CN104685064A - 高度复合pcr方法和组合物 - Google Patents

高度复合pcr方法和组合物 Download PDF

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Publication number
CN104685064A
CN104685064A CN201280075224.8A CN201280075224A CN104685064A CN 104685064 A CN104685064 A CN 104685064A CN 201280075224 A CN201280075224 A CN 201280075224A CN 104685064 A CN104685064 A CN 104685064A
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China
Prior art keywords
primer
gene seat
target gene
target
dna
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English (en)
Chinese (zh)
Inventor
B·齐默曼
M·M·希尔
P·G·拉格劳特
M·多德
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Natera Inc
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Gene Security Network Inc
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Priority claimed from US13/683,604 external-priority patent/US20130123120A1/en
Publication of CN104685064A publication Critical patent/CN104685064A/zh
Pending legal-status Critical Current

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    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
    • G16B20/20—Allele or variant detection, e.g. single nucleotide polymorphism [SNP] detection
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844—Nucleic acid amplification reactions
    • C12Q1/686—Polymerase chain reaction [PCR]
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
    • G16B20/10—Ploidy or copy number detection
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B25/00—ICT specially adapted for hybridisation; ICT specially adapted for gene or protein expression
    • G16B25/20—Polymerase chain reaction [PCR]; Primer or probe design; Probe optimisation
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B30/00—ICT specially adapted for sequence analysis involving nucleotides or amino acids

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  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Biotechnology (AREA)
  • Analytical Chemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Theoretical Computer Science (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Medical Informatics (AREA)
  • Evolutionary Biology (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
CN201280075224.8A 2012-07-24 2012-11-21 高度复合pcr方法和组合物 Pending CN104685064A (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201261675020P 2012-07-24 2012-07-24
US61/675,020 2012-07-24
PCT/US2012/066339 WO2014018080A1 (en) 2012-07-24 2012-11-21 Highly multiplex pcr methods and compositions
US13/683,604 US20130123120A1 (en) 2010-05-18 2012-11-21 Highly Multiplex PCR Methods and Compositions
US13/683,604 2012-11-21

Publications (1)

Publication Number Publication Date
CN104685064A true CN104685064A (zh) 2015-06-03

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CN201280075224.8A Pending CN104685064A (zh) 2012-07-24 2012-11-21 高度复合pcr方法和组合物

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JP (12) JP6392222B2 (https=)
KR (1) KR101890466B1 (https=)
CN (1) CN104685064A (https=)
AU (1) AU2012385961B9 (https=)
CA (1) CA2877493C (https=)
HK (1) HK1211058A1 (https=)
IL (1) IL236435A0 (https=)
RU (1) RU2650790C2 (https=)
SG (1) SG11201408813VA (https=)
WO (1) WO2014018080A1 (https=)

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CN107406882A (zh) * 2015-04-24 2017-11-28 基纳生物技术有限公司 用于次要等位基因和多态性的鉴定和定量的多重化方法
CN108334745A (zh) * 2018-03-19 2018-07-27 青岛理工大学 一种聚合酶链反应过程非线性混杂系统建模方法
CN109477138A (zh) * 2016-04-15 2019-03-15 纳特拉公司 肺癌检测方法
CN109790587A (zh) * 2016-09-30 2019-05-21 富士胶片株式会社 从100pg以下的人类基因组DNA判别其来源的方法、识别个人的方法及分析造血干细胞的植活程度的方法
CN113979895A (zh) * 2020-07-08 2022-01-28 中国科学技术大学 一种精确序列可控的自降解聚合物及其制备方法和应用
CN114829624A (zh) * 2019-12-16 2022-07-29 安捷伦科技有限公司 基因组瘢痕测定和相关方法
US11667958B2 (en) 2011-05-19 2023-06-06 Agena Bioscience, Inc. Products and processes for multiplex nucleic acid identification
CN117116359A (zh) * 2023-08-07 2023-11-24 天津大学 Dna存储中基于最大后验概率的鲁棒多序列重建方法

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US10083273B2 (en) 2005-07-29 2018-09-25 Natera, Inc. System and method for cleaning noisy genetic data and determining chromosome copy number
US11111543B2 (en) 2005-07-29 2021-09-07 Natera, Inc. System and method for cleaning noisy genetic data and determining chromosome copy number
US11111544B2 (en) 2005-07-29 2021-09-07 Natera, Inc. System and method for cleaning noisy genetic data and determining chromosome copy number
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