CN104721732B - A kind of herbal composite for treating senile dementia - Google Patents
A kind of herbal composite for treating senile dementia Download PDFInfo
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- CN104721732B CN104721732B CN201510056550.XA CN201510056550A CN104721732B CN 104721732 B CN104721732 B CN 104721732B CN 201510056550 A CN201510056550 A CN 201510056550A CN 104721732 B CN104721732 B CN 104721732B
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Abstract
A kind of herbal composite for treating senile dementia, it by weight include following active principle: 2~6 parts of rhizoma polygonati, 1~5 part of sun-dried ginseng, 1~5 part of Radix Polygalae, 1~5 part of Radix Curcumae, 0.5~4 part of rhizoma acori graminei, 0.2~2 part of Radix Notoginseng, 0.1~0.3 part of borneol, preparation method are as follows: weigh rhizoma polygonati, sun-dried ginseng, Radix Polygalae and Radix Curcumae according to the ratio, it is soaked in water after 1h, heating decocts 3 times, each 1h merges water and mentions medical fluid；It by medical filtration, is concentrated and mentions cream for water, dry, crush as medicinal extract fine powder；Weigh borneol beta-cyclodextrin inclusion, weigh rhizoma acori graminei, Radix Notoginseng crush it is spare；The beta-cyclo dextrin included compound of borneol, rhizoma acori graminei, Radix Notoginseng and medicinal extract fine powder are uniformly mixed, composition is both obtained.Herbal composite of the present invention can effectively control senile dementia illness disease progression, improve learning and memory, have great importance to the quality of life for improving dementia patients.
Description
Technical field
The invention belongs to pharmaceutical technology fields, and in particular to a kind of herbal composite for treating senile dementia.
Background technique
Senile dementia (senile dementia), also known as Alzheimer disease (Alzheimer ' s diseaes, AD)
It is a kind of progressive degenerative neurological disease.Clinic is hidden with onset, and memory, intelligence declines in chronic progressive or even part
Or it all loses, and influence daily life and social activity ability as main feature.It mostly occurs in over-65s elderly population.
Epidemiological study shows that over-65s the elderly AD illness rate is the ﹪ of 4 ﹪~8 in developed country, and China is the ﹪ of 3 ﹪~7.According to
This calculates that China has AD patient 6,000,000~8,000,000 to have become the most common dementia type at present, it is the maximum of elderly population
One of Health Killer.AD is already higher than European and American developed countries, and this kind of disease to society and family's bring pressure and financial burden
Disease greatly influences the raising of life of elderly person quality, while can also influence the national economic development and social stability indirectly.Therefore,
The prevention and treatment of AD has become very urgent society and medical problem.Motherland's medicine has unique understanding to this disease cause of disease, the interpretation of the cause, onset and process of an illness, and
Couple herbs abundant are had accumulated in long-term clinical practice.Therefore the drug for preferably going out more effectively treatment AD is that pendulum exists
Task urgently to be resolved in face of us.
Summary of the invention
The object of the present invention is to provide a kind of for treating the herbal composite of senile dementia, can prevent and treat
Senile dementia.
It is a further object of the present invention to provide a kind of for preventing and treating the system of the herbal composite of senile dementia
Preparation Method.
The present invention is realized especially by following technical scheme:
A kind of herbal composite for treating senile dementia includes following active principle: rhizoma polygonati 2~6 by weight
Part, 1~5 part of sun-dried ginseng, 1~5 part of Radix Polygalae, 1~5 part of Radix Curcumae, 0.5~4 part of rhizoma acori graminei, 0.2~2 part of Radix Notoginseng, borneol 0.1~
0.3 part.
Preferably, a kind of herbal composite for treating senile dementia includes following active principle by weight: yellow
Smart 4 parts, 3 parts of sun-dried ginseng, 3 parts of Radix Polygalae, 3 parts of Radix Curcumae, 2 parts of rhizoma acori graminei, 1 part of Radix Notoginseng, 0.2 part of borneol.
Herbal composite of the present invention is prepared by the following method:
1) rhizoma polygonati, sun-dried ginseng, Radix Polygalae and Radix Curcumae are weighed according to the ratio, is soaked in water after 1h, and heating decocts 3 times, each 1h, closes
And water mentions medical fluid；
2) by medical filtration, the water that density is 1.2~1.3 when being concentrated into 80 DEG C mentions cream, and water is mentioned cream in 65 DEG C of conditions
Lower drying crushes as medicinal extract fine powder；
3) weigh borneol beta-cyclodextrin inclusion, weigh rhizoma acori graminei, Radix Notoginseng crush it is spare；
4) beta-cyclo dextrin included compound of borneol, rhizoma acori graminei, Radix Notoginseng and medicinal extract fine powder are uniformly mixed, both obtain composition.
Herbal composite preparation method of the present invention, in step (1) water consumption be rhizoma polygonati, sun-dried ginseng, Radix Polygalae and
6 times of Radix Curcumae total weight.
Herbal composite of the present invention can used before through dilution or directly by user, and preparation can
It is prepared by common processing method known in those skilled in the art, composition powder and liquid solvent or solid carrier is mixed
After conjunction, filler, adhesive, wetting agent, disintegrating agent, sorbefacient, solvent, surfactant, flavouring agent, anti-corrosion are added
One or more of agent, lubricant, sweetener or pigment.
Herbal composite of the present invention can be processed into any pharmaceutically acceptable dosage form as needed, wherein compared with
Preferred dosage form is tablet, capsule, granule or syrup.
Application of the herbal composite of the present invention as preparation prevention and treatment senile dementia drug.
The medical mechanism of herbal composite of the present invention:
Rhizoma polygonati this product is sweet in flavor, mild-natured, has the effect of tonifying kidney and benefiting sperm.It is acted on slowly, can be taken for a long time, suitable for controlling
Deficiency of kidney-essence is treated, brain, which is become homeless, supports and the dementia of cause." Mingyi Bielu " is recorded, and " curing rheumatism, five viscera settling, long term usage are light for the medicinal energy of rhizoma polygonati
Body, macrobiosis be not hungry ".Modern pharmacology research proves that there is rhizoma polygonati intelligence development, anti-aging, enhancing to be immunized, reduce blood lipid, reduce
The multiple pharmacological effects such as blood glucose.
Sun-dried ginseng is sweet in flavor, slight bitter, mild-natured.Return lung, spleen, the heart channel of Hang-Shaoyin.It can reinforce vital energy, reinforce the spleen to benefit the lung, promote the production of body fluid, tranquilize the mind and promote the intelligence.
Shennong's Herbal: " tonifying five zang organs, soothe the nerves determine soul, and stop palpitate with fear removes pathogenic factor, improving eyesight, happy intelligence development ".Modern pharmacological research
Confirm this product ingredients containing a variety of ginsenosides, volatile oil, amino acid, microelement and organic acid, carbohydrate, vitamin etc., for
The amnesia card that a variety of causes occurs, brainfag etc. have clearly effect.
Radix Polygalae bitter, acrid in flavour and warm in nature, return heart, kidney, lung channel.Tranquilize the mind and promote the intelligence, eliminating the phlegm are had one's ideas straightened out.As said in " book on Chinese herbal medicine is just ": " function is wholwe-hearted
Kidney ... ... Yang strengthening and life essence tonifying, strong will power-assisted ".This product toil is warm-natured, property is kind lead off it is sensible, can happy gas and antitoxic heart-soothing and sedative, energy
Logical kidney qi and strong will is not forgotten, the good merchantable brand known by force for restoring normal coordination between heart and kidney, stable mind, intelligence development.
Rhizoma acori graminei is pungent, bitter, and temperature enters heart stomach meridian, has the benefits of resuscitation with aromatics, antitoxic heart-soothing and sedative, dampness elimination slit phlegm, is used for wet turbid illiteracy
It is dazed and confused to cover mind caused by clear key, often uses restoring normal coordination between heart and kidney, reducing phlegm by resuscitation together with Radix Polygalae.
The pungent scattered hardship of Radix Curcumae is let out, can relieve stagnation have one's ideas straightened out, and it is cold in nature enter the heart channel of Hang-Shaoyin, can clear away heart-fire heat, therefore can be used for that phlegm is turbid to blind thinking, heat
Fall into the coma of pericardium, compatibility rhizoma acori graminei, such as " warm disease pandect " Acorus calamus curcuma aromatica soup.
Borneol is pungent, bitter, slightly cold.Return heart, spleen, lung channel.With inducing resuscitation of having one's ideas straightened out, the benefits of clearing away heat to and alleviating pain.Modern pharmacology acts on ice
Piece main component borneol, isoborneol play the role of resist oxygen lack and sedation.
Full presciption medicine taste compatibility is precise and appropriate, giving consideration to both the incidental and fundamental, up and down and controls, based on effecting a permanent cure and control the inferior.All medicines are filled out at kidney-nourishing altogether with using
Essence, activating microcirculation and removing stasis medicinal, the function that eliminating the phlegm is had one's ideas straightened out.
The invention has the benefit that herbal composite of the present invention can be by Senescence-accelerated Mouse's (SAMP8) hippocampus
The protective effect of neuronal tissue's structure improves the cognitive function of SAMP8；Simultaneously by improving hippocampal tissue SOD and inhibition
MDA activity, reduces the content of free radical, improves the passive avoidance response capability learning memory impairment of dull-witted mouse.The Chinese herbal medicine group
Object is closed not only to patient's sufferings are alleviated, disease progression is controlled, improves learning and memory, and the quality of life for improving dementia patients has weight
The meaning wanted.Objective experimental basis is provided for clinical prevention AD simultaneously, and establishes work for further research and development 6 kind new medicine of Chinese medicine
Make basis, pushes theory of traditional Chinese medical science to objectify development to a certain extent.
Specific embodiment
The present invention will be further explained with reference to the examples below, as described below, is only to preferable implementation of the invention
Example, not limits the present invention, any person skilled in the art is possibly also with the disclosure above
Technology contents be changed to the equivalent embodiment changed on an equal basis.Without departing from the concept of the present invention, according to the present invention
Technical spirit any simple modification or equivalent variations that following embodiment is made, fall within the scope of protection of the present invention.
Application Example one
Embodiment 1
A kind of herbal composite for treating senile dementia, prepares especially by following methods:
1) 2 parts of rhizoma polygonati, 5 parts of sun-dried ginseng, 1 part of Radix Polygalae and 1 part of Radix Curcumae are weighed by weight ratio, are soaked in water after 1h,
The quality of middle water is 6 times of the total amount of above-mentioned weighed Chinese herbal medicine, and heating decocts 3 times, each 1h, merges water and mentions medical fluid；
2) by medical filtration, the water that density is 1.2~1.3 when being concentrated into 80 DEG C mentions cream, and water is mentioned cream in 65 DEG C of conditions
Lower drying crushes as medicinal extract fine powder；
3) 0.1 part of borneol beta-cyclodextrin inclusion is weighed, it is spare to weigh 2 parts of 0.5 part of rhizoma acori graminei, Radix Notoginseng crushing；
4) beta-cyclo dextrin included compound of borneol, rhizoma acori graminei, Radix Notoginseng and medicinal extract fine powder are uniformly mixed, both obtain composition.
Embodiment 2
A kind of herbal composite for treating senile dementia, prepares especially by following methods:
1) 6 parts of rhizoma polygonati, 1 part of sun-dried ginseng, 5 parts of Radix Polygalae and 5 parts of Radix Curcumae are weighed by weight ratio, are soaked in water after 1h,
The quality of middle water is 6 times of the total amount of above-mentioned weighed Chinese herbal medicine, and heating decocts 3 times, each 1h, merges water and mentions medical fluid；
2) by medical filtration, the water that density is 1.2~1.3 when being concentrated into 80 DEG C mentions cream, and water is mentioned cream in 65 DEG C of conditions
Lower drying crushes as medicinal extract fine powder；
3) 0.3 part of borneol beta-cyclodextrin inclusion is weighed, it is spare to weigh 0.2 part of 4 parts of rhizoma acori graminei, Radix Notoginseng crushing；
4) beta-cyclo dextrin included compound of borneol, rhizoma acori graminei, Radix Notoginseng and medicinal extract fine powder are uniformly mixed, both obtain composition.
Embodiment 3
A kind of herbal composite for treating senile dementia, prepares especially by following methods:
1) 4 parts of rhizoma polygonati, 3 parts of sun-dried ginseng, 3 parts of Radix Polygalae and 3 parts of Radix Curcumae are weighed by weight ratio, are soaked in water after 1h,
The quality of middle water is 6 times of the total amount of above-mentioned weighed Chinese herbal medicine, and heating decocts 3 times, each 1h, merges water and mentions medical fluid；
2) by medical filtration, the water that density is 1.2~1.3 when being concentrated into 80 DEG C mentions cream, and water is mentioned cream in 65 DEG C of conditions
Lower drying crushes as medicinal extract fine powder；
3) 0.2 part of borneol beta-cyclodextrin inclusion is weighed, it is spare to weigh 1 part of 2 parts of rhizoma acori graminei, Radix Notoginseng crushing；
4) beta-cyclo dextrin included compound of borneol, rhizoma acori graminei, Radix Notoginseng and medicinal extract fine powder are uniformly mixed, both obtain composition.
Application Example two
In order to disclose the drug effect of herbal component prevention of the present invention and treatment senile dementia, following experiment has been done: below
Chinese herbal medicine is to Alzheimer's disease model mouse learning and memory behavior, morphology improvement and the influence of oxidative stress through the invention
To illustrate its advantages.
Embodiment 4
1. experimental material
1.1 experimental animal
The Senescence-accelerated Mouse's SAMP8 (senescence accelerated mouse prone 8, SAMP8) at 7 monthly ages
Mouse 36, with resistance to rapid aging mice subbreed R1 (the senescence accelerated mouse resistance at monthly age
1, SAMR1) 12, male, 25 ± 5g of weight, by The First Affiliated Hospital of Tianjin University of Traditional Chinese Medic Senium cerebropathia research department animal
The heart provides (quality certification number: the quasi- word of W-J saliva reality kinoplaszm M the 006th).Animal adaptable fed 2 weeks, room temperature and humidity before experiment
22 DEG C~26 DEG C and 55% or so are respectively maintained at, normal illumination, drinking-water and feed are through high-temp steam sterilizing.
1.2 experimental drug
1.2.1 a kind of herbal composite for treating senile dementia: 4 parts of rhizoma polygonati, 3 parts of sun-dried ginseng, 3 parts of Radix Polygalae, Radix Curcumae 3
Part, water is weighed, wherein the quality of water is 6 times of total amount of above-mentioned weighed Chinese herbal medicine, using load weighted water by above-mentioned weighing
Good all medicines impregnate 1 hour, and heating decocts 3 times, each 1h, obtain water and mention medical fluid, merge 3 Aqueous extracts, filter, and filtrate is concentrated into
Density is that the water of 1.2~1.3 (80 DEG C) mentions cream, water is mentioned cream is placed in 65 DEG C of drying boxes and be dried into powder；2 parts of rhizoma acori graminei, three
71 parts are ground into fine powder；0.2 part of borneol is encapsulated with for use with beta-cyclodextrin.The beta-cyclo dextrin included compound of borneol, rhizoma acori graminei, Radix Notoginseng
Fine powder and rhizoma polygonati, sun-dried ginseng, Radix Polygalae, the medicinal extract fine powder of Radix Curcumae are uniformly mixed.Herb powder plus distilled water are configured to suspension,
Mass concentration is 30%, and obtain medical treatment dull-witted herbal composite.It is configured to the aqueous solution that concentration is 0.26g/ml, 4 DEG C of guarantors
It deposits spare.Wherein every gram of powder contains 4.12 grams of crude drug.
1.2.2 donepezil hydrochloride tablet (trade name Aricept, Donepezil): 10mg/ piece, manufacturing enterprise: France
PFIZER PGM company, import drugs registration certificate number: BH20040114, subpackage fill authentication code: national drug standard J20040020.
It is configured to the aqueous solution that concentration is 0.013mg/ml, 4 DEG C save backup.
1.3 main agents
SOD, MDA detection kit: biochemistry corporation,Ltd. is built up in Nanjing
1.4 key instrument
ZIL-2 mouse diving tower instrument: institute of Materia Medica,Chinese Academy of Medical Sciences
702 ultra low temperature freezers: ULT Freezer U.S.A
204 electronic analytical balance of AL: Shanghai METTLER instrument company
DU R640 protein nucleic acid analyzer: BECKMAN U.S.A
BX60 optical microscopy: OLYMPUS Japan produces
2. experimental method
2.1 group technology
36 SAMP8 mouse are randomly divided into 3 groups: model group, Aricept control group, Chinese medicine group.Blank group is by 12
SAMR1 mouse composition.
2.2 medications and materials
Chinese herbs group gives the stomach-filling of said herbal medicine composition, and (quite containing crude drug 4.12g/kg.d), western medicine group is given
Aricept solution 1.3mg/kg.d is given, once a day, blank group, model group give the distilled water stomach-filling of same dosage, total 4W.It fills
After stomach 4W, each group carries out Behavior test.Every later group takes 8 rapid broken ends on ice to take hippocampus, and it is standby to be put in -20 DEG C of preservations
With.
2.3 mouse Jumping tests
Principle: experimental provision is a rectangle reflective box, and size is 10cm × 10cm × 60cm, is separated with black plastic plate
Between 5.Bottom surface is spread with copper grid, and spacing 0.5cm can be powered, and voltage strength is controlled by a transformer.It is high that every left comer sets one
It is the platform of 4.5cm with diameter.The bottom of diving tower case is that impermeable steel grid have electric current (electric shock intensity 36v) to pass through, animal of shocking by electricity
Vola.Animal is placed in experiment instrument, environment 5min is adapted to, mouse runs away on safety board after energization, and mouse is accumulative on safety board
Time (i.e. escape latency), mouse are used as school grade by number to shock by electricity etc..Recast is test after 24 hours, this, which remembers, protects
Hold test.
The 2.4 active measurements of hippocampus SOD, MDA
Biochemistry corporation,Ltd. SOD, MDA detection kit specification are built up referring to Nanjing.
2.5 statistical method
Data useIt indicates, data statistic analysis uses spss13.0 software.Data select single factor test variance point
It analyses (one-wayANOVA).The first of identical group was compared compared with two day incubation period using two sample averages in diving tower behavior test
T examine (Independent Samples T Test).P < 0.05 indicates that difference has significant.
3. experimental result
3.1 herbal composites influence (being shown in Table 1) ethological on SAMP8 mouse diving tower
The influence preclinical on SAMP8 mouse of table 1 (n=8,)
Note: daily each group compares: * p < 0.05 compared with model group；With comparing for two days for group:△The p compared with first day
< 0.05
As shown in table 1, the results showed that blank group incubation period, there were significant differences compared with model group p < 0.05.With model group
Compare, herbal composite group and Aricept group incubation period relatively have conspicuousness to extend (p < 0.05).Using two sample average ratios
Compared with t examine, identical group of incubation period, other each group incubation periods were significant in addition to model group within second day compared with first day
Extend (p < 0.05).
Influence of 3.2 herbal components to the Hippocampus CA 3 Region histology and morphology structure of SAMP8
The Hippocampus CA 3 Region SAMP8 cell arrangement is loose, disorder, and cell quantity significantly reduces, cellular swelling, nuclear hyperchromatism, pyknosis
Phenomenon is obvious, neuron diffusivity granulovacuolar degeneration.Blank group Hippocampus CA 3 Region structure is normal, and neural identical permutation is closely neat,
It is methodically arranged, nucleus is rounded, and big and regular, kernel is clear.The SAMP8 hippocampus of mice treated through herbal composite group
The more loose disorder of the area CA3 nerve identical permutation, the cell number of plies are reduced, and cellular swelling, nuclear hyperchromatism, pyconsis and neuron particle are empty
Bubble denaturation is significantly reduced compared with model group.
Experimental result confirms that the decline of SAMP8 Strains of Mouse ability of learning and memory has its tectology basis, Chinese herbal medicine group
The cognitive function of SAMP8 mouse can be improved by the protective effect to hippocampal neuron institutional framework by closing object group.
Influence of the 3.3 herbal composite groups to SAMP8 mouse cerebral hippocampal SOD, MDA
2 herbal composite group of table to SAMP8 mouse cerebral hippocampal SOD, MDA influence (n=8,)
Note: * p < 0.05 compared with model group
As shown in Table 2, blank group is compared with model group, and SOD activity increases, MDA content declines, and has significant difference p
< 0.05.Administration group can improve SAMP8 Hippocampus of Mice SOD activity p < 0.05, have significant difference.Chinese herbal medicine group
MDA content p < 0.05 can be lowered by closing object group and Aricept, have significant difference.
Application Example three
Effect of the present composition to prevention and treatment senile dementia illness is described further below with reference to clinical trial.
Embodiment 5
Clinical data: one in the attached First Hospital internal clinic of Heilongjiang University of Chinese Medicine, Heilongjiang Provincial Hospital's nerve
55 typical patients of senile dementia symptom collect in six sections in section and No.1 Hospital Attached to Harbin Medical Univ.'s nerve, carry out
The clinical trial of Chinese medicine composition of the invention.30 people of male in this 55 patients, 25 people of women, oldest 85 years old, most
Small 55 years old, average age 63 years old.Selected case is referring to American Psychiatric Association (diagnostic and statistical manual of mental disease) the
The diagnostic criteria of three editions (ASM-III) and international sick classification standard (ICD-10) is selected.Selected case meets long paddy
River Dementia scale, score < 10.Selected case meets " the clinical research guidance original of new Chinese medicine treatment senile dementia simultaneously
Then " kidney deficiency marrow subtracts card, turbid phlegm blocking the clear orifices card, stagnation of the circulation of vital energy blood in (Ministry of Public Health formulates " new Chinese medicine guideline of clinical investigations " within 2002)
The TCM syndrome diagnostic criteria of stasis syndrome.Selected case is provided with complete history, physical examination, neuropsychological and cranial image etc.
Inspection of data.
Treatment method: it is treated according to composition suspension prepared by above-described embodiment 4, herbal composite is configured to
300 milliliters of aqueous solution, early daily, evening is secondary to be warmly taken, one time 150 milliliters, 4 weeks are 1 course for the treatment of, treat observation treatment after 1 course for the treatment of
Effect, follow-up 4 weeks.
Criterion of therapeutical effect: according to mental state scale (MMSE) evaluation criterion, judge total effects: clinical recovery: before and after treatment
Intelligence score improves 10 points or more, and total score reaches 23 points；Effective: pretherapy and post-treatment intelligence score improves 5-10 points；It is effective: treatment
Front and back intelligence score, which improves, is lower than 5 points；Invalid: pretherapy and post-treatment intelligence score is unchanged or relatively treats preceding decline.
As a result: clinical recovery 0, effective 29 (52.7%), effective 17 (30.9%), no effect 9 (16.4%).
Treatment results statistics such as table 3:
Therapeutic effect of 3 Chinese medicine composition of table to patients with Alzheimer disease
Typical case: it is neat certain, male, 76 years old.Private prosecution memory obviously declines half a year, usually forgets rigid what someone said or did
Thing the people being very familiar to or article are tended not to remember title.Power decline is calculated, slightly showing complicated calculating will
Error.Often feel waist soreness, dizziness and tinnitus, appetite stimulator.Temper is relatively original irascible, slow in reacting.Pale tongue matter is dark, there is ecchymosis,
For tongue body hypertrophy with indentation, whitish tongue is micro- greasy, and deeptensepulse is sliding.Brain CT shows: the expansion of the bilateral ventricles of the brain, brain ditch are broadening.MMES inspection is scored at
15 points.Doctor trained in Western medicine diagnosis: senile dementia, Chinese medical discrimination: deficiency of kidney essence, phlegm-blood stasis hinder key, control with kidney tonifying, essence replenishing, phlegm reduction of blood circulation promoting is opened
Key.Give the water solution treatment that the herbal composite of the preparation of above-described embodiment 5 is configured to.After treatment 1 month, memory is obvious
Enhancing, forgetful phenomenon significantly reduce.Soreness and weakness of waist and knees, burnout think of crouch it is substantially reduced, dizziness and tinnitus disappear.Mood is optimistic, main
It is dynamic to participate in some social activitieies.It looks into MMSE integral and rises to 22 points.Efficacy determination belongs to effective.
Claims (4)
1. a kind of herbal composite for treating senile dementia, which is characterized in that by weight by following active principle system
At: 4 parts of rhizoma polygonati, 3 parts of sun-dried ginseng, 3 parts of Radix Polygalae, 3 parts of Radix Curcumae, 2 parts of rhizoma acori graminei, 1 part of Radix Notoginseng, 0.2 part of borneol；Preparation method be with
Lower step:
(1) rhizoma polygonati, sun-dried ginseng, Radix Polygalae and Radix Curcumae are weighed according to the ratio, is soaked in water after 1h, and heating decocts 3 times, each 1h, merges
Water mentions medical fluid；
(2) by medical filtration, the water that density is 1.2~1.3 when being concentrated into 80 DEG C mentions cream, and water is mentioned cream under the conditions of 65 DEG C and is dried
It is dry, it crushes as medicinal extract fine powder；
(3) weigh borneol beta-cyclodextrin inclusion, weigh rhizoma acori graminei, Radix Notoginseng crush it is spare；
(4) beta-cyclo dextrin included compound of borneol, rhizoma acori graminei, Radix Notoginseng and medicinal extract fine powder are uniformly mixed to get composition.
2. a kind of herbal composite for treating senile dementia according to claim 1, which is characterized in that the medicine group
It closes object and tablet, capsule, granule or syrup is made.
3. herbal composite according to claim 1, which is characterized in that water consumption is in (1) the step of preparation method
Rhizoma polygonati, sun-dried ginseng, 6 times of Radix Polygalae and Radix Curcumae total weight.
4. application of the herbal composite described in claim 1 as preparation prevention and treatment senile dementia drug.
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| CN1118258A (en) * | 1994-09-04 | 1996-03-13 | 高齐崧 | Preparation of brain-care pill |
| CN1660392A (en) * | 2004-12-29 | 2005-08-31 | 王四旺 | 'Changyuan' capsule and preparing techniue |
| CN102631421A (en) * | 2012-04-14 | 2012-08-15 | 田景振 | Traditional Chinese medicine for treating senile dementia |
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| CN1118258A (en) * | 1994-09-04 | 1996-03-13 | 高齐崧 | Preparation of brain-care pill |
| CN1660392A (en) * | 2004-12-29 | 2005-08-31 | 王四旺 | 'Changyuan' capsule and preparing techniue |
| CN102631421A (en) * | 2012-04-14 | 2012-08-15 | 田景振 | Traditional Chinese medicine for treating senile dementia |
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| 脑舒胶囊对阿尔茨海默病大鼠神经炎症损伤的保护;秦大莲等;《中国新药杂志》;20101130;第19卷(第11期);第987页左栏第2段 |
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