CN104721732A - Chinese herbal medicine composition for treating senile dementia - Google Patents
Chinese herbal medicine composition for treating senile dementia Download PDFInfo
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- CN104721732A CN104721732A CN201510056550.XA CN201510056550A CN104721732A CN 104721732 A CN104721732 A CN 104721732A CN 201510056550 A CN201510056550 A CN 201510056550A CN 104721732 A CN104721732 A CN 104721732A
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Abstract
The invention provides a Chinese herbal medicine composition for treating senile dementia. The Chinese herbal medicine composition comprises the following effective components in parts by weight: 2-6 parts of sealwort, 1-5 parts of suncured ginseng, 1-5 parts of polygala tenuifolia, 1-5 parts of radix curcumae, 0.5-4 parts of rhizoma acori graminei, 0.2-2 parts of pseudo-ginseng and 0.1-0.3 part of borneol. The preparation method of the Chinese herbal medicine composition comprises the following steps: weighing sealwort, suncured ginseng, polygala tenuifolia and radix curcumae according to the proportions, soaking the components in water for 1 hour, heating and decocting the components for 3 times, decocting for 1 hour each time, and mixing water extract liquid medicine; filtering the liquid medicine, concentrating the liquid medicine to water extraction cream, and drying and crushing the water extraction cream into extract fine powder; weighing the borneol, wrapping the borneol with beta-cyclodextrin, weighing and crushing the rhizoma acori graminei and the pseudo-ginseng for later use; uniformly mixing the beta-cyclodextrin inclusion complex of the borneol, the rhizoma acori graminei, the pseudo-ginseng and the extract fine powder to obtain the composition. The Chinese herbal medicine composition provided by the invention can be used for effectively controlling the progression of senile dementia and perfecting learning and memory, and has great significance of improving the quality of life of patients with dementia.
Description
Technical field
The invention belongs to medical art, be specifically related to a kind of herbal composite for the treatment of alzheimer disease.
Background technology
Alzheimer disease (senile dementia) is that a kind of Progressive symmetric erythrokeratodermia degenerative neurological is sick also known as Alzheimer (Alzheimer ' s diseaes, AD).Clinical in onset concealment, memory, intelligence are that chronic progressive external goes down, and even partly or entirely lose, and have influence on daily life and doings ability is principal character.Mostly occur at over-65s elderly population.Epidemiological study shows, and over-65s old people AD prevalence is 4 ﹪ ~ 8 ﹪ in developed country, and China is 3 ﹪ ~ 7 ﹪.Calculate according to this, China has AD patient 6,000,000 ~ 8,000,000 to become modal dementia type at present, and it is one of maximum Health Killer of elderly population.The pressure that AD brings to society and family and financial burden are higher than European and American developed countries, and this kind of disease greatly affects the raising of life of elderly person quality, simultaneously also can the remote-effects national economic development and social stability.Therefore, the control of AD has become very urgent society and medical problem.Motherland's medical science has unique understanding to the primary disease cause of disease, pathogenesis, and have accumulated abundant Couple herbs in long-term clinical practice.Therefore the medicine optimizing more effective treatment AD is that pendulum is in our task urgently to be resolved hurrily in front.
Summary of the invention
The object of this invention is to provide a kind of herbal composite being used for the treatment of alzheimer disease, can prevention and therapy alzheimer disease.
Another object of the present invention is to provide a kind of preparation method of the herbal composite for prevention and therapy alzheimer disease.
The present invention realizes especially by following technical scheme:
Treat a herbal composite for alzheimer disease, comprise following active component by weight: Rhizoma Polygonati 2 ~ 6 parts, Radix Ginseng 1 ~ 5 part, Radix Polygalae 1 ~ 5 part, Radix Curcumae 1 ~ 5 part, Rhizoma Acori Graminei 0.5 ~ 4 part, Radix Notoginseng 0.2 ~ 2 part, Borneolum Syntheticum 0.1 ~ 0.3 part.
Preferably, a kind of herbal composite for the treatment of alzheimer disease, comprises following active component by weight: Rhizoma Polygonati 4 parts, Radix Ginseng 3 parts, Radix Polygalae 3 parts, Radix Curcumae 3 parts, Rhizoma Acori Graminei 2 parts, Radix Notoginseng 1 part, Borneolum Syntheticum 0.2 part.
Herbal composite of the present invention is prepared by the following method:
1) Rhizoma Polygonati, Radix Ginseng, Radix Polygalae and Radix Curcumae is taken by proportioning, after the 1h that is soaked in water, heating decoction 3 times, each 1h, merges water extraction medicinal liquid;
2) by medical filtration, when being concentrated into 80 DEG C, density is the water extraction cream of 1.2 ~ 1.3, and is dried under 65 DEG C of conditions by water extraction cream, pulverizes as extractum fine powder;
3) take Borneolum Syntheticum beta-schardinger dextrin-inclusion, take Rhizoma Acori Graminei, Radix Notoginseng is pulverized for subsequent use;
4) by the beta-cyclo dextrin included compound of Borneolum Syntheticum, Rhizoma Acori Graminei, Radix Notoginseng and extractum fine powder mix homogeneously, both compositions was obtained.
Herbal composite preparation method of the present invention, in step (1), water consumption is 6 times of Rhizoma Polygonati, Radix Ginseng, Radix Polygalae and Radix Curcumae gross weight.
Herbal composite of the present invention can by user before use through diluting or directly using, its preparation can be prepared by common processing method known in those skilled in the art, after being mixed with liquid flux or solid carrier by composition powder, then add one or more in filler, binding agent, wetting agent, disintegrating agent, absorption enhancer, solvent, surfactant, flavouring agent, antiseptic, lubricant, sweeting agent or pigment.
Herbal composite of the present invention can be processed into any pharmaceutically acceptable dosage form on demand, and wherein more preferably dosage form is tablet, capsule, granule or syrup.
Herbal composite of the present invention prevents and treats the application of alzheimer disease medicine as preparation.
The medical mechanism of herbal composite of the present invention:
Rhizoma Polygonati this product sweet in the mouth, property is put down, and has effect of the kidney invigorating and essence nourishing.Its effect slowly, can long-term taking, is suitable for treating deficiency of kidney-essence, and brain is become homeless and supported and the dementia that causes." Mingyi Bielu " is recorded, the medicinal energy of Rhizoma Polygonati " except rheumatism, settling five organs, for a long time clothes make light of one's life by commiting suicide, prolong life not hungry ".Modern pharmacology research proves, Rhizoma Polygonati has Fructus Alpiniae Oxyphyllae, slow down aging, enhancing immunity, reduces blood fat, reduces the multiple pharmacological effect such as blood glucose.
Radix Ginseng sweet in the mouth, micro-hardship, property is put down.Return lung, spleen, heart channel.Can strongly invigorating primordial QI, invigorating the spleen to benefit the lung, promotes the production of body fluid, Fructus Alpiniae Oxyphyllae of calming the nerves.Shennong's Herbal: " determine soul, spasmolytic is throbbed with fear for tonifying five ZANG-organs, peace spirit, except pathogen, and improving eyesight, happy Fructus Alpiniae Oxyphyllae ".Modern pharmacological research confirms that this product contains the compositions such as multiple ginsenoside, volatile oil, aminoacid, trace element and organic acid, saccharide, vitamin, and for the forgetful card that a variety of causes occurs, brain fag etc. have and clearly act on.
Radix Polygalae bitter in the mouth, pungent, temperature, GUIXIN, kidney, lung meridian.To calm the nerves Fructus Alpiniae Oxyphyllae, eliminate the phlegm and have one's ideas straightened out.Say as in " book on Chinese herbal medicine is just ": " the wholwe-hearted kidney of merit ... Yang strengthening and life essence tonifying, strong will power-assisted ".This product toil is warm in nature, property is kind lead off sensible, can happily gas and mind tranquilizing and the heart calming, kidney qi can be led to and strong will is not forgotten, be restoring normal coordination between the heart and kidney, stabilize mind, good merchantable brand that Fructus Alpiniae Oxyphyllae is known by force.
Rhizoma Acori Graminei is pungent, bitter, and temperature enters heart stomach warp, and have the effect of causing resuscitation with aromatic drugs, mind tranquilizing and the heart calming, removing dampness eliminating phlegm, the mind of hoodwinking clearly caused by key for turbid damp is dazed and confused, the normal and same restoring normal coordination between the heart and kidney of Radix Polygalae, inducing resuscitation and resolving phlegm.
The pungent loose hardship of Radix Curcumae is let out, and can have one's ideas straightened out by resolving depression, and cold in nature enter heart channel, can clear away heart-fire heat, therefore can be used for that expectorant turbidly hoodwinks thinking, heat falls into the coma of pericardium, and compatibility Rhizoma Acori Graminei, as " epidemic febrile disease pandect " Acorus calamus curcuma aromatica soup.
Borneolum Syntheticum is pungent, bitter, is slightly cold.GUIXIN, spleen, lung meridian.There is refreshment of having one's ideas straightened out, the effect of clearing away heat to alleviate pain.Modern pharmacology effect Borneolum Syntheticum main component Borneolum Syntheticum, isoborneol all have effect and the sedation of anoxia enduring.
Full presciption medicine taste compatibility is precise and appropriate, giving consideration to both the incidental and fundamental, up and down and control, controls the inferior to effect a permanent cure.The same use of all medicines, becomes enriching kidney essence, blood circulation promoting and blood stasis dispelling altogether, the merit of having one's ideas straightened out of eliminating the phlegm.
Beneficial effect of the present invention is: herbal composite of the present invention by the protective effect of Senescence-accelerated Mouse's (SAMP8) hippocampal neuron organizational structure to improve the cognitive function of SAMP8; Simultaneously by improving hippocampal tissue SOD and suppressing MDA active, reduce the content of free radical, improve the passive avoidance response capability learning memory impairment of dull-witted Mus.This herbal composite is not only to alleviation patient sufferings, and symptom management is in progress, and improve learning and memory, the quality of life of improving dementia patients has great importance.Simultaneously for clinical prevention AD provides objective experimental basis, and establish working foundation for further research and development Chinese medicine 6 kind new medicine, promote theory of Chinese medical science to a certain extent and to objectify development.
Detailed description of the invention
Below in conjunction with embodiment, the present invention is described further, the following stated, only to preferred embodiment of the present invention, not do other forms of restriction to the present invention, any those skilled in the art may utilize the technology contents of above-mentioned announcement to be changed to the Equivalent embodiments of equal change.Everyly do not depart from the present invention program's content, any simple modification done following examples according to technical spirit of the present invention or equivalent variations, all drop in protection scope of the present invention.
Application Example one
Embodiment 1
Treat a herbal composite for alzheimer disease, prepare especially by following methods:
1) take Rhizoma Polygonati 2 parts, Radix Ginseng 5 parts, Radix Polygalae 1 part and Radix Curcumae 1 part by weight ratio, after the 1h that is soaked in water, wherein the quality of water is 6 times of the total amount of the above-mentioned Chinese herbal medicine taken, heating decoction 3 times, and each 1h, merges water extraction medicinal liquid;
2) by medical filtration, when being concentrated into 80 DEG C, density is the water extraction cream of 1.2 ~ 1.3, and is dried under 65 DEG C of conditions by water extraction cream, pulverizes as extractum fine powder;
3) take Borneolum Syntheticum 0.1 part and use beta-schardinger dextrin-inclusion, take Rhizoma Acori Graminei 0.5 part, Radix Notoginseng 2 parts pulverizing is for subsequent use;
4) by the beta-cyclo dextrin included compound of Borneolum Syntheticum, Rhizoma Acori Graminei, Radix Notoginseng and extractum fine powder mix homogeneously, both compositions was obtained.
Embodiment 2
Treat a herbal composite for alzheimer disease, prepare especially by following methods:
1) take Rhizoma Polygonati 6 parts, Radix Ginseng 1 part, Radix Polygalae 5 parts and Radix Curcumae 5 parts by weight ratio, after the 1h that is soaked in water, wherein the quality of water is 6 times of the total amount of the above-mentioned Chinese herbal medicine taken, heating decoction 3 times, and each 1h, merges water extraction medicinal liquid;
2) by medical filtration, when being concentrated into 80 DEG C, density is the water extraction cream of 1.2 ~ 1.3, and is dried under 65 DEG C of conditions by water extraction cream, pulverizes as extractum fine powder;
3) take Borneolum Syntheticum 0.3 part and use beta-schardinger dextrin-inclusion, take Rhizoma Acori Graminei 4 parts, Radix Notoginseng 0.2 part pulverizing is for subsequent use;
4) by the beta-cyclo dextrin included compound of Borneolum Syntheticum, Rhizoma Acori Graminei, Radix Notoginseng and extractum fine powder mix homogeneously, both compositions was obtained.
Embodiment 3
Treat a herbal composite for alzheimer disease, prepare especially by following methods:
1) take Rhizoma Polygonati 4 parts, Radix Ginseng 3 parts, Radix Polygalae 3 parts and Radix Curcumae 3 parts by weight ratio, after the 1h that is soaked in water, wherein the quality of water is 6 times of the total amount of the above-mentioned Chinese herbal medicine taken, heating decoction 3 times, and each 1h, merges water extraction medicinal liquid;
2) by medical filtration, when being concentrated into 80 DEG C, density is the water extraction cream of 1.2 ~ 1.3, and is dried under 65 DEG C of conditions by water extraction cream, pulverizes as extractum fine powder;
3) take Borneolum Syntheticum 0.2 part and use beta-schardinger dextrin-inclusion, take Rhizoma Acori Graminei 2 parts, Radix Notoginseng 1 part pulverizing is for subsequent use;
4) by the beta-cyclo dextrin included compound of Borneolum Syntheticum, Rhizoma Acori Graminei, Radix Notoginseng and extractum fine powder mix homogeneously, both compositions was obtained.
Application Example two
In order to disclose the drug effect of herbal component Prevention and Curation alzheimer disease of the present invention, done following experiment: below by Chinese herbal medicine of the present invention on the impact of Alzheimer's disease model mouse learning and memory behavior, morphology improvement and oxidative stress so that its beneficial effect to be described.
Embodiment 4
1. experiment material
1.1 laboratory animal
Senescence-accelerated Mouse's SAMP8 (the senescence accelerated mouseprone 8 at 7 monthly ages, SAMP8) mice 36, with resistance to rapid aging mice subbreed R1 (the senescence accelerated mouse resistance 1 at monthly age, SAMR1) 12, male, body weight 25 ± 5g, is provided (quality certification number: No. 006th, the accurate word of the real kinoplaszm M in W-J Tianjin) by The First Affiliated Hospital of Tianjin University of Traditional Chinese Medic's Senium cerebropathia research department animal center.Animal on pretreatment adaptability is fed 2 weeks, and room temperature and humidity maintain 22 DEG C ~ 26 DEG C and about 55% respectively, normal illumination, and drinking-water and feedstuff are through high-temp steam sterilizing.
1.2 Experimental agents
1.2.1 the herbal composite of alzheimer disease is treated for one kind: Rhizoma Polygonati 4 parts, Radix Ginseng 3 parts, Radix Polygalae 3 parts, Radix Curcumae 3 parts, take water, wherein the quality of water is 6 times of the total amount of the above-mentioned Chinese herbal medicine taken, use load weighted water that above-mentioned load weighted all medicines are soaked 1 hour, heating decoction 3 times, each 1h, obtain water extraction medicinal liquid, merge 3 Aqueous extracts, filter, filtrate is concentrated into the water extraction cream that density is 1.2 ~ 1.3 (80 DEG C), is placed on by water extraction cream in 65 DEG C of drying baker and is dried into powder; Rhizoma Acori Graminei 2 parts, Radix Notoginseng 1 part are ground into fine powder; Borneolum Syntheticum 0.2 part is encapsulated with for use with beta-schardinger dextrin-.The beta-cyclo dextrin included compound of Borneolum Syntheticum, the extractum fine powder mix homogeneously of Rhizoma Acori Graminei, Radix Notoginseng fine powder and Rhizoma Polygonati, Radix Ginseng, Radix Polygalae, Radix Curcumae.Chinese medicinal powder adding distil water is mixed with suspension, and mass concentration is 30%, and obtain medical treatment dull-witted herbal composite.Be mixed with the aqueous solution that concentration is 0.26g/ml, 4 DEG C save backup.Wherein every gram of powder is containing crude drug 4.12 grams.
1.2.2 donepezil hydrochloride tablet (trade name aricept, Donepezil): 10mg/ sheet, manufacturing enterprise: French PFIZER PGM company, import drugs registration certificate number: BH20040114, point packaging authentication code: the accurate word J20040020 of traditional Chinese medicines.Be mixed with the aqueous solution that concentration is 0.013mg/ml, 4 DEG C save backup.
1.3 main agents
SOD, MDA detection kit: biochemistry corporation,Ltd. is built up in Nanjing
1.4 key instrument
ZIL-2 mice diving tower instrument: institute of Materia Medica,Chinese Academy of Medical Sciences
702 ultra cold storage freezers: ULT Freezer U.S.A
AL 204 electronic analytical balance: Shanghai METTLER instrument company
DU R640 protein nucleic acid analyser: BECKMAN U.S.A
BX60 optical microscope: OLYMPUS Japan produces
2. experimental technique
2.1 group technology
36 SAMP8 mices are divided into 3 groups at random: model group, aricept matched group, Chinese drug-treated group.Blank group is made up of 12 SAMR1 mices.
2.2 medications and drawing materials
Treatment by Chinese herbs group gives said herbal medicine compositions gavage (quite containing crude drug 4.12g/kg.d), and western medicine group gives aricept solution 1.3mg/kg.d, all once a day, and blank group, model group gives the distilled water gavage of same dosage, 4W altogether.After gavage 4W, each group is all carried out Behavior test.Often group is got 8 rapid broken ends on ice and is got Hippocampus afterwards, is put in-20 DEG C and saves backup.
2.3 mice Jumping test
Principle: experimental provision is a rectangle reflective box, and size is 10cm × 10cm × 60cm, is separated between 5 with black plastic plate.Bottom surface paving is with copper grid, and spacing is 0.5cm, can be energized, and voltage strength is controlled by a transformator.Between every, left comer puts the platform that a high and diameter is 4.5cm.The bottom of diving tower case is that steel grid have electric current (electric shock intensity 36v) to pass through thoroughly, electric shock animal vola.Placed by animal in experiment instrument, conform 5min, and after energising, Mus runs away on safety board, and the number of times that the cumulative time of Mus on safety board (i.e. escape latency), Mus are shocked by electricity etc. are as school grade.Recast test after 24 hours, namely this remember maintenance test.
The mensuration of 2.4 Hippocampus SOD, MDA activity
Biochemistry corporation,Ltd. SOD, MDA detection kit description is built up with reference to Nanjing.
2.5 statistical method
Data acquisition is used
represent, data statistic analysis all uses spss13.0 software.Data select one factor analysis of variance (one-wayANOVA).In diving tower behavior test, identical group first to compare the t that employing two sample average compares and checks (IndependentSamples T Test) with two day incubation period.P<0.05 represents that difference has significant.
3. experimental result
3.1 herbal composites are on the ethological impact of SAMP8 mice diving tower (see table 1)
Table 1 on the preclinical impact of SAMP8 mice (n=8,
)
Note: each group of every day is compared: * compares p < 0.05 with model group; With comparing for two days of group:
△p < 0.05 is compared with first day
As shown in table 1, result shows: blank group to compare that there were significant differences incubation period with model group p < 0.05.Compare with model group, herbal composite group and aricept group compare incubation period has significance to extend (p < 0.05).The t inspection adopting two sample averages to compare, the incubation period of identical group compares with first day, and within second day, except model group, other respectively organizes equal significant prolongation incubation period (p < 0.05).
3.2 herbal components are on the impact of the Hippocampus CA 3 Region histology and morphology structure of SAMP8
SAMP8 Hippocampus CA 3 Region cell arrangement is loose, disorderly, and cell quantity obviously reduces, the cellular swelling, and nuclear hyperchromatism, pyconsis are obvious, neuron diffusivity granulovacuolar degeneration.It is normal that blank organizes Hippocampus CA 3 Region structure, and closely neatly, be methodically arranged, nucleus is rounded in neuron arrangement, and regular greatly, kernel is clear.SAMP8 hippocampus of mice CA3 district neuron arrangement through the treatment of herbal composite group is comparatively loose disorderly, and the cell number of plies reduces, and cellular swelling, nuclear hyperchromatism, pyconsis and neuron granulovacuolar degeneration comparatively model group obviously reduce.
Experimental result confirms that the decline of SAMP8 Strains of Mouse ability of learning and memory has its tectology basis, and herbal composite group is by improving the cognitive function of SAMP8 mice to the protective effect of hippocampal neuron organizational structure.
3.3 herbal composite groups are on the impact of SAMP8 mouse brain Hippocampus SOD, MDA
Table 2 herbal composite group on the impact of SAMP8 mouse brain Hippocampus SOD, MDA (n=8,
)
Note: * compares p < 0.05 with model group
As shown in Table 2, blank group compares with model group, and SOD activity increases, MDA content declines, and has significant difference p < 0.05.Administration group all can improve the active p < 0.05 of SAMP8 Hippocampus of Mice SOD, has significant difference.Herbal composite group and aricept all can lower MDA content p < 0.05, have significant difference.
Application Example three
Below in conjunction with clinical experiment, the present composition is described further the effect of preventing and treating alzheimer disease disease.
Embodiment 5
Clinical data: in a section and No.1 Hospital Attached to Harbin Medical Univ.'s nerve, 55 typical patients of alzheimer disease symptom collect in six sections in Heilongjiang University of Chinese Medicine's attached First Hospital internal clinic, Heilongjiang Provincial Hospital's nerve, carry out the clinical experiment of Chinese medicine composition of the present invention.Male 30 people in these 55 patients, women 25 people, oldest 85 years old, minimum 55 years old, 63 years old mean age.Selected case is all selected with reference to the diagnostic criteria of the sick criteria for classification (ICD-10) of American Psychiatric Association's (psychotic diagnostic and statistical manual) third edition (ASM-III) and the world.Selected case all meets Chang Gu river Dementia scale, scoring < 10.MethodsThe cases enrolled meets in " guideline of clinical investigations of new Chinese medicine treatment senile dementia " (within 2002, Ministry of Public Health formulates " new Chinese medicine guideline of clinical investigations ") TCM syndrome diagnostic criteria that marrow of suffering from a deficiency of the kidney subtracts card, turbid phlegm blocking the clear orifices card, syndrome of qi stagnation and blood stasis simultaneously.Selected case all possesses the inspections of data such as complete history, physical examination, neuropsychological and cranial image.
Therapeutic Method: the compositions suspension prepared according to above-described embodiment 4 is treated, and herbal composite is mixed with the aqueous solution of 300 milliliters, every day early, late secondary decoction being taken warmly, one time 150 milliliters, within 4 weeks, be 1 course for the treatment of, treat observe the curative effect after 1 course for the treatment of, follow up a case by regular visits to 4 weeks.
Criterion of therapeutical effect: according to mental state scale (MMSE) evaluation criterion, judge total effects: clinical recovery: before and after treatment, intelligence mark improves more than 10 points, and total score reaches 23 points; Effective: before and after treatment, intelligence mark raising 5-10 divides; Effective: before and after treatment, intelligence mark improves lower than 5 points; Invalid: treatment front and back intelligence mark is unchanged or comparatively treatment is front declines.
Result: clinical recovery 0 example, effective 29 examples (52.7%), effective 17 examples (30.9%), no effect 9 (16.4%).
Therapeutic outcome statistics is as table 3:
Table 3 Chinese medicine composition is to the therapeutic effect of patients with Alzheimer disease
Model case: together certain, man, 76 years old.Private prosecution memory obviously goes down half a year, the thing usually forgotten firm what someone said or did, and for the people be very familiar to or article, often can not remember title.Computing power goes down, and slightly aobvious complicated calculating will make mistakes.Normal feel waist soreness, dizziness and tinnitus, loss of appetite.Temper is comparatively original irascible, bradykinesia.Light red tongue matter is dark, and have ecchymosis, the large companion's indentation of corpulent tongue, tongue is white micro-greasy, deep-rolling pulse.Brain CT shows: the bilateral ventricles of the brain are expanded, and brain ditch is broadening.MMES checks be divided into 15 points.Western medicine diagnose: alzheimer disease, Chinese medical discrimination: deficiency of kidney essence, expectorant stasis blocking key, control with kidney tonifying, essence replenishing, phlegm reduction of blood circulation promoting is had one's ideas straightened out.The water solution treatment that the herbal composite giving above-described embodiment 5 preparation is mixed with.Treat after 1 month, memory obviously strengthens, and forgetful phenomenon obviously reduces.Soreness of the waist and knees, asthenia are thought to crouch and are obviously alleviated, and dizziness and tinnitus disappears.Mood is optimistic, initiatively participates in some social activity.Look into MMSE integration and rise to 22 points.Efficacy determination belongs to effective.
Claims (6)
1. treat a herbal composite for alzheimer disease, it is characterized in that comprising following active component by weight: Rhizoma Polygonati 2 ~ 6 parts, Radix Ginseng 1 ~ 5 part, Radix Polygalae 1 ~ 5 part, Radix Curcumae 1 ~ 5 part, Rhizoma Acori Graminei 0.5 ~ 4 part, Radix Notoginseng 0.2 ~ 2 part, Borneolum Syntheticum 0.1 ~ 0.3 part.
2. a kind of herbal composite for the treatment of alzheimer disease according to claim 1, is characterized in that comprising following active component by weight: Rhizoma Polygonati 4 parts, Radix Ginseng 3 parts, Radix Polygalae 3 parts, Radix Curcumae 3 parts, Rhizoma Acori Graminei 2 parts, Radix Notoginseng 1 part, Borneolum Syntheticum 0.2 part.
3. a kind of herbal composite for the treatment of alzheimer disease according to claim 1 and 2, is characterized in that: this pharmaceutical composition makes tablet, capsule, granule or syrup.
4. the preparation method of herbal composite according to claim 1, is characterized in that comprising the following steps:
1) Rhizoma Polygonati, Radix Ginseng, Radix Polygalae and Radix Curcumae is taken by proportioning, after the 1h that is soaked in water, heating decoction 3 times, each 1h, merges water extraction medicinal liquid;
2) by medical filtration, when being concentrated into 80 DEG C, density is the water extraction cream of 1.2 ~ 1.3, and is dried under 65 DEG C of conditions by water extraction cream, pulverizes as extractum fine powder;
3) take Borneolum Syntheticum beta-schardinger dextrin-inclusion, take Rhizoma Acori Graminei, Radix Notoginseng is pulverized for subsequent use;
4) by the beta-cyclo dextrin included compound of Borneolum Syntheticum, Rhizoma Acori Graminei, Radix Notoginseng and extractum fine powder mix homogeneously, both compositions was obtained.
5. preparation method according to claim 4, is characterized in that: in step (1), water consumption is 6 times of Rhizoma Polygonati, Radix Ginseng, Radix Polygalae and Radix Curcumae gross weight.
6. herbal composite according to claim 1 prevents and treats the application of alzheimer disease medicine as preparation.
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| CN108355056A (en) * | 2018-05-10 | 2018-08-03 | 云南彝山天宝生物医药有限公司 | A kind of drug and preparation method thereof for treating senile dementia |
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