CN104666996A - Traditional Chinese medicine composition for refreshing and resisting fatigue and preparation method and application of traditional Chinese medicine composition - Google Patents
Traditional Chinese medicine composition for refreshing and resisting fatigue and preparation method and application of traditional Chinese medicine composition Download PDFInfo
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Abstract
The invention discloses a traditional Chinese medicine composition for refreshing and resisting fatigue, and a preparation method and an application of the traditional Chinese medicine composition. The traditional Chinese medicine composition for refreshing and resisting fatigue is prepared from the following active ingredient raw materials in parts by weight: 1-10 parts of ginseng, 1-15 parts of polygonatum kingianum, 10-25 parts of poria cocos, 8-20 parts of puerarin, 5-20 parts of mulberry, 2-18 parts of corn stigma, 1-20 parts of lotus leaves, 1-6 parts of broadleaf holly leaves, 3-15 parts of liquorice and 2-16 parts of chrysanthemum. The medicinal and edible raw materials are selected, so that the traditional Chinese medicine composition is good in taste, significant in refreshing effect, safe and easy to widely popularize, and does not cause any toxic or side effect.
Description
Technical field
The present invention relates to field of health care food, particularly a kind of Chinese medicine composition and preparation method thereof of resisting fatigue of refreshing oneself and application.
Background technology
Modern due to rhythm of life fast, in addition often in the face of the work of high challenge, require mental skill for a long time and there will be neurolysis, listless, confused swollen, the bradykinesia of brains, whenever now, some can be refreshed oneself by coffee for drinking beverage, strong tea, refrigerant food etc.Caffeine is contained in coffee or strong tea, the topmost effect of caffeine is stimulating central nervous system, contemplative faculty and the allaying tiredness i.e. so-called function of refreshing oneself of brain can be improved, but while refreshing oneself, people can be made to be in lasting excited state, thus easily ignore the fatigue of self, cause physical ability to overdraw.Drink a large amount of coffee and also addictedly can cause habituation, the time, otherwise will be dog-tired listless once supplementary to wanting to have a drink.Refrigerant food can give people of short duration refrigerant sense, also can allow people's refreshment, produces straightforward sensation, eliminates tired meaning.Shortcoming is, can not solve feeling bad after feeling sleepy, and people is more clear-headed, but brain is still very tried out, is difficult to the sensation be subject to.
Therefore be necessary for the problems referred to above, a kind of existing anti-fatigue effect of refreshing oneself of development, again safely, the product that has no side effect.
Summary of the invention
Based on this, be necessary for the problems referred to above, Chinese medicine composition of a kind of resisting fatigue of refreshing oneself and preparation method thereof and application are provided.
The concrete technical scheme solved the problems of the technologies described above is as follows:
A Chinese medicine composition for resisting fatigue of refreshing oneself, its active component is prepared from by the raw material of following weight portion: Radix Ginseng 1 ~ 10 part, Rhizoma Polygonati 1 ~ 15 part, 10 ~ 25 parts, Poria, Radix Puerariae 8 ~ 20 parts, Fructus Mori 5 ~ 20 parts, Stigma Maydis 2 ~ 18 parts, 1 ~ 20 part, Folium Nelumbinis, Folium Ilicis 1 ~ 6 part, 3 ~ 15 parts, Radix Glycyrrhizae, Flos Chrysanthemi 2 ~ 16 parts.
Wherein in some embodiments, its active component is prepared from by the raw material of following weight portion: Radix Ginseng 3 ~ 8 parts, Rhizoma Polygonati 2 ~ 13 parts, 12 ~ 22 parts, Poria, Radix Puerariae 10 ~ 18 parts, Fructus Mori 7 ~ 18 parts, Stigma Maydis 5 ~ 15 parts, 5 ~ 15 parts, Folium Nelumbinis, Folium Ilicis 2 ~ 5 parts, 5 ~ 12 parts, Radix Glycyrrhizae, Flos Chrysanthemi 4 ~ 14 parts.
Wherein in some embodiments, its active component is prepared from by the raw material of following weight portion: Radix Ginseng 4 ~ 6 parts, Rhizoma Polygonati 4 ~ 6 parts, 14 ~ 16 parts, Poria, Radix Puerariae 14 ~ 16 parts, Fructus Mori 14 ~ 16 parts, Stigma Maydis 11 ~ 13 parts, 9 ~ 11 parts, Folium Nelumbinis, Folium Ilicis 2 ~ 4 parts, 8 ~ 10 parts, Radix Glycyrrhizae, Flos Chrysanthemi 8 ~ 10 parts.
Radix Ginseng: sweet, micro-hardship, tepor; Strongly invigorating primordial QI, multiple arteries and veins takes off admittedly, and invigorating the spleen to benefit the lung, promotes the production of body fluid and nourish blood, Fructus Alpiniae Oxyphyllae of calming the nerves;
Rhizoma Polygonati: sweet is flat; Boosting qi and nourishing yin, spleen invigorating, lung moistening, kidney tonifying; For deficiency of spleen-QI and stomach-QI, fatigue and asthenia;
Poria: sweet is light, flat; Promoting diuresis to eliminate damp pathogen, spleen invigorating, mind calming;
Radix Puerariae: sweet, pungent, cool; Expelling pathogenic factors from muscles for reducing heat, promoting the production of body fluid to quench thirst, yang invigorating antidiarrheal;
Fructus Mori: sweet, acid, cold; Nourishing YIN and supplementing blood, promotes the production of body fluid and moisturizes;
Stigma Maydis: sweet, light, flat, inducing diuresis to remove edema, suppressing the hyperactive liver function of gallbladder promoting;
Folium Nelumbinis: bitter is flat; Clearing away summer-heat and eliminating dampness, sending up the lucid YANG, cooling blood for hemostasis;
Flos Chrysanthemi: sweet, bitter, be slightly cold; Fresh breeze heat clearing away, suppressing the hyperactive liver improving eyesight, heat-clearing and toxic substances removing;
The present composition according to the theory of Chinese medicine " monarch ", add Radix Ginseng, Rhizoma Polygonati is monarch drug, has boosting qi and nourishing yin, spleen invigorating Fructus Alpiniae Oxyphyllae it; Adding Radix Puerariae, Fructus Mori is ministerial drug, has nourishing YIN and supplementing blood, effect of moisturizing of promoting the production of body fluid, and can resist tired tired tired, can reduce the dry property of Radix Ginseng; Interpolation Poria, Stigma Maydis, Folium Nelumbinis are adjuvant drug, have effect of heat clearing away, promoting diuresis to eliminate damp pathogen; Adding Folium Ilicis, Flos Chrysanthemi, Radix Glycyrrhizae for making medicine, there is dispelling wind heat, effect of improving eyesight.
The present invention also provides a kind of preparation method of Chinese medicine composition of above-mentioned resisting fatigue of refreshing oneself, and comprises the steps:
(1) non-Leaf-feeding insects, the grains of sand, the impurity of Radix Ginseng, Rhizoma Polygonati, Poria, Radix Puerariae, Fructus Mori, Stigma Maydis, Folium Nelumbinis, Folium Ilicis, Radix Glycyrrhizae and Flos Chrysanthemi is removed, for subsequent use;
(2) according to above-mentioned proportioning, the raw material in step (1) is weighed, be crushed to 60 ~ 100 orders;
(3) extract with efficient high-pressure difference low temperature continous way extracting and developing concentration technique, filter with concentrated;
(4) dry to the material spray concentrated, receive dry powder.
Wherein in some embodiments, described preparation method also comprises described dry powder is prepared into granule, tablet or powder.
Wherein in some embodiments, described granule is by step (4) gained dry powder, adds maltodextrin, granulates, to obtain final product.
The present invention also provides a kind of above-mentioned Chinese medicine composition preparing the application of refreshing oneself in the health food of resisting fatigue.
The present invention also provides a kind of health food of resisting fatigue of refreshing oneself, and described health food includes the Chinese medicine composition of above-mentioned resisting fatigue of refreshing oneself.
The present invention compared to the advantage of prior art and beneficial effect is:
The present invention is through a large amount of experiment of inventor and research, selected medicine and food raw materials, draw the Chinese medicine composition of resisting fatigue effect of refreshing oneself, and determine its optimum proportioning, gained Chinese medicine composition significantly can improve people's neurolysis, listless, confused swollen, the unresponsive symptom of brains, and good mouthfeel, any toxic and side effects can not be brought, safety, be easy to extensive popularization.
Detailed description of the invention
Raw materials usedly in embodiment be commercially available convenient source.
Below with reference to specific embodiment, the present invention will be further described.
Embodiment 1
A Chinese medicine composition for resisting fatigue of refreshing oneself, its active component is prepared from by the raw material of following weight portion: Radix Ginseng 1 part, Rhizoma Polygonati 15 parts, 25 parts, Poria, Radix Puerariae 8 parts, Fructus Mori 5 parts, Stigma Maydis 18 parts, 1 part, Folium Nelumbinis, Folium Ilicis 6 parts, 3 parts, Radix Glycyrrhizae, Flos Chrysanthemi 16 parts, maltodextrin 9 parts.
Preparation process is as follows:
(1) non-Leaf-feeding insects, the grains of sand, the impurity of Radix Ginseng, Rhizoma Polygonati, Poria, Radix Puerariae, Fructus Mori, Stigma Maydis, Folium Nelumbinis, Folium Ilicis, Radix Glycyrrhizae and Flos Chrysanthemi is removed, for subsequent use;
(2) according to above-mentioned proportioning, the raw material in step (1) is weighed, be crushed to 60 ~ 70 orders;
(3) water that the raw material after step (2) being processed adds 30 times of medical material amounts extracts 1 time in-0.1-35Mpa High Pressure Difference, centrifugal, collect extracting solution, 200 orders filter, and filtrate filters with 500 μm of purpose ceramic-film filters again, gained filtrate concentrates through reverse osmosis membrane, be concentrated into the half that weight is crude drug weight, anti-fatigue Chinese medicine of must refreshing oneself concentrated solution, spraying dry (air intake 175 DEG C, air-out 120 DEG C), collect spray drying powder, obtain dry powder;
(4) by step (3) gained dry powder, add according to the load weighted maltodextrin of said ratio, granulate, obtain finished product.
Embodiment 2
A Chinese medicine composition for resisting fatigue of refreshing oneself, its active component is prepared from by the raw material of following weight portion: Radix Ginseng 10 parts, Rhizoma Polygonati 1 part, 10 parts, Poria, Radix Puerariae 8 parts, Fructus Mori 20 parts, Stigma Maydis 2 parts, 20 parts, Folium Nelumbinis, Folium Ilicis 1 part, 15 parts, Radix Glycyrrhizae, Flos Chrysanthemi 2 parts, maltodextrin 1 part.
Preparation method is with embodiment 1.
Embodiment 3
A Chinese medicine composition for resisting fatigue of refreshing oneself, its active component is prepared from by the raw material of following weight portion: Radix Ginseng 5 parts, Rhizoma Polygonati 5 parts, 15 parts, Poria, Radix Puerariae 15 parts, Fructus Mori 15 parts, Stigma Maydis 12 parts, 10 parts, Folium Nelumbinis, Folium Ilicis 3 parts, 9 parts, Radix Glycyrrhizae, Flos Chrysanthemi 9 parts, maltodextrin 4 parts.
Preparation method is with embodiment 1.
Embodiment 4 is refreshed oneself the Chinese medicine composition zoopery of resisting fatigue
The Chinese medicine composition of the resisting fatigue of refreshing oneself of embodiment 3 is adopted to test swimming mice
Implement medicine
The Chinese medicine composition of the resisting fatigue of refreshing oneself of embodiment 3.
Laboratory animal
Healthy BABL/c mice, 75, at 2 monthly ages, weight 18-22g, freely drinks water, diet, and animal observation adaptation, after 5 days, is tested.Animal is divided into Normal group at random, swim matched group and anti-fatigue Chinese medicinal composition group of refreshing oneself (low dosage, middle dosage, high dose group) totally five groups.Often organize 15 animals.The crude drug dosage of anti-fatigue Chinese medicinal composition of refreshing oneself group low dosage, middle dosage, high dose group is respectively: low (1250mg/kg), in (2500mg/kg), high (5000mg/kg) dosage, every day gavage 1 time, continue 2 weeks, the distilled water of Normal group and swimming control animals gavage equivalent.
Mouse swimming test and observation index
Before formal swimming, animal swimming instruction 5 times.(1) exhausted swimming: anti-fatigue Chinese medicinal composition of refreshing oneself 3 dosage groups and swimming matched group are all in 1 gavage after 30 minutes, be placed in the swimming with a load attached to the body that swimming device starts 3% simultaneously, water temperature 30 DEG C, swimming is until power exhausts (submerged does not rise for 30 seconds).The record exhausted swimming time.(2) 90min swimming: anti-fatigue Chinese medicinal composition of refreshing oneself 3 dosage groups and swimming control animals all after last gavage 30 minutes, be placed in swimming device, water temperature 30 DEG C, swimming time is 90min simultaneously.Normal group is not swum.After swimming terminates, win eyeball of mouse blood sampling immediately, centrifuging and taking serum, measure blood sugar content and lactic acid content, blood urea nitrogen content and hepatic glycogen content.
Table 1 respectively compare (min) by the group mice exhausted swimming time
The swimming of table 2 each group mice terminates rear blood glucose, blood lactase acid, blood urea nitrogen and hepatic glycogen testing result and compares
Result
4.1 refresh oneself the impact of anti-fatigue Chinese medicinal composition on the mice exhausted swimming time
From table 1, compared with swimming matched group, the basic, normal, high dosage component of Chinese medicine composition group is other to be extended to some extent to the exhausted swimming time, and difference has significance.
4.2 refresh oneself anti-fatigue Chinese medicinal composition on mice swimming after blood glucose, blood milk surum, blood urea nitrogen, hepatic glycogen impact.Found out by table 2, compare with Normal group, swimming matched group blood glucose, hepatic glycogen content all reduce, and blood lactase acid, urea nitrogen levels raise, and difference all has significance.Compare with swimming matched group, the blood glucose regulating liver-QI glycogen levels of anti-fatigue Chinese medicinal composition of refreshing oneself group three dosage groups is gone up all to some extent, blood lactase acid and urea nitrogen levels decline to some extent, wherein, blood glucose and blood urea nitrogen change have certain measuring effect trend, and anti-fatigue Chinese medicinal composition of refreshing oneself middle and high dosage group blood sugar content is significantly higher than swimming matched group; Anti-fatigue Chinese medicinal composition high dose group blood urea nitrogen level is significantly lower than swimming matched group.Anti-fatigue Chinese medicinal composition 3 dosage group hepatic glycogen levels are all higher than swimming matched group, and difference has significance.
This experimental result shows, and uses and refreshes oneself after anti-fatigue Chinese medicinal composition, and on middle and high dosage level, animal exhausted swimming time significant prolongation, the anti-fatigue Chinese medicinal composition that shows originally to refresh oneself has antifatigue effect of refreshing oneself significantly.Simultaneously, blood glucose, the hepatic glycogen level of animal are gone up, the decomposition of body internal protein also reduces, show as the horizontal ascensional range of blood urea nitrogen to reduce, illustrate that the present invention's anti-fatigue Chinese medicinal composition of refreshing oneself has and improves necton blood glucose and Body development level, reduces the effect that body internal protein decomposes, thus the generation of effective delay fatigue.
In sum, the refresh oneself Chinese medicine composition of resisting fatigue of the present invention has the effect of resisting fatigue of refreshing oneself significantly.Embodiment 5 is refreshed oneself anti-fatigue Chinese medicinal composition contrast experiment
The Chinese medicine composition of the resisting fatigue of refreshing oneself of embodiment 3 is adopted to carry out effect contrast test
Trial drug
The Chinese medicine composition of the resisting fatigue of refreshing oneself of embodiment 3 and certain brand American Ginseng tea.
Object of study
8 week age mice 30, body weight 18-22g, random packet for certain brand American Ginseng tea group with to refresh oneself anti-fatigue Chinese medicine group, often organize 15.
Observation index: exhausted swimming time (experimental procedure is with embodiment 4), blood lactase acid and hepatic glycogen (experimental procedure is with embodiment 4).
Experimental result is in table 3.
Certain brand American Ginseng tea of table 3 (0.4ml/ only) and embodiment 3 Chinese medicine composition (0.4ml/ only) effect contrast experiment
Experimental result
By with certain brand American Ginseng tea animal effect contrast experiment, known, embodiment 3 Chinese medicine composition can extend the mice exhausted swimming time, and swimming time difference is highly significant; Blood lactase acid level obviously declines, and has significant difference; Hepatic glycogen obviously raises, and diversity is remarkable.
The above embodiment only have expressed several embodiment of the present invention, and it describes comparatively concrete and detailed, but therefore can not be interpreted as the restriction to the scope of the claims of the present invention.It should be pointed out that for the person of ordinary skill of the art, without departing from the inventive concept of the premise, can also make some distortion and improvement, these all belong to protection scope of the present invention.Therefore, the protection domain of patent of the present invention should be as the criterion with claims.
Claims (8)
1. the Chinese medicine composition of a resisting fatigue of refreshing oneself, it is characterized in that, its active component is prepared from by the raw material of following weight portion: Radix Ginseng 1 ~ 10 part, Rhizoma Polygonati 1 ~ 15 part, 10 ~ 25 parts, Poria, Radix Puerariae 8 ~ 20 parts, Fructus Mori 5 ~ 20 parts, Stigma Maydis 2 ~ 18 parts, 1 ~ 20 part, Folium Nelumbinis, Folium Ilicis 1 ~ 6 part, 3 ~ 15 parts, Radix Glycyrrhizae, Flos Chrysanthemi 2 ~ 16 parts.
2. the Chinese medicine composition of resisting fatigue of refreshing oneself according to claim 1, it is characterized in that, its active component is prepared from by the raw material of following weight portion: Radix Ginseng 3 ~ 8 parts, Rhizoma Polygonati 2 ~ 13 parts, 12 ~ 22 parts, Poria, Radix Puerariae 10 ~ 18 parts, Fructus Mori 7 ~ 18 parts, Stigma Maydis 5 ~ 15 parts, 5 ~ 15 parts, Folium Nelumbinis, Folium Ilicis 2 ~ 5 parts, 5 ~ 12 parts, Radix Glycyrrhizae, Flos Chrysanthemi 4 ~ 14 parts.
3. the Chinese medicine composition of resisting fatigue of refreshing oneself according to claim 2, it is characterized in that, its active component is prepared from by the raw material of following weight portion: Radix Ginseng 4 ~ 6 parts, Rhizoma Polygonati 4 ~ 6 parts, 14 ~ 16 parts, Poria, Radix Puerariae 14 ~ 16 parts, Fructus Mori 14 ~ 16 parts, Stigma Maydis 11 ~ 13 parts, 9 ~ 11 parts, Folium Nelumbinis, Folium Ilicis 2 ~ 4 parts, 8 ~ 10 parts, Radix Glycyrrhizae, Flos Chrysanthemi 8 ~ 10 parts.
4. a preparation method for the Chinese medicine composition of the resisting fatigue of refreshing oneself described in any one of claims 1 to 3, is characterized in that, comprise the steps:
(1) non-Leaf-feeding insects, the grains of sand, the impurity of Radix Ginseng, Rhizoma Polygonati, Poria, Radix Puerariae, Fructus Mori, Stigma Maydis, Folium Nelumbinis, Folium Ilicis, Radix Glycyrrhizae and Flos Chrysanthemi is removed, for subsequent use;
(2) according to the proportioning described in any one of claims 1 to 3, the raw material in step (1) is weighed, be crushed to 60 ~ 100 orders;
(3) extract with efficient high-pressure difference low temperature continous way extracting and developing concentration technique, filter with concentrated;
(4) dry to the material spray concentrated, receive dry powder.
5. the preparation method of the Chinese medicine composition of resisting fatigue of refreshing oneself according to claim 4, is characterized in that, described preparation method also comprises described dry powder is prepared into granule, tablet or powder.
6. the preparation method of the Chinese medicine composition of resisting fatigue of refreshing oneself according to claim 5, is characterized in that, described granule is by step (4) gained dry powder, adds maltodextrin, granulates, to obtain final product.
7. the Chinese medicine composition as described in any one of claims 1 to 3 is preparing the application of refreshing oneself in the health food of resisting fatigue.
8. a health food for resisting fatigue of refreshing oneself, is characterized in that, described health food includes the Chinese medicine composition of the resisting fatigue of refreshing oneself as described in any one of claims 1 to 3.
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Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN106106925A (en) * | 2016-06-28 | 2016-11-16 | 禹州市鼎信中药科技有限公司 | A kind of Radix Ginseng agate click alternative tea formula and production technology thereof |
| CN106581519A (en) * | 2017-02-21 | 2017-04-26 | 上海世道健康科技有限公司 | Traditional Chinese medicinal composition for treating chronic fatigue syndrome, and preparation method thereof |
| CN106857986A (en) * | 2017-02-20 | 2017-06-20 | 哈尔滨凝昇科技有限公司 | A kind of health preserving tea and preparation method thereof |
| CN107865164A (en) * | 2017-11-28 | 2018-04-03 | 丁强 | One seed ginseng energy health preserving tea and its preparation technology |
| CN113575723A (en) * | 2021-07-29 | 2021-11-02 | 山西振东五和健康科技股份有限公司 | Red bean and coix seed instant tea and preparation method and application thereof |
| CN113786453A (en) * | 2021-06-25 | 2021-12-14 | 广州泽力医药科技有限公司 | Preparation method of polygonatum sibiricum extract rich in polygonatum sibiricum polysaccharide and various active ingredients |
| CN114533824A (en) * | 2022-01-20 | 2022-05-27 | 合肥职业技术学院 | Anti-fatigue medicinal and edible composition and preparation method thereof |
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| CN102335335A (en) * | 2010-07-27 | 2012-02-01 | 张立中 | Traditional Chinese medicine preparation with effects of health care and physical fatigue alleviation |
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Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106106925A (en) * | 2016-06-28 | 2016-11-16 | 禹州市鼎信中药科技有限公司 | A kind of Radix Ginseng agate click alternative tea formula and production technology thereof |
| CN106857986A (en) * | 2017-02-20 | 2017-06-20 | 哈尔滨凝昇科技有限公司 | A kind of health preserving tea and preparation method thereof |
| CN106581519A (en) * | 2017-02-21 | 2017-04-26 | 上海世道健康科技有限公司 | Traditional Chinese medicinal composition for treating chronic fatigue syndrome, and preparation method thereof |
| CN107865164A (en) * | 2017-11-28 | 2018-04-03 | 丁强 | One seed ginseng energy health preserving tea and its preparation technology |
| CN113786453A (en) * | 2021-06-25 | 2021-12-14 | 广州泽力医药科技有限公司 | Preparation method of polygonatum sibiricum extract rich in polygonatum sibiricum polysaccharide and various active ingredients |
| CN113786453B (en) * | 2021-06-25 | 2022-07-12 | 广州泽力医药科技有限公司 | Preparation method of polygonatum sibiricum extract rich in polygonatum sibiricum polysaccharide and various active ingredients |
| CN113575723A (en) * | 2021-07-29 | 2021-11-02 | 山西振东五和健康科技股份有限公司 | Red bean and coix seed instant tea and preparation method and application thereof |
| CN114533824A (en) * | 2022-01-20 | 2022-05-27 | 合肥职业技术学院 | Anti-fatigue medicinal and edible composition and preparation method thereof |
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