en) * | 2011-05-30 | 2011-10-26 | 葛双铭 | Nourishing health care wine |
| CN103446201B (en) * | 2012-05-29 | 2017-11-24 | 江中药业股份有限公司 | A kind of composition for preventing and treating anaphylactia and preparation method thereof |
| CN103948030B (en) * | 2014-04-30 | 2016-06-01 | 新时代健康产业（集团）有限公司 | A kind of Qi deficiency physique protective foods and its preparation method |
| CN104547541A (en) * | 2014-12-11 | 2015-04-29 | 张莘蔓 | Medicinal composition for reinforcing deficiency and preparation method thereof |
Citations (1)
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|---|---|---|---|---|
| CN1076368A (en) * | 1993-02-20 | 1993-09-22 | 李汝清 | Compound glossy ganoderma nutrient solution and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN1076368A (en) * | 1993-02-20 | 1993-09-22 | 李汝清 | Compound glossy ganoderma nutrient solution and preparation method thereof |
Non-Patent Citations (4)
| Title |
|---|
| 八珍汤对血虚小鼠红细胞免疫功能作用的实验研究 . 潘洪平，张兴，黄冬华.广西医科大学学报，第17卷第6期. 2000 |
| 八珍汤对血虚小鼠红细胞免疫功能作用的实验研究. 潘洪平，张兴，黄冬华.广西医科大学学报，第17卷第6期. 2000 * |
| 十全大补汤对小鼠免疫功能影响的实验研究 . 曹志然，周文英，陈淑兰，马晓莉，冯天铸.中国中医基础医学杂志，第6卷第10期. 2000 |
| 十全大补汤对小鼠免疫功能影响的实验研究 . 曹志然，周文英，陈淑兰，马晓莉，冯天铸.中国中医基础医学杂志，第6卷第10期. 2000 * |
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