CN104606252A

CN104606252A - Pressure reducing and drying method for periplaneta americana

Info

Publication number: CN104606252A
Application number: CN201510096345.6A
Authority: CN
Inventors: 苏静; 许翠萍; 牛凤菊; 张为胜; 李诗标
Original assignee: Jinan Kangzhong Pharmaceutical Research and Development Co Ltd
Current assignee: Jinan Kangzhong Pharmaceutical Research and Development Co Ltd
Priority date: 2015-03-05
Filing date: 2015-03-05
Publication date: 2015-05-13

Abstract

The invention relates to a pressure reducing and drying method for periplaneta americana. Live periplaneta americana is put into milk for pressure reducing and drying. The prepared periplaneta americana is high in activity, small in peculiar smell during oral administration and excellent in compliance of patients.

Description

The decompression drying method of a kind of periplaneta americana

Invention field

The present invention relates to medicine method for making, particularly the decompression drying method of a kind of periplaneta americana, belong to medical art.

Background technology

Periplaneta americana belongs to Insecta, Blattaria Blattidae animal, and " Blatta seu periplaneta " is loaded in Shennong's Herbal for its popular name, the beginning of being used as medicine, and is listed in middle product, meaning " taste: salty, cold; Control: the hard cold and heat of Blood stasis, removing mass are poly-, laryngopharynx numbness, endogenous cold loss of fecundity ".Now there are some researches show, the large sickle in America has and has good tissue repair activity to various traumatic surface and digestive tract ulcer; There is boosting, improve sanguimotor activity; There is the activity of anti-bacteria and anti-virus; There is antitumor, strengthen immunologic function activity.

The processing method of the large sickle in prior art America, is to kill by soak with ethanol after catching or boiling water scalds dead, dries or dry.With the large sickle in America of prior art processing, abnormal flavour is extra heavy, and mouthfeel is very poor, directly affects the compliance of patient.Over the past thousands of years, people always encourage patient medication with " good medicine tastes bitter ".But the reality of society is, people hang back in face of good medicine bitter to the taste, even talk " hardship " complexion changed.Although periplaneta americana is to various diseases determined curative effect, patient also keeps someone at a respectful distance.Improve mouthfeel by processing, raising curative effect is very necessary.

Summary of the invention

The object of this invention is to provide the drying means that a kind of periplaneta americana is new, the oral abnormal flavour of obtained periplaneta americana is little.

The object of the invention is to be realized by drying under reduced pressure in milk:

A decompression drying method for periplaneta americana, the periplaneta americana that lives puts into milk drying under reduced pressure.

The decompression drying method of a kind of periplaneta americana of the present invention, is characterized in that: drying under reduced pressure is: less than 60 DEG C drying under reduced pressure.

The decompression drying method of a kind of periplaneta americana of the present invention, is characterized in that: the consumption of milk is 2-5 times of periplaneta americana by weight.

The decompression drying method of a kind of periplaneta americana of the present invention, is characterized in that: drying under reduced pressure is that pressure is at below 2kPa.

So far the present invention is completed.The periplaneta americana biological activity that the present invention obtains is high, oral free from extraneous odour, and the compliance of patient is high.

Below by test example, usefulness of the present invention is described.Test example is intended to further illustrate beneficial effect of the present invention below, but not restriction of the present invention.

By same mass products periplaneta americana, process by the following method.

1) boiling water scalds dead oven dry: scald with boiling water dead, less than 60 DEG C oven dry, pulverize;

2) drying under reduced pressure in milk: the milk putting into 2 times by weight, puts in constant temperature drying under reduced pressure case, at pressure 2kPa, dry, pulverize under temperature 60 C.

The periplaneta americana mouthfeel of test example one, distinct methods processing compares

Get the Periplaneta Americana powder that boiling water scalds drying under reduced pressure in dead oven dry and milk respectively, mix well with warm water, be made up of 10 people and appraise group through discussion, everyone is oral two kinds of Periplaneta Americana powder respectively, evaluate the mouthfeel concept such as " very well ", " better ", " can accept ", " poor ", " very poor ".The results are shown in Table 1

The Periplaneta Americana powder mouthfeel of table 1 distinct methods drying compares

	Very well	Better	Can accept	Poor	Very poor
						Drying under reduced pressure in milk	0 people	6 people	4 people	0 people	0 people
Boiling water scalds dead oven dry	0 people	0 people	0 people	2 people	8 people

Result shows, and the periplaneta americana of drying under reduced pressure in milk is described, oral abnormal flavour is little, and mouthfeel is good, and the compliance of patient is good.

Test example two, different processing methods compare the protective effect that ethanol causes gastric mucosa damage.

Choose healthy SD rat, male and female half and half, weight 180-220g, be divided into matched group at random, boiling water scalds drying under reduced pressure group in dead oven dry group, milk, often organize 10, test group gastric infusion every day 1 time, 1 2mg/kg(solid contents after testing milk lyophilizing is 12%, in milk, the periplaneta americana of drying under reduced pressure is in clean periplaneta americana), continuous 7 days, matched group gave equivalent distilled water.Before experiment, the first fasting 48h of rat, freely drinks water, after last administration, 1h every rat oral gavage dehydrated alcohol 1mL/ only, take off cervical vertebra after 1h and put to death animal, close cardia by clip, inject 1% formaldehyde 5mL from pylorus, folder closes pylorus again, put into 1% formalin and fix 10min, cut off coat of the stomach along greater gastric curvature, measure damaged length, as gastric mucosal damage index, and suppression ratio is calculated using damaged length (width is greater than 1 mm to be doubled) summation.The results are shown in Table 2.

Suppression ratio (%)=(matched group ulcer index one administration group ulcer index) ÷ matched group ulcer index × 100%.

The periplaneta americana of table 2 distinct methods drying is compared the protective effect that ethanol causes gastric mucosa damage

Group	Dosage	Gastric mucosal damage index (mm)	Suppression ratio (%)
				Matched group		111.2±13.4
Boiling water scalds dead oven dry group	2mg/kg	70.5±12.5	35.7
				Drying under reduced pressure group in milk	2mg/kg	51.7±11.6	53.5

Result shows, in milk, the periplaneta americana of drying under reduced pressure is better than to the protective effect that ethanol causes gastric mucosa damage the periplaneta americana that boiling water scalds dead oven dry, and the periplaneta americana good effect of drying under reduced pressure in milk is described.

Detailed description of the invention

embodiment 1

5kg periplaneta americana alive, puts into the milk of 10kg, puts in constant temperature drying under reduced pressure case, at pressure 2kPa, dry under temperature 60 C, obtains free from extraneous odour periplaneta americana.

embodiment 2

5kg periplaneta americana alive, puts into the milk of 25kg, puts in constant temperature drying under reduced pressure case, at pressure 2.5kPa, dry under temperature 50 C, obtains free from extraneous odour periplaneta americana.

embodiment 3

5kg periplaneta americana alive, puts into the milk of 15kg, puts in constant temperature drying under reduced pressure case, at pressure 3kPa, dry under temperature 60 C, obtains free from extraneous odour periplaneta americana.

embodiment 4

5kg periplaneta americana alive, puts into the milk of 25kg, puts in constant temperature drying under reduced pressure case, at pressure 2.6kPa, dry under temperature 60 C, obtains free from extraneous odour periplaneta americana.

Claims

1. a decompression drying method for periplaneta americana, is characterized in that: the periplaneta americana that lives puts into milk drying under reduced pressure.

2. the decompression drying method of a kind of periplaneta americana according to claim 1, is characterized in that: drying under reduced pressure is: less than 60 DEG C drying under reduced pressure.

3. the decompression drying method of a kind of periplaneta americana according to claim 1, is characterized in that: the consumption of milk is 2-5 times of periplaneta americana by weight.

4. the decompression drying method of a kind of Eupolyphaga Seu Steleophaga according to claim 1, is characterized in that: drying under reduced pressure is that pressure is at below 2kPa.