CN104645342A - Processing method of periplaneta americana without peculiar taste - Google Patents
Processing method of periplaneta americana without peculiar taste Download PDFInfo
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- CN104645342A CN104645342A CN201510096341.8A CN201510096341A CN104645342A CN 104645342 A CN104645342 A CN 104645342A CN 201510096341 A CN201510096341 A CN 201510096341A CN 104645342 A CN104645342 A CN 104645342A
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- periplaneta americana
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Abstract
The invention provides a processing method of periplaneta americana without peculiar taste. The method is characterized by adding milk in the processing process. The periplaneta americana processed by the method has the advantages of little peculiar taste in oral taking, good mouthfeel, good curative effect and high compliance of patients.
Description
Invention field
The present invention relates to medicine, particularly the processing method of a kind of free from extraneous odour periplaneta americana, belong to medical art.
Background technology
Periplaneta americana belongs to Insecta, Blattaria Blattidae animal, and " Blatta seu periplaneta " is loaded in Shennong's Herbal for its popular name, the beginning of being used as medicine, and is listed in middle product, meaning " taste: salty, cold; Control: the hard cold and heat of Blood stasis, removing mass are poly-, laryngopharynx numbness, endogenous cold loss of fecundity ".Now there are some researches show, it is active that the large sickle in America has good tissue repair to various traumatic surface and digestive tract ulcer; There is boosting, improve blood circulation, antibacterial, antiviral, antitumor, enhancing immunologic function activity.
The processing method of the large sickle in prior art America, is to kill by soak with ethanol after catching or boiling water scalds dead, dries or 60 DEG C of oven dry.With the large sickle in America of prior art processing, the medicine made, particularly powder, when taking, abnormal flavour is extra heavy, and mouthfeel is very poor, directly affects the compliance of patient.Over the past thousands of years, people always encourage patient medication with " good medicine tastes bitter ".But the reality of society is, people hang back in face of good medicine bitter to the taste, even talk " hardship " complexion changed.To the medicine that periplaneta americana is made, particularly powder, " keeping someone at a respectful distance ".Under the former medicable prerequisite of medicine keeping periplaneta americana to make, by safety, easy, economic, feasible processing method, it is very necessary and urgent for realizing " good medicine is not bitter ".
Summary of the invention
The object of this invention is to provide the processing method of a kind of free from extraneous odour periplaneta americana.
Object of the present invention is achieved through the following technical solutions:
A processing method for free from extraneous odour periplaneta americana, is characterized in that: the course of processing adds milk.
The processing method of a kind of free from extraneous odour periplaneta americana of the present invention, is characterized in that: the amount adding milk is fresh periplaneta americana by weight: milk=more than 1:0.5.
The processing method of a kind of free from extraneous odour periplaneta americana of the present invention, is characterized in that: periplaneta americana soak with ethanol of living is killed or boiling water scalds dead, dry after adding milk.
The processing method of a kind of free from extraneous odour periplaneta americana of the present invention, is characterized in that: the periplaneta americana that lives puts into the 1-10 milk that boils doubly by weight, dry.
The processing method of a kind of free from extraneous odour periplaneta americana of the present invention, is characterized in that: dry periplaneta americana is dry after adding milk.
The processing method of a kind of free from extraneous odour periplaneta americana of the present invention, is characterized in that: dry periplaneta americana is dry after adding milk, and the amount adding milk is dry periplaneta americana by weight: milk=more than 1:1.
The processing method of a kind of free from extraneous odour periplaneta americana of the present invention, is characterized in that: dry periplaneta americana adds milk powder, mixing, pulverizes; The amount adding milk powder is dry periplaneta americana by weight: milk powder=1:0.1-3.
So far the present invention is completed.The periplaneta americana of the present invention's processing, good effect, oral abnormal flavour is little, and mouthfeel is good, and the compliance of patient is high.
Below by test example, usefulness of the present invention is described.Test example is intended to further illustrate beneficial effect of the present invention below, but not restriction of the present invention.
Through test of many times, we find that the larger effect improving periplaneta americana abnormal flavour of milk consumption is more obvious, when milk consumption is less than 0.5 times of fresh periplaneta americana by weight, mouthfeel is improved not obvious, therefore, mouthfeel test example milk consumption is 1 times of periplaneta americana by weight, and the actual effect that technical scheme of the present invention is brought is described.
The periplaneta americana mouthfeel of test example one, different processing methods compares
1, by same mass products periplaneta americana, process by the following method.
1) dry: kill by soak with ethanol, less than 60 DEG C oven dry, pulverize;
2) oven dry with milk: kill by soak with ethanol, adds the milk of 1 ︰ 1 by weight, less than 60 DEG C oven dry, pulverizes.
2, mouthfeel evaluation is made up of 10 people and appraises group through discussion, everyone is the warm water for oral use oven dry of mixing well and the periplaneta americana powder that adds milk post-drying respectively, evaluates the mouthfeel misty idea such as " free from extraneous odour ", " abnormal flavour is little ", " can accept ", " abnormal flavour is large ", " abnormal flavour is very large ".Evaluation result is in table 1:
The periplaneta americana mouthfeel of table 1 distinct methods processing compares
| Free from extraneous odour | Abnormal flavour is little | Can accept | Abnormal flavour is large | Abnormal flavour is very large | |
| Oven dry with milk | 2 people | 3 people | 5 people | ||
| Dry | 2 people | 8 people |
Result shows, and the periplaneta americana course of processing adds milk, and oral abnormal flavour is little, and mouthfeel is good.
Test example two, different processing methods compare the protective effect that ethanol causes gastric mucosa damage.
1, the same a collection of periplaneta americana will caught, processes by the following method.
1) lyophilizing: kill by soak with ethanol, lyophilizing, pulverizes;
2) lyophilizing after adding milk: kill by soak with ethanol, adds the milk of 1 ︰ 2, lyophilizing by weight, pulverizes.
2, to ethanol cause gastric mucosa damage protective effect compare
Choose healthy SD rat, male and female half and half, weight 180-220g, be divided into lyophilizing group, lyophilizing group with milk, matched group at random, often organize 10, every day gastric infusion 1 time, 1 2mg/kg(solid contents after testing milk lyophilizing is 12%, the periplaneta americana of lyophilizing with milk is in sterling), continuous 7 days, matched group gave equivalent distilled water.Before experiment, the first fasting 48h of rat, freely drinks water, after last administration, 1h every rat oral gavage dehydrated alcohol 1mL/ only, take off cervical vertebra after 1h and put to death animal, close cardia by clip, inject 1% formaldehyde 5mL from pylorus, folder closes pylorus again, put into 1% formalin and fix 10min, cut off coat of the stomach along greater gastric curvature, measure damaged length, as gastric mucosal damage index, and suppression ratio is calculated using damaged length (width is greater than 1 mm to be doubled) summation.
Suppression ratio (%)=(matched group ulcer index one administration group ulcer index) ÷ matched group ulcer index × 100%.The results are shown in Table 2.
Table 2 different processing methods compares the protective effect that ethanol causes gastric mucosa damage
| Group | Dosage | Gastric mucosal damage index (mm) | Suppression ratio (%) |
| Matched group | 102.3±12.8 | ||
| Lyophilizing group | 2mg/kg | 63.4±16.7 | 38.03 |
| Add milk lyophilizing group | 2mg/kg | 54.8±17.2 | 46.43 |
Result shows, the periplaneta americana of lyophilizing after adding milk is better than the periplaneta americana of lyophilizing to the protective effect that ethanol causes gastric mucosa damage, illustrates that the periplaneta americana course of processing adds milk, good effect.
The periplaneta americana liver protective effect of test example three, distinct methods processing compares
1, the same a collection of periplaneta americana will caught, processes by the following method.
1) dry: scald with boiling water dead, less than 60 DEG C oven dry, pulverize;
2) milk post-drying is added: scald with boiling water dead, add the milk of 1 ︰ 0.5 by weight, less than 60 DEG C oven dry, pulverize.
2, CCl is adopted
4the impact test of caused Liver Damage in Rats.
The healthy SD rat of body weight 180-220g, is divided into oven dry group at random, adds milk post-drying group, matched group, often organizes 10; Contrast with test group in experiment the 1st, 5 days subcutaneous injection 50%CCl
4vegetable oil suspension 5mL/kg, from experiment to start day respectively every day gastric infusion 1 time, 1 3g/kg(adds the periplaneta americana of lyophilizing after milk in sterling), matched group gives equal-volume distilled water, continuous 9 days, drug withdrawal 24 hours eye sockets got blood, survey serum glutamic pyruvic transminase with reitman-frankel method.The results are shown in Table 3.
Table 3 different processing methods is to CCl
4the impact of caused hepatic injury rat blood serum glutamate pyruvate transaminase
| Group | Dosage (g/kg) | Glutamate pyruvate transaminase in serum |
| Matched group | 363.4±127.5 | |
| Oven dry group | 3 | 175.6±113.9 |
| Add milk post-drying group | 3 | 119.7±101.4 |
Result shows, adds the periplaneta americana of milk post-drying to rat CCl
4the protective effect of caused hepatic injury, higher than the periplaneta americana group of drying, illustrates that the periplaneta americana course of processing adds milk, good effect.
The periplaneta americana anticancer effect of test example four, different processing methods compares
1, the same a collection of periplaneta americana will caught, processes by the following method.
1) lyophilizing: kill by soak with ethanol, lyophilizing, pulverizes;
2) lyophilizing after adding milk: kill by soak with ethanol, adds the milk of 1 ︰ 3, lyophilizing by weight, pulverizes.
2, the periplaneta americana of different processing methods anti-human lung source adenocarcinoma cell SPCA-1 effectiveness comparison.
1) prepare the periplaneta americana powder that American-cockroach-extract gets different processing methods respectively, respectively decoct with water twice, add water 8 times amount for the first time, decocts 2 hours, add water 8 times amount for the second time, decocts 1 hour, merges medicinal liquid, medicinal liquid filters, and get filtrate, being concentrated into relative density is 1.10(60 DEG C) time, adding ethanol makes alcohol content reach 75%, precipitation, leaves standstill 36 hours, Aspirate supernatant, reclaims ethanol, concentrated, dry, pulverize, obtain the American-cockroach-extract of different processing methods.
2) tumor cell line people lung source adenocarcinoma cell SPCA-1, uses RPMI-1649 culture fluid, 37 DEG C, 5%CO2, and relative humidity 100% is cultivated, and attached cell 0.25% trypsinization goes down to posterity.
3) method MTT colorimetric method for determining extract is to the inhibitory action of growth of tumour cell.To take the logarithm trophophase cell, be mixed with cell suspension with fresh RPMI-1640 culture fluid, suspension cell 1 × 105/ml attached cell 0.8 × 105/ml.Suspension cell is inoculated in after adding variable concentrations Experimental agents respectively in 96 well culture plates; Attached cell is first inoculated in 96 well culture plates, adds variable concentrations Experimental agents respectively after every hole 90 μ l24h.Final volume is every hole 100 μ l and often group establishes 3 parallel holes, grouping: by reagent group (culture fluid+cell suspension+variable concentrations is by reagent), negative control group (culture fluid+cell suspension), medicine color comparator group (culture fluid+variable concentrations is by reagent), blank group (culture fluid+normal saline).Tested concentration is followed successively by 10 μ g/ml, 30 μ g/ml, 50 μ g/ml.Put 37 DEG C, after cultivating 72h in 5%CO2 incubator, after adding MTT solution 10 μ l concussion mixing to every hole, continue to cultivate 4h, add SDS90 μ l to stop cultivating, 37 DEG C are spent the night, and then on micro oscillator, shake 10min under room temperature, microplate reader measures the absorbance (OD value) at 570nm wavelength place, experiment repetition 3 times.
Calculate growth inhibition ratio as follows:
Growth inhibition ratio (%)=(N group OD average-B organizes OD average)-(T group OD average-TC organizes OD average)/N group OD average-B organizes OD average × 100%.
4) suppression ratio the results are shown in Table 4.
Table 4 different processing methods is to the suppression ratio results contrast of SPCA-1
| Suppression ratio (%) | 10（μg/ml） | 30（μg/ml） | 50（μg/ml） |
| Lyophilizing | 62.45 | 78.31 | 82.94 |
| Add lyophilizing after milk | 65.47 | 83.59 | 93.25 |
Result shows, the periplaneta americana adding lyophilizing after milk higher than lyophilizing, illustrates that the periplaneta americana course of processing adds milk, good effect to people's lung source adenocarcinoma cell SPCA-1 inhibitory action.
Detailed description of the invention
embodiment 1
Periplaneta americana soak with ethanol of living is killed, and weighing is 2.5kg, adds milk 1.25kg, less than 60 DEG C oven dry.
embodiment 2
Periplaneta americana boiling water of living scalds dead, and weighing is 3kg, adds milk 30kg, less than 60 DEG C oven dry.
embodiment 3
3kg lives periplaneta americana, puts into the 5kg milk that boils and scalds dead, put in freeze dryer, be refrigerated to less than-10 DEG C, be evacuated to below drying chamber pressure 30Pa, subliming by heating; The temperature of distillation should control below 40 DEG C, and the temperature of resolution phase controls below 45 DEG C, to dry.
embodiment 4
Periplaneta americana boiling water of living scalds dead, and weighing is 3kg, adds milk 3kg, dries.
embodiment 5
Periplaneta americana soak with ethanol of living is killed, and weighing is 1kg, adds milk 1kg, less than 60 DEG C oven dry.
embodiment 6
Periplaneta americana boiling water of living scalds dead, and weighing is 3kg, adds milk 20kg, less than 60 DEG C oven dry.
embodiment 7
3kg lives periplaneta americana, puts into the 30kg milk that boils and scalds dead, put in freeze dryer, lyophilizing.
embodiment 8
3kg lives periplaneta americana, puts into the 9kg milk that boils and scalds dead, less than 80 DEG C oven dry.
embodiment 9
3kg lives periplaneta americana, puts into the 4kg milk that boils and scalds dead, dry.
embodiment 10
3kg lives periplaneta americana, puts into the 3kg milk that boils and scalds dead, dry.
embodiment 11
The dry periplaneta americana of 3kg, adds milk 3kg, and less than 80 DEG C dry.
embodiment 11
The dry periplaneta americana of 3kg, adds milk 30kg, and less than 60 DEG C dry.
embodiment 12
The dry periplaneta americana of 3kg, adds milk 90kg, and less than 60 DEG C dry.
embodiment 13
The dry periplaneta americana of 3kg, adds milk powder 0.3kg, mixing, pulverizes.
embodiment 14
The dry periplaneta americana of 3kg, adds milk powder 9kg, mixing, pulverizes.
embodiment 15
The dry periplaneta americana of 3kg, adds milk powder 4.5kg, mixing, pulverizes.
Claims (7)
1. a processing method for free from extraneous odour periplaneta americana, is characterized in that: the course of processing adds milk.
2. the processing method of a kind of free from extraneous odour periplaneta americana according to claim 1, is characterized in that: the amount adding milk is fresh periplaneta americana by weight: milk=more than 1:0.5.
3. the processing method of a kind of free from extraneous odour periplaneta americana according to claim 1, is characterized in that: periplaneta americana soak with ethanol of living is killed or boiling water scalds dead, dry after adding milk.
4. the processing method of a kind of free from extraneous odour periplaneta americana according to claim 1, is characterized in that: the periplaneta americana that lives puts into the 1-10 milk that boils doubly by weight, dry.
5. the processing method of a kind of free from extraneous odour periplaneta americana according to claim 1, is characterized in that: dry periplaneta americana is dry after adding milk.
6. according to the processing method of a kind of free from extraneous odour periplaneta americana of claim 1 or claim 5, it is characterized in that: dry periplaneta americana is dry after adding milk, and the amount adding milk is dry periplaneta americana by weight: milk=more than 1:1.
7. the processing method of a kind of free from extraneous odour periplaneta americana according to claim 1, is characterized in that: dry periplaneta americana adds milk powder, mixing, pulverizes; The amount adding milk powder is dry periplaneta americana by weight: milk powder=1:0.1-3.
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101167749A (en) * | 2007-11-09 | 2008-04-30 | 重庆医药工业研究院有限责任公司 | Preparing method for improving toad venom taste |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN101167749A (en) * | 2007-11-09 | 2008-04-30 | 重庆医药工业研究院有限责任公司 | Preparing method for improving toad venom taste |
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