CN103919813A - Preparation method of periplaneta americana superfine-grinding granulate piece - Google Patents
Preparation method of periplaneta americana superfine-grinding granulate piece Download PDFInfo
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- CN103919813A CN103919813A CN201410181331.XA CN201410181331A CN103919813A CN 103919813 A CN103919813 A CN 103919813A CN 201410181331 A CN201410181331 A CN 201410181331A CN 103919813 A CN103919813 A CN 103919813A
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Abstract
The invention relates to a preparation method of a traditional Chinese medicine piece, and in particular relates to a preparation method of a periplaneta americana superfine-grinding granulate piece. The preparation method mainly comprises the steps of fasting, catching and killing, drying, degreasing, superfine grinding, mixing, pelletizing, completely mixing, and packing by quantity, etc. The preparation method has the advantages that any excipient, binding agent and other auxiliary materials are not added, the natural characteristics of the traditional Chinese medicine are kept in a hundred percent, the advantages of the traditional Chinese medicine are remained, and a patient is convenient to take; the process is regular, the parameters are easy to detect and control, and large-scale and mass production is easily carried out; petroleum ether with boiling range of 60 to 90 DEG C is used as a degreasing solvent, which is high in volatility, nontoxic and easy to remove; in addition, petroleum ether is reusable, so that the resource is saved.
Description
Technical field
The present invention relates to a kind of preparation method of the prepared slices of Chinese crude drugs, particularly relate to a kind of preparation method of periplaneta americana superfine powder granule pieces.
Background technology
Periplaneta americana (Periploneta americana) is the insecticide of volume maximum in Blattidae.Become long 29～35 millimeters of polypide, bronzing, wing is longer than abdomen end.Feeler is very long, in the middle of pronotary, has larger butterfly brown speckle, and the trailing edge of speckle has complete yellow band stricture of vagina.Before 300,015,000 years, they just occur on earth; After Japan's nuclear explosion, only having them is only survivor.
The dry polypide of periplaneta americana is traditional Chinese crude drug, and salty in the mouth cold in nature, returns liver,spleen,kidney warp.There is promoting blood circulation to remove blood stasis, the functions such as infantile malnutrition, inducing diuresis to remove edema that disappear of detoxifying.Cure mainly lump in the abdomen, infantile malnutrition, beriberi edema, furuncle, toxic swelling and worm venom.
Modern study finds, periplaneta americana epidermis contains sclerotin and chitin, the elements such as bromine, zinc, nickel, violent, potassium, calcium, titanium, chlorine, sulfur, silicon, aluminum, magnesium.Muscle is hydrolyzed 13 seed amino acids.In addition, health is preserved the plain B of micro-life
1b
2, nicotinic acid and ascorbic acid etc., lymph is containing trehalose, trehalase, glycoprotein, inositol, protocatechuic acid Fructus Vitis viniferae glycoside etc.All containing ergothioneine, 1-methyl-2-pyridinium carboxylate, trigonelline, glycine, betanin, anus alkali, trimethylamine, adenine etc.The report periplaneta americana main chemical compositions such as what of Dali College mainly contain pheromone, free amino acid and neuropeptide etc. in positive spring, mainly contain 10 several amino acids, wherein 7 kinds of essential amino acids, 2 kinds of human body semi-dispensable amino acids.The large Lian of modern pharmacological research discovered America (1) ethanol extraction has growth inhibited effect to multiple JEG-3, can promote apoptosis of tumor cells; (2) worm powder has nonspecific immunity regulating action, can improve cell-specific immunity and body fluid specific immunity; (3) hepatic injury is had to protective effect; (4) can promote the growth of wound surface granulation, accelerate tissue repair; (5) there are obvious antiinflammatory, analgesic activity.
Inventor's research shows, in the ethanol extraction (rehabilitation is new) of periplaneta americana, contains several amino acids.Kilnitamin has obvious antiinflammatory action, and its Free Amino Acids is main component, accounts for more than 15% (in the dry product) of extract; Also contain a small amount of multicomponent alcoholics compound, for promoting the effective ingredient of granulation hyperplasia; And sticky sugared propylhomoserin (name temporarily), for regulating the material of immunity of organism, be mainly molecule amount and be distributed in the aminoacid of 300 ~ 1300Da and the conjugate of non-aminoacid aglucon, it accounts for the new 10%(of rehabilitation in dry product in conjunction with aminoacid).In addition, also contain a certain amount of nucleoside pyrimidine bases, can strengthening heart and boosting pressure. improve microcirculation, excited breathing, diuresis, increases the heart, brain, lung, the blood flow of kidney.
Periplaneta americana is because there being above-mentioned many good pharmacologically actives, so use or make clinically or directly corresponding preparations extensive use.Because periplaneta americana belongs to insects medical material, there is special niff, therefore directly use popularization difficulty larger as medicine clinically.For this reason, in prior art, the application of periplaneta americana is adopted ethanol extraction more, removes the method for fat constituent, refining effective ingredients enrichment again, add various excipient etc. simultaneously and make the preparation of corresponding different purposes, as the Kangfuxin Liquid for burn and scald and digestive tract ulcer treatment, for the Ganglong capsule for the treatment of hepatitis B, for the Xinmailong injection of heart failure treatment.These means not only processing technique are loaded down with trivial details, and cause various nutrient substance contained in periplaneta americana and effective ingredient run off or can not get fully playing.
Summary of the invention
The object of the invention is to overcome the deficiencies in the prior art, a kind of preparation method of periplaneta americana superfine powder granule pieces is provided, the all natural characteristic that adopts the method effectively can effectively keep this Chinese crude drug self to have, and improve dissolution rate and the stripping quantity of effective ingredient, thereby accomplish to greatest extent the utilization of resource.
Object of the present invention is achieved through the following technical solutions:
A preparation method for periplaneta americana superfine powder granule pieces, comprises the following steps:
(1) fasting: stop the feedstuff of throwing something and feeding, essential drinking water is only provided for 3 ~ 7 days before adult bombay canary is catched and killed.
(2) catch and kill: adopt high-temperature vapor to scald that dead method is nuisanceless catches and kills overdue fasting adult bombay canary;
(3) dry: by dry above-mentioned dead worm rapid decompression, control temperature is 50 ~ 60 DEG C, degree of drying is pinched worm tripe with hands and can be crumbed and be advisable, now water content approximately 3% ~ 9%;
(4) defat: get above-mentioned dry worm, add petroleum ether (60 ~ 90 DEG C of boiling ranges) soak degreasing in the ratio of 100kg:50 ~ 90kg, soak time approximately 16 ~ 24 hours, then leaches polypide, under 40 ~ 60 DEG C of conditions, low temperature decompression drying is extremely without petroleum ether taste.Dry worm after defat is containing oil quantity approximately 3% ~ 8%;
(5) micronizing: the dry worm after extracting degreasing is ground into micropowders with high-frequency vibration mill under cryogenic conditions, granularity is 120 ~ 300 orders;
(6) mix: get the fine powder mix homogeneously after (5) pulverizing, keep color and luster consistent;
(7) granulate: get (6) mixed micropowders and granulate, the grain graininess making is about 12 ~ 40 orders;
(8) always mixed: get the granule mix homogeneously that (7) make, or tabletting or filled capsules, make the content difference of every batch of product, each sample point particulate samples be no more than 2%;
(9) weight packaging.
Preferably, what step (1) was described stop throwing something and feeding, and the feedstuff time is that adult is catched and killed first 4 ~ 6 days, and main purpose is the feces draining in polypide, suitably consumes the useless fat of cylinder accumulation.
The described high-temperature vapor of step (2) scalds dead method killing living worm fast.Live worm from entering high-temperature vapor region, to shifting out, be no more than 5 minutes, both can kill by high temperature thus antibacterial and other microorganisms on polypide surface, can retain to greatest extent again the active effective ingredient of periplaneta americana.
Preferably, the described water content of step (3) can adopt the first method (oven drying method) of an annex IX H aquametry of " Chinese Pharmacopoeia " version in 2010 to measure, and moisture Control is 4 ~ 7%.Moisture is too high, is unfavorable for preserving; Moisture Control is too low, and energy consumption is too high, is unfavorable for cost control.
Preferably, when the described defat of step (4) the dry worm of every 100kg to add petroleum ether be 70kg, the polypide fat content control after defat is 3% ~ 6%.Petroleum ether liquid after filtering polypide can reclaim petroleum ether solvent, continues to use, at every turn the petroleum ether approximately 30% of defat institute loss as lower batch of dry CHONGTUO fatsolvent.
Preferably, described grain graininess control 12 ~ 24 order granules of step (7) must not be lower than 85%.Described granule adopts conventional granulating process to granulate.
Advantage of the present invention and effect are as follows
1, the present invention does not add the adjuvants such as any excipient, binding agent, and 100% keeps all natural characteristic that has of Chinese medicine self, has kept the advantage of Chinese medicine, facilitates again patient to take;
2, technological specification of the present invention, parameter is easy to detect and controls, and is applicable to scale and produces in enormous quantities;
3, the present invention selects the petroleum ether of 60 ~ 90 DEG C of boiling ranges as degreasing solvent, and high volatility is nontoxic, and easily removal, and petroleum ether can be reused, and has saved resource;
4, gained periplaneta americana superfine powder granule pieces of the present invention and periplaneta americana ethanol extraction compare Multiple components, and result is as follows:
As seen from the above table; although the raw material that periplaneta americana corresponding preparations is used---periplaneta americana ethanol extraction has just carried out enrichment in the effective ingredient aspect such as free amino acid, small-molecular peptides and pyrimidine base, lose a large amount of to the useful protein of human body, fat, mineral and vitamin; Although and the content of total sugar, free amino acid decreases in the periplaneta americana superfine powder granule pieces of employing institute of the present invention output, wherein the content of the useful protein of human body, fat, minerals and vitamins is but increased considerably.
Detailed description of the invention
Followingly by embodiment, the present invention is described in further detail, these embodiment are only used for illustrating the present invention, but protection scope of the present invention is not limit by embodiment.
Embodiment 1
A preparation method for periplaneta americana superfine powder granule pieces, is prepared in accordance with the following steps:
(1) fasting: stop the feedstuff of throwing something and feeding, essential drinking water is only provided for 3 days before adult bombay canary is catched and killed;
(2) catch and kill: adopt high-temperature vapor to scald that dead method is nuisanceless catches and kills overdue fasting adult bombay canary, periplaneta americana is from entering high-temperature vapor region, and to shifting out vapor region, the time of staying is no more than 5 minutes;
(3) dry: by dry above-mentioned dead worm rapid decompression, control temperature is 50 ± 2 DEG C, degree of drying is pinched worm tripe with hands and can be crumbed and be advisable, and now water content is 3%;
(4) defat: get above-mentioned dry worm, add petroleum ether (60 ~ 90 DEG C of boiling ranges) soak degreasing in the ratio of 100kg:50kg, soak time approximately 16 hours, then leaches polypide, under 40 DEG C of conditions, low temperature decompression drying is extremely without petroleum ether taste.Dry worm after defat is containing oil quantity approximately 8%;
(5) micronizing: the dry worm after extracting degreasing is ground into micropowders with high-frequency vibration mill under cryogenic conditions, controls granularity at 120 ~ 180 orders;
(6) mix: get the fine powder mix homogeneously after (5) pulverizing, keep color and luster consistent;
(7) granulate: get (6) mixed micropowders and granulate, the grain graininess making is 12 ~ 24 orders (accounting for more than 85%);
(8) always mixed: get the granule mix homogeneously that (7) make, or tabletting or filled capsules, make the content difference of every batch of product, each sample point particulate samples be no more than 2%;
(9) weight packaging.
Embodiment 2
A preparation method for periplaneta americana superfine powder granule pieces, is prepared in accordance with the following steps:
(1) fasting: stop the feedstuff of throwing something and feeding, essential drinking water is only provided for 5 days before adult bombay canary is catched and killed;
(2) catch and kill: adopt high-temperature vapor to scald that dead method is nuisanceless catches and kills overdue fasting adult bombay canary;
(3) dry: by dry above-mentioned dead worm rapid decompression, control temperature is 55 ± 2 DEG C, degree of drying is pinched worm tripe with hands and can be crumbed and be advisable, and now water content is 6%;
(4) defat: get above-mentioned dry worm, add petroleum ether (60 ~ 90 DEG C of boiling ranges) soak degreasing in the ratio of 100kg:70kg, soak time approximately 24 hours, then leaches polypide, under 50 DEG C of conditions, low temperature decompression drying is extremely without petroleum ether taste.Dry worm after defat is containing oil quantity approximately 6%;
(5) micronizing: the dry worm after extracting degreasing is ground into micropowders with high-frequency vibration mill under cryogenic conditions, controls granularity at 180 ~ 240 orders;
(6) mix: get the fine powder mix homogeneously after (5) pulverizing, keep color and luster consistent;
(7) granulate: get (6) mixed micropowders and granulate, the grain graininess making is 24 ~ 30 orders (accounting for more than 85%);
(8) always mixed: get the granule mix homogeneously that (7) make, or tabletting or filled capsules, make the content difference of every batch of product, each sample point particulate samples be no more than 2%;
(9) weight packaging.
Embodiment 3
A preparation method for periplaneta americana superfine powder granule pieces, is prepared in accordance with the following steps:
(1) fasting: stop the feedstuff of throwing something and feeding, essential drinking water is only provided for 7 days before adult bombay canary is catched and killed;
(2) catch and kill: adopt high-temperature vapor to scald that dead method is nuisanceless catches and kills overdue fasting adult bombay canary;
(3) dry: by dry above-mentioned dead worm rapid decompression, control temperature is 60 ± 2 DEG C, degree of drying is pinched worm tripe with hands and can be crumbed and be advisable, and now water content is 9%;
(4) defat: get above-mentioned dry worm, add petroleum ether (60 ~ 90 DEG C of boiling ranges) soak degreasing in the ratio of 100kg:90kg, soak time approximately 18 hours, then leaches polypide, under 60 DEG C of conditions, low temperature decompression drying is extremely without petroleum ether taste.Dry worm after defat is containing oil quantity approximately 3%;
(5) micronizing: the dry worm after extracting degreasing is ground into micropowders with high-frequency vibration mill under cryogenic conditions, controls granularity at 240 ~ 300 orders;
(6) mix: get the fine powder mix homogeneously after (5) pulverizing, keep color and luster consistent;
(7) granulate: get (6) mixed micropowders and granulate, the grain graininess making is about 30 ~ 40 orders (accounting for more than 85%);
(8) always mixed: get the granule mix homogeneously that (7) make, or tabletting or filled capsules, make the content difference of every batch of product, each sample point particulate samples be no more than 2%;
(9) weight packaging.
Claims (7)
1. a preparation method for periplaneta americana superfine powder granule pieces, is characterized in that the method carries out as follows:
(1) fasting: stop the feedstuff of throwing something and feeding, essential drinking water is only provided for 3 ~ 7 days before adult bombay canary is catched and killed;
(2) catch and kill: adopt high-temperature vapor to scald that dead method is nuisanceless catches and kills overdue fasting adult bombay canary;
(3) dry: above-mentioned dead worm rapid decompression at 50 ~ 60 DEG C is dried to hands and pinches worm tripe and can crumb, water content is controlled at 3% ~ 9%;
(4) defat: get above-mentioned dry worm, add the petroleum ether soak degreasing of 60 ~ 90 DEG C of boiling ranges in the ratio of 100kg:50 ~ 90kg, soak time is controlled at 16 ~ 24 hours, then polypide is leached, under 40 ~ 60 DEG C of conditions, low temperature decompression drying is extremely without petroleum ether taste, and the dry worm after defat is controlled at 3% ~ 8% containing oil quantity;
(5) micronizing: the dry worm after extracting degreasing is ground into micropowders with high-frequency vibration mill under cryogenic conditions, and granularity is controlled at 120 ~ 300 orders;
(6) mix: get the fine powder mix homogeneously after (5) pulverizing, keep color and luster consistent;
(7) granulate: get (6) mixed micropowders and granulate, the grain graininess making is controlled at 12 ~ 40 orders;
(8) always mixed: get the granule mix homogeneously that (7) make, or tabletting or filled capsules, make the content difference of every batch of product, each sample point particulate samples be no more than 2%;
(9) weight packaging.
2. the preparation method of a kind of periplaneta americana superfine powder granule pieces according to claim 1, is characterized in that described the stopping of step (1) feedstuff time of throwing something and feeding is that adult is catched and killed first 4 ~ 6 days.
3. the preparation method of a kind of periplaneta americana superfine powder granule pieces according to claim 1, it is characterized in that the described high-temperature vapor of step (2) scalds dead method, periplaneta americana is from entering high-temperature vapor region, and to shifting out vapor region, the time of staying is no more than 5 minutes.
4. the preparation method of a kind of periplaneta americana superfine powder granule pieces according to claim 1, is characterized in that the described water content of step (3) is controlled at 4 ~ 7%.
5. the preparation method of a kind of periplaneta americana superfine powder granule pieces according to claim 1, while it is characterized in that the described defat of step (4) the dry worm of every 100kg to add petroleum ether be 70kg, the dry worm after defat is 3% ~ 6% containing oil quantity.
6. the preparation method of a kind of periplaneta americana superfine powder granule pieces according to claim 1, is characterized in that according to the prepared granule of step (7), granularity is that 12 ~ 24 object grain amounts must not be lower than 85% of total particle quantity.
7. the preparation method of a kind of periplaneta americana superfine powder granule pieces according to claim 4, is characterized in that petroleum ether solvent used is recyclable to be repeatedly used.
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Cited By (6)
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| CN104606252A (en) * | 2015-03-05 | 2015-05-13 | 济南康众医药科技开发有限公司 | Pressure reducing and drying method for periplaneta americana |
| CN104644683A (en) * | 2015-02-26 | 2015-05-27 | 王福明 | American cockroach chewable tablet, preparation method and use |
| CN104784214A (en) * | 2014-12-21 | 2015-07-22 | 昆明赛诺制药有限公司 | A periplaneta americana extract micropore osmotic pump tablet and a preparing method thereof |
| CN104872080A (en) * | 2015-06-05 | 2015-09-02 | 袁玥 | Artificial feeding method of mantises |
| CN104872381A (en) * | 2015-06-05 | 2015-09-02 | 袁玥 | Special feed for young mantises artificially cultured |
| CN107349224A (en) * | 2017-07-17 | 2017-11-17 | 山东巧宾农业科技有限公司 | Application of the blattaria in terms of body fat rate is reduced |
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Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN104784214A (en) * | 2014-12-21 | 2015-07-22 | 昆明赛诺制药有限公司 | A periplaneta americana extract micropore osmotic pump tablet and a preparing method thereof |
| CN104784214B (en) * | 2014-12-21 | 2019-05-31 | 昆明赛诺制药股份有限公司 | A kind of American-cockroach-extract micro hole seep irrigation and preparation method thereof |
| CN104644683A (en) * | 2015-02-26 | 2015-05-27 | 王福明 | American cockroach chewable tablet, preparation method and use |
| CN104606252A (en) * | 2015-03-05 | 2015-05-13 | 济南康众医药科技开发有限公司 | Pressure reducing and drying method for periplaneta americana |
| CN104872080A (en) * | 2015-06-05 | 2015-09-02 | 袁玥 | Artificial feeding method of mantises |
| CN104872381A (en) * | 2015-06-05 | 2015-09-02 | 袁玥 | Special feed for young mantises artificially cultured |
| CN107349224A (en) * | 2017-07-17 | 2017-11-17 | 山东巧宾农业科技有限公司 | Application of the blattaria in terms of body fat rate is reduced |
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Address after: Economic and Technological Development Zone Information Industry Base in Yunnan province Kunming city forest road 650000 No. 160 Applicant after: Kunming cinorch pharmaceutical Limited by Share Ltd Address before: Economic development zone information industry base in Yunnan province Kunming city forest road 650000 Applicant before: Kunming Sinoway Natural Pharmaceuticals Co., Ltd. |
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Application publication date: 20140716 |