CN104666996B - Refresh oneself antifatigue Chinese medicine composition and preparation method and application - Google Patents
Refresh oneself antifatigue Chinese medicine composition and preparation method and application Download PDFInfo
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- CN104666996B CN104666996B CN201510067225.3A CN201510067225A CN104666996B CN 104666996 B CN104666996 B CN 104666996B CN 201510067225 A CN201510067225 A CN 201510067225A CN 104666996 B CN104666996 B CN 104666996B
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Abstract
The invention discloses a kind of antifatigue Chinese medicine composition and preparation method and application of refreshing oneself, the active component for refreshing oneself antifatigue Chinese medicine composition is prepared by the raw material of following parts by weight：1~10 part of ginseng, 1~15 part of sealwort, 10~25 parts of Poria cocos, 8~20 parts of the root of kudzu vine, 5~20 parts of mulberries, 2~18 parts of corn stigma, 1~20 part of lotus leaf, 1~6 part of Ilex Latifolia Thunb, 3~15 parts of radix glycyrrhizae, 2~16 parts of chrysanthemum.The selected medicine and food raw materials of Chinese medicine composition of the present invention, good mouthfeel, refreshing effect are notable, and will not bring any toxic side effect, safety, are easy to be widely popularized.
Description
Technical field
The present invention relates to field of health care food, more particularly to a kind of antifatigue Chinese medicine composition and preparation method thereof of refreshing oneself
With application.
Background technology
Modern often occurs that spirit is tired with brain for a long time in face of the work of high challenge in addition because rhythm of life is fast
It is exhausted, listless, brains is confused swollen, slow in reacting, whenever now, some can pass through coffee for drinking beverage, strong tea, refrigerant food
Etc. refreshing oneself.Contain caffeine in coffee or strong tea, the most important effect of caffeine is stimulating central nervous system, can improve brain
The power to think and dispelling fatigue be the so-called function refreshed oneself, but while refresh oneself, can make one in continuing excited state, from
And easily ignore the fatigue of itself, cause physical efficiency to overdraw.Drinking a large amount of coffees addicted can also cause habituation, and the time is once to desired
Have a drink supplement, otherwise will be dog-tired listless.Refrigerant food can give people of short duration refrigerant sense, can also allow people to wake up
Brain, straightforward sensation is produced, eliminate tired meaning.Shortcoming is, it is impossible to solves feeling bad after feeling sleepy, people is more clear-headed, but brain is also
It is very tried out, it is difficult to the sensation received.
It is therefore desirable in view of the above-mentioned problems, develop a kind of existing anti-fatigue effect of refreshing oneself, but it is safe and free of toxic and side effects
Product.
The content of the invention
Based on this, it is necessary in view of the above-mentioned problems, providing a kind of antifatigue Chinese medicine composition and preparation method thereof of refreshing oneself
With application.
The concrete technical scheme for solving above-mentioned technical problem is as follows：
A kind of antifatigue Chinese medicine composition of refreshing oneself, its active component are prepared by the raw material of following parts by weight：People
1~10 part of ginseng, 1~15 part of sealwort, 10~25 parts of Poria cocos, 8~20 parts of the root of kudzu vine, 5~20 parts of mulberries, 2~18 parts of corn stigma, lotus leaf
1~20 part, 1~6 part of Ilex Latifolia Thunb, 3~15 parts of radix glycyrrhizae, 2~16 parts of chrysanthemum.
In wherein some embodiments, its active component is prepared by the raw material of following parts by weight：3~8 parts of ginseng,
2~13 parts of sealwort, 12~22 parts of Poria cocos, 10~18 parts of the root of kudzu vine, 7~18 parts of mulberries, 5~15 parts of corn stigma, 5~15 parts of lotus leaf,
2~5 parts of Ilex Latifolia Thunb, 5~12 parts of radix glycyrrhizae, 4~14 parts of chrysanthemum.
In wherein some embodiments, its active component is prepared by the raw material of following parts by weight：4~6 parts of ginseng,
4~6 parts of sealwort, 14~16 parts of Poria cocos, 14~16 parts of the root of kudzu vine, 14~16 parts of mulberries, 11~13 parts of corn stigma, 9~11 parts of lotus leaf,
2~4 parts of Ilex Latifolia Thunb, 8~10 parts of radix glycyrrhizae, 8~10 parts of chrysanthemum.
Ginseng：Sweet, slight bitter, tepor；Reinforce vital energy, veins takes off admittedly, reinforce the spleen to benefit the lung, blood-nourishing of promoting the production of body fluid, tranquilize the mind and promote the intelligence；
Sealwort：It is sweet, put down；Boosting qi and nourishing yin, invigorating the spleen, moistening lung, kidney-nourishing；For deficiency of spleen-QI and stomach-QI, fatigue and asthenia；
Poria cocos：It is sweet, it is light, put down；Clearing damp and promoting diuresis, invigorating the spleen, calming heart；
The root of kudzu vine：It is sweet, it is pungent, it is cool；Expelling pathogenic factors from muscles and skin is brought down a fever, and is promoted the production of body fluid to quench thirst, Shengyang Zhixie；
Mulberries：It is sweet, acid, tremble with fear；Nourishing yin and supplementing blood, fluid dryness；
Corn stigma：It is sweet, light, flat, inducing diuresis to remove edema, soothing the liver cholagogic；
Lotus leaf：Hardship, put down；Clearing away summer-heat and eliminating dampness, sending up the lucid yang, cooling blood and hemostasis；
Chrysanthemum：It is sweet, it is bitter, it is slightly cold；Fresh breeze heat-clearing, flat liver improving eyesight are clearing heat and detoxicating；
The present composition adds ginseng, sealwort is monarch drug in a prescription, is supported with tonifying Qi according to the theory of Chinese medicine " monarch "
The moon, invigorating the spleen intelligence development it；The addition root of kudzu vine, mulberries are ministerial drug, have the effect of nourishing yin and supplementing blood, fluid dryness, can resist tired tired tired, energy
Reduce the dry property of ginseng；It is adjutant to add Poria cocos, corn stigma, lotus leaf, has the effect of heat-clearing, clearing damp and promoting diuresis；Addition Ilex Latifolia Thunb,
Chrysanthemum, radix glycyrrhizae have the effect of dispelling wind heat, improving eyesight to make medicine.
The present invention also provides a kind of preparation method of above-mentioned antifatigue Chinese medicine composition of refreshing oneself, and comprises the following steps：
(1) the non-food of ginseng, sealwort, Poria cocos, the root of kudzu vine, mulberries, corn stigma, lotus leaf, Ilex Latifolia Thunb, radix glycyrrhizae and chrysanthemum is removed
It is standby with position, the grains of sand, impurity；
(2) weighed according to above-mentioned with the raw material compared in step (1), be crushed to 60~100 mesh；
(3) extracted with efficient high-pressure difference low temperature continous way extracting and developing concentration technique, filter and concentrate；
(4) material spray concentrated is dried, receives dry powder.
In wherein some embodiments, the preparation method also includes the dry powder to be prepared into granule, tablet or powder
Agent.
In wherein some embodiments, the granule is by dry powder obtained by step (4), adds maltodextrin, is pelletized, i.e.,
.
The present invention also provides a kind of application of above-mentioned Chinese medicine composition in antifatigue health food of refreshing oneself is prepared.
The present invention also provides a kind of antifatigue health food of refreshing oneself, the health food include it is above-mentioned refresh oneself it is antifatigue
Chinese medicine composition.
The present invention compared to prior art the advantages of and have the beneficial effect that：
The present invention is largely tested and studied through inventor, selected medicine and food raw materials, has drawn antifatigue effect of refreshing oneself
Chinese medicine composition, and its optimum proportioning is determined, gained Chinese medicine composition can significantly improve people's neurolysis, be beaten without essence
Adopt, brains dusk is swollen, unresponsive symptom, and good mouthfeel, will not bring any toxic side effect, safety, be easy to be widely popularized.
Embodiment
Raw materials used in embodiment is commercially available convenient source.
Below with reference to specific embodiment, the present invention will be further described.
Embodiment 1
A kind of antifatigue Chinese medicine composition of refreshing oneself, its active component are prepared by the raw material of following parts by weight：People
Ginseng 1 part, 15 parts of sealwort, 25 parts of Poria cocos, 8 parts of the root of kudzu vine, 5 parts of mulberries, 18 parts of corn stigma, 1 part of lotus leaf, 6 parts of Ilex Latifolia Thunb, 3 parts of radix glycyrrhizae,
16 parts of chrysanthemum, 9 parts of maltodextrin.
Preparation process is as follows：
(1) the non-food of ginseng, sealwort, Poria cocos, the root of kudzu vine, mulberries, corn stigma, lotus leaf, Ilex Latifolia Thunb, radix glycyrrhizae and chrysanthemum is removed
It is standby with position, the grains of sand, impurity；
(2) weighed according to above-mentioned with the raw material compared in step (1), be crushed to 60~70 mesh；
(3) water that the raw material after step (2) processing is added into 30 times of medicinal material amounts extracts 1 time in -0.1-35Mpa High Pressure Differences, from
The heart, extract solution, the filtration of 200 mesh are collected, filtrate is filtered with 500 μm of purpose ceramic-film filters again, and gained filtrate concentrates through reverse osmosis membrane,
The half that weight is crude drug weight is concentrated into, the anti-fatigue traditional Chinese that must refresh oneself concentrate, is spray-dried (175 DEG C of air intake, air-out
120 DEG C), spray dried powder is collected, obtains dry powder；
(4) by dry powder obtained by step (3), add according to the load weighted maltodextrin of said ratio, granulation, obtain finished product.
Embodiment 2
A kind of antifatigue Chinese medicine composition of refreshing oneself, its active component are prepared by the raw material of following parts by weight：People
10 parts of ginseng, 1 part of sealwort, 10 parts of Poria cocos, 8 parts of the root of kudzu vine, 20 parts of mulberries, 2 parts of corn stigma, 20 parts of lotus leaf, 1 part of Ilex Latifolia Thunb, radix glycyrrhizae 15
Part, 2 parts of chrysanthemum, 1 part of maltodextrin.
Preparation method is the same as embodiment 1.
Embodiment 3
A kind of antifatigue Chinese medicine composition of refreshing oneself, its active component are prepared by the raw material of following parts by weight：People
5 parts of ginseng, 5 parts of sealwort, 15 parts of Poria cocos, 15 parts of the root of kudzu vine, 15 parts of mulberries, 12 parts of corn stigma, 10 parts of lotus leaf, 3 parts of Ilex Latifolia Thunb, radix glycyrrhizae 9
Part, 9 parts of chrysanthemum, 4 parts of maltodextrin.
Preparation method is the same as embodiment 1.
The Chinese medicine composition zoopery that embodiment 4 is refreshed oneself antifatigue
Swimming mouse is tested using the antifatigue Chinese medicine composition of refreshing oneself of embodiment 3
Implement medicine
The antifatigue Chinese medicine composition of refreshing oneself of embodiment 3.
Experimental animal
Healthy BABL/c mouse, 75,2 monthly ages, weight 18-22g, free water, diet, animal observation adaptation 5 days
Afterwards, tested.Animal is randomly divided into Normal group, swim control group and anti-fatigue Chinese medicinal composition group of refreshing oneself (low dosage,
Middle dosage, high dose group) totally five groups.Every group of 15 animals.Anti-fatigue Chinese medicinal composition of refreshing oneself group low dosage, middle dosage, high agent
The crude drug dosage of amount group is respectively：Low (1250mg/kg), in (2500mg/kg), high (5000mg/kg) dosage, daily gavage
1 time, continue 2 weeks, the distilled water of Normal group and swimming control animals gavage equivalent.
Mouse swimming test and observation index
Before formal swimming, animal swimming instruction 5 times.(1) exhausted swimming：3 dosage of anti-fatigue Chinese medicinal composition of refreshing oneself
Group and swimming control group after 1 gavage 30 minutes, while be placed in swimming device start 3% swimming with a load attached to the body, water temperature 30
DEG C, swimming is until power exhausts (submerged does not rise for 30 seconds).Record the exhausted swimming time.(2) 90min swims：Refresh oneself antifatigue
3 dosage groups of Chinese medicine composition and swimming control animals are placed in swimming device, water 30 minutes after last gavage
30 DEG C of temperature, swimming time 90min.Normal group is not swum.After swimming terminates, eyeball of mouse blood sampling, centrifugation are won immediately
Serum is taken, determines blood-sugar content and lactic acid content, blood urea nitrogen content and hepatic glycogen content.
The each group mouse exhausted swimming time of table 1 compares (min)
The swimming of each group mouse of table 2 terminates rear blood glucose, blood lactase acid, blood urea nitrogen and hepatic glycogen testing result and compared
As a result
4.1 refresh oneself influence of the anti-fatigue Chinese medicinal composition to the mouse exhausted swimming time
From table 1, compared with control group of swimming, the basic, normal, high dosage group of Chinese medicine composition group is respectively to exhausted swimming
Time has extended, and difference has conspicuousness.
4.2 refresh oneself anti-fatigue Chinese medicinal composition to mouse swim after blood glucose, blood whey, blood urea nitrogen, hepatic glycogen influence.
Found out by table 2, compared with Normal group, swimming control group blood glucose, hepatic glycogen content reduce, blood lactase acid, urea nitrogen levels
Rise, difference have conspicuousness.Compared with control group of swimming, the blood glucose of anti-fatigue Chinese medicinal composition of refreshing oneself three dosage groups of group and
Hepatic glycogen level has been gone up, and blood lactase acid has declined with urea nitrogen levels, wherein, blood glucose and urea nitrogen change have it is certain
Measuring effect trend, the middle and high dosage group blood-sugar content of anti-fatigue Chinese medicinal composition of refreshing oneself are significantly higher than swimming control group；It is antifatigue
Chinese medicine composition high dose group blood urea nitrogen is horizontal to be substantially less than swimming control group.3 dosage group livers of anti-fatigue Chinese medicinal composition
Glycogen levels are above control group of swimming, and difference has conspicuousness.
This experimental result shows that after anti-fatigue Chinese medicinal composition of refreshing oneself, on middle and high dosage level, animal power exhausts
Property swimming time significantly extend, the anti-fatigue Chinese medicinal composition that shows originally to refresh oneself has significant antifatigue effect of refreshing oneself.It is meanwhile dynamic
The horizontal rise of blood glucose, hepatic glycogen of thing, vivo protein are decomposed and also reduced, and are shown as the horizontal ascensional range of blood urea nitrogen and are reduced,
Illustrate that the present invention refreshes oneself anti-fatigue Chinese medicinal composition with raising necton blood glucose and Body development level, reduction vivo protein
The effect of decomposition, so as to the generation of effective delay fatigue.
In summary, the present invention refreshes oneself antifatigue Chinese medicine composition with antifatigue effect of significantly refreshing oneself.Implement
Example 5 is refreshed oneself anti-fatigue Chinese medicinal composition contrast experiment
Effect contrast test is carried out using the antifatigue Chinese medicine composition of refreshing oneself of embodiment 3
Trial drug
Refresh oneself antifatigue Chinese medicine composition and certain brand Amercian ginseng tea of embodiment 3.
Research object
8 week old mouse 30, body weight 18-22g, certain brand Amercian ginseng tea group and anti-fatigue traditional Chinese of refreshing oneself are grouped at random
Group, every group 15.
Observation index：(experimental procedure is same for exhausted swimming time (experimental procedure is with embodiment 4), blood lactase acid and hepatic glycogen
Embodiment 4).
Experimental result is shown in Table 3.
Certain the brand Amercian ginseng tea (0.4ml/ is only) of table 3 and the Chinese medicine composition of embodiment 3 (0.4ml/ is only) effect contrast experiment
Experimental result
By with certain brand Amercian ginseng tea animal effect contrast experiment, it is known that, the Chinese medicine composition of embodiment 3 can extend mouse
Exhausted swimming time, swimming time difference are in highly significant；Blood lactase acid level is decreased obviously, and has significant difference；Glycogen
Former significantly raised, otherness is notable.
Embodiment described above only expresses the several embodiments of the present invention, and its description is more specific and detailed, but simultaneously
Therefore the limitation to the scope of the claims of the present invention can not be interpreted as.It should be pointed out that for one of ordinary skill in the art
For, without departing from the inventive concept of the premise, various modifications and improvements can be made, these belong to the guarantor of the present invention
Protect scope.Therefore, the protection domain of patent of the present invention should be determined by the appended claims.
Claims (8)
1. a kind of antifatigue Chinese medicine composition of refreshing oneself, it is characterised in that its active component is by the raw material system of following parts by weight
It is standby to form：1~10 part of ginseng, 1~15 part of sealwort, 10~25 parts of Poria cocos, 8~20 parts of the root of kudzu vine, 5~20 parts of mulberries, corn stigma 2~
18 parts, 1~20 part of lotus leaf, 1~6 part of Ilex Latifolia Thunb, 3~15 parts of radix glycyrrhizae, 2~16 parts of chrysanthemum.
2. antifatigue Chinese medicine composition according to claim 1 of refreshing oneself, it is characterised in that its active component is by following
The raw material of parts by weight is prepared：3~8 parts of ginseng, 2~13 parts of sealwort, 12~22 parts of Poria cocos, 10~18 parts of the root of kudzu vine, mulberries 7~
18 parts, 5~15 parts of corn stigma, 5~15 parts of lotus leaf, 2~5 parts of Ilex Latifolia Thunb, 5~12 parts of radix glycyrrhizae, 4~14 parts of chrysanthemum.
3. antifatigue Chinese medicine composition according to claim 2 of refreshing oneself, it is characterised in that its active component is by following
The raw material of parts by weight is prepared：4~6 parts of ginseng, 4~6 parts of sealwort, 14~16 parts of Poria cocos, 14~16 parts of the root of kudzu vine, mulberries 14~
16 parts, 11~13 parts of corn stigma, 9~11 parts of lotus leaf, 2~4 parts of Ilex Latifolia Thunb, 8~10 parts of radix glycyrrhizae, 8~10 parts of chrysanthemum.
4. a kind of preparation method of the antifatigue Chinese medicine composition of refreshing oneself described in any one of claims 1 to 3, its feature exist
In comprising the following steps：
(1) the non-edible portion of ginseng, sealwort, Poria cocos, the root of kudzu vine, mulberries, corn stigma, lotus leaf, Ilex Latifolia Thunb, radix glycyrrhizae and chrysanthemum is removed
Position, the grains of sand, impurity, it is standby；
(2) being weighed according to described in any one of claims 1 to 3 with the raw material compared in step (1), it is crushed to 60~
100 mesh；
(3) extracted with efficient high-pressure difference low temperature continous way extracting and developing concentration technique, filter and concentrate；
(4) material spray concentrated is dried, receives dry powder.
5. the preparation method of antifatigue Chinese medicine composition according to claim 4 of refreshing oneself, it is characterised in that the preparation
Method also includes the dry powder to be prepared into granule, tablet or pulvis.
6. the preparation method of antifatigue Chinese medicine composition according to claim 5 of refreshing oneself, it is characterised in that the particle
Agent is by dry powder obtained by step (4), adds maltodextrin, granulation, produces.
7. application of the Chinese medicine composition in antifatigue health food of refreshing oneself is prepared as described in any one of claims 1 to 3.
8. a kind of antifatigue health food of refreshing oneself, it is characterised in that the health food includes appointing just like claims 1 to 3
Antifatigue Chinese medicine composition of refreshing oneself described in one.
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Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106106925A (en) * | 2016-06-28 | 2016-11-16 | 禹州市鼎信中药科技有限公司 | A kind of Radix Ginseng agate click alternative tea formula and production technology thereof |
| CN106857986A (en) * | 2017-02-20 | 2017-06-20 | 哈尔滨凝昇科技有限公司 | A kind of health preserving tea and preparation method thereof |
| CN106581519A (en) * | 2017-02-21 | 2017-04-26 | 上海世道健康科技有限公司 | Traditional Chinese medicinal composition for treating chronic fatigue syndrome, and preparation method thereof |
| CN107865164A (en) * | 2017-11-28 | 2018-04-03 | 丁强 | One seed ginseng energy health preserving tea and its preparation technology |
| CN113786453B (en) * | 2021-06-25 | 2022-07-12 | 广州泽力医药科技有限公司 | Preparation method of polygonatum sibiricum extract rich in polygonatum sibiricum polysaccharide and various active ingredients |
| CN113575723A (en) * | 2021-07-29 | 2021-11-02 | 山西振东五和健康科技股份有限公司 | Red bean and coix seed instant tea and preparation method and application thereof |
| CN114533824A (en) * | 2022-01-20 | 2022-05-27 | 合肥职业技术学院 | Anti-fatigue medicinal and edible composition and preparation method thereof |
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| CN102335335A (en) * | 2010-07-27 | 2012-02-01 | 张立中 | Traditional Chinese medicine preparation with effects of health care and physical fatigue alleviation |
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| CN102335335A (en) * | 2010-07-27 | 2012-02-01 | 张立中 | Traditional Chinese medicine preparation with effects of health care and physical fatigue alleviation |
Non-Patent Citations (1)
| Title |
|---|
| 抗疲劳防治亚健康中药整理与研究;周宝宽;《中华中医药学刊》;20080131;第26卷(第1期);第193-195页 * |
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