CN104685360B - 用于选择和去选择用产生免疫应答的疗法治疗的癌症患者的质谱方法 - Google Patents
用于选择和去选择用产生免疫应答的疗法治疗的癌症患者的质谱方法 Download PDFInfo
- Publication number
- CN104685360B CN104685360B CN201380043182.4A CN201380043182A CN104685360B CN 104685360 B CN104685360 B CN 104685360B CN 201380043182 A CN201380043182 A CN 201380043182A CN 104685360 B CN104685360 B CN 104685360B
- Authority
- CN
- China
- Prior art keywords
- cancer
- yeast
- treatment
- patient
- sample
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
- H01J49/00—Particle spectrometers or separator tubes
- H01J49/0027—Methods for using particle spectrometers
- H01J49/0036—Step by step routines describing the handling of the data generated during a measurement
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0011—Cancer antigens
- A61K39/001154—Enzymes
- A61K39/001164—GTPases, e.g. Ras or Rho
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
- G01N33/57407—Specifically defined cancers
- G01N33/57438—Specifically defined cancers of liver, pancreas or kidney
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
- G01N33/6848—Methods of protein analysis involving mass spectrometry
- G01N33/6851—Methods of protein analysis involving laser desorption ionisation mass spectrometry
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
- G16B20/20—Allele or variant detection, e.g. single nucleotide polymorphism [SNP] detection
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
- G16B20/50—Mutagenesis
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B40/00—ICT specially adapted for biostatistics; ICT specially adapted for bioinformatics-related machine learning or data mining, e.g. knowledge discovery or pattern finding
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B40/00—ICT specially adapted for biostatistics; ICT specially adapted for bioinformatics-related machine learning or data mining, e.g. knowledge discovery or pattern finding
- G16B40/10—Signal processing, e.g. from mass spectrometry [MS] or from PCR
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
- G16H10/00—ICT specially adapted for the handling or processing of patient-related medical or healthcare data
- G16H10/60—ICT specially adapted for the handling or processing of patient-related medical or healthcare data for patient-specific data, e.g. for electronic patient records
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
- G16H50/00—ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics
- G16H50/20—ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
- G16H50/00—ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics
- G16H50/50—ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for simulation or modelling of medical disorders
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
- G16H50/00—ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics
- G16H50/70—ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for mining of medical data, e.g. analysing previous cases of other patients
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2560/00—Chemical aspects of mass spectrometric analysis of biological material
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A90/00—Technologies having an indirect contribution to adaptation to climate change
- Y02A90/10—Information and communication technologies [ICT] supporting adaptation to climate change, e.g. for weather forecasting or climate simulation
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Physics & Mathematics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Chemical & Material Sciences (AREA)
- Medical Informatics (AREA)
- Bioinformatics & Computational Biology (AREA)
- Spectroscopy & Molecular Physics (AREA)
- Immunology (AREA)
- Public Health (AREA)
- Biotechnology (AREA)
- Biophysics (AREA)
- Biomedical Technology (AREA)
- Analytical Chemistry (AREA)
- Epidemiology (AREA)
- Urology & Nephrology (AREA)
- Theoretical Computer Science (AREA)
- Evolutionary Biology (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- Hematology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Data Mining & Analysis (AREA)
- Pathology (AREA)
- Databases & Information Systems (AREA)
- Genetics & Genomics (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Oncology (AREA)
- Mycology (AREA)
- Food Science & Technology (AREA)
- Cell Biology (AREA)
- Biochemistry (AREA)
- General Physics & Mathematics (AREA)
- Artificial Intelligence (AREA)
- Computer Vision & Pattern Recognition (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261664308P | 2012-06-26 | 2012-06-26 | |
| US201261664329P | 2012-06-26 | 2012-06-26 | |
| US61/664,329 | 2012-06-26 | ||
| US61/664,308 | 2012-06-26 | ||
| PCT/US2013/032024 WO2014003853A1 (en) | 2012-06-26 | 2013-03-15 | Mass-spectral method for selection, and de-selection, of cancer patients for treatment with immune response generating therapies |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN104685360A CN104685360A (zh) | 2015-06-03 |
| CN104685360B true CN104685360B (zh) | 2018-02-13 |
Family
ID=48045749
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201380043182.4A Active CN104685360B (zh) | 2012-06-26 | 2013-03-15 | 用于选择和去选择用产生免疫应答的疗法治疗的癌症患者的质谱方法 |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US9653272B2 (enExample) |
| EP (1) | EP2864792A1 (enExample) |
| JP (1) | JP6355630B2 (enExample) |
| KR (1) | KR102103319B1 (enExample) |
| CN (1) | CN104685360B (enExample) |
| AU (1) | AU2013281221B2 (enExample) |
| CA (1) | CA2878044C (enExample) |
| HK (1) | HK1209835A1 (enExample) |
| IL (1) | IL236266A0 (enExample) |
| MX (1) | MX365418B (enExample) |
| SG (1) | SG11201408652SA (enExample) |
| TW (1) | TWI639001B (enExample) |
| WO (1) | WO2014003853A1 (enExample) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2864792A1 (en) | 2012-06-26 | 2015-04-29 | Biodesix, Inc. | Mass-spectral method for selection, and de-selection, of cancer patients for treatment with immune response generating therapies |
| US11594403B1 (en) | 2014-12-03 | 2023-02-28 | Biodesix Inc. | Predictive test for prognosis of myelodysplastic syndrome patients using mass spectrometry of blood-based sample |
| US10037874B2 (en) | 2014-12-03 | 2018-07-31 | Biodesix, Inc. | Early detection of hepatocellular carcinoma in high risk populations using MALDI-TOF mass spectrometry |
| JP6647315B2 (ja) | 2015-01-09 | 2020-02-14 | イーチュービクス コーポレイション | 組み合わせ免疫療法のための方法および組成物 |
| EP3286213B1 (en) | 2015-04-20 | 2021-08-04 | Etubics Corporation | Methods and compositions for combination immunotherapy |
| WO2016175990A1 (en) * | 2015-04-30 | 2016-11-03 | Biodesix, Inc. | Bagged filtering method for selection and deselection of features for classification |
| US10974077B2 (en) | 2015-06-03 | 2021-04-13 | Montefiore Medical Center | Low intensity focused ultrasound for treating cancer and metastasis |
| CN112710723B (zh) * | 2015-07-13 | 2024-11-12 | 佰欧迪塞克斯公司 | 受益于pd-1抗体药物的肺癌患者的预测性测试和分类器开发方法 |
| JP6952056B2 (ja) * | 2016-01-22 | 2021-10-20 | オートレイシーズ, インク.Otraces, Inc. | 疾患診断を改善するシステム及び方法 |
| WO2017136139A1 (en) * | 2016-02-01 | 2017-08-10 | Biodesix, Inc. | Predictive test for melanoma patient benefit from interleukin-2 (il2) therapy |
| US11232940B2 (en) * | 2016-08-02 | 2022-01-25 | Virgin Instruments Corporation | Method and apparatus for surgical monitoring using MALDI-TOF mass spectrometry |
| EP3566054A4 (en) | 2017-01-05 | 2020-12-09 | Biodesix, Inc. | PROCESS FOR IDENTIFYING CANCER PATIENTS LIKELY TO BENEFIT FROM IMMUNOTHERAPY FOR LASTING SUSTAINABLE SUB-GROUPS OF PATIENTS WHO HAVE A BAD PROGNOSIS GENERALLY |
| EP3631839B1 (en) * | 2017-05-22 | 2024-04-03 | Beckman Coulter, Inc. | Integrated sample processing system with multiple detection capability |
| WO2019094802A1 (en) | 2017-11-09 | 2019-05-16 | Montefiore Medical Center | Low energy immune priming for treating cancer and metastasis |
| WO2019118873A2 (en) | 2017-12-15 | 2019-06-20 | Iovance Biotherapeutics, Inc. | Systems and methods for determining the beneficial administration of tumor infiltrating lymphocytes, and methods of use thereof and beneficial administration of tumor infiltrating lymphocytes, and methods of use thereof |
| EP3773691A4 (en) | 2018-03-29 | 2022-06-15 | Biodesix, Inc. | Apparatus and method for identification of primary immune resistance in cancer patients |
| WO2020167471A1 (en) * | 2019-02-15 | 2020-08-20 | Biodesix, Inc. | Predictive test for identification of early stage nsclc patients at high risk of recurrence after surgery |
| CN110674947B (zh) * | 2019-09-02 | 2021-02-19 | 三峡大学 | 基于Stacking集成框架的光谱特征变量选择与优化方法 |
| EP4046183A1 (en) * | 2019-10-17 | 2022-08-24 | DH Technologies Development Pte. Ltd. | Threshold-based ida exclusion list |
| CN112164448B (zh) * | 2020-09-25 | 2021-06-22 | 上海市胸科医院 | 免疫治疗疗效预测模型训练方法、预测系统及方法和介质 |
| CN116685259A (zh) * | 2020-10-19 | 2023-09-01 | 本-古里安大学B.G.内盖夫技术和应用公司 | 尿细菌对抗生素的敏感性的快速直接鉴定和确定 |
Family Cites Families (62)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2486400B1 (fr) | 1980-07-09 | 1986-05-30 | Univablot | Medicaments a base de levures ou de leurs extraits insolubles |
| NZ199722A (en) | 1981-02-25 | 1985-12-13 | Genentech Inc | Dna transfer vector for expression of exogenous polypeptide in yeast;transformed yeast strain |
| US4514506A (en) | 1982-02-23 | 1985-04-30 | The Government Of The United States As Represented By The Secretary Of The Department Of Health And Human Services | Method for the identification and purification of human lung tumor-associated antigens (hLTAA) and clinical detection and determination of these antigens |
| US4775622A (en) | 1982-03-08 | 1988-10-04 | Genentech, Inc. | Expression, processing and secretion of heterologous protein by yeast |
| JPS61219387A (ja) * | 1985-03-27 | 1986-09-29 | Suntory Ltd | 新規な酵母プラスミドおよびその形質転換体 |
| US5310654A (en) | 1985-07-31 | 1994-05-10 | The Board Of Trustees Of The Leland Stanford Junior University | Method for determining virulence of Yersinia |
| US5234830A (en) | 1988-02-03 | 1993-08-10 | Suntory Limited | DNA encoding a KEX2 endoprotease without a C-terminal hydrophobic region |
| IL95019A0 (en) | 1989-08-09 | 1991-06-10 | Mycogen Corp | Process for encapsulation of biologicals |
| US5830463A (en) | 1993-07-07 | 1998-11-03 | University Technology Corporation | Yeast-based delivery vehicles |
| US5413914A (en) | 1993-07-07 | 1995-05-09 | The Regents Of The University Of Colorado | Yeast assay to identify inhibitors of dibasic amino acid processing endoproteases |
| US5648226A (en) | 1993-07-22 | 1997-07-15 | Ludwig Institute For Cancer Research | Isolated peptides derived from tumor rejection antigens, and their use |
| EP0721341A4 (en) | 1993-08-06 | 1998-04-22 | Cytel Corp | CLONING AND DESCRIPTION OF FULL MAGE-1 GENE CHARACTERISTICS |
| US5550214A (en) | 1994-02-10 | 1996-08-27 | Brigham And Women's Hospital | Isolated antigenic oncogene peptide fragments and uses |
| US5747282A (en) | 1994-08-12 | 1998-05-05 | Myraid Genetics, Inc. | 17Q-linked breast and ovarian cancer susceptibility gene |
| US5840839A (en) | 1996-02-09 | 1998-11-24 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Alternative open reading frame DNA of a normal gene and a novel human cancer antigen encoded therein |
| US5858378A (en) | 1996-05-02 | 1999-01-12 | Galagen, Inc. | Pharmaceutical composition comprising cryptosporidium parvum oocysts antigen and whole cell candida species antigen |
| US20070048860A1 (en) | 1997-10-10 | 2007-03-01 | The Government Of The Usa, As Represented By The Secretary, Department Of Health And Human Services | Carcinoembryonic antigen (CEA) peptides |
| US20010055589A1 (en) | 1998-06-17 | 2001-12-27 | University Of Connecticut | Cancer immunotherapy improved by prior radiotherapy |
| US20020044948A1 (en) | 2000-03-15 | 2002-04-18 | Samir Khleif | Methods and compositions for co-stimulation of immunological responses to peptide antigens |
| ES2260078T3 (es) | 2000-04-06 | 2006-11-01 | Seer Pharmaceuticals, Llc. | Sistema de administracion microbiana. |
| US7083787B2 (en) | 2000-11-15 | 2006-08-01 | Globeimmune, Inc. | Yeast-dendritic cell vaccines and uses thereof |
| AU2002252456A1 (en) | 2001-03-23 | 2002-10-08 | Aphton Corporation | Combination treatment of pancreatic cancer |
| AU2003301021C1 (en) | 2002-12-16 | 2010-02-18 | Globelmmune, Inc. | Yeast-based vaccines as immunotherapy |
| US7439042B2 (en) | 2002-12-16 | 2008-10-21 | Globeimmune, Inc. | Yeast-based therapeutic for chronic hepatitis C infection |
| US8135136B2 (en) | 2004-09-06 | 2012-03-13 | Koninklijke Philips Electronics N.V. | Audio signal enhancement |
| US20070287719A1 (en) * | 2005-03-11 | 2007-12-13 | Pfizer Inc | Salts, Prodrugs and Formulations of 1-[5-(4-Amino-7-Isopropyl-7H-Pyrrolo[2,3-D]Pyrimidine-5-Carbonyl)-2-Methoxy-Phenyl]-3-(2,4-Dichloro-Phenyl)-Urea |
| US8013927B2 (en) | 2005-07-08 | 2011-09-06 | Nikon Corporation | Solid-state image sensors |
| US20100034840A1 (en) | 2005-07-11 | 2010-02-11 | David Apelian | Compositions and methods for eliciting an immune response to escape mutants of targeted therapies |
| US20070172503A1 (en) | 2005-12-13 | 2007-07-26 | Mycologics,Inc. | Compositions and Methods to Elicit Immune Responses Against Pathogenic Organisms Using Yeast Based Vaccines |
| MX2008009929A (es) | 2006-02-02 | 2008-10-01 | Globeimmune Inc | Vacuna a base de levadura para inducir una respuesta inmune. |
| CN101448848B (zh) | 2006-03-27 | 2013-12-04 | 全球免疫股份有限公司 | Ras突变及其相关组合物和方法 |
| US7867775B2 (en) | 2006-03-31 | 2011-01-11 | Biodesix, Inc. | Selection of head and neck cancer patients for treatment with drugs targeting EGFR pathway |
| US7736905B2 (en) * | 2006-03-31 | 2010-06-15 | Biodesix, Inc. | Method and system for determining whether a drug will be effective on a patient with a disease |
| US7906342B2 (en) | 2006-03-31 | 2011-03-15 | Biodesix, Inc. | Monitoring treatment of cancer patients with drugs targeting EGFR pathway using mass spectrometry of patient samples |
| US7858389B2 (en) | 2006-03-31 | 2010-12-28 | Biodesix, Inc. | Selection of non-small-cell lung cancer patients for treatment with monoclonal antibody drugs targeting EGFR pathway |
| US8024282B2 (en) | 2006-03-31 | 2011-09-20 | Biodesix, Inc. | Method for reliable classification of samples in clinical diagnostics using an improved method of classification |
| US7858390B2 (en) | 2006-03-31 | 2010-12-28 | Biodesix, Inc. | Selection of colorectal cancer patients for treatment with drugs targeting EGFR pathway |
| WO2008085024A1 (en) * | 2007-01-12 | 2008-07-17 | Erasmus University Medical Center Rotterdam | Identification and detection of peptides relating to specific disorders |
| JP5570819B2 (ja) | 2007-02-02 | 2014-08-13 | グローブイミューン,インコーポレイテッド | 酵母を含む組成物および酵母を増殖させる方法 |
| EP2134358A1 (en) | 2007-03-19 | 2009-12-23 | Globeimmune, Inc. | Compositions and methods for targeted ablation of mutational escape of targeted therapies for cancer |
| WO2009149714A1 (en) | 2008-06-11 | 2009-12-17 | Bruenner Nils Aage | Selection of colorectal cancer patients for neo-adjuvant and adjuvant systemic anti-cancer treatment |
| US8728489B2 (en) | 2008-09-19 | 2014-05-20 | Globeimmune, Inc. | Immunotherapy for chronic hepatitis C virus infection |
| WO2010065626A1 (en) | 2008-12-02 | 2010-06-10 | Globeimmune, Inc. | Genotyping tools, methods and kits |
| WO2010080804A1 (en) * | 2009-01-06 | 2010-07-15 | Bristol-Myers Squibb Company | Biomarkers and methods for determining sensitivity to epidermal growth factor receptor modulators |
| EP2419126B1 (en) | 2009-04-17 | 2018-01-10 | Globeimmune, Inc. | Combination immunotherapy compositions against cancer and methods |
| JP2011001315A (ja) | 2009-06-19 | 2011-01-06 | Cellex Corp | 膵臓癌の免疫療法剤 |
| JP5913103B2 (ja) | 2009-09-14 | 2016-04-27 | ザ リージェンツ オブ ザ ユニバーシティ オブ コロラド,ア ボディー コーポレイトTHE REGENTS OF THE UNIVERSITY OF COLORADO,a body corporate | 酵母ベースの免疫療法組成物を含む組合せ物及び被験者のスクリーニング方法 |
| EP2539704A4 (en) | 2010-02-24 | 2015-12-02 | Biodesix Inc | CANCER PATIENT SELECTION FOR ADMINISTRATION OF THERAPEUTIC AGENTS USING MASS SPECTROMETRY ANALYSIS |
| JP2013522302A (ja) | 2010-03-14 | 2013-06-13 | グローブイミューン,インコーポレイテッド | 酵母系免疫療法を使用した感染症の薬理ゲノミクス及び治療反応性ガイド治療 |
| WO2012019127A2 (en) | 2010-08-05 | 2012-02-09 | The Regents Of The University Of Colorado | Combination yeast-based immunotherapy and arginine therapy for the treatment of myeloid-derived supressor cell-associated diseases |
| GB201021289D0 (en) | 2010-12-15 | 2011-01-26 | Immatics Biotechnologies Gmbh | Novel biomarkers for a prediction of the outcome of an immunotherapy against cancer |
| EP2651439B1 (en) | 2010-12-17 | 2018-09-19 | Globeimmune, Inc. | Compositions and methods for the treatment or prevention of human adenovirus-36 infection |
| EP2668504A4 (en) | 2011-01-28 | 2015-06-10 | Biodesix Inc | PREDICTIVE TEST FOR SELECTING PATIENTS WITH METASTATIC BREAST CANCERS TO RECEIVE HORMONE THERAPY AND POLY THERAPY |
| AP2013007110A0 (en) | 2011-02-12 | 2013-09-30 | Globeimmune Inc | Yeast-based therapeutic for chronic hepatitis B infection |
| AU2012228937B2 (en) | 2011-03-17 | 2016-11-03 | Globeimmune, Inc. | Yeast-Brachyury immunotherapeutic compositions |
| BR112013032381B1 (pt) | 2011-06-14 | 2021-01-12 | Globeimmune, Inc. | composições à base de levedura e métodos para o tratamento ou prevenção de infecção pelo vírus da hepatite delta |
| RU2017143985A (ru) | 2011-08-17 | 2019-02-14 | Глоубиммьюн, Инк. | Иммунотерапевтические композиции на основе дрожжей-muc1 и способы их применения |
| CA2856981A1 (en) | 2011-11-23 | 2013-06-27 | Uti Limited Partnership | Expression signature for staging and prognosis of prostate, breast and leukemia cancers |
| JP2015514222A (ja) | 2012-04-13 | 2015-05-18 | エラスムス・ユニヴァーシティ・メディカル・センター・ロッテルダム | トリプルネガティブ乳癌についてのバイオマーカー |
| US9279798B2 (en) * | 2012-05-29 | 2016-03-08 | Biodesix, Inc. | Deep-MALDI TOF mass spectrometry of complex biological samples, e.g., serum, and uses thereof |
| EP2864792A1 (en) | 2012-06-26 | 2015-04-29 | Biodesix, Inc. | Mass-spectral method for selection, and de-selection, of cancer patients for treatment with immune response generating therapies |
| CH715107B1 (fr) | 2018-06-18 | 2021-12-30 | Montres Breguet Sa | Mécanisme de réglage pour mécanisme d'affichage d'horlogerie à rouleau. |
-
2013
- 2013-03-15 EP EP13714124.8A patent/EP2864792A1/en not_active Withdrawn
- 2013-03-15 CA CA2878044A patent/CA2878044C/en active Active
- 2013-03-15 AU AU2013281221A patent/AU2013281221B2/en active Active
- 2013-03-15 WO PCT/US2013/032024 patent/WO2014003853A1/en not_active Ceased
- 2013-03-15 US US13/835,909 patent/US9653272B2/en active Active
- 2013-03-15 MX MX2014015665A patent/MX365418B/es active IP Right Grant
- 2013-03-15 KR KR1020157001998A patent/KR102103319B1/ko active Active
- 2013-03-15 CN CN201380043182.4A patent/CN104685360B/zh active Active
- 2013-03-15 SG SG11201408652SA patent/SG11201408652SA/en unknown
- 2013-03-15 JP JP2015520167A patent/JP6355630B2/ja active Active
- 2013-03-15 HK HK15110515.8A patent/HK1209835A1/xx unknown
- 2013-05-03 TW TW102115975A patent/TWI639001B/zh active
-
2014
- 2014-12-15 IL IL236266A patent/IL236266A0/en unknown
-
2017
- 2017-05-02 US US15/584,275 patent/US10593529B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| US20170271136A1 (en) | 2017-09-21 |
| MX365418B (es) | 2019-06-03 |
| CA2878044C (en) | 2021-10-26 |
| AU2013281221B2 (en) | 2018-05-17 |
| HK1209835A1 (en) | 2016-04-08 |
| EP2864792A1 (en) | 2015-04-29 |
| MX2014015665A (es) | 2015-06-17 |
| CN104685360A (zh) | 2015-06-03 |
| JP6355630B2 (ja) | 2018-07-11 |
| IL236266A0 (en) | 2015-02-26 |
| KR102103319B1 (ko) | 2020-04-22 |
| CA2878044A1 (en) | 2014-01-03 |
| WO2014003853A1 (en) | 2014-01-03 |
| US20130344111A1 (en) | 2013-12-26 |
| US9653272B2 (en) | 2017-05-16 |
| TW201400812A (zh) | 2014-01-01 |
| US10593529B2 (en) | 2020-03-17 |
| KR20150023881A (ko) | 2015-03-05 |
| AU2013281221A1 (en) | 2015-02-12 |
| TWI639001B (zh) | 2018-10-21 |
| SG11201408652SA (en) | 2015-01-29 |
| JP2015528110A (ja) | 2015-09-24 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN104685360B (zh) | 用于选择和去选择用产生免疫应答的疗法治疗的癌症患者的质谱方法 | |
| JP7175951B2 (ja) | 免疫原性変異体ペプチドスクリーニングプラットフォーム | |
| Faridi et al. | Spliced peptides and cytokine-driven changes in the immunopeptidome of melanoma | |
| CN109803981B (zh) | 用于头颈鳞状细胞癌和其他癌症免疫治疗的新型肽和支架 | |
| AU2019227813A1 (en) | Neoantigen identification with pan-allele models | |
| CN113527421A (zh) | 用于结直肠癌(crc)和其他癌症免疫治疗的新型肽和肽组合物及其支架 | |
| KR20180089522A (ko) | 유방암 및 기타 암에 대한 면역요법에서의 사용을 위한 펩티드 및 펩티드의 조합 | |
| Polyakova et al. | Proteogenomics meets cancer immunology: mass spectrometric discovery and analysis of neoantigens | |
| WO2020023845A2 (en) | Methods for identifying rna editing-derived epitopes that elicit immune responses in cancer | |
| CN107810193B (zh) | 用于结直肠癌(crc)和其他癌症免疫治疗的新型肽和肽组合物及其支架 | |
| Shoshan et al. | Proteomics in cancer vaccine development | |
| Marcu | The HLA Ligand Atlas. Defining Actionable Targets For T-Cell-Based Immunotherapy | |
| HK40074082A (en) | Immunogenic mutant peptide screening platform | |
| Barbero et al. | Assessing Major Histocompatibility Complex-Associated Peptide Proteomics assay as a tool to predict immunogenicity potential of protein therapeutics and antigens | |
| Zhang et al. | Large-Scale Proteome and Phosphoproteome Quantification by Data Independent Acquisition on Ultra-High Field Orbitrap Mass Spectrometers | |
| HK40053169A (en) | Novel peptides and combination of peptides and scaffolds thereof for use in immunotherapy against colorectal carcinoma (crc) and other cancers | |
| HK1242779B (zh) | 免疫原性突变体肽筛选平台 | |
| Zhukov et al. | Protein profiling for premalignant tissue |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant |