CN101040929A - Method for preparing compound lotus seed oral liquid - Google Patents
Method for preparing compound lotus seed oral liquid Download PDFInfo
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- CN101040929A CN101040929A CN 200710052113 CN200710052113A CN101040929A CN 101040929 A CN101040929 A CN 101040929A CN 200710052113 CN200710052113 CN 200710052113 CN 200710052113 A CN200710052113 A CN 200710052113A CN 101040929 A CN101040929 A CN 101040929A
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Abstract
The invention relates to a process for preparing compound lotus seed oral liquid which can be used for treating nervous prostration, insomnia and cardiopalmus. The oral liquid is prepared from lotus seeds, wild jujuba seeds, dried orange peel and bee honey through steps of disintegrating, mixing, extracting with water, alcohol depositing, reclaiming ethanol, merging the extracts, finally charging bee honey and auxiliary materials.
Description
Technical field
The invention belongs to the Chinese medicine preparation manufacture method, is a kind of preparation method of FUFANG LIANXIN KOUFUYE more specifically.
Background technology
Neurosis is all diseases due to multifactor, and wherein neurasthenia's sickness rate height accounts for more than 10% of internal medicine outpatient, accounts for 40% of nerve, psychiatric department outpatient service, and is not bright so far to its definite cause of disease.The neurasthenia is a kind of cerebral nerve functional disorder and disease that the mind ﹠ body mobility that causes weakens, generally show as clinically: mental deficiency, tired mind, internal external stimulus sensitivity, anxious state of mind, shortage patience, insomnia, dreaminess, psychological physiology hinder etc., this has had a strong impact on modern's quality of life.
The insomnia that the treatment by Chinese herbs neurasthenia causes, dreaminess, cardiopalmus, dysphoria with smothery sensation have unique advantage.FUFANG LIANXIN KOUFUYE reaches mind calming by adjusting internal organs imbalance of YIN and YANG, disharmony between QI and blood, calms the nerves, nourishes blood, the effect of clearing heat and relieving fidgetness.Neither can addiction, do not produce dependency yet, and have no side effect, the incomparable advantage of chemical medicine is arranged in this field, curative effect be better than the Western medicine sleeping pill take the back easily addiction, dependence, take the phenomenon of poisoning for a long time.
Pericarpium Citri Reticulatae is the important component part of FUFANG LIANXIN KOUFUYE, is the dry mature skin of rutaceae orange and cultigen thereof, has another name called Pericarpium Citri tangerinae, has functions such as regulating qi-flowing for strengthening spleen, drying dampness to eliminate phlegm, raising immunity.The traditional extraction process of Pericarpium Citri Reticulatae is for to use water boiling and extraction, and uses ethanol extraction among the present invention.Adopt ethanol extraction through evidence, Pericarpium Citri Reticulatae main component content of hesperidin obviously improves, and impurity content reduces, and with this process application in FUFANG LIANXIN KOUFUYE, the clinical total effects rate of FUFANG LIANXIN KOUFUYE also brings up to 93.22% by original 90%.
Summary of the invention
The objective of the invention is the object of the present invention is to provide a kind of preparation method of FUFANG LIANXIN KOUFUYE.FUFANG LIANXIN KOUFUYE is made by Plumula Nelumbinis, Semen Ziziphi Spinosae, Pericarpium Citri Reticulatae, Mel four flavor crude drug.
The present invention is achieved like this, get Plumula Nelumbinis 10-30 weight portion, Ziziphi Spinosae 15-30 weight portion, after mixing thoroughly, pulverizing pours in the medicine pot, decoct with water 2-3 time, each 1-3 hour, collecting decoction filters, and filtrate decompression is concentrated into and surveys relative density in the time of 30-70 ℃ is the clear paste of 1.01-1.35, be placed into room temperature, add ethanol and make and contain alcohol amount and reach 55% to 85%, stir cold preservation 24-48 hour, get supernatant, reclaim ethanol, continue to be concentrated into that to survey relative density in the time of 70 ℃ be 1.20 clear paste, extracting solution one; Other gets Pericarpium Citri Reticulatae 20-50 weight portion, is ground into coarse powder, alcohol reflux 1-3 time, each 1-3 hour, add for the first time ethanol 300-500ml, 200-400ml filters the back merging filtrate for the second time, reclaim ethanol, continue to be concentrated into that to survey relative density in the time of 70 ℃ be 1.20 clear paste, extracting solution two; Extracting solution one, extracting solution two mixings are got mixed liquor; Get above-mentioned mixed liquor, other gets Mel 10-45 weight portion, antiseptic is an amount of, boils, and leaves standstill, and filters, and joins in the clear paste, is made into full dose, embedding, promptly.
Advantage of the present invention is: have the effect of clearing away heart-fire for tranquillization, be used for the neurasthenia, disease is seen insomnia, dreaminess, cardiopalmus, dysphoria with smothery sensation.
The specific embodiment
Plumula Nelumbinis 100g Semen Ziziphi Spinosae 150g Pericarpium Citri Reticulatae 200 Mel 100g get Plumula Nelumbinis, Semen Ziziphi Spinosae decocts with water secondary, each 2 hours, add 10 times of water gagings for the first time, for the second time add 8 times of water gagings, collecting decoction filters, filtrate decompression is concentrated in the time of 70 ℃ and surveys relative density is 1.10 clear paste, place room temperature, add ethanol and make and contain the alcohol amount and reach 70%, cold preservation 24 hours, get supernatant, reclaim ethanol, continue to be concentrated into that to survey relative density in the time of 70 ℃ be 1.20 clear paste, extracting solution one; Other gets Pericarpium Citri Reticulatae 200 weight portions, is ground into coarse powder, alcohol reflux secondary, each 2 hours, add for the first time ethanol 400ml, the 300ml for the second time that refluxes filters the back merging filtrate, reclaim ethanol, continue to be concentrated into that to survey relative density in the time of 70 ℃ be 1.20 clear paste, extracting solution two; Extracting solution one, extracting solution two are mixed, get mixed liquor; Other gets Mel 100g, and sucrose 700g is heated to 85-95 ℃ of insulation 1 hour, adds sodium benzoate 3g, filters, and joins in the above-mentioned mixed liquor, and adding distil water is mixed with 1000ml, stirs evenly, and filters, and packing gets oral liquid.
The technical study that Pericarpium Citri Reticulatae extracts
Traditional handicraft: get Pericarpium Citri Reticulatae 50g, be ground into coarse powder, decoct with water secondary, each 2 hours, add 10 times of water gagings for the first time, add 8 times of water gagings for the second time, collecting decoction filters, and filtrate decompression is concentrated into and surveys relative density in the time of 70 ℃ is 1.10 clear paste, place room temperature, add ethanol and make and contain the alcohol amount and reach 70%, cold preservation 24 hours, get supernatant, reclaim ethanol, add the water standardize solution to 250ml, recording content of hesperidin is 0.43mg/ml.
Improve back technology: get Pericarpium Citri Reticulatae 50g, be ground into coarse powder, use the alcohol reflux secondary, each 2 hours, add ethanol 400ml for the first time, 300ml filters the back merging filtrate for the second time, reclaims ethanol, adds the water standardize solution to 250ml, and recording content of hesperidin is 0.76mg/ml.
This shows obviously increase of main component Determination of Hesperidin Content branch in the Pericarpium Citri Reticulatae after the improvement technology.
Clinical trial
Treatment neurasthenia case is totally 420 examples, checking group compound lotus seed liquid 280 examples, matched group NAOXINSHU 140 examples, each organizes age, the state of an illness, course of disease equal proportion checking group and matched group there was no significant difference, (seeing Table 1, P＞0.05) illustrates that respectively organizing clinical data has good comparability.
1. clinical curative effect analysis
Checking group (compound lotus seed liquid) case 280 examples, matched group (NAOXINSHU) case 140 examples are through treating for 1 course of treatment checking group total effects 93.22%, produce effects 65.36%, effective 27.86%, invalid 6.79%, matched group total effects 92.86%, produce effects 63.57%, effective 29.29%, invalid 7.14%.Two groups of contrast there was no significant differences.(seeing Table 2, P＞0.05)
Clinical each disease example number and curative effect see Table 3, and traditional Chinese medical science typing example number and curative effect see Table 4, severity extent classification example number and see Table 5 course of treatment.
2. safety evaluatio
280 routine cases are organized in checking, accept compound lotus seed liquid treatment front and back and matched group 140 routine cases and accept before and after the NAOXINSHU treatment complete inspection liver, renal function.Liver function comprises GOT, GPT, and renal function comprises BUN, Cr, and the result shows two groups of livers, renal function all in range of normal value, does not also see the electrocardiographic abnormality report, the toxicity after two groups all discovery is taken medicine in clinical observation.(two groups of adverse reaction rates are 0%).
3. conclusion
Compound lotus seed liquid is made up of Plumula Nelumbinis, Semen Ziziphi Spinosae, Pericarpium Citri Reticulatae, be Yujiang Pharmaceutical Factory on the basis of folk remedy, through repeatedly screening prescription, refine a kind of new oral liquid that forms with modern scientific method.Plumula Nelumbinis has the merit of clearing heart fire, relieving restlessness in the side, and Semen Ziziphi Spinosae has mind tranquilizing and the heart calming, the energy of the liver benefiting blood, and Pericarpium Citri Reticulatae has regulating qi-flowing for strengthening spleen, the effect of drying dampness to eliminate phlegm.Share and play clearing away heart-fire for tranquillization altogether, the effect of calmness has certain tonic effect.
This test adopts the clinical trial design of parallel control at random to treat neurasthenia's 280 examples with compound lotus seed liquid, carrying out clinical efficacy and safety investigates, and select for use do not had a toxicity by clinical proof determined curative effect NAOXINSHU in contrast, therapeutic outcome shows, checking group compound lotus seed liquid total effective rate 93.22%, 92.86% close with the matched group NAOXINSHU.This product does not have any untoward reaction.
Clinical efficacy result and safety evaluatio all show, checking group compound lotus seed liquid and matched group NAOXINSHU have equally calm the nerves, calm, tonic effect, to all diseases of treatment neurasthenia, the giddy of being insomnia, feelings will change, poor appetite all has significant curative effect.Through clinical verification compound lotus seed liquid to neurasthenia's state of an illness light, in, weight person's curative effect is different, is respectively 96.5%, 83.78%.This result provides good foundation for clinical timely medication.
The pharmacological results and clinical trial prove, this medicine be a kind ofly good clear away heart-fire, calm the nerves, calm, tonic medicine, it proves effective soon, duration of efficacy is long, clothes are nontoxic for a long time, drug withdrawal does not have rebound effect, and this medicine can enhancing body's immunological function and to the adaptive faculty of adverse circumstances, suppresses the central nervous system, calmness appears, the hypnosis phenomenon.Be to treat and prevent neurasthenic ideal medicine.
The general clinical data table of table 1
| Group | The example number | Outpatient service/ward example number | Sex man/woman | The length of one's sleep before the treatment (time) | Treatment time (my god) | The course of disease (moon) |
| The checking group | 280 | 88/192 | 122/158 | 4.9 | 20 | 4.17 |
| Matched group | 140 | 42/98 | 61/79 | 5.1 | 20 | 4.15 |
Compound lotus seed liquid (checking group) is learned by statistics with the general data of the selected case of NAOXINSHU (matched group) treatment neurasthenia's clinical verification and is handled P＞0.05 there was no significant difference.
Table 2 total effects table
| Group | The example number | Produce effects | Effectively | Invalid | Total effective rate % |
| The checking group | 280 | 183 | 78 | 19 | |
| Percentage rate % | 65.36 | 27.86 | 6.79 | 93.22 | |
| Matched group | 140 | 89 | 41 | 10 | |
| Percentage rate % | 63.57 | 29.29 | 7.14 | 92.86 |
Compound lotus seed liquid (checking group) is learned by statistics with NAOXINSHU (matched group) treatment neurasthenia effective percentage and is handled P＞0.05 there was no significant difference.
Table 3 clinical each disease example number and curative effect table
| Disease | The checking group | Matched group | ||||||||
| The example number | Produce effects | Effectively | Invalid | Total effective rate (%) | The example number | Produce effects | Effectively | Invalid | Total effective rate (%) | |
| Be insomnia | 280 | 183 | 78 | 19 | 93.22 | 140 | 89 | 41 | 10 | 92.86 |
| Feelings will changes | 220 | 106 | 85 | 29 | 86.82 | 104 | 48 | 34 | 22 | 78.85 |
| Dizzy | 190 | 144 | 32 | 14 | 92.63 | 84 | 56 | 24 | 3 | 95.24 |
| Poor appetite | 126 | 65 | 48 | 13 | 89.68 | 66 | 29 | 27 | 10 | 84.85 |
The clinical disease of compound lotus seed liquid (checking group) and NAOXINSHU (matched group) treatment neurasthenia: be insomnia, smart will changes, dizzy, poor appetite effective percentage statistical procedures P＞0.05 there was no significant difference.
Table 4 traditional Chinese medical science each pattern of syndrome example number and curative effect table
| Traditional Chinese medical science typing | The checking group | Matched group | ||||||||
| The example number | Produce effects | Effectively | Invalid | Total effective rate (%) | The example number | Produce effects | Effectively | Invalid | Total effective rate (%) | |
| Pathogenic fire derived from stagnation of liver-QI | 94 | 61 | 30 | 3 | 96.81 | 45 | 32 | 11 | 2 | 95.56 |
| Disturb in the expectorant heat | 48 | 29 | 13 | 6 | 87.5 | 28 | 23 | 1 | 4 | 85.71 |
| Hyperactivity of fire caused by deficiency of YIN | 47 | 31 | 13 | 3 | 93.61 | 24 | 16 | 5 | 3 | 87.5 |
| Deficiency of both the heart and spleen | 55 | 35 | 18 | 2 | 96.36 | 26 | 17 | 8 | 1 | 96.15 |
| The heart and gallbladder deficiency of vital energy | 36 | 24 | 9 | 2 | 91.67 | 17 | 9 | 7 | 1 | 94.12 |
Compound lotus seed liquid (checking group) and NAOXINSHU (matched group) treatment neurasthenia traditional Chinese medical science typing: disturb in pathogenic fire derived from stagnation of liver-QI, the expectorant heat, the effective percentage of hyperactivity of fire caused by deficiency of YIN, deficiency of both the heart and spleen, the heart and gallbladder deficiency of vital energy learns by statistics and handle P＞0.05 there are no significant difference.
Table 5 severity extent classification example number and curative effect table
| Classification | The checking group | Matched group | ||||||||
| The example number | Produce effects | Effectively | Invalid | Total effective rate (%) | The example number | Produce effects | Effectively | Invalid | Total effective rate (%) | |
| Slightly | 143 | 110 | 28 | 5 | 96.5 | 66 | 46 | 17 | 3 | 95.45 |
| Moderate | 100 | 64 | 30 | 6 | 94 | 48 | 30 | 15 | 3 | 93.75 |
| Severe | 37 | 22 | 9 | 6 | 83.78 | 26 | 14 | 8 | 4 | 84.62 |
Compound lotus seed liquid (checking group) and NAOXINSHU (matched group) the treatment neurasthenia state of an illness is light, in, the severe classification, effective percentage is learned by statistics and is handled P＞0.05 there are no significant difference.
Claims (1)
1, a kind of preparation method of FUFANG LIANXIN KOUFUYE is characterized in that getting Plumula Nelumbinis 10-30 weight portion, Ziziphi Spinosae 15-30 weight portion, pours into after pulverizing is mixed thoroughly in the medicine pot, add the decocting that 10-12 doubly measures and boil 2-3 time, each 1-3 hour, collecting decoction, filter, filtrate decompression is concentrated into and surveys relative density in the time of 30-70 ℃ is the clear paste of 1.01-1.35, is placed into room temperature, adding ethanol makes and contains alcohol amount and reach 55% to 85%, stir, supernatant is got in cold preservation, reclaim ethanol, get extracting solution one; Other gets Pericarpium Citri Reticulatae 20-50 weight portion, is ground into coarse powder, alcohol reflux 1-3 time, each 1-3 hour, add ethanol 300-500ml for the first time, for the second time 200-400ml, filter, merging filtrate reclaims ethanol, gets extracting solution two, extracting solution one, extracting solution two, Mel 10-45 weight portion are mixed, add adjuvant, filter, make oral formulations.
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| CN 200710052113 CN101040929A (en) | 2007-04-29 | 2007-04-29 | Method for preparing compound lotus seed oral liquid |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104418929A (en) * | 2013-09-02 | 2015-03-18 | 河北以岭医药研究院有限公司 | Separation and identification methods of effective components in preparation of Chinese medicinal composition |
| CN112450433A (en) * | 2020-10-23 | 2021-03-09 | 瑞腾丰科技发展(北京)有限公司 | Medicinal and edible preparation with immunity enhancing function and preparation method thereof |
| CN114431318A (en) * | 2022-03-01 | 2022-05-06 | 盛俊华 | Food therapy tea drink for conditioning |
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2007
- 2007-04-29 CN CN 200710052113 patent/CN101040929A/en active Pending
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104418929A (en) * | 2013-09-02 | 2015-03-18 | 河北以岭医药研究院有限公司 | Separation and identification methods of effective components in preparation of Chinese medicinal composition |
| CN104418929B (en) * | 2013-09-02 | 2018-04-17 | 河北以岭医药研究院有限公司 | The separation of active ingredient and identification method in a kind of Chinese medicinal composition preparation |
| CN112450433A (en) * | 2020-10-23 | 2021-03-09 | 瑞腾丰科技发展(北京)有限公司 | Medicinal and edible preparation with immunity enhancing function and preparation method thereof |
| CN114431318A (en) * | 2022-03-01 | 2022-05-06 | 盛俊华 | Food therapy tea drink for conditioning |
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